| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann L Armstrong, Hans J Barrach, Michael G Ehrlic. Identification of the metalloproteinase stromelysin in the physis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 20. issue 2. 2002-04-11. PMID:11918308. |
for long bone growth to occur, calcification of the matrix must commence in the lower hypertrophic zone of the growth plate. |
2002-04-11 |
2023-08-12 |
cattle |
| H Ohara, T Tamayama, K Maemura, K Kanbara, H Hayasaki, M Abe, M Watanab. Immunocytochemical demonstration of glucose transporters in epiphyseal growth plate chondrocytes of young rats in correlation with autoradiographic distribution of 2-deoxyglucose in chondrocytes of mice. Acta histochemica. vol 103. issue 4. 2002-03-19. PMID:11700943. |
however, in the hypertrophic zone, silver grain density was high in matrix and chondrocytes. |
2002-03-19 |
2023-08-12 |
mouse |
| K Masutomo, N Makino, M S Fushik. Effects of losartan on the collagen degradative enzymes in hypertrophic and congestive types of cardiomyopathic hamsters. Molecular and cellular biochemistry. vol 224. issue 1-2. 2002-03-15. PMID:11693196. |
the present study was undertaken to determine the effects of at1 receptor blockade which occurred in response to losartan, on the extracellular matrix (ecm) degradation process in the bio 14.6 (n = 12) and bio 53.58 (n = 12) strains which are referred as models of hypertrophic and dilated cardiomyopathy, respectively. |
2002-03-15 |
2023-08-12 |
Not clear |
| J Turnay, N Olmo, M A Lizarbe, K von der Mar. Changes in the expression of annexin A5 gene during in vitro chondrocyte differentiation: influence of cell attachment. Journal of cellular biochemistry. vol 84. issue 1. 2002-03-13. PMID:11746522. |
as a major constituent of cartilage matrix vesicles, which are released from microvilli of hypertrophic chondrocytes, it is involved in calcium uptake necessary for the initial stages of cartilage calcification. |
2002-03-13 |
2023-08-12 |
chicken |
| J Turnay, N Olmo, M A Lizarbe, K von der Mar. Changes in the expression of annexin A5 gene during in vitro chondrocyte differentiation: influence of cell attachment. Journal of cellular biochemistry. vol 84. issue 1. 2002-03-13. PMID:11746522. |
the downregulation of annexin a5 expression in cells growing as matrix-rich aggregates was reverted when extracellular matrix components were removed and cells were reseeded onto tissue culture plastic, suggesting that cell spreading, formation of focal contacts and stress fibers stimulated annexin a5 expression in proliferating as well as in hypertrophic chondrocytes. |
2002-03-13 |
2023-08-12 |
chicken |
| Emiko Ogawa, Yoshihiko Saito, Koichiro Kuwahara, Masaki Harada, Yoshihiro Miyamoto, Ichiro Hamanaka, Noboru Kajiyama, Nobuki Takahashi, Takehiko Izumi, Rika Kawakami, Ichiro Kishimoto, Yoshihisa Naruse, Nozomu Mori, Kazuwa Naka. Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression. Cardiovascular research. vol 53. issue 2. 2002-03-11. PMID:11827696. |
brain natriuretic peptide (bnp) is a cardiac hormone mainly synthesized in ventricles and its expression is markedly increased in ventricular hypertrophy that involves the accumulation of extracellular matrix proteins, such as fibronectin (fn). |
2002-03-11 |
2023-08-12 |
Not clear |
| T K Jeffery, J C Wanstal. Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacology & therapeutics. vol 92. issue 1. 2002-03-04. PMID:11750034. |
it involves thickening of all three layers of the blood vessel wall (due to hypertrophy and/or hyperplasia of the predominant cell type within each layer), as well as extracellular matrix deposition. |
2002-03-04 |
2023-08-12 |
Not clear |
| Sujata G Pandit, Prasanthi Govindraj, Joachim Sasse, Peter J Neame, John R Hassel. The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs. The Biochemical journal. vol 361. issue Pt 2. 2002-02-14. PMID:11772395. |
immunostaining localized fgfr3 to the pericellular region of reserve chondrocytes and to the extracellular matrix in the hypertrophic zone. |
2002-02-14 |
2023-08-12 |
human |
| Sujata G Pandit, Prasanthi Govindraj, Joachim Sasse, Peter J Neame, John R Hassel. The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs. The Biochemical journal. vol 361. issue Pt 2. 2002-02-14. PMID:11772395. |
these results suggest that the transmembrane form of fgfr3 increasingly undergoes proteolytic cleavage towards the hypertrophic zone to produce an extracellular-domain fragment of fgfr3, which is present in large amounts in the matrix of hypertrophic cells. |
2002-02-14 |
2023-08-12 |
human |
| Y Ogawa, N Tamura, H Chusho, K Naka. Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart. Canadian journal of physiology and pharmacology. vol 79. issue 8. 2002-02-07. PMID:11558681. |
in addition to cardiac myocyte hypertrophy, proliferation and increased extracellular matrix production of cardiac fibroblasts occur in response to cardiac overload. |
2002-02-07 |
2023-08-12 |
mouse |
| S Beavan, A Horner, S Bord, D Ireland, J Compsto. Colocalization of glucocorticoid and mineralocorticoid receptors in human bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 8. 2002-01-30. PMID:11499872. |
in the neonatal rib cartilage, staining for gralpha, gralphabeta, and mr was present in approximately one-half of the resting and hypertrophic chondrocytes and in most of proliferating chondrocytes and chondrocytes within the mineralizing matrix. |
2002-01-30 |
2023-08-12 |
human |
| S L Felisbino, H F Carvalh. Growth cartilage calcification and formation of bone trabeculae are late and dissociated events in the endochondral ossification of Rana catesbeiana. Cell and tissue research. vol 306. issue 2. 2002-01-22. PMID:11702243. |
in stage-46 tadpoles and 1-year-old animals, the hypertrophic cartilage had a smooth contact with the bone marrow and the matrix showed no calcification or endochondral bone formation. |
2002-01-22 |
2023-08-12 |
Not clear |
| S L Felisbino, H F Carvalh. Growth cartilage calcification and formation of bone trabeculae are late and dissociated events in the endochondral ossification of Rana catesbeiana. Cell and tissue research. vol 306. issue 2. 2002-01-22. PMID:11702243. |
calcium deposits appeared as isolated or coalesced spherical structures in the extracellular matrix of hypertrophic cartilage. |
2002-01-22 |
2023-08-12 |
Not clear |
| A Schubert, T Walther, V Falk, C Binner, N Löscher, A Kanev, S Bleiziffer, T Rauch, R Autschbach, F W Moh. Extracellular matrix gene expression correlates to left ventricular mass index after surgical induction of left ventricular hypertrophy. Basic research in cardiology. vol 96. issue 4. 2002-01-11. PMID:11518194. |
extracellular matrix gene expression correlates to left ventricular mass index after surgical induction of left ventricular hypertrophy. |
2002-01-11 |
2023-08-12 |
Not clear |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure. vol 23. issue 3-4. 2001-12-28. PMID:11499562. |
prominent among these is transforming growth factor-beta (tgf-beta) because it promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the two hallmarks of diabetic renal disease. |
2001-12-28 |
2023-08-12 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure. vol 23. issue 3-4. 2001-12-28. PMID:11499562. |
neutralizing anti-tgf-beta antibodies prevent the hypertrophic and matrix stimulatory effects of high glucose in these cells. |
2001-12-28 |
2023-08-12 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure. vol 23. issue 3-4. 2001-12-28. PMID:11499562. |
we demonstrate that short-term treatment of diabetic mice with neutralizing monoclonal antibodies against tgf-beta significantly reduces kidney weight and glomerular hypertrophy and attenuates the increase in extracellular matrix mrnas. |
2001-12-28 |
2023-08-12 |
mouse |
| S Chen, S W Hong, M C Iglesias-de la Cruz, M Isono, A Casaretto, F N Ziyade. The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy. Renal failure. vol 23. issue 3-4. 2001-12-28. PMID:11499562. |
the data we review here strongly support the hypothesis that elevated production or activity of the tgf-beta system mediates diabetic renal hypertrophy and extracellular matrix expansion. |
2001-12-28 |
2023-08-12 |
mouse |
| O Jacenko, D Chan, A Franklin, S Ito, C B Underhill, J F Bateman, M R Campbel. A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. The American journal of pathology. vol 159. issue 6. 2001-12-18. PMID:11733375. |
a dominant interference collagen x mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. |
2001-12-18 |
2023-08-12 |
mouse |
| O Jacenko, D Chan, A Franklin, S Ito, C B Underhill, J F Bateman, M R Campbel. A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. The American journal of pathology. vol 159. issue 6. 2001-12-18. PMID:11733375. |
electron microscopy revealed a disrupted hexagonal lattice network in the hypertrophic chondrocyte pericellular matrix in tg growth plates, as well as altered mineral deposition. |
2001-12-18 |
2023-08-12 |
mouse |