| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong-hyeon Kim, Dong-joo Choi, Hey-kyeong Jeong, Jun Kim, Dae Won Kim, Soo Young Choi, Sang-Myun Park, Young Ho Suh, Ilo Jou, Eun-Hye Jo. DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1. Neurobiology of disease. vol 60. 2014-06-15. PMID:23969237. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder caused by the death of dopaminergic neurons in the substantia nigra. |
2014-06-15 |
2023-08-12 |
mouse |
| Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarrí. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease. Toxicology. vol 319. 2014-06-10. PMID:24607817. |
parkinson's disease (pd) is a neurodegenerative disease secondary to the loss of dopaminergic neurons in the substantia nigra. |
2014-06-10 |
2023-08-12 |
mouse |
| Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarrí. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease. Toxicology. vol 319. 2014-06-10. PMID:24607817. |
additionally, 100mg/kg silymarin treatment significantly diminished the number of apoptotic cells and preserved dopaminergic neurons in the substantia nigra of mptp-intoxicated mice. |
2014-06-10 |
2023-08-12 |
mouse |
| Tetsuji Mori, Taketoshi Wakabayashi, Haruyuki Ogawa, Yukie Hirahara, Taro Koike, Hisao Yamad. Increased histone H3 phosphorylation in neurons in specific brain structures after induction of status epilepticus in mice. PloS one. vol 8. issue 10. 2014-06-05. PMID:24147063. |
after unilateral ablation of dopaminergic neurons in the substantia nigra by injection of 6-hydroxydopamine, the distribution of ph3(+) neurons changed in the caudate putamen. |
2014-06-05 |
2023-08-12 |
mouse |
| Janice C Wong, Lili-Naz Hazrat. Parkinson's disease, parkinsonism, and traumatic brain injury. Critical reviews in clinical laboratory sciences. vol 50. issue 4-5. 2014-05-30. PMID:24156652. |
in laboratory studies, animal models of traumatic brain injury demonstrate neuronal loss in the substantia nigra, altered dopaminergic metabolism, or altered synuclein pathology. |
2014-05-30 |
2023-08-12 |
Not clear |
| Busisiwe C Maseko, Nina Patzke, Kjell Fuxe, Paul R Mange. Architectural organization of the african elephant diencephalon and brainstem. Brain, behavior and evolution. vol 82. issue 2. 2014-05-29. PMID:24021932. |
the dopaminergic neurons of the substantia nigra appear to form distinct islands separated from each other by large fibre pathways, an appearance unique to the elephant. |
2014-05-29 |
2023-08-12 |
Not clear |
| Yan Liu, Yan-Wu Li, Ya-Lan Tang, Xin Liu, Jun-Hao Jiang, Qing-Gen Li, Jian-Yong Yua. Vitamin D: preventive and therapeutic potential in Parkinson's disease. Current drug metabolism. vol 14. issue 9. 2014-05-19. PMID:24160295. |
the motor symptoms largely result from the continued death of dopaminergic neurons in the substantia nigra, despite use of current therapeutic interventions. |
2014-05-19 |
2023-08-12 |
Not clear |
| Louise M Collins, Aisling M Gavin, Sinead Walsh, Aideen M Sullivan, Sean L Wyatt, Gerard W O'Keeffe, Yvonne M Nolan, André Toulous. Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease. SpringerPlus. vol 3. 2014-05-14. PMID:24826373. |
we have previously demonstrated that mitogen-activated protein kinase phosphatase 1, mkp1, is expressed in the developing and rat adult substantia nigra and striatum, where it promotes the growth of nigral dopaminergic neurons. |
2014-05-14 |
2023-08-13 |
rat |
| Christian Hölsche. Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. The Journal of endocrinology. vol 221. issue 1. 2014-05-12. PMID:23999914. |
in animal models of pd, exendin-4 showed protection of dopaminergic neurons in the substantia nigra and prevention of dopamine loss in the basal ganglia while preserving motor control. |
2014-05-12 |
2023-08-12 |
Not clear |
| Nady Braidy, Subash Selvaraju, Musthafa Mohamed Essa, Ragini Vaishnav, Samir Al-Adawi, Abdullah Al-Asmi, Hamed Al-Senawi, Ammar Abd Alrahman Alobaidy, Ritu Lakhtakia, Gilles J Guillemi. Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons. Oxidative medicine and cellular longevity. vol 2013. 2014-05-12. PMID:24223235. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) is an environmental toxin which selectively induces oxidative damage and mitochondrial and proteasomal dysfunctions to dopaminergic neurons in the substantia nigra leading to parkinsonian syndrome in animal models and humans. |
2014-05-12 |
2023-08-12 |
human |
| Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Antonio Dominguez-Meijide, Rita Valenzuela, Begoña Villar-Cheda, Ana I Rodríguez-Pere. Dopamine-angiotensin interactions in the basal ganglia and their relevance for Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23925977. |
regulatory interactions between the dopaminergic and renin-angiotensin systems have recently been described in the substantia nigra and striatum. |
2014-05-09 |
2023-08-12 |
Not clear |
| Bing Han, Jia Hu, Jingyu Shen, Yonglin Gao, Yan Lu, Tian Wan. Neuroprotective effect of hydroxysafflor yellow A on 6-hydroxydopamine-induced Parkinson's disease in rats. European journal of pharmacology. vol 714. issue 1-3. 2014-05-06. PMID:23791614. |
in the present work, we examined whether hsya had the neuroprotective effect on dopaminergic neurons of substantia nigra in a rat model of pd. |
2014-05-06 |
2023-08-12 |
mouse |
| Franz Marxreiter, Benjamin Ettle, Verena E L May, Hakan Esmer, Christina Patrick, Christine Lund Kragh, Jochen Klucken, Beate Winner, Olaf Riess, Jürgen Winkler, Eliezer Masliah, Silke Nube. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiology of disease. vol 59. 2014-05-05. PMID:23867236. |
clinically, pd is defined by motor symptoms that are predominantly attributed to the dopaminergic cell loss in the substantia nigra. |
2014-05-05 |
2023-08-12 |
mouse |
| Chu Lan Lao, Yen-Hsi Kuo, Yueh-Ting Hsieh, Jin-Chung Che. Intranasal and subcutaneous administration of dopamine D3 receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice. Neurotoxicity research. vol 24. issue 4. 2014-04-29. PMID:23820985. |
parkinson's disease (pd) is a neurodegenerative disease with a hallmark motor defect caused by the death of dopaminergic neurons in the substantia nigra. |
2014-04-29 |
2023-08-12 |
mouse |
| Karolina Pytka, Małgorzata Zygmunt, Barbara Filipe. [Pharmacotherapy of Parkinson's disease: progress or regress?]. Postepy higieny i medycyny doswiadczalnej (Online). vol 67. 2014-04-29. PMID:24018435. |
parkinson's disease (pd) is a chronic, progressive disease of the central nervous system (cns), characterized by a slow loss of dopaminergic neurons in the substantia nigra, leading to significant decrease in dopamine (da) levels in the striatum. |
2014-04-29 |
2023-08-12 |
Not clear |
| Debasmita Tripathy, Reena Haobam, Ranju Nair, Kochupurackal P Mohanakuma. Engraftment of mouse embryonic stem cells differentiated by default leads to neuroprotection, behaviour revival and astrogliosis in parkinsonian rats. PloS one. vol 8. issue 9. 2014-04-28. PMID:24069147. |
striatal grafts exhibited the presence of tyrosine hydroxylase positive cells, and the percentage of dopaminergic neurons in the substantia nigra was also found to be higher in the ipsilateral side of 7 days and mes grafted animals. |
2014-04-28 |
2023-08-12 |
mouse |
| Shin-Ichi Muramats. [Gene therapy for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 11. 2014-04-21. PMID:23196456. |
to protect nigrostriatal projection by delivering the neurturin gene, a trophic factor for dopaminergic neurons, both in the putamen and the substantia nigra. |
2014-04-21 |
2023-08-12 |
Not clear |
| M A Fahim, S Shehab, A Nemmar, A Adem, S Dhanasekaran, M Y Hasa. Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level. Physiological research. vol 62. issue 3. 2014-04-21. PMID:23489189. |
daily treatment of pq for three weeks induces selective dopaminergic neuronal loss in the substantia nigra and significant behavioral and peripheral motor deficit effects. |
2014-04-21 |
2023-08-12 |
rat |
| Karin Löw, Patrick Aebischer, Bernard L Schneide. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human gene therapy. vol 24. issue 6. 2014-04-17. PMID:23600720. |
recombinant adeno-associated viral (aav) vectors of serotypes 6, 8, and 9 were characterized as tools for gene delivery to dopaminergic neurons in the substantia nigra for future gene therapeutic applications in parkinson's disease. |
2014-04-17 |
2023-08-12 |
Not clear |
| Karin Löw, Patrick Aebischer, Bernard L Schneide. Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles. Human gene therapy. vol 24. issue 6. 2014-04-17. PMID:23600720. |
while vectors of all three serotypes transduced nigral dopaminergic neurons with equal efficiency when directly injected to the substantia nigra, aav6 was clearly superior to aav8 and aav9 for retrograde transduction of nigral neurons after striatal delivery. |
2014-04-17 |
2023-08-12 |
Not clear |