| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Chieh Lin, Hsiu-Chu Chou, Bor-Luen Chiang, Chung-Ming Che. CTGF upregulation correlates with MMP-9 level in airway remodeling in a murine model of asthma. Archives of medical science : AMS. vol 13. issue 3. 2020-09-30. PMID:28507585. |
connective tissue growth factor (ctgf) mediates hypertrophy, proliferation, and extracellular matrix synthesis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
an approach to in vitro manufacturing of hypertrophic cartilage matrix for bone repair. |
2020-09-30 |
2023-08-13 |
human |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
devitalized hypertrophic cartilage matrix (dcm) is an attractive concept for an off-the-shelf bone graft substitute. |
2020-09-30 |
2023-08-13 |
human |
| Bach Quang Le, Clemens Van Blitterswijk, Jan De Boe. An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair. Bioengineering (Basel, Switzerland). vol 4. issue 2. 2020-09-30. PMID:28952514. |
upon implantation, dcm can trigger the natural endochondral ossification process, but only when the hypertrophic cartilage matrix has been reconstituted correctly. |
2020-09-30 |
2023-08-13 |
human |
| Taryn E Travis, Pejhman Ghassemi, Nicholas J Prindeze, Lauren T Moffatt, Bonnie C Carney, Abdulnaser Alkhalil, Jessica C Ramella-Roman, Jeffrey W Shup. Matrix Metalloproteinases Are Differentially Regulated and Responsive to Compression Therapy in a Red Duroc Model of Hypertrophic Scar. Eplasty. vol 18. 2020-09-30. PMID:29375731. |
matrix metalloproteinases are differentially regulated and responsive to compression therapy in a red duroc model of hypertrophic scar. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jun Qi, Yifei Liu, Kesu Hu, Yi Zhang, Yangyang Wu, Xia Zhan. MicroRNA-26a inhibits hyperplastic scar formation by targeting Smad2. Experimental and therapeutic medicine. vol 15. issue 5. 2020-09-30. PMID:29731824. |
hypertrophic scar (hs) is a fibrotic disease in which excessive extracellular matrix forms due to the response of fibroblasts to tissue damage. |
2020-09-30 |
2023-08-13 |
human |
| Kevin A Murach, Davis A Englund, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterso. Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy. Frontiers in physiology. vol 9. 2020-09-30. PMID:29896117. |
satellite cells respond to muscle damage, and also play an important role in extracellular matrix remodeling during loading-induced hypertrophy. |
2020-09-30 |
2023-08-13 |
Not clear |
| M M Akhtar, P M Elliot. Anderson-Fabry disease in heart failure. Biophysical reviews. vol 10. issue 4. 2020-09-30. PMID:29909504. |
gb3 accumulation induces pathology via the release of pro-inflammatory cytokines, growth-promoting factors and by oxidative stress, resulting in myocardial extracellular matrix remodelling, left ventricular hypertrophy (lvh), vascular dysfunction and interstitial fibrosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Eduardo T Santana, Regiane Dos Santos Feliciano, Andrey J Serra, Eduardo Brigidio, Ednei L Antonio, Paulo J F Tucci, Lubov Nathanson, Mariana Morris, José A Silv. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. Frontiers in physiology. vol 7. 2020-09-29. PMID:27932994. |
we analyzed 48 mrnas expressions of nine different signal transduction pathways (cell survival and metabolism signs, matrix extracellular, cell cycle, oxidative stress, apoptosis, calcium signaling, hypertrophy markers, angiogenesis, and inflammation) in rat left ventricle 1 week after mi generated by both coronary occlusion and ab-rf. |
2020-09-29 |
2023-08-13 |
rat |
| O P Molodykh, I V Sorokina, E V Vinogradova, V I Kapustina, A A Khodako. Ultrastructure of the Liver in Response to Cyclophosphamide and Triterpenoids. Bulletin of experimental biology and medicine. vol 168. issue 3. 2020-09-28. PMID:31938907. |
the cytotoxic effect of betulonic acid manifests in modification of the fine structure of hepatocyte mitochondria, sequestration of glycogen, intensification of autophagic processes, emergence of necrobiotic changes in hepatocytes and endotheliocytes; betulonic acid amide actively modifies the mitochondrial fine structure (hypertrophic organelles, matrix rarefaction, uneven dilatation of cristae). |
2020-09-28 |
2023-08-13 |
Not clear |
| Wenqiang Yan, Xingquan Xu, Qian Xu, Ziying Sun, Qing Jiang, Dongquan Sh. Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up. Regenerative biomaterials. vol 7. issue 1. 2020-09-28. PMID:32153994. |
the ha hydrogel combined with prp-treated group showed more hyaline-like cartilage exhibited by macroscopic appearance and histological staining in terms of extracellular matrix and type ii collagen without formation of hypertrophic cartilage, indicating its capacity to improve cartilage healing in the minipig model evaluated at 6 months, with full-thickness cartilage defect of 8.5 mm diameter and osteochondral defect of 6.5 mm diameter, 5 mm depth exhibiting apparent regeneration. |
2020-09-28 |
2023-08-13 |
rabbit |
| Eri Shirakami, Sho Yamakawa, Kenji Hayashid. Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence. Burns & trauma. vol 8. 2020-09-28. PMID:32341924. |
hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jingjie Luan, Haitao Tao, Yue S. Taladegib controls early chondrocyte hypertrophy via inhibiting smoothened/Gli1 pathway. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509193. |
abs treatment accelerated the process of chondrocyte hypertrophy and upregulated the expression of type x collagen, matrix metalloproteinase-13 (mmp-13), runx-2 but decreased type ii collagen, sox-9, and aggrecan both in protein and mrna levels, which abolished by the present of taladegib with the activation of smo and gli1. |
2020-09-28 |
2023-08-13 |
human |
| Asish K Ghos. p300 in Cardiac Development and Accelerated Cardiac Aging. Aging and disease. vol 11. issue 4. 2020-09-28. PMID:32765954. |
stress-induced vascular injury activates pathways involved in pathogenesis of accelerated cardiac aging that includes cellular dysfunction, pathological cardiac hypertrophy, diabetic cardiomyopathy, cardiac matrix remodeling, cardiac dysfunction and heart failure. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jinwei Zhang, Jideng Ma, Xiankun Zhou, Silu Hu, Liangpeng Ge, Jing Sun, Penghao Li, Keren Long, Long Jin, Qianzi Tang, Lingyan Liu, Xuewei Li, Surong Shuai, Mingzhou L. Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis. Frontiers in genetics. vol 11. 2020-09-28. PMID:32849828. |
hypoxia differentially modulated the expression profile of adipose-associated genes, including adipokines, lipogenesis, lipolysis, hyperplasia, hypertrophy, inflammatory, and extracellular matrix. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yücel Ağırdi. The growth plate: a physiologic overview. EFORT open reviews. vol 5. issue 8. 2020-09-28. PMID:32953135. |
its structure comprises chondrocytes suspended in a collagen matrix that go through several stages of maturation until they finally die, and are replaced by osteoblasts, osteoclasts, and lamellar bone.the process of endochondral ossification is coordinated by chondrocytes and a variety of humoral factors including growth hormone, parathyroid hormone, oestrogen, growth factors, cytokines, and various signalling pathways.chondrocytes progress from a resting state to enter the phases of proliferation and hypertrophy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Mengfei Cao, Wei Yuan, Meiling Peng, Ziqi Mao, Qianru Zhao, Xia Sun, Jinchuan Ya. Role of CyPA in cardiac hypertrophy and remodeling. Bioscience reports. vol 39. issue 12. 2020-09-23. PMID:31825469. |
cypa from blood vessels and the heart itself participate in a variety of signaling pathways to regulate the production of reactive oxygen species (ros) and mediate inflammation, promote cardiomyocyte hypertrophy and proliferation of cardiac fibroblasts, stimulate endothelial injury and vascular smooth muscle hyperplasia, and promote the dissolution of extracellular matrix (ecm) by activating matrix metalloproteinases (mmps). |
2020-09-23 |
2023-08-13 |
Not clear |
| Sandra Camarero-Espinosa, Justin J Cooper-Whit. Combinatorial presentation of cartilage-inspired peptides on nanopatterned surfaces enables directed differentiation of human mesenchymal stem cells towards distinct articular chondrogenic phenotypes. Biomaterials. vol 210. 2020-09-10. PMID:31060868. |
human articular cartilage is a complex multi-zonal tissue in which cells displaying three chondrocyte phenotypes (persistent, transient and hypertrophic) are supported and maintained by distinctly different (zonal) combinations of extracellular matrix (ecm) molecules. |
2020-09-10 |
2023-08-13 |
human |
| Alaeddine El Jamal, Anne Briolay, Saida Mebarek, Benoit Le Goff, Frédéric Blanchard, David Magne, Leyre Brizuela, Carole Bougaul. Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 34. issue 12. 2020-09-10. PMID:31373726. |
in addition, when the osteogenic culture medium was supplemented with fingolimod, alkaline phosphatase activity, matrix mineralization, and bone formation markers were significantly reduced in osteoblasts and hypertrophic chondrocytes. |
2020-09-10 |
2023-08-13 |
mouse |
| Fangfang Yang, Erfei Chen, Yunshu Yang, Fu Han, Shichao Han, Gaofeng Wu, Min Zhang, Jian Zhang, Juntao Han, Linlin Su, Dahai H. The Akt/FoxO/p27 Journal of cellular and molecular medicine. vol 23. issue 9. 2020-09-04. PMID:31270945. |
the akt/foxo/p27 hypertrophic scars (hs) are characterized by the excessive production and deposition of extracellular matrix (ecm) proteins. |
2020-09-04 |
2023-08-13 |
Not clear |