| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esperanza García, Ricardo Santana-Martínez, Carlos A Silva-Islas, Ana Laura Colín-González, Sonia Galván-Arzate, Yessica Heras, Perla D Maldonado, Julio Sotelo, Abel Santamarí. S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free radical research. vol 48. issue 2. 2014-07-24. PMID:24147739. |
our findings suggest that sac can exert neuroprotection since the origin of the dopaminergic lesion-at the substantia nigra (sn)-not only by means of direct antioxidant actions, but also through nrf2 nuclear transactivation and phase 2 enzymes upregulation. |
2014-07-24 |
2023-08-12 |
mouse |
| Carla Pais Fonseca, Susana Gama, Ana Saavedra, Graça Baltaza. H2O2- or l-DOPA-injured dopaminergic neurons trigger the release of soluble mediators that up-regulate striatal GDNF through different signalling pathways. Biochimica et biophysica acta. vol 1842. issue 7. 2014-07-24. PMID:24632468. |
in the present work, we evaluated whether the factors released by ventral midbrain-challenged cells were able to alter gdnf expression in striatal cells, the targets of dopaminergic neurons projecting from the substantia nigra, and investigated the signalling pathways involved. |
2014-07-24 |
2023-08-12 |
Not clear |
| Alessandra Zanon, Aleksandar Rakovic, Hagen Blankenburg, Nadezhda T Doncheva, Christine Schwienbacher, Alice Serafin, Adrian Alexa, Christian X Weichenberger, Mario Albrecht, Christine Klein, Andrew A Hicks, Peter P Pramstaller, Francisco S Domingues, Irene Pichle. Profiling of Parkin-binding partners using tandem affinity purification. PloS one. vol 8. issue 11. 2014-07-22. PMID:24244333. |
it is characterized by a rather selective loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein-enriched lewy body inclusions. |
2014-07-22 |
2023-08-12 |
drosophila_melanogaster |
| Celia van der Merwe, Ben Loos, Chrisna Swart, Craig Kinnear, Franclo Henning, Lize van der Merwe, Komala Pillay, Nolan Muller, Dan Zaharie, Lize Engelbrecht, Jonathan Carr, Soraya Bardie. Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations. Biochemical and biophysical research communications. vol 447. issue 2. 2014-07-22. PMID:24721425. |
parkinson's disease (pd), defined as a neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. |
2014-07-22 |
2023-08-13 |
Not clear |
| Yue-Hua Wang, Hai-Tao Yu, Xiao-Ping Pu, Guan-Hua D. Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. Molecules (Basel, Switzerland). vol 18. issue 12. 2014-07-18. PMID:24288000. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (da) neurons at the substantia nigra. |
2014-07-18 |
2023-08-12 |
rat |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
at 7 d after the 6-ohda injection, 6-ohda led to a severe loss of tyrosine hydroxylase (th)-positive dopaminergic neurons in the striatum and substantia nigra (sn). |
2014-07-14 |
2023-08-12 |
mouse |
| Ashwin G Ramayya, Amrit Misra, Gordon H Baltuch, Michael J Kahan. Microstimulation of the human substantia nigra alters reinforcement learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 20. 2014-07-10. PMID:24828643. |
animal studies have shown that substantia nigra (sn) dopaminergic (da) neurons strengthen action-reward associations during reinforcement learning, but their role in human learning is not known. |
2014-07-10 |
2023-08-13 |
human |
| Oskar Karlsson, Nils Gunnar Lindquis. Melanin affinity and its possible role in neurodegeneration. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 12. 2014-07-09. PMID:23821370. |
although there are many clues to the particular vulnerability of dopaminergic neurons of substantia nigra in parkinson's disease, the critical factors are not known. |
2014-07-09 |
2023-08-12 |
Not clear |
| Marusela Oliveras-Salvá, Anne-Sophie Van Rompuy, Bavo Heeman, Chris Van den Haute, Veerle Baekeland. Loss-of-function rodent models for parkin and PINK1. Journal of Parkinson's disease. vol 1. issue 3. 2014-07-07. PMID:23939304. |
however, up till now these models fail to reproduce the main hallmarks of parkinson's disease: the dopaminergic cell loss in the substantia nigra and the presence of cytoplasmic inclusions, named lewy bodies, in the remaining dopaminergic neurons. |
2014-07-07 |
2023-08-12 |
Not clear |
| Henriqueta Dias Cardoso, Eraldo Fonseca dos Santos Junior, David Filipe de Santana, Catarina Gonçalves-Pimentel, Monara Kaélle Angelim, Alinny R Isaac, Cláudia Jacques Lagranha, Rubem Carlos Araújo Guedes, Eduardo Isidoro Beltrão, Edgar Morya, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochimica et biophysica acta. vol 1840. issue 6. 2014-07-03. PMID:24361617. |
our previous study demonstrated that essential fatty acid (efa) dietary restriction over two generations induced midbrain dopaminergic cell loss and oxidative stress in the substantia nigra (sn) but not in the striatum of young rats. |
2014-07-03 |
2023-08-12 |
rat |
| Simone A van den Berge, Miriam E van Strien, Elly M Ho. Resident adult neural stem cells in Parkinson's disease--the brain's own repair system? European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872414. |
one important pathological process in the brain of parkinson disease (pd) patients is the degeneration of the dopaminergic neurons in the substantia nigra, which leads to a decline in striatal dopamine levels and motor dysfunction. |
2014-07-02 |
2023-08-12 |
human |
| Vanessa Stuckenholz, Michael Bacher, Monika Balzer-Geldsetzer, Daniel Alvarez-Fischer, Wolfgang H Oertel, Richard C Dodel, Carmen Noelke. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. Journal of Parkinson's disease. vol 3. issue 2. 2014-06-25. PMID:23938346. |
parkinson's disease (pd) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (sn). |
2014-06-25 |
2023-08-12 |
mouse |
| Ji Yong Lee, Sung Hoon Kim, Ah-Ra Ko, Jin Suk Lee, Ji Hea Yu, Jung Hwa Seo, Byung Pil Cho, Sung-Rae Ch. Therapeutic effects of repetitive transcranial magnetic stimulation in an animal model of Parkinson's disease. Brain research. vol 1537. 2014-06-25. PMID:23998987. |
behavioral assessments such as amphetamine-induced rotational test and treadmill locomotion test were performed, and the dopaminergic (da) neurons of substantia nigra pas compacta (snc) and striatum were histologically examined. |
2014-06-25 |
2023-08-12 |
rat |
| Sachiko Tanaka, Atsuko Ishii, Hirokazu Ohtaki, Seiji Shioda, Takemi Yoshida, Satoshi Numazaw. Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24289537. |
parkinson's disease (pd) is an age-related progressive neurodegenerative disorder caused by selective loss of dopaminergic neurons from the substantia nigra (sn) to the striatum. |
2014-06-25 |
2023-08-12 |
mouse |
| Sandeep Vasant More, Hemant Kumar, Seong Mook Kang, Soo-Yeol Song, Kippeum Lee, Dong-Kug Cho. Advances in neuroprotective ingredients of medicinal herbs by using cellular and animal models of Parkinson's disease. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2014-06-24. PMID:24073012. |
parkinson's disease (pd) is a multifactorial disorder, which is neuropathologically identified by age-dependent neurodegeneration of dopaminergic neurons in the substantia nigra. |
2014-06-24 |
2023-08-12 |
Not clear |
| David Charles, Christopher Tolleson, Thomas L Davis, Chandler E Gill, Anna L Molinari, Mark J Bliton, Michael G Tramontana, Ronald M Salomon, Chris Kao, Lily Wang, Peter Hedera, Fenna T Phibbs, Joseph S Neimat, Peter E Konra. Pilot study assessing the feasibility of applying bilateral subthalamic nucleus deep brain stimulation in very early stage Parkinson's disease: study design and rationale. Journal of Parkinson's disease. vol 2. issue 3. 2014-06-20. PMID:23938229. |
preliminary evidence suggests that subthalamic nucleus stimulation may also be efficacious in early parkinson's disease, and results of animal studies suggest that it may spare dopaminergic neurons in the substantia nigra. |
2014-06-20 |
2023-08-12 |
Not clear |
| P G Coune, J C Bensadoun, P Aebischer, B L Schneide. Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. Journal of Parkinson's disease. vol 1. issue 4. 2014-06-20. PMID:23939344. |
here, we explored the effect of human alpha-synuclein in the rat substantia nigra following aav-mediated gene delivery inducing a moderate loss of dopaminergic neurons together with motor impairments. |
2014-06-20 |
2023-08-12 |
human |
| Hongkuan Yang, Mingchun Yang, Hongpeng Guan, Ziyi Liu, Shiguang Zhao, Shigeko Takeuchi, Daijiro Yanagisawa, Ikuo Tooyam. Mitochondrial ferritin in neurodegenerative diseases. Neuroscience research. vol 77. issue 1-2. 2014-06-19. PMID:23916831. |
ftmt expression was also detected in dopaminergic neurons in the substantia nigra and was increased in patients with restless legs syndrome, while ftmt had a protective effect against cell death in a neuroblastoma cell line model of parkinson's disease. |
2014-06-19 |
2023-08-12 |
human |
| Santiago Ballaz, Ingrid Morales, Manuel Rodríguez, José A Obes. Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:23996657. |
oxidative stress and glutamatergic overactivity are key biochemical features accompanying the loss of dopaminergic neurons in the substantia nigra that characterizes parkinson's disease (pd). |
2014-06-17 |
2023-08-12 |
human |
| Xian-Ming Luo, Hai Lin, Wei Wang, Marilyn S Geaney, Lee Law, Shaun Wynyard, Shamim B Shaikh, Henry Waldvogel, Richard L M Faull, Robert B Elliott, Stephen J M Skinner, Jacqueline E Lee, Paul L-J Ta. Recovery of neurological functions in non-human primate model of Parkinson's disease by transplantation of encapsulated neonatal porcine choroid plexus cells. Journal of Parkinson's disease. vol 3. issue 3. 2014-06-17. PMID:24002224. |
parkinson's disease (pd) is a neurodegenerative disease that is primarily characterized by degeneration of dopaminergic (da) neurons in the substantia nigra (sn) and a loss of their fibre projections in the striatum. |
2014-06-17 |
2023-08-12 |
monkey |