| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze'ev Hochber. Mechanisms of steroid impairment of growth. Hormone research. vol 58 Suppl 1. 2003-03-17. PMID:12373012. |
direct effects at the growth plate include the suppression of multiple gene expression, chondrocyte proliferation and matrix proteoglycan synthesis, sulfation, release and mineralization as well as the augmentation of hypertrophic cell apoptosis. |
2003-03-17 |
2023-08-12 |
Not clear |
| T Kawakami, A Kimura, M Yamada, S Matsuura, T Horio, H Hasegawa, H Kand. Localization of matrix proteins of hard tissue in osteochondromas. European journal of medical research. vol 7. issue 7. 2003-03-13. PMID:12176684. |
between the cartilage and spongy bone, which is a metaphysis-like region, a chondroidal pattern appeared in the matrix of hypertrophy cartilage. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yujiro Sakamoto, Yoshiro Takan. Morphological influence of ascorbic acid deficiency on endochondral ossification in osteogenic disorder Shionogi rat. The Anatomical record. vol 268. issue 2. 2003-02-25. PMID:12221715. |
in condylar cartilage, hypertrophic chondrocytes were encased in a thickened calcification zone, and groups of nonhypertrophic chondrocytes occasionally formed cell nests surrounded by a metachromatic matrix in the hypertrophic cell zone. |
2003-02-25 |
2023-08-12 |
rat |
| S Milz, A Boszczyk, R Put. [Development and functional structure of the epiphyseal plate]. Der Orthopade. vol 31. issue 9. 2003-02-19. PMID:12232700. |
the extracellular matrix between the hypertrophic chondrocytes becomes calcified and is subsequently replaced in an ossification process by lamellar bone. |
2003-02-19 |
2023-08-12 |
Not clear |
| Y Ihara, Y J Suzuki, K Kitta, L R Jones, T Iked. Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin. Cell calcium. vol 32. issue 1. 2003-02-14. PMID:12127059. |
thus, carp, gpx1, and genes encoding extracellular matrix proteins may participate in the development of cardiac hypertrophy and fibrosis, and changes in serca2, ant1, and nm_026586 mrna expression may be involved in transition from concentric to dilated cardiac hypertrophy. |
2003-02-14 |
2023-08-12 |
mouse |
| William S Bradham, Himali Gunasinghe, Jennifer R Holder, Marlina Multani, Donna Killip, Marianne Anderson, Denise Meyer, William H Spencer, Guillermo Torre-Amione, Francis G Spinal. Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Journal of the American College of Cardiology. vol 40. issue 12. 2003-02-14. PMID:12505230. |
release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy. |
2003-02-14 |
2023-08-12 |
Not clear |
| William S Bradham, Himali Gunasinghe, Jennifer R Holder, Marlina Multani, Donna Killip, Marianne Anderson, Denise Meyer, William H Spencer, Guillermo Torre-Amione, Francis G Spinal. Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Journal of the American College of Cardiology. vol 40. issue 12. 2003-02-14. PMID:12505230. |
this study examined plasma levels of certain matrix metalloproteinase (mmp) and tissue inhibitor of matrix metalloproteinase (timp) species before and after alcohol-induced myocardial infarction (mi) in patients with hypertrophic obstructive cardiomyopathy (hocm). |
2003-02-14 |
2023-08-12 |
Not clear |
| Daniela Grimm, Hans C Jabusch, Peter Kossmehl, Michaela Huber, Sabine Fredersdorf, Daniel P Griese, Bernhard K Krämer, Eckhard P Krome. Experimental diabetes and left ventricular hypertrophy: effects of beta-receptor blockade. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 11. issue 4. 2003-02-05. PMID:12140129. |
left ventricular hypertrophy involves growth of cardiomyocytes, as well as remodeling of extracellular matrix proteins (ecmps). |
2003-02-05 |
2023-08-12 |
rat |
| Deborah Ferrari, Robert A Koshe. Dlx5 is a positive regulator of chondrocyte differentiation during endochondral ossification. Developmental biology. vol 252. issue 2. 2003-01-16. PMID:12482714. |
the expansion in the extent of hypertrophic maturation detectable histologically is accompanied by expanded and upregulated domains of expression of molecular markers of chondrocyte maturation, particularly type x collagen and osteopontin, and by expansion of mineralized cartilage matrix, which is characteristic of terminal hypertrophic differentiation. |
2003-01-16 |
2023-08-12 |
chicken |
| Lars Rothermund, Reinhold Kreutz, Peter Kossmehl, Sabine Fredersdorf, Mehdi Shakibaei, Gundula Schulze-Tanzil, Martin Paul, Daniela Grim. Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy. American journal of hypertension. vol 15. issue 7 Pt 1. 2003-01-10. PMID:12118914. |
the objective of this study was to analyze extracellular matrix protein (ecmp) expression in ang ii-dependent left ventricular (lv) hypertrophy (lvh), lv dysfunction, and to investigate right ventricular changes. |
2003-01-10 |
2023-08-12 |
Not clear |
| Kimihide Kusafuka, Yuji Hiraki, Chisa Shukunami, Teruo Kayano, Tamiko Takemur. Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage. Acta histochemica. vol 104. issue 2. 2002-12-30. PMID:12086337. |
type ii collagen was deposited in all matrices during endochondral ossification, whereas aggrecan was deposited in the matrix of hypertrophic cartilage, especially around lacunae. |
2002-12-30 |
2023-08-12 |
human |
| Kimihide Kusafuka, Yuji Hiraki, Chisa Shukunami, Teruo Kayano, Tamiko Takemur. Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage. Acta histochemica. vol 104. issue 2. 2002-12-30. PMID:12086337. |
on the other hand, the novel cartilage-specific matrix protein chm-i was localized in interterritorial regions of the matrix in mature to hypertrophic cartilage, especially around lacunae. |
2002-12-30 |
2023-08-12 |
human |
| Isabelle Mercier, Mylan Pham-Dang, Robert Clement, Hugues Gosselin, Federico Colombo, Jean-Lucien Rouleau, Angelino Calderon. Elevated mean arterial pressure in the ovariectomized rat was normalized by ET(A) receptor antagonist therapy: absence of cardiac hypertrophy and fibrosis. British journal of pharmacology. vol 136. issue 5. 2002-12-23. PMID:12086977. |
the following study examined the effect of ovariectomy on ventricular contractility, cardiac hypertrophy and extracellular matrix protein expression. |
2002-12-23 |
2023-08-12 |
rat |
| Mark A Sussman, Andrew McCulloch, Thomas K Bor. Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circulation research. vol 91. issue 10. 2002-12-05. PMID:12433833. |
this review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy. |
2002-12-05 |
2023-08-12 |
Not clear |
| Sandro Goruppi, Joseph V Bonventre, John M Kyriaki. Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. The EMBO journal. vol 21. issue 20. 2002-11-26. PMID:12374743. |
diabetic nephropathy begins with mesangial cell hypertrophy and hyperplasia, combined with excess matrix deposition. |
2002-11-26 |
2023-08-12 |
Not clear |
| Gareth R John, Sai Latha Shankar, Bridget Shafit-Zagardo, Aldo Massimi, Sunhee C Lee, Cedric S Raine, Celia F Brosna. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nature medicine. vol 8. issue 10. 2002-11-22. PMID:12357247. |
within and around active ms plaques lacking remyelination, jagged1 was expressed at high levels by hypertrophic astrocytes, whereas notch1 and hes5 localized to cells with an immature oligodendrocyte phenotype, and tgf-beta 1 was associated with perivascular extracellular matrix in the same areas. |
2002-11-22 |
2023-08-12 |
human |
| Motohide Isono, Sheldon Chen, Soon Won Hong, M Carmen Iglesias-de la Cruz, Fuad N Ziyade. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochemical and biophysical research communications. vol 296. issue 5. 2002-10-24. PMID:12207925. |
activation of the transforming growth factor-beta (tgf-beta) system has been implicated in the pathological changes of diabetic nephropathy such as renal hypertrophy and accumulation of extracellular matrix. |
2002-10-24 |
2023-08-12 |
mouse |
| C William Wu, Elena V Tchetina, Fackson Mwale, Karen Hasty, Isabelle Pidoux, Agnes Reiner, Jeffrey Chen, Harold E Van Wart, A Robin Pool. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 4. 2002-10-03. PMID:11918221. |
using bovine fetal chondrocytes isolated from physeal cartilages and separated into a distinct prehypertrophic subpopulation, we show that in serum-free culture they elaborate an extracellular matrix and differentiate into hypertrophic chondrocytes. |
2002-10-03 |
2023-08-12 |
cattle |
| Gary M Williams, Michael J Iatropoulo. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicologic pathology. vol 30. issue 1. 2002-09-26. PMID:11890475. |
they can also be graded or continuous (nonbinary), as with enzyme induction, organelle hypertrophy, and extracellular matrix elaboration, occurring either at the intra- or extra (supra) cellular level. |
2002-09-26 |
2023-08-12 |
Not clear |
| Takashi Miyazawa, Yoshihiro Ogawa, Hideki Chusho, Akihiro Yasoda, Naohisa Tamura, Yasato Komatsu, Alexander Pfeifer, Franz Hofmann, Kazuwa Naka. Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193576. |
using cultured fetal mouse tibias, an in vitro model system of endochondral ossification, we also demonstrated that cnp cannot increase the longitudinal bone growth, and chondrocytic proliferation and hypertrophy, and cartilage matrix synthesis in prkg2(-/-) mice. |
2002-09-23 |
2023-08-12 |
mouse |