| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arijit Bhattacharjee, Dhirendra S Katt. A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening. ALTEX. 2022-03-08. PMID:35258089. |
treatment with il1β induced oa-like traits in goat cartilage explants and caused a shift in cartilage homeostasis towards enhanced catabolism, resulting in higher matrix degradation, overexpression of degradative and inflammatory mediators and chondrocyte hypertrophy. |
2022-03-08 |
2023-08-13 |
human |
| Arijit Bhattacharjee, Dhirendra S Katt. A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening. ALTEX. 2022-03-08. PMID:35258089. |
finally, we evaluated the translational relevance of the developed ex vivo oa model by comparing it with late-stage oa patient samples and observed a striking resemblance in terms of matrix degradation, expression of degradative enzymes, chondrocyte hypertrophy and inflammation. |
2022-03-08 |
2023-08-13 |
human |
| Yingying Guo, Dan Li, Xian-Feng Cen, Hong-Liang Qiu, Yu-Lan Ma, Yi Liu, Si-Hui Huang, Li-Bo Liu, Man Xu, Qi-Zhu Tan. Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-03-04. PMID:35242278. |
an important pathophysiological consequence of pressure overload-induced cardiac hypertrophy is adverse cardiac remodeling, including structural changes in cardiomyocytes and extracellular matrix. |
2022-03-04 |
2023-08-13 |
mouse |
| Yun Bai, Xiaoshan Gong, Rui Dong, Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Don. Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224160. |
here, we identified a lncrna, named hypertrophic chondrocyte angiogenesis-related lncrna (hcar), and proved it to promote the endochondral bone repair by upregulating the expression of matrix metallopeptidase 13 (mmp13) and vascular endothelial growth factor α (vegfa) in hypertrophic chondrocytes. |
2022-02-28 |
2023-08-13 |
Not clear |
| Yun Bai, Xiaoshan Gong, Rui Dong, Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Don. Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224160. |
lnc-hcar knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the cd31 |
2022-02-28 |
2023-08-13 |
Not clear |
| Anthony J Hayes, John Whitelock, James Melros. Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216048. |
cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. |
2022-02-26 |
2023-08-13 |
Not clear |
| Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J Lovoulos, Martin A Schwartz, Jay D Humphrey, George Tellide. mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI insight. vol 7. issue 3. 2022-02-08. PMID:35132962. |
medial thickening results from smooth muscle cell hypertrophy and extracellular matrix accumulation, including matricellular proteins. |
2022-02-08 |
2023-08-13 |
mouse |
| Mapula Razwinani, Keolebogile Shirley Motaun. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie. 2022-02-05. PMID:35121053. |
the study investigated the influence of friedelin, resinone, tingenone and betulin plant-based secondary metabolite compounds on cellular proliferation, extracellular matrix (ecm) components synthesis, expression of chondrogenic markers and maturation of differentiated chondrocytes (cell proliferation and hypertrophy) in porcine adipose-derived mesenchymal stem cells (padmscs) undergoing chondrogenic differentiation. |
2022-02-05 |
2023-08-13 |
Not clear |
| Shunuo Zhang, Yixin Zhang, Peiru Mi. Single-Cell and Bulk Transcriptome Data Integration Reveals Dysfunctional Cell Types and Aberrantly Expressed Genes in Hypertrophic Scar. Frontiers in genetics. vol 12. 2022-01-20. PMID:35047019. |
hypertrophic scar (hs) is a common skin disorder characterized by excessive extracellular matrix (ecm) deposition. |
2022-01-20 |
2023-08-13 |
Not clear |
| Jinying Liu, Hongjian Lian, Jiang Yu, Jie Wu, Xiangyang Chen, Peng Wang, Lei Tian, Yunfei Yang, Jiaqi Yang, Dong Li, Shuzhen Gu. Study on diverse pathological characteristics of heart failure in different stages based on proteomics. Journal of cellular and molecular medicine. 2022-01-20. PMID:35048506. |
the results of the kegg pathway enrichment analysis and go function annotation revealed critical pathways associated with the transition from cardiac hypertrophy to heart failure, such as energy pathways and matrix reorganization. |
2022-01-20 |
2023-08-13 |
mouse |
| Jennifer M Petrosino, Jacob Z Longenecker, Colin D Angel, Scott A Hinger, Colton R Martens, Federica Accorner. CCN2 participates in overload-induced skeletal muscle hypertrophy. Matrix biology : journal of the International Society for Matrix Biology. 2022-01-19. PMID:35045313. |
overall, our study highlights the contribution of muscle-derived extracellular matrix factor ccn2 for proper hypertrophic muscle growth. |
2022-01-19 |
2023-08-13 |
mouse |
| Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wan. Keratinocyte growth factor-2 regulates signal-transducing adaptor protein-2-mediated signal transducer and activator of transcription 3 signaling and reduces skin scar formation. The Journal of investigative dermatology. 2022-01-09. PMID:34999107. |
hypertrophic scar (hs) is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix (ecm). |
2022-01-09 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
this study investigated whether transforming growth factor-β receptor i (tgf-βri) and tgf-βrii mediate matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
the upregulated expression of tgf-βri and tgf-βrii mediates the abnormal chondrocyte hypertrophy and extracellular matrix degeneration observed in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Michalis Panteli, James S H Vun, Ippokratis Pountos, Anthony J Howard, Elena Jones, Peter V Giannoudi. Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights. Journal of cellular and molecular medicine. 2022-01-05. PMID:34984803. |
there was a lower bmp expression in non-union site and absent in the extracellular matrix, with no difference observed between atrophic and hypertrophic non-unions. |
2022-01-05 |
2023-08-13 |
human |
| Maria Marketou, Joanna Kontaraki, Spyros Maragkoudakis, Christos Danelatos, Sofia Papadaki, Stelios Zervakis, Anthoula Plevritaki, Panos Vardas, Fragiskos Parthenakis, George Kochiadaki. Effects of sodium-glucose cotransporter-2 inhibitors on cardiac structural and electrical remodeling: from myocardial cytology to cardiodiabetology. Current vascular pharmacology. 2021-12-28. PMID:34961447. |
sglt2i ameliorate myocardial extracellular matrix remodeling, cardiomyocyte stiffness and concentric hypertrophy, achieving beneficial remodeling of the left ventricle with significant implications for the pathogenesis and outcome of heart failure. |
2021-12-28 |
2023-08-13 |
Not clear |
| Ming-Xiao Zhang, Qing-Xin Tian, Jian-Long Li. [The myocardial protective effect of propofol on rats with experimental myocardial infarction and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 6. 2021-12-28. PMID:34961861. |
furthermore, after myocardial infarction, the administration of propofol significantly improved the diastolic strain rate, down-regulated the mrna expression levels of myocardial hypertrophy markers, atrial natriuretic peptide and β-myosin heavy chain, and reversed the up-regulation of matrix metalloproteinase 2 (mmp2), mmp9 and tissue inhibitor of metalloproteinase-2 (timp-2) induced by myocardial infarction. |
2021-12-28 |
2023-08-13 |
rat |
| Hongpeng Zhang, Hao Wang, Cuibao Jiang, Hongwei Wang, Yong Xia, Danpeng Shen, Fan Xie, Nianmin Qi, Kaiyang L. Fractional laser-assisted administration of human umbilical cord mesenchymal stem cells to reduce hypertrophic scars in rabbit ears. Lasers in surgery and medicine. 2021-12-28. PMID:34962300. |
the formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. |
2021-12-28 |
2023-08-13 |
human |
| Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Gu. The immune microenvironment in cartilage injury and repair. Acta biomaterialia. 2021-12-13. PMID:34896634. |
the inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and progression of cartilage injury to osteoarthritis. |
2021-12-13 |
2023-08-13 |
Not clear |