| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shunuo Zhang, Yixin Zhang, Peiru Mi. Single-Cell and Bulk Transcriptome Data Integration Reveals Dysfunctional Cell Types and Aberrantly Expressed Genes in Hypertrophic Scar. Frontiers in genetics. vol 12. 2022-01-20. PMID:35047019. |
hypertrophic scar (hs) is a common skin disorder characterized by excessive extracellular matrix (ecm) deposition. |
2022-01-20 |
2023-08-13 |
Not clear |
| Jinying Liu, Hongjian Lian, Jiang Yu, Jie Wu, Xiangyang Chen, Peng Wang, Lei Tian, Yunfei Yang, Jiaqi Yang, Dong Li, Shuzhen Gu. Study on diverse pathological characteristics of heart failure in different stages based on proteomics. Journal of cellular and molecular medicine. 2022-01-20. PMID:35048506. |
the results of the kegg pathway enrichment analysis and go function annotation revealed critical pathways associated with the transition from cardiac hypertrophy to heart failure, such as energy pathways and matrix reorganization. |
2022-01-20 |
2023-08-13 |
mouse |
| Jennifer M Petrosino, Jacob Z Longenecker, Colin D Angel, Scott A Hinger, Colton R Martens, Federica Accorner. CCN2 participates in overload-induced skeletal muscle hypertrophy. Matrix biology : journal of the International Society for Matrix Biology. 2022-01-19. PMID:35045313. |
overall, our study highlights the contribution of muscle-derived extracellular matrix factor ccn2 for proper hypertrophic muscle growth. |
2022-01-19 |
2023-08-13 |
mouse |
| Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wan. Keratinocyte growth factor-2 regulates signal-transducing adaptor protein-2-mediated signal transducer and activator of transcription 3 signaling and reduces skin scar formation. The Journal of investigative dermatology. 2022-01-09. PMID:34999107. |
hypertrophic scar (hs) is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix (ecm). |
2022-01-09 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
this study investigated whether transforming growth factor-β receptor i (tgf-βri) and tgf-βrii mediate matrix degradation and abnormal hypertrophy in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Ying Zhang, Zhengzheng Li, Ying He, Meng Zhang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Che. Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes. Toxicon : official journal of the International Society on Toxinology. 2022-01-07. PMID:34995556. |
the upregulated expression of tgf-βri and tgf-βrii mediates the abnormal chondrocyte hypertrophy and extracellular matrix degeneration observed in t-2 toxin-induced hypertrophic chondrocytes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Michalis Panteli, James S H Vun, Ippokratis Pountos, Anthony J Howard, Elena Jones, Peter V Giannoudi. Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights. Journal of cellular and molecular medicine. 2022-01-05. PMID:34984803. |
there was a lower bmp expression in non-union site and absent in the extracellular matrix, with no difference observed between atrophic and hypertrophic non-unions. |
2022-01-05 |
2023-08-13 |
human |
| Maria Marketou, Joanna Kontaraki, Spyros Maragkoudakis, Christos Danelatos, Sofia Papadaki, Stelios Zervakis, Anthoula Plevritaki, Panos Vardas, Fragiskos Parthenakis, George Kochiadaki. Effects of sodium-glucose cotransporter-2 inhibitors on cardiac structural and electrical remodeling: from myocardial cytology to cardiodiabetology. Current vascular pharmacology. 2021-12-28. PMID:34961447. |
sglt2i ameliorate myocardial extracellular matrix remodeling, cardiomyocyte stiffness and concentric hypertrophy, achieving beneficial remodeling of the left ventricle with significant implications for the pathogenesis and outcome of heart failure. |
2021-12-28 |
2023-08-13 |
Not clear |
| Ming-Xiao Zhang, Qing-Xin Tian, Jian-Long Li. [The myocardial protective effect of propofol on rats with experimental myocardial infarction and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 6. 2021-12-28. PMID:34961861. |
furthermore, after myocardial infarction, the administration of propofol significantly improved the diastolic strain rate, down-regulated the mrna expression levels of myocardial hypertrophy markers, atrial natriuretic peptide and β-myosin heavy chain, and reversed the up-regulation of matrix metalloproteinase 2 (mmp2), mmp9 and tissue inhibitor of metalloproteinase-2 (timp-2) induced by myocardial infarction. |
2021-12-28 |
2023-08-13 |
rat |
| Hongpeng Zhang, Hao Wang, Cuibao Jiang, Hongwei Wang, Yong Xia, Danpeng Shen, Fan Xie, Nianmin Qi, Kaiyang L. Fractional laser-assisted administration of human umbilical cord mesenchymal stem cells to reduce hypertrophic scars in rabbit ears. Lasers in surgery and medicine. 2021-12-28. PMID:34962300. |
the formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. |
2021-12-28 |
2023-08-13 |
human |
| Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Gu. The immune microenvironment in cartilage injury and repair. Acta biomaterialia. 2021-12-13. PMID:34896634. |
the inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and progression of cartilage injury to osteoarthritis. |
2021-12-13 |
2023-08-13 |
Not clear |
| b' Jos\\xc3\\xa9 Vald\\xc3\\xa9s-Fern\\xc3\\xa1ndez, Tania L\\xc3\\xb3pez-Mart\\xc3\\xadnez, Purificaci\\xc3\\xb3n Ripalda-Cembor\\xc3\\xa1in, Isabel A Calvo, Borja S\\xc3\\xa1ez, Juan Antonio Romero-Torrecilla, Javier Aldazabal, Emma Mui\\xc3\\xb1os-L\\xc3\\xb3pez, Ver\\xc3\\xb3nica Montiel, Josune Orbe, Jos\\xc3\\xa9 Antonio Rodr\\xc3\\xadguez, Jos\\xc3\\xa9 Antonio P\\xc3\\xa1ramo, Felipe Pr\\xc3\\xb3sper, Froil\\xc3\\xa1n Granero-Molt\\xc3\\xb. Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 36. issue 11. 2021-12-10. PMID:34173256.' |
during secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix metalloproteinase (mmp)-13, produced by hypertrophic chondrocytes, and the gelatinase mmp-9, produced by cells of hematopoietic lineage. |
2021-12-10 |
2023-08-13 |
mouse |
| Harunur Rashid, Haiyan Chen, Amjad Jave. Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. Matrix biology plus. vol 12. 2021-12-07. PMID:34805821. |
runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. |
2021-12-07 |
2023-08-13 |
Not clear |
| Megumi Nakamura, Mu-Chen Yang, Keijyu Ashida, Miyuki Mayanagi, Yasuyuki Sasan. Calcification and resorption of mouse Meckel's cartilage analyzed by von Kossa and tartrate-resistant acid phosphatase histochemistry and scanning electron microscopy/energy-dispersive X-ray spectrometry. Anatomical science international. 2021-12-03. PMID:34859366. |
the results demonstrated that the intermediate portion of meckel's cartilage is resorbed by chondroclasts after chondrocyte hypertrophy and cartilage matrix calcification and that the mineral concentration of calcified meckel's cartilage is comparable to that of the surrounding bone. |
2021-12-03 |
2023-08-13 |
mouse |
| Dylan O'Toole, Ali Abdullah I Zaeri, Stuart A Nicklin, Anne T French, Christopher M Loughrey, Tamara P Marti. Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular signalling. vol 76. 2021-11-29. PMID:32891693. |
cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ecm), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yao Wang, Xiaojing Sun, Xianglan Su. The Functions of LncRNA H19 in the Heart. Heart, lung & circulation. 2021-11-29. PMID:34840062. |
for example, lncrna h19 (h19), also known as a fetal gene abundant in adult heart and skeletal muscles and evolutionarily conserved in humans and mice, has a regulatory role in aortic aneurysm, myocardial hypertrophy, extracellular matrix reconstitution, and coronary artery diseases. |
2021-11-29 |
2023-08-13 |
mouse |
| Weipeng Ge, Cuiliu Hou, Wei Zhang, Xiaoxiao Guo, Pan Gao, Xiaomin Song, Ran Gao, Ying Liu, Wenjun Guo, Bolun Li, Hongmei Zhao, Jing Wan. Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation. Journal of molecular and cellular cardiology. vol 152. 2021-11-23. PMID:33301800. |
pathological cardiac remodeling, characterized by excessive deposition of extracellular matrix proteins and cardiac hypertrophy, leads to the development of heart failure. |
2021-11-23 |
2023-08-13 |
Not clear |
| Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamur. Biglycan expression and its function in human ligamentum flavum. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33649499. |
to investigate the involvement of bgn in the pathomechanism of human ligamentum hypertrophy, first we confirmed increased expression of bgn by immunohistochemistry in the extracellular matrix of hypertrophied lf of lss patients compared to lf without hypertrophy. |
2021-11-22 |
2023-08-13 |
human |
| Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang, Birong Don. Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33977869. |
silencing of long noncoding inhba antisense rna1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microrna-141-3p/myeloid cell leukemia 1 axis. |
2021-11-10 |
2023-08-13 |
human |