| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Alvarez, M Balbín, F Santos, M Fernández, S Ferrando, J M Lópe. Different bone growth rates are associated with changes in the expression pattern of types II and X collagens and collagenase 3 in proximal growth plates of the rat tibia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 1. 2000-02-11. PMID:10646117. |
an intimate relationship between morphological and kinetic changes associated with chondrocyte hypertrophy and changes in the expression pattern of matrix collagens and collagenase 3 was observed. |
2000-02-11 |
2023-08-12 |
rat |
| F De Luca, J A Uyeda, V Mericq, E E Mancilla, J A Yanovski, K M Barnes, M H Zile, J Baro. Retinoic acid is a potent regulator of growth plate chondrogenesis. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614657. |
in this system, ra inhibited longitudinal bone growth by three mechanisms: 1) decreased chondrocyte proliferation, (assessed by 3h-thymidine incorporation), particularly in the proliferative zone of the growth plate; 2) decreased matrix synthesis (assessed by 35so4 incorporation into glycosaminoglycans); and 3) decreased cell hypertrophy (determined histologically). |
2000-01-13 |
2023-08-12 |
rat |
| F De Luca, J A Uyeda, V Mericq, E E Mancilla, J A Yanovski, K M Barnes, M H Zile, J Baro. Retinoic acid is a potent regulator of growth plate chondrogenesis. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614657. |
we conclude that ra, acting through rars, negatively regulates longitudinal bone growth by inhibiting growth plate chondrocyte proliferation, chondrocyte hypertrophy, and matrix synthesis. |
2000-01-13 |
2023-08-12 |
rat |
| D Grimm, S R Holmer, G A Riegger, E P Krome. Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol-induced heart failure in the rat. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 6. 2000-01-13. PMID:10615017. |
compared to ctrl, iso induced left ventricular hypertrophy (lvh), fibrosis, and overexpression of extracellular matrix proteins. |
2000-01-13 |
2023-08-12 |
rat |
| A Poliard, M C Ronzière, A M Freyria, D Lamblin, D Herbage, O Kellerman. Lineage-dependent collagen expression and assembly during osteogenic or chondrogenic differentiation of a mesoblastic cell line. Experimental cell research. vol 253. issue 2. 2000-01-11. PMID:10585261. |
chondrogenic c1 cells first elaborate a type ii collagen network and then acquire hypertrophic chondrocyte properties while assembling a type x collagen matrix as in the growth plate. |
2000-01-11 |
2023-08-12 |
Not clear |
| K Yagami, J Y Suh, M Enomoto-Iwamoto, E Koyama, W R Abrams, I M Shapiro, M Pacifici, M Iwamot. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. The Journal of cell biology. vol 147. issue 5. 1999-12-30. PMID:10579728. |
matrix gla protein (mgp), a gamma-carboxyglutamic acid (gla)-rich, vitamin k-dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development. |
1999-12-30 |
2023-08-12 |
chicken |
| K Fukada, S Shibata, S Suzuki, K Ohya, T Kurod. In situ hybridisation study of type I, II, X collagens and aggrecan mRNas in the developing condylar cartilage of fetal mouse mandible. Journal of anatomy. vol 195 ( Pt 3). 1999-12-14. PMID:10580848. |
the primarily formed chondrocytes in the cartilage matrix had already shown the appearance of hypertrophy and expressed types i, ii and x collagens and aggrecan mrnas simultaneously. |
1999-12-14 |
2023-08-12 |
mouse |
| A Cerr. Lectin histochemistry of the hyaline layer around the larvae of Patiriella species (Asteroidea) with different developmental modes. Journal of morphology. vol 242. issue 2. 1999-12-08. PMID:10521870. |
lectin labeling shows that hypertrophy of the hyaline layer of p. exigua, in particular the outer coarse meshwork, involves elaboration of the carbohydrate composition of the matrix. |
1999-12-08 |
2023-08-12 |
Not clear |
| A M Costa, S Peyrol, L C Pôrto, J P Comparin, J L Foyatier, A Desmoulièr. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. The American journal of pathology. vol 155. issue 5. 1999-11-30. PMID:10550323. |
our results show that, in hypertrophic scars, pressure therapy restores in part the extracellular matrix organization observed in normal scar and induces the disappearance of alpha-smooth muscle actin-expressing myofibroblasts, probably by apoptosis. |
1999-11-30 |
2023-08-12 |
Not clear |
| M W Orth, J I Fenton, K A Chlebek-Brow. Biochemical characterization of cartilage degradation in embryonic chick tibial explant cultures. Poultry science. vol 78. issue 11. 1999-11-26. PMID:10560834. |
these results suggest that chondrocytes in the tibiae undergo hypertrophy, degrade the extracellular matrix, and die. |
1999-11-26 |
2023-08-12 |
chicken |
| E B Hunziker, E Kapfinger, C Saage. Hypertrophy of growth plate chondrocytes in vivo is accompanied by modulations in the activity state and surface area of their cytoplasmic organelles. Histochemistry and cell biology. vol 112. issue 2. 1999-11-22. PMID:10460464. |
the rate of longitudinal bone growth is regulated primarily by modulations in the activity of epiphyseal plate hypertrophic chondrocytes, these being manifested as changes in cell and matrix volume. |
1999-11-22 |
2023-08-12 |
rat |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs. vol 165. issue 2. 1999-11-16. PMID:10516421. |
quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. |
1999-11-16 |
2023-08-12 |
human |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs. vol 165. issue 2. 1999-11-16. PMID:10516421. |
a computer image analysis of immunostained extracellular matrix (ecm) proteins (collagen types i, ii, iii and v, fibronectin and tenascin) in hypertrophic layers in the mandibular condyle and temporal bone of human fetuses, which ranged in gestational age from 12 to 32 weeks, was performed. |
1999-11-16 |
2023-08-12 |
human |
| C Farquharson, D Lester, E Seawright, D Jefferies, B Housto. Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy. Bone. vol 25. issue 4. 1999-11-02. PMID:10511106. |
a partial failure of chondrocyte hypertrophy was observed, although collagen type x immunoreactivity was noted within the interstitial matrix. |
1999-11-02 |
2023-08-12 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 8. 1999-09-30. PMID:10457260. |
chick embryo hypertrophic chondrocytes maintained in suspension synthesized type ii and type x collagen and organized their extracellular matrix, forming a tissue highly reminiscent of true cartilage, which eventually mineralized. |
1999-09-30 |
2023-08-12 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 8. 1999-09-30. PMID:10457260. |
hypertrophic chondrocytes cultured in adherent conditions in the presence of retinoic acid underwent further differentiation to osteoblast-like cells (i.e., they resumed cell proliferation, switched to type i collagen synthesis, and produced a mineralizing bone-like matrix). |
1999-09-30 |
2023-08-12 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 8. 1999-09-30. PMID:10457260. |
these data indicate that pth/pthrp inhibit both the mineralization of a cartilage-like matrix and apoptosis (mimicked in the suspension culture) and the production of a mineralizing bone-like matrix, characterizing further differentiation of hypertrophic chondrocytes to osteoblasts like cells (mimicked in adhesion culture). |
1999-09-30 |
2023-08-12 |
chicken |
| M Lajemi, S Gautier, A Beneto. [Rigidity of large arteries and cardiovascular risk. epidemiological aspects and genetic determinants]. Pathologie-biologie. vol 47. issue 6. 1999-09-23. PMID:10472072. |
aging, environmental and genetic factors are responsible for structural and functional changes of the arterial wall media (hypertrophy, extracellular matrix accumulation, calcium deposits) and of the vascular endothelium (decrease in the release of vasodilators and increased synthesis of vasoconstrictors), all that leading to a diminution of elasticity and increased stiffness. |
1999-09-23 |
2023-08-12 |
human |
| N Nishijo, S Takamine, F Sugiyama, K Kimoto, K Taniguchi, H Horiguchi, T Ogata, K Murakami, A Fukamizu, K Yagam. Vascular remodeling in hypertensive transgenic mice. Experimental animals. vol 48. issue 3. 1999-09-23. PMID:10480026. |
they progressively developed remarkable vascular hypertrophy composed of dedifferentiation of vascular smooth muscle cells (vsmcs) and extracellular matrix accumulation in the thoracic aorta, and vsmc hyperplasia was predominant in the abdominal aorta. |
1999-09-23 |
2023-08-12 |
mouse |
| M Polo, P D Smith, Y J Kim, X Wang, F Ko, M C Robso. Effect of TGF-beta2 on proliferative scar fibroblast cell kinetics. Annals of plastic surgery. vol 43. issue 2. 1999-09-20. PMID:10454327. |
keloids, hypertrophic scars, and burn hypertrophic scars are all forms of proliferative scarring characterized by overabundant matrix formation. |
1999-09-20 |
2023-08-12 |
rat |