| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ildikó Miklya, Noémi Pencz, Florencia Hafenscher, Patricia Gölt. [The role of alpha-synuclein in Parkinson's disease]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 16. issue 2. 2014-10-16. PMID:24978050. |
the middle stage of the disease hits the dopaminergic neurons of the substantia nigra; and the neocortex is affected only in the late stage of the disease. |
2014-10-16 |
2023-08-13 |
Not clear |
| Omar Ouachikh, Wisam Dieb, Franck Durif, Aziz Hafid. Anterior ventral tegmental area dopaminergic neurons are not involved in the motivational effects of bromocriptine, pramipexole and cocaine in drug-free rats. Behavioural brain research. vol 262. 2014-10-14. PMID:24361908. |
dopaminergic neuronal loss targets the substantia nigra and the ventral tegmental area (vta). |
2014-10-14 |
2023-08-12 |
rat |
| Sandra Oster, Khaled Radad, Dieter Scheller, Marlen Hesse, Wladimir Balanzew, Heinz Reichmann, Gabriele Gill. Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture. European journal of pharmacology. vol 724. 2014-10-14. PMID:24365490. |
in parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. |
2014-10-14 |
2023-08-12 |
mouse |
| Chutikorn Nopparat, James E Porter, Manuchair Ebadi, Piyarat Govitrapon. 1-Methyl-4-phenylpyridinium-induced cell death via autophagy through a Bcl-2/Beclin 1 complex-dependent pathway. Neurochemical research. vol 39. issue 2. 2014-10-07. PMID:24326530. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), a neurotoxin, has been shown to initiate an apoptotic cascade by increasing ros in the dopaminergic neurons of the substantia nigra, leading to the morphological and physiological features associated with parkinson's disease. |
2014-10-07 |
2023-08-12 |
Not clear |
| Christopher Snyder, Kirk Mantion. The effects of morphine on Parkinson's-related genes PINK1 and PARK2. Medical science monitor basic research. vol 20. 2014-10-06. PMID:24800761. |
it is caused by the loss of dopaminergic neurons in the substantia nigra. |
2014-10-06 |
2023-08-13 |
Not clear |
| Chen Li, Fang Zhang, Limin Shi, Haoyun Zhang, Zibin Tian, Junxia Xie, Hong Jian. Nesfatin-1 decreases excitability of dopaminergic neurons in the substantia nigra. Journal of molecular neuroscience : MN. vol 52. issue 3. 2014-09-30. PMID:24222376. |
nesfatin-1 decreases excitability of dopaminergic neurons in the substantia nigra. |
2014-09-30 |
2023-08-12 |
rat |
| Sara Bandrés, Raquel Durán, Francisco Barrero, Manuel Ramírez, Francisco Vive. [Proteomic biomarkers in Parkinson's disease]. Revista de neurologia. vol 58. issue 4. 2014-09-29. PMID:24504879. |
parkinson's disease (pd) is a neurodegenerative disorder that affects movement and is caused by the death of the dopaminergic neurons in the compact part of the substantia nigra. |
2014-09-29 |
2023-08-12 |
Not clear |
| Yuan-Yi Ma, Shu-Zhen Kong, Li-Jiang Yang, Jin-Lan Meng, Le-Chun Lv, Min H. [Sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157467. |
[sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. |
2014-09-26 |
2023-08-12 |
rat |
| Yuan-Yi Ma, Shu-Zhen Kong, Li-Jiang Yang, Jin-Lan Meng, Le-Chun Lv, Min H. [Sexual dimorphisms of dopaminergic neurons in rat substantia nigra]. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157467. |
parkinson's disease (pd), caused by the mesencephalic substantia nigra (sn) dopaminergic neuronal loss, displays sexual difference, i.e., the incidence is higher and the symptoms are more intense in males than that in females. |
2014-09-26 |
2023-08-12 |
rat |
| Tetsuya Ishii, Koji Et. Fetal stem cell transplantation: Past, present, and future. World journal of stem cells. vol 6. issue 4. 2014-09-26. PMID:25258662. |
although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from parkinson's disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. |
2014-09-26 |
2023-08-13 |
human |
| Kai-Yvonne Shivers, Anastasia Nikolopoulou, Saima Ishaq Machlovi, Shankar Vallabhajosula, Maria E Figueiredo-Pereir. PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochimica et biophysica acta. vol 1842. issue 9. 2014-09-25. PMID:24970746. |
in the current studies, we report that repeated microinfusion of pgj2 into the substantia nigra of non-transgenic mice, induces three stages of pathology that mimic the slow-onset cellular and behavioral pathology of pd: mild (one injection) when only motor deficits are detectable, intermediate (two injections) when neuronal and motor deficits as well as microglia activation are detectable, and severe (four injections) when dopaminergic neuronal loss is massive accompanied by microglia activation and motor deficits. |
2014-09-25 |
2023-08-13 |
mouse |
| Rocío M de Pablos, Antonio J Herrera, Ana M Espinosa-Oliva, Manuel Sarmiento, Mario F Muñoz, Alberto Machado, José L Vener. Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24565378. |
since sensitivity to inflammation is not the same in all brain structures, the aim of this work was to test whether physiological conditions as stress could enhance susceptibility to inflammation in the substantia nigra, where death of dopaminergic neurons takes place in parkinson's disease. |
2014-09-16 |
2023-08-12 |
Not clear |
| Rong-Pei Liu, Ming Zou, Jian-Yong Wang, Juan-Juan Zhu, Jun-Mei Lai, Li-Li Zhou, Song-Fang Chen, Xiong Zhang, Jian-Hong Zh. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24618100. |
paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallmark of parkinson's disease (pd). |
2014-09-16 |
2023-08-12 |
Not clear |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
the levels of several striatal dopaminergic markers and the number of surviving dopaminergic neurons in the substantia nigra (sn) were also assessed. |
2014-09-03 |
2023-08-12 |
monkey |
| Shannon L Rhodes, Daniel D Buchanan, Ismaïl Ahmed, Kent D Taylor, Marie-Anne Loriot, Janet S Sinsheimer, Jeff M Bronstein, Alexis Elbaz, George D Mellick, Jerome I Rotter, Beate Rit. Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin. Neurobiology of disease. vol 62. 2014-09-03. PMID:24121126. |
pathologic features of parkinson's disease (pd) include death of dopaminergic neurons in the substantia nigra, presence of α-synuclein containing lewy bodies, and iron accumulation in pd-related brain regions. |
2014-09-03 |
2023-08-12 |
Not clear |
| Lars Tatenhorst, Lars Tönges, Kim-Ann Saal, Jan C Koch, Éva M Szegő, Mathias Bähr, Paul Lingo. Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease. Journal of neuropathology and experimental neurology. vol 73. issue 8. 2014-09-02. PMID:25003236. |
fasudil 100 mg/kg did not significantly increase the number of dopaminergic cells in the substantia nigra after 12 weeks versus lesion controls. |
2014-09-02 |
2023-08-13 |
mouse |
| Irina Lonskaya, Nicole M Desforges, Michaeline L Hebron, Charbel E-H Mouss. Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance. PloS one. vol 8. issue 12. 2014-08-31. PMID:24386307. |
although autosomal recessive early onset pd linked to parkin mutations does not exhibit α-synuclein accumulation, while autosomal dominant and sporadic pd manifest with α-synuclein inclusions, loss of dopaminergic substantia nigra neurons is a common denominator in pd. |
2014-08-31 |
2023-08-12 |
Not clear |
| Eve M Simcox, Amy Reeve, Doug Turnbul. Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease. Biochemical Society transactions. vol 41. issue 6. 2014-08-29. PMID:24256264. |
pd (parkinson's disease) is a common progressive neurodegenerative disorder which is characterized by the loss of dopaminergic neurons within the substantia nigra. |
2014-08-29 |
2023-08-12 |
Not clear |
| Zakiya Qualls, Dwayne Brown, Carlana Ramlochansingh, Laura L Hurley, Yousef Tizab. Protective effects of curcumin against rotenone and salsolinol-induced toxicity: implications for Parkinson's disease. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24122264. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder that results from the loss of or damage to dopaminergic cells in the substantia nigra. |
2014-08-28 |
2023-08-12 |
human |
| Fabio A Zucca, Emy Basso, Francesca A Cupaioli, Emanuele Ferrari, David Sulzer, Luigi Casella, Luigi Zecc. Neuromelanin of the human substantia nigra: an update. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24155156. |
dopaminergic neurons of the substantia nigra selectively degenerate over the course of parkinson's disease. |
2014-08-28 |
2023-08-12 |
human |