| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Spencer, L Chi, M X Zh. Biochemical characterization of benomyl inhibition on endometrial growth during decidualization in rats. Advances in experimental medicine and biology. vol 444. 1999-03-10. PMID:10026946. |
measured endometrial parameters were the wet weight, protein for hypertrophy, dna indicative of hyperplasia; enzymatic biomarkers- isocitrate dehydrogenase (icdh) and the matrix metalloproteinases (mmps); and serum progesterone which hormonally maintains decidual growth. |
1999-03-10 |
2023-08-12 |
rat |
| I Koffi, P Lacolley, M Kirchengaast, J P Pomiès, S Laurent, A Beneto. Prevention of arterial structural alterations with verapamil and trandolapril and consequences for mechanical properties in spontaneously hypertensive rats. European journal of pharmacology. vol 361. issue 1. 1999-03-04. PMID:9851541. |
we compared the chronic effects in spontaneously hypertensive rats (shr) of low doses of an angiotensin converting enzyme inhibitor, trandolapril, a ca2+ channel antagonist, verapamil, and their combination (trandolapril-verapamil), on arterial mechanical properties, arterial wall hypertrophy and extracellular matrix proteins. |
1999-03-04 |
2023-08-12 |
rat |
| R K Dubey, D G Gillespie, E K Jackso. Adenosine inhibits collagen and total protein synthesis in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). vol 33. issue 1 Pt 2. 1999-02-26. PMID:9931103. |
thus, exogenous a2b receptor agonists and drugs that modulate endogenous adenosine levels may protect against vasoocclusive disorders by attenuating extracellular matrix synthesis by and cellular hypertrophy of vascular smcs. |
1999-02-26 |
2023-08-12 |
Not clear |
| T Szuwart, H Kierdorf, U Kierdorf, G Cleme. Ultrastructural aspects of cartilage formation, mineralization, and degeneration during primary antler growth in fallow deer (Dama dama). Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 180. issue 6. 1999-02-25. PMID:9862029. |
concomitant with cell hypertrophy, formation of a lacunar and a perilacunar extracellular matrix was observed, the latter containing numerous collagenous fibers. |
1999-02-25 |
2023-08-12 |
Not clear |
| T Szuwart, H Kierdorf, U Kierdorf, G Cleme. Ultrastructural aspects of cartilage formation, mineralization, and degeneration during primary antler growth in fallow deer (Dama dama). Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 180. issue 6. 1999-02-25. PMID:9862029. |
the hypertrophic chondrocytes of the mineralized cartilage then degenerated, a process that was also occasionally observed in more distally located cells surrounded by still unmineralized matrix. |
1999-02-25 |
2023-08-12 |
Not clear |
| H Watanabe, Y Yamad. Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nature genetics. vol 21. issue 2. 1999-02-25. PMID:9988279. |
during endochondral bone formation, hypertrophic chondrocytes die and the cartilage is replaced with bone matrix. |
1999-02-25 |
2023-08-12 |
mouse |
| H Watanabe, Y Yamad. Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nature genetics. vol 21. issue 2. 1999-02-25. PMID:9988279. |
these results indicate that lp is important for the formation of proteoglycan aggregates and normal organization of hypertrophic chondrocytes, and suggest that cartilage matrix has a role in chondrocyte differentiation and maturation. |
1999-02-25 |
2023-08-12 |
mouse |
| J Mollenhauer, M T Mok, K B King, M Gupta, S Chubinskaya, H Koepp, A A Col. Expression of anchorin CII (cartilage annexin V) in human young, normal adult, and osteoarthritic cartilage. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 47. issue 2. 1999-02-12. PMID:9889256. |
anx v epitopes are also located in the pericellular matrix of hypertrophic cartilage. |
1999-02-12 |
2023-08-12 |
human |
| M Turcani, H Rup. Development of pressure overload induced cardiac hypertrophy is unaffected by long-term treatment with losartan. Molecular and cellular biochemistry. vol 188. issue 1-2. 1999-02-05. PMID:9823028. |
left ventricular hypertrophy with adequate wall thickness, preserved adult phenotype and extracellular matrix may be useful in the prevention of heart failure. |
1999-02-05 |
2023-08-12 |
rat |
| M Riminucci, J N Bradbeer, A Corsi, C Gentili, F Descalzi, R Cancedda, P Bianc. Vis-à-vis cells and the priming of bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 13. issue 12. 1999-02-03. PMID:9844103. |
we further showed that in an in vitro avian model of chondrocyte differentiation in vitro to osteoblast-like cells, early hypertrophic chondrocytes replated as adherent cells turned on the expression of high levels of bsp in conjunction with the switch to collagen type i synthesis and matrix mineralization. |
1999-02-03 |
2023-08-12 |
Not clear |
| V Szuts, U Möllers, K Bittner, G Schürmann, S Muratoglu, F Deák, I Kiss, P Bruckne. Terminal differentiation of chondrocytes is arrested at distinct stages identified by their expression repertoire of marker genes. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 6. 1999-02-02. PMID:9840445. |
during endochondral bone formation, cells in the emerging cartilaginous model transit through a cascade of several chondrocyte differentiation stages, each characterized by a specific expression repertoire of matrix macromolecules, until, as a final step, the hypertrophic cartilage is replaced by bone. |
1999-02-02 |
2023-08-12 |
chicken |
| E J Mackie, L I Murph. The role of tenascin-C and related glycoproteins in early chondrogenesis. Microscopy research and technique. vol 43. issue 2. 1999-01-28. PMID:9822997. |
with progressive development of endochondral bones, tenascin-c is absent from the matrix surrounding proliferating and hypertrophic chondrocytes, but remains in a restricted distribution in peripheral epiphyseal cartilage. |
1999-01-28 |
2023-08-12 |
chicken |
| L C Gerstenfeld, C D Toma, J L Schaffer, W J Landi. Chondrogenic potential of skeletal cell populations: selective growth of chondrocytes and their morphogenesis and development in vitro. Microscopy research and technique. vol 43. issue 2. 1999-01-28. PMID:9823002. |
the differentiation of chondrocytes during this process in vivo is characterized by progressive morphological changes associated with the hypertrophy of these cells and is defined by biochemical changes that result in the mineralization of the extracellular matrix. |
1999-01-28 |
2023-08-12 |
chicken |
| L C Gerstenfeld, C D Toma, J L Schaffer, W J Landi. Chondrogenic potential of skeletal cell populations: selective growth of chondrocytes and their morphogenesis and development in vitro. Microscopy research and technique. vol 43. issue 2. 1999-01-28. PMID:9823002. |
the conditions for promoting cell growth, hypertrophy, and extracellular matrix mineralization of embryonic chicken chondrocytes in vitro include ascorbic acid supplementation and the presence of an organic phosphate source. |
1999-01-28 |
2023-08-12 |
chicken |
| L C Gerstenfeld, C D Toma, J L Schaffer, W J Landi. Chondrogenic potential of skeletal cell populations: selective growth of chondrocytes and their morphogenesis and development in vitro. Microscopy research and technique. vol 43. issue 2. 1999-01-28. PMID:9823002. |
the differentiation of hypertrophic chondrocytes in vitro is associated with a 10-15-fold increase in alkaline phosphatase enzyme activity and deposition of mineral within the extracellular matrix. |
1999-01-28 |
2023-08-12 |
chicken |
| L C Gerstenfeld, C D Toma, J L Schaffer, W J Landi. Chondrogenic potential of skeletal cell populations: selective growth of chondrocytes and their morphogenesis and development in vitro. Microscopy research and technique. vol 43. issue 2. 1999-01-28. PMID:9823002. |
ultrastructural examination reveals cellular and extracellular morphology similar to that of hypertrophic cells in vivo with chondrocytes embedded in a well formed extracellular matrix of randomly distributed collagen fibrils and proteoglycan. |
1999-01-28 |
2023-08-12 |
chicken |
| G E Holl. Changes in muscularis externa of rat small intestine after myenteric ablation with benzalkonium chloride: electron microscopic and morphometric study. Digestive diseases and sciences. vol 43. issue 12. 1999-01-22. PMID:9881499. |
the resulting severe hypertrophy (cell hypertrophy of 96-133% and hyperplasia) differs from working hypertrophy by the distribution and degree of muscle thickening and by characteristics of the extracellular matrix: narrowing of muscle interspaces of 43%; lack of increased collagen; changes in the ratio of interstitial cells of cajal (iccs) to fibroblasts from 1.6:1 to 0.8:1 with no numerical decrease in either type of cell; decreased interconnections of iccs to muscles and nerves due to deformed iccs; a 197% increase in vascularization (capillaries, venules) and lymphatics in both muscle layers and in the myenteric plexus cleft, possibly initiated by release of fibroblast growth factor from myelin fragmentation after nerve damage; and increased macrophages, plasma cells, monocytes and mast cells in the myenteric plexus cleft. |
1999-01-22 |
2023-08-12 |
rat |
| R Ziswiler, K Steinmann-Niggli, A Kappeler, C Daniel, H P Mart. Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. Journal of the American Society of Nephrology : JASN. vol 9. issue 11. 1999-01-19. PMID:9808091. |
therapy of nephritic rats by mmf resulted in a significant amelioration of glomerular histology, assessed by glomerular cellularity, synthesis of alpha-smooth muscle actin, extracellular matrix deposition, and glomerular hypertrophy. |
1999-01-19 |
2023-08-12 |
rat |
| M E Cooper, Z Cao, J R Rumble, K Jandeleit, T J Allen, R E Gilber. Attenuation of diabetes-associated mesenteric vascular hypertrophy with perindopril: morphological and molecular biological studies. Metabolism: clinical and experimental. vol 47. issue 12 Suppl 1. 1999-01-15. PMID:9867067. |
diabetes was associated with smooth muscle hypertrophy and extracellular matrix (ecm) accumulation. |
1999-01-15 |
2023-08-12 |
human |
| K Umemura, S Kikuchi, Y Suzuki, M Nakashim. Inhibitory effect of tranilast on hypertrophic collagen production in the spontaneously hypertensive rat heart. Japanese journal of pharmacology. vol 78. issue 2. 1999-01-14. PMID:9829619. |
in the present study, we have investigated the effect of this drug on cardiac hypertrophy in spontaneously hypertensive rats (shr), with a focus on the cardiac collagen matrix, which is associated with myocardial stiffness. |
1999-01-14 |
2023-08-12 |
rat |