| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donghong Fang, Xuesi Wan, Wanping Deng, Hongyu Guan, Weijian Ke, Haipeng Xiao, Yanbing L. Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and therapeutic medicine. vol 4. issue 5. 2021-10-21. PMID:23226741. |
however, only middle and high doses of fxst prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. |
2021-10-21 |
2023-08-12 |
rat |
| Zhi Cong Wang, Hui Jun Sun, Kai Hua Li, Chao Fu, Mo Zhen Li. Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289054. |
icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy icariin (ica), a traditional chinese medicine, has been demonstrated to be a promoting compound for extracellular matrix synthesis and gene expression of chondrocytes. |
2021-10-21 |
2023-08-13 |
rat |
| Ning Wang, Lu Lu, Qi Feng Cao, Subo Qian, Jie Ding, Chen Wang, Huangqi Duan, Haibo Shen, Jun Q. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34237300. |
the bladder undergoes profound structural alterations after bladder outlet obstruction (boo), characterized by hypertrophy of the bladder wall and accumulation of extracellular matrix (ecm). |
2021-10-19 |
2023-08-13 |
mouse |
| Matthew Anderson-Baron, Melanie Kunze, Aillette Mulet-Sierra, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B Adesid. Nasal Chondrocyte-Derived Soluble Factors Affect Chondrogenesis of Cocultured Mesenchymal Stem Cells. Tissue engineering. Part A. vol 27. issue 1-2. 2021-10-15. PMID:32122264. |
engineered cartilage from cocultures exposed to the pure nc construct exhibited reduced chondrogenic potential relative to control constructs, shown by reduced extracellular matrix deposition and increased expression of hypertrophic markers. |
2021-10-15 |
2023-08-13 |
human |
| Irma Bernadette Simbolon Sitohang, Sondang Aemilia P Sirait, Fadhila Dea Safir. Fractional carbon dioxide laser for treating hypertrophic scars: A systematic review of randomised trials. The Australasian journal of dermatology. 2021-10-12. PMID:34628639. |
hypertrophic scars present collagen deposition and an abnormal extracellular matrix that cause abnormal shape changes and limit normal movement. |
2021-10-12 |
2023-08-13 |
Not clear |
| Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Le. SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression. NPJ Regenerative medicine. vol 6. issue 1. 2021-10-06. PMID:34535669. |
the knockdown of spry4 in healthy chondrocytes caused an increase in hypertrophy, senescence, reactive oxygen species (ros) production, and extracellular matrix (ecm) protease expression. |
2021-10-06 |
2023-08-13 |
human |
| Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xi. Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts. Molecular medicine reports. vol 24. issue 1. 2021-10-05. PMID:33955514. |
a hypertrophic scar (hps) is characterized by abnormal cell proliferation and the overproduction of extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |
| Fred S Lamb, Hyehun Choi, Michael R Miller, Ryan J Star. TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis. American journal of hypertension. vol 33. issue 10. 2021-09-29. PMID:32498083. |
this "phenotypic switching" promotes proliferation and production of extracellular matrix proteins which are associated with medial hypertrophy. |
2021-09-29 |
2023-08-13 |
mouse |
| Cheong Hoon Seo, Hui Song Cui, June-Bum Ki. Altered K Translational research : the journal of laboratory and clinical medicine. vol 236. 2021-09-29. PMID:33905948. |
altered k hypertrophic scars are the most common post-burn complications characterized by fibroblast proliferation and excessive extracellular matrix deposition. |
2021-09-29 |
2023-08-13 |
Not clear |
| Wenjie Guo, Weijing Feng, Xianglin Fan, Jing Huang, Caiwen Ou, Minsheng Che. Osteomodulin is a Potential Genetic Target for Hypertrophic Cardiomyopathy. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33715137. |
its features include abnormal cardiomyocyte hypertrophy, microvascular dysfunction, and increased accumulation of intercellular matrix. |
2021-09-28 |
2023-08-13 |
Not clear |
| Yongsheng Li, Wei Chen, Yao Dai, Yuting Huang, Zongming Chen, Tingfei Xi, Zheng Zhou, Hairong Li. Decellularized sturgeon cartilage extracellular matrix scaffold inhibits chondrocyte hypertrophy in vitro and in vivo. Journal of tissue engineering and regenerative medicine. vol 15. issue 8. 2021-09-14. PMID:34032003. |
decellularized sturgeon cartilage extracellular matrix scaffold inhibits chondrocyte hypertrophy in vitro and in vivo. |
2021-09-14 |
2023-08-13 |
mouse |
| João Santos-Faria, Cristina Gavina, Patrícia Rodrigues, João Coelho, Paula da Costa Martins, Adelino Leite-Moreira, Inês Falcão-Pire. MicroRNAs and ventricular remodeling in aortic stenosis. Revista portuguesa de cardiologia. vol 39. issue 7. 2021-08-31. PMID:32682570. |
we hypothesized that their expression in myocardial biopsies from patients with as could be linked with the degree of left ventricular (lv) hypertrophy and remodeling and to plasma levels of important biomarkers of extracellular matrix turnover. |
2021-08-31 |
2023-08-13 |
Not clear |
| Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Le. Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis. Pharmaceutics. vol 13. issue 8. 2021-08-31. PMID:34452101. |
as the pathological processes in the oa cartilage microenvironment, such as the alterations in the extracellular matrix, are initiated and dictated by the physiological state of the chondrocytes, in-depth knowledge of chondrocyte hypertrophy is necessary to enhance our understanding of the disease pathology and develop therapeutic agents. |
2021-08-31 |
2023-08-13 |
Not clear |
| Falguni Das, Amit Bera, Nandini Ghosh-Choudhury, Kavitha Sataranatarajan, Amrita Kamat, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology. Cellular signalling. vol 86. 2021-08-30. PMID:34224844. |
together, our findings provide a novel mechanism for mtor activation via ezh2 to induce mesangial cell hypertrophy and matrix expansion during early progression of diabetic nephropathy. |
2021-08-30 |
2023-08-13 |
mouse |
| Cheng-Hsuan Tsai, Chien-Ting Pan, Yi-Yao Chang, Zheng-Wei Chen, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Li. Left ventricular remodeling and dysfunction in primary aldosteronism. Journal of human hypertension. vol 35. issue 2. 2021-08-26. PMID:33067554. |
several mechanisms may explain the process of aldosterone-induced lv remodeling, including directly profibrotic and hypertrophic effects of aldosterone on myocardium, increased reactive oxygen species and profibrotic molecules, dysregulation of extracellular matrix metabolism, endothelium dysfunction and circulatory macrophages activation. |
2021-08-26 |
2023-08-13 |
Not clear |
| Rajiv S Raktoe, Ludo van Haasterecht, Nelda Antonovaite, Luca Bartolini, Remco van Doorn, Paul P M van Zuijlen, Marie Louise Groot, Abdoelwaheb El Ghalbzour. The effect of TGFβRI inhibition on extracellular matrix structure and stiffness in hypertrophic scar-specific fibroblast-derived matrix models. Biochemical and biophysical research communications. vol 559. 2021-08-25. PMID:33964734. |
the effect of tgfβri inhibition on extracellular matrix structure and stiffness in hypertrophic scar-specific fibroblast-derived matrix models. |
2021-08-25 |
2023-08-13 |
Not clear |
| Alexandra M Garvin, Bilal S Khokhar, Michael P Czubryt, Taben M Hal. RAS inhibition in resident fibroblast biology. Cellular signalling. vol 80. 2021-08-23. PMID:33370581. |
ang ii-mediated cardiomyocyte hypertrophy in combination with cardiac fibroblast proliferation, activation, and extracellular matrix production compromise cardiac function and increase mortality in humans. |
2021-08-23 |
2023-08-13 |
Not clear |
| Ichiro Kurokawa, Alison M Layton, Rei Ogaw. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis. Dermatology and therapy. vol 11. issue 4. 2021-08-20. PMID:34115308. |
transforming growth factor-β (tgfβ), il-6, matrix metalloproteinase (mmp), igf-1, and b cells are found in keloid or hypertrophic scar tissues. |
2021-08-20 |
2023-08-13 |
Not clear |
| Claudia Kusmic, Alessio Vizzoca, Monia Taranta, Lorena Tedeschi, Lisa Gherardini, Gualtiero Pelosi, Ambra Giannetti, Sara Tombelli, Settimio Grimaldi, Francesco Baldini, Claudio Domenici, Maria Giovanna Trivella, Caterina Cint. Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy. Journal of cardiovascular translational research. 2021-08-19. PMID:34409583. |
myocardial hypertrophy, in the presence of different degree of myocardial fibrosis, is paralleled by significant molecular, cellular, and histological changes inducing alteration of cardiac extracellular matrix composition as well as sarcomeres and cytoskeleton remodeling. |
2021-08-19 |
2023-08-13 |
mouse |
| Navya Gupta, Anuradha Bishnoi, Don Mathew, Amanjot Arora, Sanjeev Handa, Jyotdeep Kaur, Dipankar De, Arnab Pa. Hypertrophic post-acne scarring is associated with a single nucleotide polymorphism (rs243865) in the matrix metalloproteinase-2 gene. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. vol 18. issue 12. 2021-08-18. PMID:33373134. |
hypertrophic post-acne scarring is associated with a single nucleotide polymorphism (rs243865) in the matrix metalloproteinase-2 gene. |
2021-08-18 |
2023-08-13 |
Not clear |