| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C G Pham, A E Harpf, R S Keller, H T Vu, S Y Shai, J C Loftus, R S Ros. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. American journal of physiology. Heart and circulatory physiology. vol 279. issue 6. 2000-12-28. PMID:11087248. |
alterations in the extracellular matrix occur during the cardiac hypertrophic process. |
2000-12-28 |
2023-08-12 |
Not clear |
| b' M T Engsig, Q J Chen, T H Vu, A C Pedersen, B Therkidsen, L R Lund, K Henriksen, T Lenhard, N T Foged, Z Werb, J M Delaiss\\xc3\\xa. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. The Journal of cell biology. vol 151. issue 4. 2000-12-22. PMID:11076971.' |
hypertrophic cartilage also expresses vascular endothelial growth factor (vegf), which binds to extracellular matrix and is made bioavailable by mmp-9 (bergers, g., r. brekken, g. mcmahon, t.h. |
2000-12-22 |
2023-08-12 |
mouse |
| L Legeai-Mallet, A Rossi, C Benoist-Lasselin, R Piazza, J F Mallet, A L Delezoide, A Munnich, J Bonaventure, L Zylberber. EXT 1 gene mutation induces chondrocyte cytoskeletal abnormalities and defective collagen expression in the exostoses. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 8. 2000-12-11. PMID:10934647. |
the unexpected presence of collagen type i unevenly distributed in the cartilage matrix further suggested that some of the hypertrophic chondrocytes detected in the cartilaginous caps of the exostoses underwent accelerated differentiation. |
2000-12-11 |
2023-08-12 |
Not clear |
| S Moskalewski, A Hyc, A Osiecka-Iwan, P Strzelczy. [Molecular basis of achondroplasia, hypochondroplasia, and thanatophoric dysplasia]. Chirurgia narzadow ruchu i ortopedia polska. vol 65. issue 3. 2000-12-08. PMID:11057021. |
fibroblast growth factor 2 (fgf2) inhibits proliferation and hypertrophy of chondrocytes in the growth plate, synthesis of cartilage matrix, terminal differentiation of hypertrophic chondrocytes and matrix calcification. |
2000-12-08 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
however, immunolocalization in extracellular matrix was restricted to the hypertrophic zones of both lines. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
in the hypertrophic zone of low td incidence line, immunolocalization of tgf-beta1 in the extracellular matrix adjacent to collapsed cartilage canals (matrix streaks) was significantly greater than immunolocalization between patent cartilage canals. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
results indicate that chondrocytes of all zones of the growth plate contain tgf-beta1 but do not release it into extracellular matrix until hypertrophy has occurred. |
2000-11-30 |
2023-08-12 |
Not clear |
| G M Hargrove, J Dufresne, C Whiteside, D A Muruve, N C Won. Diabetes mellitus increases endothelin-1 gene transcription in rat kidney. Kidney international. vol 58. issue 4. 2000-11-13. PMID:11012888. |
mesangial cell hypertrophy and increased extracellular matrix (ecm) contribute to mesangial expansion in early progressive diabetic nephropathy. |
2000-11-13 |
2023-08-12 |
rat |
| C Farquharson, D Jefferie. Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia. Poultry science. vol 79. issue 7. 2000-11-09. PMID:10901201. |
immunolocalization studies of matrix components suggest an abnormal distribution within the td growth plate that is consistent with a failure of the chondrocytes to fully hypertrophy. |
2000-11-09 |
2023-08-12 |
chicken |
| N Guarino, H Shima, P Pur. Structural immaturity of the pylorus muscle in infantile hypertrophic pyloric stenosis. Pediatric surgery international. vol 16. issue 4. 2000-11-07. PMID:10898230. |
recent reports indicate that extracellular matrix and cytoskeleton plasmalemmal elements are altered in infantile hypertrophic pyloric stenosis (ihps). |
2000-11-07 |
2023-08-12 |
Not clear |
| G Costache, D Popov, A Georgescu, M Cenuse, V V Jinga, M Simionesc. The effects of simultaneous hyperlipemia-hyperglycemia on the resistance arteries, myocardium and kidney glomeruli. Journal of submicroscopic cytology and pathology. vol 32. issue 1. 2000-10-13. PMID:10877102. |
the hd hamsters displayed also modifications that may be dependent on or may lead to an increase in blood pressure, such as: a) approximately 2 fold increase in the activity of serum angiotensin converting enzyme; b) approximately 4.8 fold enhancement of erythrocytes fragility (as a measure of the oxidative stress); c) left ventricular hypertrophy associated with a progressive disarray of cardiomyocyte contractile fibers, interruptions of the z bands, and accumulation of collagen-rich extracellular matrix indicative of interstitial fibrosis; d) the kidney glomerular capillaries appeared partially or totally collapsed, with a thickened basement membrane which appeared polymorphic, and in some locations made up of successive layers connected by fine bridges and intercalated nodules; in addition, an increase (approximately 1.50 fold) of the mesangial volume was indicative of glomerulosclerosis. |
2000-10-13 |
2023-08-12 |
Not clear |
| D Duprez, M De Buyzere, E R Rietzschel, D L Clemen. Aldosterone and vascular damage. Current hypertension reports. vol 2. issue 3. 2000-10-13. PMID:10981167. |
moreover, aldosterone is involved in vascular smooth muscle cell hypertrophy and hyperplasia, as well as in vascular matrix impairment and endothelial dysfunction. |
2000-10-13 |
2023-08-12 |
Not clear |
| A J Ingram, L James, H Ly, K Thai, L Cai, J W Schole. Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney international. vol 58. issue 3. 2000-10-12. PMID:10972671. |
in vivo, intraglomerular hypertension results in resident cell hypertrophy, proliferation and matrix protein production, leading to glomerulosclerosis. |
2000-10-12 |
2023-08-12 |
Not clear |
| S Kagami, S Kondo, M Urushihara, K Löster, W Reutter, T Saijo, A Kitamura, S Kobayashi, Y Kurod. Overexpression of alpha1beta1 integrin directly affects rat mesangial cell behavior. Kidney international. vol 58. issue 3. 2000-10-12. PMID:10972673. |
glomerular mesangial cell (mc) proliferation, hypertrophy, and abnormal matrix remodeling characterized by increased expression of fibronectin, laminin and collagen type iv, and neoexpression of collagen i and iii are the main biological features of progressive glomerulonephritis (gn). |
2000-10-12 |
2023-08-12 |
rat |
| V J Matukas, B J Panner, J L Orbiso. Studies on ultrastructural identification and distribution of protein-polysaccharide in cartilage matrix. The Journal of cell biology. vol 32. issue 2. 2000-09-14. PMID:10976228. |
when the matrix of epiphyseal cartilage is compared to that of the zone of hypertrophic cells, fibers are similar but the granules in the latter zone are larger and more numerous. |
2000-09-14 |
2023-08-12 |
chicken |
| A D Widgerow, L A Chait, R Stals, P J Stal. New innovations in scar management. Aesthetic plastic surgery. vol 24. issue 3. 2000-08-17. PMID:10890953. |
tension on a scar from many directions or intermittently will result in a hypertrophic scar, possibly initiated by lymphocytes but definitely related to a prolongation of the inflammatory process, with increased fibroblast activity and overabundant extracellular matrix secretion [24,26]. |
2000-08-17 |
2023-08-12 |
Not clear |
| J M Taylor, J D Rovin, J T Parson. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. The Journal of biological chemistry. vol 275. issue 25. 2000-08-16. PMID:10749882. |
here we report that signals provided by extracellular matrix proteins (ecm) augment the pe-induced hypertrophic response of cardiomyocytes and provide evidence that ecm-dependent signaling is mediated in part by the protein tyrosine kinase, focal adhesion kinase (fak). |
2000-08-16 |
2023-08-12 |
rat |
| M D'Angelo, Z Yan, M Nooreyazdan, M Pacifici, D S Sarment, P C Billings, P S Lebo. MMP-13 is induced during chondrocyte hypertrophy. Journal of cellular biochemistry. vol 77. issue 4. 2000-08-15. PMID:10771523. |
during development, mrna for matrix metalloproteinase-13 (mmp-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. |
2000-08-15 |
2023-08-12 |
chicken |
| E Ogawa, Y Saito, M Harada, S Kamitani, K Kuwahara, Y Miyamoto, M Ishikawa, I Hamanaka, N Kajiyama, N Takahashi, O Nakagawa, I Masuda, I Kishimoto, K Naka. Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775482. |
cardiac hypertrophy involves the accumulation of extracellular matrix proteins, such as fibronectin, leading to increasing myocardial stiffness, ventricular dysfunction and heart failure. |
2000-08-11 |
2023-08-12 |
human |
| E Ogawa, Y Saito, M Harada, S Kamitani, K Kuwahara, Y Miyamoto, M Ishikawa, I Hamanaka, N Kajiyama, N Takahashi, O Nakagawa, I Masuda, I Kishimoto, K Naka. Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775482. |
these findings demonstrate that the interaction of fibronectin and rgd-dependent integrins is involved in the hypertrophic responses of myocyte in vitro, and suggest that extracellular matrix proteins such as fibronectin are not merely passive adhesive molecules but are active participants in processes leading to myocyte hypertrophy. |
2000-08-11 |
2023-08-12 |
human |