| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Ma, Honglin Liu, Tongtong Xia, Zhenghao Zhang, Shengchao Ma, Yinju Hao, Jiangyong Shen, Yideng Jiang, Nan L. HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8. Acta biochimica et biophysica Sinica. 2023-11-25. PMID:38006215. |
human hypertrophic scar-derived fibroblasts (hsfbs) have been shown to exert more potent promoting effects on extracellular matrix (ecm) accumulation than normal skin-derived fibroblasts (nsfbs) and are associated with enhanced hs formation. |
2023-11-25 |
2023-11-28 |
human |
| Binyu Song, Yuhan Zhu, Ying Zhao, Kai Wang, Yixuan Peng, Lin Chen, Zhou Yu, Baoqiang Son. Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar. International wound journal. 2023-11-21. PMID:37986676. |
hypertrophic scar (hs) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. |
2023-11-21 |
2023-11-29 |
Not clear |
| Marc G Jeschke, Fiona M Wood, Esther Middelkoop, Ardeshir Bayat, Luc Teot, Rei Ogawa, Gerd G Gauglit. Scars. Nature reviews. Disease primers. vol 9. issue 1. 2023-11-16. PMID:37973792. |
although the underlying mechanisms of hypertrophic scars and keloid lesions are not well defined, evidence suggests that the changes in the extracellular matrix are perpetuated by ongoing inflammation in susceptible individuals, resulting in a fibrotic phenotype. |
2023-11-16 |
2023-11-20 |
Not clear |
| Xuan Kan, Ruidi Guan, Jianwei Hao, Chunyuan Zhao, Yanan Su. Integrative analysis of immune-related signature profiles in eosinophilic chronic rhinosinusitis with nasal polyposis. FEBS open bio. 2023-11-07. PMID:37867480. |
functional analyses revealed several significant associations with ecrswnp, including focal adhesion, hypertrophic cardiomyopathy, and extracellular matrix (ecm)-receptor interactions. |
2023-11-07 |
2023-11-08 |
Not clear |
| Cheng Zeng, Jing Liu, Xialei Zheng, Xinqun Hu, Yuhu H. Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension. Respiratory research. vol 24. issue 1. 2023-11-02. PMID:37915044. |
the mechanisms involved in this process include inflammation, vascular matrix remodeling, endothelial cell apoptosis and proliferation, vasoconstriction, vascular smooth muscle cell proliferation and hypertrophy. |
2023-11-02 |
2023-11-08 |
Not clear |
| Lourdes Alcaide-Ruggiero, Verónica Molina-Hernández, Juan Morgaz, J Andrés Fernández-Sarmiento, María M Granados, Rocío Navarrete-Calvo, José Pérez, Setefilla Quirós-Carmona, José M Carrillo, Ramón Cugat, Juan M Domíngue. Immunohistochemical Analysis of Knee Chondral Defect Repair after Autologous Particulated Cartilage and Platelet-Rich Plasma Treatment in Sheep. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894837. |
significant differences were found in collagens associated with matrix maturity (ii and v), degradation (ix), structure and mechanics (vi), and hypertrophy (x) between healthy cartilage and rls- or ha-repaired cartilage. |
2023-10-30 |
2023-11-08 |
Not clear |
| Linlin Sun, Miao Ding, Fuhua Chen, Dingyu Zhu, Xinmiao Xi. Long non‑coding RNA L13Rik promotes high glucose-induced mesangial cell hypertrophy and matrix protein expression by regulating miR-2861/CDKN1B axis. PeerJ. vol 11. 2023-10-24. PMID:37868060. |
long non‑coding rna l13rik promotes high glucose-induced mesangial cell hypertrophy and matrix protein expression by regulating mir-2861/cdkn1b axis. |
2023-10-24 |
2023-11-08 |
Not clear |
| Linlin Sun, Miao Ding, Fuhua Chen, Dingyu Zhu, Xinmiao Xi. Long non‑coding RNA L13Rik promotes high glucose-induced mesangial cell hypertrophy and matrix protein expression by regulating miR-2861/CDKN1B axis. PeerJ. vol 11. 2023-10-24. PMID:37868060. |
given the role of long non coding rna (lncrna) in regulating mc hypertrophy and extracellular matrix (ecm) accumulation, our aim was to identify functional lncrnas during mc hypertrophy. |
2023-10-24 |
2023-11-08 |
Not clear |
| Maja Schlittler, Peter P Pramstaller, Alessandra Rossini, Marzia De Bortol. Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Perspective from Fibroblasts. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834293. |
the disease is characterized by cardiomyocyte hypertrophy and myocardial fibrosis, which is defined as the excessive deposition of extracellular matrix proteins, mainly collagen i and iii, in the myocardium. |
2023-10-14 |
2023-10-15 |
Not clear |
| Hirai Suito, Kaoru Fujikawa, Masafumi Ohsak. ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats. Journal of anatomy. 2023-10-10. PMID:37814911. |
the extracellular matrix of hypertrophic chondrocytes was calcified. |
2023-10-10 |
2023-10-15 |
rat |
| Kevin G Burt, Dan C Viola, Lauren E Lisiewski, Joseph M Lombardi, Louis F Amorosa, Nadeen O Chahin. An in vivo model of ligamentum flavum hypertrophy from early-stage inflammation to fibrosis. JOR spine. vol 6. issue 3. 2023-10-02. PMID:37780823. |
in this study, we created an injury model to test the hypothesis that lf needle scrape injury in the rat will result in hypertrophy of the lf characterized by altered tissue geometry, matrix organization, composition and inflammation. |
2023-10-02 |
2023-10-07 |
rat |
| Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Fen. Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance. Materials today. Bio. vol 23. 2023-09-28. PMID:37766899. |
aunps inhibited the formation of gaps, without chondrocytes and extracellular matrix, between the proliferative and hypertrophy zones of the gp cartilage, and the gaps were noticeable in the lps group. |
2023-09-28 |
2023-10-07 |
mouse |
| Yunxian Dong, Xiaoling Cao, Jinsheng Huang, Zhicheng Hu, Chufen Chen, Miao Chen, Qian Long, Zhongye Xu, Dongming Lv, Yanchao Rong, Shengkang Luo, Haibin Wang, Wuguo Deng, Bing Tan. Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-22. PMID:37739092. |
hypertrophic scar (hs) is a fibrotic skin condition and characterized by abnormal proliferation of myofibroblasts and accumulation of extracellular matrix. |
2023-09-22 |
2023-10-07 |
human |
| Liu Yang, Yajuan Song, Tong Wang, Zhiwei Cui, JunZheng Wu, Yi Shi, Zhou Yu, Baoqiang Son. Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation. Journal of cosmetic dermatology. 2023-09-15. PMID:37710417. |
hypertrophic scar (hs) is caused by the abnormal proliferation of fibroblasts and excessive deposition of extracellular matrix (ecm). |
2023-09-15 |
2023-10-07 |
Not clear |
| Natalia J Braams, Azar Kianzad, Jessie van Wezenbeek, Jeroen N Wessels, Samara M A Jansen, Stine Andersen, Anco Boonstra, Esther J Nossent, J Tim Marcus, Ahmed A Bayoumy, Clarissa Becher, Marie-José Goumans, Asger Andersen, Anton Vonk Noordegraaf, Frances S de Man, Harm Jan Bogaard, Lilian J Meijboo. Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension. Circulation. Heart failure. 2023-09-07. PMID:37675561. |
it is unknown whether incomplete reversal of rv remodeling results from extracellular matrix expansion (diffuse interstitial fibrosis) or cellular hypertrophy, and whether residual rv remodeling relates to altered diastolic function. |
2023-09-07 |
2023-10-07 |
Not clear |
| Roberto Boi, Kerstin Ebefors, Jenny Nyströ. The role of the mesangium in glomerular function. Acta physiologica (Oxford, England). 2023-09-02. PMID:37658606. |
the expansion is normally due to matrix expansion in combination with either proliferation or hypertrophy. |
2023-09-02 |
2023-09-07 |
Not clear |
| Daniel Naveed Tavakol, Trevor R Nash, Youngbin Kim, Siyu He, Sharon Fleischer, Pamela L Graney, Jessie A Brown, Martin Liberman, Manuel Tamargo, Andrew Harken, Adolfo A Ferrando, Sally Amundson, Guy Garty, Elham Azizi, Kam W Leong, David J Brenner, Gordana Vunjak-Novakovi. Modeling and countering the effects of cosmic radiation using bioengineered human tissues. Biomaterials. vol 301. 2023-08-26. PMID:37633022. |
we further determined the extent of inflammatory, oxidative stress, and matrix remodeling gene expression changes, and found that these changes were associated with an early hypertrophic phenotype in ect and myeloid skewing in ebm. |
2023-08-26 |
2023-09-07 |
human |
| Domenico Ribatti, Antonio d'Amat. Bone angiocrine factors. Frontiers in cell and developmental biology. vol 11. 2023-08-21. PMID:37601109. |
vascular endothelial growth factor (vegf), one of several angiogenic molecules, is a significant regulator of blood vessel invasion, cartilage remodeling, and ossification of freshly created bone matrix; chondrocyte proliferation and hypertrophy are facilitated by the production of vegfa and vegf receptor-2 (vegfr-2), which is stimulated by fibroblast growth factors (fgfs). |
2023-08-21 |
2023-09-07 |
Not clear |
| Sree Samanvitha Kuppa, Hyung-Keun Kim, Ju-Yeon Kang, Seok-Cheol Lee, Hong-Yeol Yang, Jaishree Sankaranarayanan, Jong-Keun Seo. Polynucleotides Suppress Inflammation and Stimulate Matrix Synthesis in an In Vitro Cell-Based Osteoarthritis Model. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569659. |
chondrocyte hypertrophy and inflammation promote extracellular matrix degradation (ecm). |
2023-08-12 |
2023-08-16 |
human |
| Francesca Veronesi, Viviana Costa, Daniele Bellavia, Valentina Basoli, Gianluca Giavares. Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation. Cells. vol 12. issue 14. 2023-07-29. PMID:37508486. |
osteoarthritis (oa) is a joint disorder characterized by progressive degeneration of cartilage extracellular matrix (ecm), chondrocyte hypertrophy and apoptosis and inflammation. |
2023-07-29 |
2023-08-14 |
Not clear |