| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toru Yasuda, Yasuto Nakata, Hideki Mochizuk. α-Synuclein and neuronal cell death. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:22936307. |
neuropathological hallmarks of pd are prominent loss of dopaminergic (da) neurons in the substantia nigra and formation of intraneuronal protein inclusions termed lewy bodies, composed mainly of α-synuclein (αsyn). |
2014-02-13 |
2023-08-12 |
Not clear |
| Andreia Neves Carvalho, Carla Marques, Elsa Rodrigues, Colin J Henderson, C Roland Wolf, Paulo Pereira, Maria João Gam. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:23129554. |
parkinson's disease (pd) is neuropathologically characterized by selective death of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracytoplasmic inclusions of aggregated proteins. |
2014-02-13 |
2023-08-12 |
mouse |
| E Hensleigh, L M Pritchar. Glucocorticoid receptor expression and sub-cellular localization in dopamine neurons of the rat midbrain. Neuroscience letters. vol 556. 2014-02-10. PMID:24121048. |
glucocorticoid receptors were observed in dopaminergic neurons in both the substantia nigra (sn) and ventral tegmental area (vta). |
2014-02-10 |
2023-08-12 |
rat |
| Michaeline L Hebron, Irina Lonskaya, Charbel E-H Mouss. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models. Human molecular genetics. vol 22. issue 16. 2014-02-06. PMID:23666528. |
parkinson's disease is a movement disorder characterized by death of dopaminergic substantia nigra (sn) neurons and brain accumulation of α-synuclein. |
2014-02-06 |
2023-08-12 |
mouse |
| Karim Fifel, Ouria Dkhissi-Benyahya, Howard M Coope. Lack of long-term changes in circadian, locomotor, and cognitive functions in acute and chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse models of Parkinson's disease. Chronobiology international. vol 30. issue 6. 2014-01-29. PMID:23758587. |
although both acute and chronic treatment regimes induced 70% degeneration of dopaminergic neurons in the substantia nigra, neither circadian nor cognitive alterations were observed even after nearly 1 yr. |
2014-01-29 |
2023-08-12 |
mouse |
| R Satpute, V Lomash, M Kaushal, R Bhattachary. Neuroprotective effects of α-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice. Human & experimental toxicology. vol 32. issue 7. 2014-01-24. PMID:23821591. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) is a neurotoxin associated with drug abuse and causes permanent symptoms of parkinson's disease (pd) by destroying dopaminergic neurons in the substantia nigra of the brain. |
2014-01-24 |
2023-08-12 |
mouse |
| Hueng-Chuen Fan, Shyi-Jou Chen, Horng-Jyh Harn, Shinn-Zong Li. Parkinson's disease: from genetics to treatments. Cell transplantation. vol 22. issue 4. 2014-01-23. PMID:23127617. |
the hallmark pathological features of pd are loss of dopaminergic neurons in the substantia nigra (sn) and the presence of neuronal intracellular lewy body (lb) inclusions. |
2014-01-23 |
2023-08-12 |
Not clear |
| Carmen Noelker, Vanessa Stuckenholz, Jens-Peter Reese, Daniel Alvarez-Fischer, Roman Sankowski, Tanja Rausch, Wolfgang H Oertel, Andreas Hartmann, Sonya van Patten, Yousef Al-Abed, Michael Bache. CNI-1493 attenuates neuroinflammation and dopaminergic neurodegeneration in the acute MPTP mouse model of Parkinson's disease. Neuro-degenerative diseases. vol 12. issue 2. 2014-01-17. PMID:23147695. |
parkinson's disease (pd) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. |
2014-01-17 |
2023-08-12 |
mouse |
| Ingrid Morales, Magdalena Sabate, Manuel Rodrigue. Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's disease. The European journal of neuroscience. vol 38. issue 1. 2014-01-15. PMID:23565852. |
similar responses were not observed for nigrostriatal neurons, which showed no dopaminergic striatal denervation, no microglial activation in the substantia nigra and no changes in the number of dopaminergic cells in the substantia nigra. |
2014-01-15 |
2023-08-12 |
rat |
| Keon Sung Shin, Hyun Sook Choi, Ting Ting Zhao, Kwang Hoon Suh, Ik Hyun Kwon, Soon Ok Choi, Myung Koo Le. Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Archives of pharmacal research. vol 36. issue 6. 2014-01-13. PMID:23539311. |
these results suggest that berberine leads to the degeneration of dopaminergic neuronal cells in the substantia nigra in the rat model of pd with chronic l-dopa administration. |
2014-01-13 |
2023-08-12 |
rat |
| Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H Jensen, Deniz Kirik, Marina Romero-Ramo. Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease. Neurobiology of disease. vol 56. 2014-01-10. PMID:23567651. |
when examined at long-term, all three α-synuclein forms resulted in pathological accumulations of α-synuclein in striatal fibers and dopaminergic cell death in the substantia nigra. |
2014-01-10 |
2023-08-12 |
human |
| Stéphanie Pain, Alice Gochard, Sylvie Bodard, Zuhal Gulhan, Caroline Prunier-Aesch, Sylvie Chalo. Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:23083629. |
pd is mainly characterized by a selective degeneration of the dopaminergic neurons in the substantia nigra. |
2014-01-07 |
2023-08-12 |
mouse |
| Stéphanie Pain, Alice Gochard, Sylvie Bodard, Zuhal Gulhan, Caroline Prunier-Aesch, Sylvie Chalo. Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 5. 2014-01-07. PMID:23083629. |
results showed that tyrosine hydroxylase activity and dopaminergic transporter density were reduced in striatum and substantia nigra of mice and that this reduction was dependent on the cumulative dose of mptp injected. |
2014-01-07 |
2023-08-12 |
mouse |
| Candan Depboylu, Lukas Maurer, Andreas Matusch, Guido Hermanns, Andrea Windolph, Martin Béhé, Wolfgang H Oertel, Günter U Höglinge. Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry. NeuroImage. vol 79. 2014-01-06. PMID:23631981. |
in 6-hydroxydopamine-lesioned mice, however, neither ld nor ppx significantly influenced the stably reduced fp-cit spect signal (ld: -66%; ppx: -66%; controls -66%), th-immunoreactivity (ld: -70%; ppx: -72%; controls: -77%) and dat-immunoreactivity (ld: -70%; ppx: -75%; controls: -75%) in the striatum or the number of th-positive cells in the substantia nigra (ld: -88%; ppx: -88%; controls: -86%), compared to lesioned mice without dopaminergic treatment. |
2014-01-06 |
2023-08-12 |
mouse |
| Akane Hayashi, Naoya Matsunaga, Hiroyuki Okazaki, Keisuke Kakimoto, Yoshinori Kimura, Hiroki Azuma, Eriko Ikeda, Takeshi Shiba, Mayumi Yamato, Ken-Ichi Yamada, Satoru Koyanagi, Shigehiro Ohd. A disruption mechanism of the molecular clock in a MPTP mouse model of Parkinson's disease. Neuromolecular medicine. vol 15. issue 2. 2014-01-03. PMID:23292542. |
parkinson's disease (pd) is a common neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in the substantia nigra and dopamine depletion in the striatum. |
2014-01-03 |
2023-08-12 |
mouse |
| Craig F Ferris, Mathieu Marella, Brian Smerkers, Thomas M Barchet, Benjamin Gershman, Akemi Matsuno-Yagi, Takao Yag. A phenotypic model recapitulating the neuropathology of Parkinson's disease. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381808. |
animals showed loss of dopaminergic (da) neurons and the appearance of putative lewy bodies in the substantia nigra. |
2014-01-01 |
2023-08-12 |
rat |
| Hideaki Matsui, Roberto Gavinio, Takeshi Asano, Norihito Uemura, Hidefumi Ito, Yoshihito Taniguchi, Yoshito Kobayashi, Takakuni Maki, Jie Shen, Shunichi Takeda, Kengo Uemura, Hodaka Yamakado, Ryosuke Takahash. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Human molecular genetics. vol 22. issue 12. 2013-12-31. PMID:23449626. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by selective dopaminergic cell loss in the substantia nigra, but its pathogenesis remains unclear. |
2013-12-31 |
2023-08-12 |
human |
| Oliver D Howes, Matthew Williams, Kemal Ibrahim, Garret Leung, Alice Egerton, Philip K McGuire, Federico Turkheime. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24097339. |
however, it is not known if the dopaminergic dysfunction is limited to the striatal terminals of dopamine neurons, or is also evident in the dopamine neuron cell bodies, which mostly originate in the substantia nigra. |
2013-12-31 |
2023-08-12 |
human |
| Hélène Hall, Michael Jewett, Natalie Landeck, Nathalie Nilsson, Ulrika Schagerlöf, Giampiero Leanza, Deniz Kiri. Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors. PloS one. vol 8. issue 5. 2013-12-30. PMID:23705016. |
intraneuronal inclusions containing alpha-synuclein (a-syn) constitute one of the pathological hallmarks of parkinson's disease (pd) and are accompanied by severe neurodegeneration of a9 dopaminergic neurons located in the substantia nigra. |
2013-12-30 |
2023-08-12 |
human |
| Benjamin Grieb, Constantin von Nicolai, Gerhard Engler, Andrew Sharott, Ismini Papageorgiou, Wolfgang Hamel, Andreas K Engel, Christian K Mol. Decomposition of abnormal free locomotor behavior in a rat model of Parkinson's disease. Frontiers in systems neuroscience. vol 7. 2013-12-18. PMID:24348346. |
to this end, we video-monitored 23 h of free locomotor behavior and extracted several behavioral measures before and after the expression of a severe parkinsonian phenotype following bilateral 6-hydroxydopamine (6-ohda) lesions of the rat dopaminergic substantia nigra. |
2013-12-18 |
2023-08-12 |
rat |