| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abu Mohammad Syed, Sourav Kundu, Chetan Ram, Uttam Kulhari, Akhilesh Kumar, Madhav Nilakanth Mugale, Purusottam Mohapatra, Upadhyayula Suryanarayana Murty, Bidya Dhar Sah. Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice. Free radical biology & medicine. 2022-05-05. PMID:35513128. |
oxidative damage and accumulation of extracellular matrix (ecm) components play a crucial role in the adverse outcome of cardiac hypertrophy. |
2022-05-05 |
2023-08-13 |
mouse |
| Kyle Sylakowski, Mintai Peter Hwang, Amritha Justin, Diana Whaley, Yadong Wang, Alan Well. The matricellular protein decorin delivered intradermally with coacervate improves wound resolution in the CXCR3-deficient mouse model of hypertrophic scarring. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2022-04-26. PMID:35470921. |
we investigated the use of decorin as a therapeutic by administering the matrix protein anchored in a slow-release coacervate in a hypertrophic scarring mouse model. |
2022-04-26 |
2023-08-13 |
mouse |
| Gianluca Di Bella, Francesco Cappelli, Roberto Licordari, Paolo Piaggi, Mariapaola Campisi, Diego Bellavia, Fabio Minutoli, Luca Gentile, Massimo Russo, Cesare de Gregorio, Federico Perfetto, Anna Mazzeo, Calogero Falletta, Francesco Clemenza, Giuseppe Vita, Scipione Carerj, Giovanni Donato Aquar. Prevalence and diagnostic value of extra-left ventricle echocardiographic findings in transthyretin-related cardiac amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2022-04-25. PMID:35465808. |
cardiac amyloidosis (ca) is cardiomyopathy with a hypertrophic phenotype characterised by diffuse deposition of anomalous fibrillar proteins in the extracellular matrix. |
2022-04-25 |
2023-08-13 |
Not clear |
| Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun Tl Hughes, Fawaz Ghali, Kehinde Ros. A time to heal: microRNA and circadian dynamics in cutaneous wound repair. Clinical science (London, England : 1979). vol 136. issue 8. 2022-04-21. PMID:35445708. |
on the other hand, keloids and hypertrophic scars arise from overactive repair mechanisms that fail to cease in a timely fashion, leading to excessive production of extracellular matrix (ecm) components such as such as collagen. |
2022-04-21 |
2023-08-13 |
Not clear |
| Hui Song Cui, Dong Hyun Kim, So Young Joo, Yoon Soo Cho, June-Bum Kim, Cheong Hoon Se. Exosomes derived from human hypertrophic scar fibroblasts induces smad and TAK1 signaling in normal dermal fibroblasts. Archives of biochemistry and biophysics. 2022-04-17. PMID:35430216. |
post-burn hypertrophic scars are characterized by excessive accumulation of extracellular matrix secreted by fibroblasts. |
2022-04-17 |
2023-08-13 |
human |
| Bo-Yu Yang, Zhi-Yuan Zhou, Shi-Yun Liu, Ming-Jun Shi, Xi-Jian Liu, Tian-Ming Cheng, Guo-Ying Deng, Ye Tian, Jian Song, Xuan-Hao L. Porous Se@SiO Frontiers in bioengineering and biotechnology. vol 10. 2022-04-07. PMID:35387298. |
porous se@sio hypertrophic scarring, which is characterized by excessive extracellular matrix deposition and abnormal fibroblast homeostasis, is an undesirable outcome of dermal wound healing. |
2022-04-07 |
2023-08-13 |
Not clear |
| Zhaojie Lyu, Yifeng Da, Hongkai Liu, Zhihao Wang, Yong Zhu, Jing Tia. Chsy1 deficiency reduces extracellular matrix productions and aggravates cartilage injury in osteoarthritis. Gene. 2022-04-07. PMID:35390446. |
it was found that chsy1 deficiency resulted in a reduction of extracellular matrix production in chondrocytes and a promotion of endochondral osteogenesis, which was indicated by the decreased expression of early chondrocytes genes (col2a1, sox9), and the increased expression of cartilage hypertrophy genes (col10a1, runx2, mmp13, mmp3). |
2022-04-07 |
2023-08-13 |
mouse |
| Amy Larson, Christina J Codden, Gordon S Huggins, Hassan Rastegar, Frederick Y Chen, Barry J Maron, Ethan J Rowin, Martin S Maron, Michael T Chi. Altered intercellular communication and extracellular matrix signaling as a potential disease mechanism in human hypertrophic cardiomyopathy. Scientific reports. vol 12. issue 1. 2022-03-26. PMID:35338173. |
altered intercellular communication and extracellular matrix signaling as a potential disease mechanism in human hypertrophic cardiomyopathy. |
2022-03-26 |
2023-08-13 |
human |
| Y B Meng, J Lei, H R Zhang, Z M Hao, P Y Bai, P Dua. [Clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 3. 2022-03-24. PMID:35325970. |
[clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns]. |
2022-03-24 |
2023-08-13 |
Not clear |
| Alberto Aimo, Oriol Iborra-Egea, Nicola Martini, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Michele Emdin, Antoni Bayes-Geni. Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis. Scientific reports. vol 12. issue 1. 2022-03-19. PMID:35304529. |
we identified 6 causative motives of post-mi remodeling (cardiomyocyte cell death, impaired myocyte contractility, extracellular matrix remodeling and fibrosis, hypertrophy, renin-angiotensin-aldosterone system activation, and inflammation), 4 pirfenidone targets and 21 bioflags (indirect effectors). |
2022-03-19 |
2023-08-13 |
Not clear |
| Ye Lu, Chengyuan Zhang, Shilin Jiang, Feng Yua. Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-14. PMID:35280506. |
the results showed that administration of anti-dlx5 improved pathological changes of osteoarthritis cartilages, characterized by decreased chondrocyte proliferation, chondrocyte hypertrophy, and matrix damage. |
2022-03-14 |
2023-08-13 |
Not clear |
| Kimberley C W Wang, Graham M Donovan, Sejal Saglani, Thais Mauad, Alan L James, John G Elliot, Peter B Nobl. Growth of the airway smooth muscle layer from late gestation to childhood is mediated initially by hypertrophy and subsequently hyperplasia. Respirology (Carlton, Vic.). 2022-03-10. PMID:35266251. |
this study characterized thickening of the asm layer from foetal life to childhood and elucidated the underlying mechanism in terms of hypertrophy, hyperplasia and extracellular matrix (ecm) deposition. |
2022-03-10 |
2023-08-13 |
Not clear |
| Arijit Bhattacharjee, Dhirendra S Katt. A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening. ALTEX. 2022-03-08. PMID:35258089. |
treatment with il1β induced oa-like traits in goat cartilage explants and caused a shift in cartilage homeostasis towards enhanced catabolism, resulting in higher matrix degradation, overexpression of degradative and inflammatory mediators and chondrocyte hypertrophy. |
2022-03-08 |
2023-08-13 |
human |
| Arijit Bhattacharjee, Dhirendra S Katt. A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening. ALTEX. 2022-03-08. PMID:35258089. |
finally, we evaluated the translational relevance of the developed ex vivo oa model by comparing it with late-stage oa patient samples and observed a striking resemblance in terms of matrix degradation, expression of degradative enzymes, chondrocyte hypertrophy and inflammation. |
2022-03-08 |
2023-08-13 |
human |
| Yingying Guo, Dan Li, Xian-Feng Cen, Hong-Liang Qiu, Yu-Lan Ma, Yi Liu, Si-Hui Huang, Li-Bo Liu, Man Xu, Qi-Zhu Tan. Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-03-04. PMID:35242278. |
an important pathophysiological consequence of pressure overload-induced cardiac hypertrophy is adverse cardiac remodeling, including structural changes in cardiomyocytes and extracellular matrix. |
2022-03-04 |
2023-08-13 |
mouse |
| Yun Bai, Xiaoshan Gong, Rui Dong, Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Don. Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224160. |
here, we identified a lncrna, named hypertrophic chondrocyte angiogenesis-related lncrna (hcar), and proved it to promote the endochondral bone repair by upregulating the expression of matrix metallopeptidase 13 (mmp13) and vascular endothelial growth factor α (vegfa) in hypertrophic chondrocytes. |
2022-02-28 |
2023-08-13 |
Not clear |
| Yun Bai, Xiaoshan Gong, Rui Dong, Zhen Cao, Ce Dou, Chuan Liu, Jianmei Li, Fei Kang, Jingjin Dai, Chunrong Zhao, Zhansong Tian, Jiulin Tan, Qijie Dai, Shiwu Don. Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224160. |
lnc-hcar knockdown in hypertrophic chondrocytes restrained the cartilage matrix remodeling and decrease the cd31 |
2022-02-28 |
2023-08-13 |
Not clear |
| Anthony J Hayes, John Whitelock, James Melros. Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216048. |
cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. |
2022-02-26 |
2023-08-13 |
Not clear |
| Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J Lovoulos, Martin A Schwartz, Jay D Humphrey, George Tellide. mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI insight. vol 7. issue 3. 2022-02-08. PMID:35132962. |
medial thickening results from smooth muscle cell hypertrophy and extracellular matrix accumulation, including matricellular proteins. |
2022-02-08 |
2023-08-13 |
mouse |
| Mapula Razwinani, Keolebogile Shirley Motaun. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie. 2022-02-05. PMID:35121053. |
the study investigated the influence of friedelin, resinone, tingenone and betulin plant-based secondary metabolite compounds on cellular proliferation, extracellular matrix (ecm) components synthesis, expression of chondrogenic markers and maturation of differentiated chondrocytes (cell proliferation and hypertrophy) in porcine adipose-derived mesenchymal stem cells (padmscs) undergoing chondrogenic differentiation. |
2022-02-05 |
2023-08-13 |
Not clear |