| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z R Yousef, M S Marbe. The open artery hypothesis: potential mechanisms of action. Progress in cardiovascular diseases. vol 42. issue 6. 2000-07-12. PMID:10871164. |
almost immediately, neurohormones are activated that alter hemodynamic load, and, later, stimulate myocyte hypertrophy, while locally, inflammatory processes clear necrotic debris, reorganize the extracellular matrix, and orchestrate scar formation. |
2000-07-12 |
2023-08-12 |
Not clear |
| N Joki, S Kaname, M Hirakata, Y Hori, T Yamaguchi, T Fujita, T Katoh, K Kurokaw. Tyrosine-kinase dependent TGF-beta and extracellular matrix expression by mechanical stretch in vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. vol 23. issue 2. 2000-06-21. PMID:10770255. |
vascular hypertrophy, which is characterized by proliferation of vascular smooth muscle cells (vsmc) and accumulation of extracellular matrix (ecm), is a major pathological change in blood vessels after chronic exposure to hypertension. |
2000-06-21 |
2023-08-12 |
rat |
| M O Boluyt, O H Bin. Matrix gene expression and decompensated heart failure: the aged SHR model. Cardiovascular research. vol 46. issue 2. 2000-06-12. PMID:10773227. |
impaired functional performance despite hypertrophic enlargement, and an excessive accumulation of extracellular matrix, are hallmarks of the decompensated failing heart. |
2000-06-12 |
2023-08-12 |
rat |
| B Nedelec, A Ghahary, P G Scott, E E Tredge. Control of wound contraction. Basic and clinical features. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791174. |
because the prolonged presence of myofibroblasts, producing an imbalance in extracellular matrix proteins and proteases, probably exacerbates hypertrophic scars and wound contraction, accelerating the rate of apoptotic cell death to reduce the cell number to that seen in normal scar may be a useful strategy for providing effective and efficient treatment of scar contracture. |
2000-06-08 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. |
2000-05-18 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
cyclic matrix deformation greatly stimulated proliferation of immature chondrocytes, but not that of hypertrophic chondrocytes. |
2000-05-18 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
synthesis of cartilage matrix protein (cmp/matrilin-1), a mature chondrocyte marker, and type x collagen, a hypertrophic chondrocyte marker, was up-regulated by stretch-induced matrix deformation. |
2000-05-18 |
2023-08-12 |
Not clear |
| C H Lohmann, Z Schwartz, G G Niederauer, B D Boya. [Degree of differentiation of chondrocytes and their pretreatment with platelet-derived-growth factor. Regulating induction of cartilage formation in resorbable tissue carriers in vivo]. Der Orthopade. vol 29. issue 2. 2000-05-03. PMID:10743633. |
prior in vitro studies showed that platelet derived growth factor-bb (pdgf-bb), but not transforming growth factor beta-1 (tgf-beta 1), basic fibroblast growth factor, or bone morphogenetic protein-2 promoted proliferation and extracellular matrix sulfation of resting zone chondrocytes without causing the cells to exhibit a hypertrophic chondrocyte phenotype. |
2000-05-03 |
2023-08-12 |
mouse |
| D C Han, B B Hoffman, S W Hong, J Guo, F N Ziyade. Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. American journal of physiology. Renal physiology. vol 278. issue 4. 2000-05-02. PMID:10751224. |
in conclusion, therapy with antisense tgf-beta1 odn decreases tgf-beta1 production and attenuates high-glucose-induced proximal tubular cell hypertrophy in vitro and partially prevents the increase in kidney weight and extracellular matrix expression in diabetic mice. |
2000-05-02 |
2023-08-12 |
mouse |
| V Mericq, J A Uyeda, K M Barnes, F De Luca, J Baro. Regulation of fetal rat bone growth by C-type natriuretic peptide and cGMP. Pediatric research. vol 47. issue 2. 2000-03-30. PMID:10674345. |
we conclude that cnp stimulates longitudinal bone growth by increasing chondrocyte proliferation, chondrocyte hypertrophy, and cartilage matrix production. |
2000-03-30 |
2023-08-12 |
rat |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
the purpose of this study was to elucidate the morphological changes in the collagen of the extracellular matrix (ecm) in the hearts of pigs with hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
our findings of an overall increase of collagen content suggested that the accumulation of collagen matrix might be another factor responsible for the diastolic dysfunction of hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| A R Klatt, D P Nitsche, B Kobbe, M Mörgelin, M Paulsson, R Wagene. Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development. The Journal of biological chemistry. vol 275. issue 6. 2000-03-16. PMID:10660556. |
it is found both inside the lacunae and in the interterritorial matrix of the resting, proliferating, hypertrophic, and calcified cartilage zones, whereas the expression is lower in the superficial articular cartilage. |
2000-03-16 |
2023-08-12 |
mouse |
| N Suda, S Shibata, K Yamazaki, T Kuroda, P V Senior, F Beck, V E Hammon. Parathyroid hormone-related protein regulates proliferation of condylar hypertrophic chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 11. 2000-03-07. PMID:10571683. |
immunolocalization of type x collagen, the extracellular matrix specifically expressed by hypertrophic chondrocytes, was greatly reduced in the condylar cartilage of homozygous pthrp-knockout mice compared with wild-type mice. |
2000-03-07 |
2023-08-12 |
mouse |
| J Higaki, M Aoki, R Morishita, I Kida, Y Taniyama, N Tomita, K Yamamoto, A Moriguchi, Y Kaneda, T Ogihar. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669640. |
angiotensin ii (ang ii) stimulates cardiac hypertrophy as well as the production of extracellular matrix. |
2000-03-03 |
2023-08-12 |
human |
| P J Duke, D Montufar-Soli. Exposure to altered gravity affects all stages of endochondral cartilage differentiation. Advances in space research : the official journal of the Committee on Space Research (COSPAR). vol 24. issue 6. 2000-02-29. PMID:11542628. |
once cartilage has developed, in rats, further differentiation (hypertrophy, matrix production) was also affected by spaceflight and hind limb suspension. |
2000-02-29 |
2023-08-12 |
rat |
| P Teofoli, S Barduagni, M Ribuffo, A Campanella, O De Pita', P Pudd. Expression of Bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars. Journal of dermatological science. vol 22. issue 1. 2000-02-25. PMID:10651227. |
keloids and hypertrophic scars represent a model of altered wound healing characterized by overproduction of extracellular matrix and dermal fibroblasts with high mitotic rate. |
2000-02-25 |
2023-08-12 |
Not clear |
| J Johnson, T Shinomura, H Eberspaecher, G Pinero, B Decrombrugghe, M Höö. Expression and localization of PG-Lb/epiphycan during mouse development. Developmental dynamics : an official publication of the American Association of Anatomists. vol 216. issue 4-5. 2000-02-22. PMID:10633869. |
our results show that pg-lb/epiphycan gene expression is an intermediate marker for chondrogenesis, and that the protein can be localized to the extracellular matrix surrounding resting, proliferating, and hypertrophic chondrocytes by immunofluorescence histochemistry. |
2000-02-22 |
2023-08-12 |
mouse |
| K Sebeková, J Dämmrich, Z Krivosíková, A Heidlan. The effect of oral protease administration in the rat remnant kidney model. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 199. issue 3. 2000-02-14. PMID:10639701. |
the protein/dna ratio in isolated glomeruli and tubules, as an estimate of glomerular matrix accumulation and hypertrophy of tubules, was enhanced in 5/6 nx groups and a tendency towards lower values was observed after e treatment. |
2000-02-14 |
2023-08-12 |
rat |