| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoying Wang, Guiyun Cui, Xinxin Yang, Zunsheng Zhang, Hongjuan Shi, Jie Zu, Fang Hua, Xia She. Intracerebral administration of ultrasound-induced dissolution of lipid-coated GDNF microbubbles provides neuroprotection in a rat model of Parkinson's disease. Brain research bulletin. vol 103. 2014-12-03. PMID:24583079. |
parkinson's disease (pd) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. |
2014-12-03 |
2023-08-12 |
rat |
| Carmen Noelker, Lydie Morel, Anke Osterloh, Daniel Alvarez-Fischer, Thomas Lescot, Minka Breloer, Maike Gold, Wolfgang H Oertel, Carmen Henze, Patrick P Michel, Richard C Dodel, Lixia Lu, Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease. Journal of neuroinflammation. vol 11. 2014-12-01. PMID:24886419. |
increasing evidence suggests that inflammation associated with microglial cell activation in the substantia nigra (sn) of patients with parkinson disease (pd) is not only a consequence of neuronal degeneration, but may actively sustain dopaminergic (da) cell loss over time. |
2014-12-01 |
2023-08-13 |
Not clear |
| Jin Han Nam, Eunju Leem, Min-Tae Jeon, Young-Je Kim, Un Ju Jung, Myung-Sook Choi, Sungho Maeng, Byung Kwan Jin, Sang Ryong Ki. Inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo. Neuroreport. vol 25. issue 7. 2014-11-28. PMID:24488033. |
inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo. |
2014-11-28 |
2023-08-12 |
rat |
| Daping Xu, Hongwei Duan, Zaijun Zhang, Wei Cui, Liang Wang, Yewei Sun, Ming Lang, Pui Man Hoi, Yifan Han, Yuqiang Wang, Simon MingYuen Le. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 2. 2014-11-24. PMID:24233519. |
tn-2 significantly reversed the loss of dopaminergic neurons in the substantia nigra and the decrease in dopamine level in the striatum induced by mptp in mice. |
2014-11-24 |
2023-08-12 |
mouse |
| Amy Reeve, Eve Simcox, Doug Turnbul. Ageing and Parkinson's disease: why is advancing age the biggest risk factor? Ageing research reviews. vol 14. 2014-11-21. PMID:24503004. |
in this review we focus specifically on the neuronal population associated with the motor symptoms of parkinson's disease, the dopaminergic neurons of the substantia nigra, and try to understand how ageing puts these neurons at risk to the extent that a slight change in protein metabolism or mitochondrial function can push the cells over the edge leading to catastrophic cell death and many of the symptoms seen in parkinson's disease. |
2014-11-21 |
2023-08-12 |
Not clear |
| Martin Darvas, Charles W Henschen, Richard D Palmite. Contributions of signaling by dopamine neurons in dorsal striatum to cognitive behaviors corresponding to those observed in Parkinson's disease. Neurobiology of disease. vol 65. 2014-11-13. PMID:24491966. |
yet, early stage pd is not characterized by pathology in the pfc but by a loss of dopaminergic (da) projections from the substantia nigra to the dorsal striatum. |
2014-11-13 |
2023-08-12 |
mouse |
| Tiago Martins Rodrigues, André Jerónimo-Santos, Tiago Fleming Outeiro, Ana Maria Sebastião, Maria José Diógene. Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease. Drugs & aging. vol 31. issue 4. 2014-11-13. PMID:24610720. |
parkinson's disease (pd) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2014-11-13 |
2023-08-12 |
human |
| Sian E Davies, Penelope J Hallett, Thomas Moens, Gaynor Smith, Emily Mangano, Hyoung Tae Kim, Alfred L Goldberg, Ji-Long Liu, Ole Isacson, George K Tofari. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of disease. vol 64. 2014-11-12. PMID:24388974. |
accordingly, aav-mediated expression of wild-type but not the catalytically inactive nedd4 decreased the α-synuclein-induced dopaminergic cell loss in the rat substantia nigra and reduced α-synuclein accumulation. |
2014-11-12 |
2023-08-12 |
rat |
| Boyu Li, Yuhe Yuan, Wanqing Zhang, Wenbin He, Jinfeng Hu, Naihong Che. Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. Neuroscience letters. vol 566. 2014-11-11. PMID:24440618. |
parkinson's disease (pd) is a major age-related neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra par compacta (snpc) and accumulation of aggregated alpha-synuclein in brain areas. |
2014-11-11 |
2023-08-12 |
Not clear |
| Doo Chul Choi, Yoon-Jee Chae, Savan Kabaria, Amrita Datta Chaudhuri, Mohit Raja Jain, Hong Li, M Maral Mouradian, Eunsung Jun. MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 38. 2014-11-11. PMID:25232110. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2014-11-11 |
2023-08-13 |
mouse |
| José R L P Cavalcanti, Joacil G Soares, Francisco G Oliveira, Fausto P Guzen, André L B Pontes, Twyla B Sousa, Jeferson S Cavalcante, Expedito S Nascimento, Judney C Cavalcante, Miriam S M O Cost. A cytoarchitectonic and TH-immunohistochemistry characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in the rock cavy (Kerodon rupestris). Journal of chemical neuroanatomy. vol 55. 2014-11-06. PMID:24444614. |
the organization of these dopaminergic nuclei in the rock cavy brain is very similar to that found in other animals of the rodentia order, except for the presence of the tail of the substantia nigra, which is found only in the species under study. |
2014-11-06 |
2023-08-12 |
Not clear |
| Emilda Pino, Ryoji Amamoto, Lu Zheng, Matthias Cacquevel, Juan-Carlos Sarria, Graham W Knott, Bernard L Schneide. FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra. Human molecular genetics. vol 23. issue 6. 2014-10-31. PMID:24158851. |
foxo3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra. |
2014-10-31 |
2023-08-12 |
human |
| Emilda Pino, Ryoji Amamoto, Lu Zheng, Matthias Cacquevel, Juan-Carlos Sarria, Graham W Knott, Bernard L Schneide. FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra. Human molecular genetics. vol 23. issue 6. 2014-10-31. PMID:24158851. |
we find that dopaminergic neurons are particularly vulnerable to changes in foxo3 activity in the substantia nigra. |
2014-10-31 |
2023-08-12 |
human |
| David Vauzour, John T Pinto, Arthur J L Cooper, Jeremy P E Spence. The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling. The Biochemical journal. vol 463. issue 1. 2014-10-31. PMID:24938188. |
parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. |
2014-10-31 |
2023-08-13 |
Not clear |
| M J Tobia, R Guo, U Schwarze, W Boehmer, J Gläscher, B Finckh, A Marschner, C Büchel, K Obermayer, T Somme. Neural systems for choice and valuation with counterfactual learning signals. NeuroImage. vol 89. 2014-10-29. PMID:24321554. |
the depletion procedure revealed significantly different neural responses to expected value in the vmpfc, caudate, and dopaminergic midbrain in the vicinity of the substantia nigra (sn). |
2014-10-29 |
2023-08-12 |
human |
| Jason Vytlacil, Andrew Kayser, Asako Miyakawa, Mark D'Esposit. An approach for identifying brainstem dopaminergic pathways using resting state functional MRI. PloS one. vol 9. issue 1. 2014-10-28. PMID:24498023. |
in a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal region (caudate) that was modulated by both a pharmacological challenge (the administration of the dopaminergic agonist bromocriptine) and a dopamine-sensitive cognitive trait (an individual's working memory capacity). |
2014-10-28 |
2023-08-12 |
Not clear |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Dhanraj Vijayraja, Nataraj Ashokkumar, Srinivasagam Rajasankar, Thamilarasan Manivasaga. Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice. Annals of neurosciences. vol 17. issue 3. 2014-10-24. PMID:25205886. |
parkinson's disease (pd) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure. |
2014-10-24 |
2023-08-13 |
mouse |
| Mia Kim, Ki-Ho Cho, Mal-Soon Shin, Jae-Min Lee, Han-Sam Cho, Chang-Ju Kim, Dong-Hoon Shin, Hyeon Jeong Yan. Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24535622. |
our results revealed that the injection of mptp/p induced dopaminergic neuronal death in the substantia nigra and fiber loss in the striatum. |
2014-10-21 |
2023-08-12 |
mouse |
| Daniel J Minnema, Kim Z Travis, Charles B Breckenridge, Nicholas C Sturgess, Mark Butt, Jeffrey C Wolf, Dan Zadory, Melissa J Beck, James M Mathews, Merrill O Tisdel, Andrew R Cook, Philip A Botham, Lewis L Smit. Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice. Regulatory toxicology and pharmacology : RTP. vol 68. issue 2. 2014-10-18. PMID:24389362. |
dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of c57bl/6j mice. |
2014-10-18 |
2023-08-12 |
mouse |
| X T Fan, F Zhao, Y Ai, A Andersen, P Hardy, F Ling, G A Gerhardt, Z Zhang, J E Quinter. Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency. Brain research. vol 1552. 2014-10-16. PMID:24398457. |
unilateral mptp-administration rendered the animals with hemiparkinsonian symptoms, including dopaminergic deficiencies in the substantia nigra and the premotor and motor cortices, and with statistically significant decreases in basal glutamate levels in the primary motor cortex on the side ipsilateral to the mptp-lesion. |
2014-10-16 |
2023-08-12 |
monkey |