| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jasvant Ram Ananthasayanam, Prashanth Anandan, Arunkumar Mohanakrishnan, Keerthi Charith. Precision Imaging in Neurodegeneration: The Superiority of Diffusion Tensor Imaging Over Conventional MRI in Differentiating Parkinson's Disease From Atypical Parkinsonian Syndromes. Cureus. vol 16. issue 9. 2024-10-09. PMID:39381485. |
background parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to motor and non-motor symptoms. |
2024-10-09 |
2024-10-11 |
Not clear |
| Jasvant Ram Ananthasayanam, Prashanth Anandan, Arunkumar Mohanakrishnan, Keerthi Charith. Precision Imaging in Neurodegeneration: The Superiority of Diffusion Tensor Imaging Over Conventional MRI in Differentiating Parkinson's Disease From Atypical Parkinsonian Syndromes. Cureus. vol 16. issue 9. 2024-10-09. PMID:39381485. |
dti detected significant fa value reductions in the substantia nigra in pd patients (mean fa: 0.440), which is consistent with the degeneration of dopaminergic neurons characteristic of pd. |
2024-10-09 |
2024-10-11 |
Not clear |
| Nour Shaheen, Ahmed Shaheen, Mahmoud Osama, Abdulqadir J Nashwan, Vishal Bharmauria, Oliver Flout. MicroRNAs regulation in Parkinson's disease, and their potential role as diagnostic and therapeutic targets. NPJ Parkinson's disease. vol 10. issue 1. 2024-10-05. PMID:39369002. |
parkinson's disease (pd) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. |
2024-10-05 |
2024-10-08 |
Not clear |
| Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-10-04 |
2024-10-07 |
mouse |
| Toni Mueller, Parker Jeffrey, Yecheng He, Xiaosen Ouyang, David Westbrook, Victor Darley-Usmar, Matthew S Goldberg, Laura Volpicelli-Daley, Jianhua Zhan. Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345452. |
we examined dopaminergic neurodegeneration in the substantia nigra using stereology of tyrosine hydroxylase-immunoreactive cells 4 months and 6 months after intrastriatal injection of α-synuclein preformed fibrils or monomeric α-synuclein control in control, central nervous system (cns)-cathepsin d overexpressing and cns-specific zkscan3 ko mice. |
2024-09-30 |
2024-10-02 |
mouse |
| Hongkai Yao, Weifang Tong, Yunping Song, Ruoyu Li, Xuerui Xiang, Wen Cheng, Yunjiao Zhou, Yijing He, Yi Yang, Yunxi Liu, Siguang Li, Lingjing Ji. Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson's disease. Journal of neuroinflammation. vol 21. issue 1. 2024-09-29. PMID:39342308. |
the primary pathological change in parkinson's disease (pd) is the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2024-09-29 |
2024-10-01 |
mouse |
| Xiyu Gao, Shoupeng Fu, Jingru Wen, Aohan Yan, Shuo Yang, Yiming Zhang, Dianfeng Liu, Dewei H. Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice. Journal of agricultural and food chemistry. 2024-09-27. PMID:39331469. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, the etiology of which remains unclear. |
2024-09-27 |
2024-10-01 |
mouse |
| Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracellular α-synuclein (ɑ-syn) aggregates known as lewy bodies and lewy neurites. |
2024-09-23 |
2024-09-26 |
mouse |
| Zhihao Mao, Yuning Zhang, Yirong Liang, Chenglai Xia, Lan Tan. Liver X receptor α contribution to neuroinflammation and glial cells activation induced by MPTP: Implications for Parkinson's disease. Neuroscience. 2024-09-21. PMID:39306319. |
the immune system has been implicated in hallmarks of pd including aggregation of α-synuclein and death of dopaminergic neurons in the substantia nigra. |
2024-09-21 |
2024-09-24 |
mouse |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. Brain : a journal of neurology. 2024-09-16. PMID:39282945. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-09-16 |
2024-09-19 |
Not clear |
| Laura Patricia Perez-Abshana, Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273169. |
parkinson's disease (pd) is a multifactorial, chronic, and progressive neurodegenerative disorder inducing movement alterations as a result of the loss of dopaminergic (daergic) neurons of the pars compacta in the substantia nigra and protein aggregates of alpha synuclein (α-syn). |
2024-09-14 |
2024-09-16 |
Not clear |
| Yu Qiao, Jiayuan Kou, Ye Tian, Wenkai Ma, Yang Yu, Jingjing Pang, Yingting Pei, Yu Zhang, Bin Ye, Ziying Xie, Jinying Liu, Zhihui Wang, Lujing Wang, Xu Gao, Ning Ma, Yanfen Zhan. Subcellular localization and function analysis of PINK1 mitron in PD progression: mitron modulates mitochondrial morphology to regulate neuronal death. The Journal of biological chemistry. 2024-09-14. PMID:39276929. |
loss or degeneration of the dopaminergic neurons in the substantia nigra and development of lewy bodies in dopaminergic neurons were the defining pathologic changes. |
2024-09-14 |
2024-09-18 |
mouse |
| Servet Tunoğlu, Beyzanur Yalçın, Ezgi Nurdan Yenilmez Tunoğlu, Zerrin Karaaslan, Başar Bilgiç, Haşmet Ayhan Hanağası, Erdem Tüzün, Cem İsmail Küçükal. Gene Expression Levels Related to Histone Acetylation are Altered in Parkinson Disease Patients. Noro psikiyatri arsivi. vol 67. issue 3. 2024-09-11. PMID:39258138. |
parkinson's disease (pd) is a neurodegenerative disorder distinguished from other neurodegenerative disorders by the loss of dopaminergic neurons in the substantia nigra region of the brain, and is the most common neurodegenerative disorder, along with alzheimer's disease. |
2024-09-11 |
2024-09-13 |
Not clear |
| Madhu Priya, Surekha A Dubey, Jahnavi P Gorripat. An Alternative Approach for the Rehabilitation of a Complete Denture Patient With Parkinson's Disease. Cureus. vol 16. issue 8. 2024-09-09. PMID:39246958. |
lewy bodies containing α-synuclein and a reduction in dopaminergic neurons in the substantia nigra, which impairs the region's capacity to promote voluntary movements, are the main neuropathological findings. |
2024-09-09 |
2024-09-11 |
Not clear |
| Maria Beatriz Barbosa da Silva, Ellen Cristine Ferreira da Silva, Maria Eduarda Ferreira da Silva Bispo, Thais de Souza Nogueira, Josevan Cerqueira Leal, Felipe Augusto Dos Santos Mende. Association between cognitive performance and manual dexterity in patients with Parkinson's disease. Physiotherapy research international : the journal for researchers and clinicians in physical therapy. vol 29. issue 4. 2024-09-05. PMID:39235186. |
parkinson's disease (pd) is a progressive neurological condition resulting from the degeneration of dopaminergic neurons in the substantia nigra. |
2024-09-05 |
2024-09-08 |
Not clear |
| Min Shao, Chen Zhao, Zhijian Pan, Xuanjun Yang, Cheng Gao, Gloria Hio-Cheng Kam, Hefeng Zhou, Simon Ming-Yuen Le. Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo. Chemico-biological interactions. 2024-09-05. PMID:39233265. |
pre-treatment mitigated loss of tyrosine hydroxylase (th)-positive neurons in the substantia nigra and striatal dopaminergic fibers, restoring dopamine levels and ameliorating motor deficits in pd mice. |
2024-09-05 |
2024-09-08 |
mouse |
| Syeda Fatima A Zaidi, Shafin Bin Amin, Maham Shahi. Letter to the Editor: Increasing incidence of Parkinson's disease in patients with epilepsy: A Nationwide Cohort Study. Journal of the neurological sciences. vol 465. 2024-09-03. PMID:39226711. |
it is also mentioned that pd is a progressive neurodegenerative disorder of dopaminergic neurons in the substantia nigra, and the incidence of the two diseases. |
2024-09-03 |
2024-09-06 |
Not clear |
| Mingmin Yan, Qian Zhang, Yu Chen, Chenyi Zhu, Dan Wang, Jie Tan, Bihua He, Qin Li, Xiaorong Deng, Yue Wa. α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD. Frontiers in neuroscience. vol 18. 2024-09-03. PMID:39224576. |
parkinson's disease (pd) is characterized by the accumulation of misfolded α-synuclein protein and the loss of dopaminergic neurons in the substantia nigra. |
2024-09-03 |
2024-09-05 |
Not clear |
| Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. |
neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). |
2024-09-03 |
2024-09-05 |
Not clear |
| Xiang Zuo, Hui-Juan Bai, Qi-Li Zhao, Shu-Hui Zhang, Xin Zhao, Xi-Zeng Fen. 17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice. Molecular neurobiology. 2024-09-02. PMID:39222261. |
this exacerbated neuronal apoptosis, ultimately intensifying dopaminergic neuronal degeneration and death in the substantia nigra and striatum of pd mice. |
2024-09-02 |
2024-09-04 |
mouse |