| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dustin R Wakeman, Stephanie Weiss, John R Sladek, John D Elsworth, Brian Bauereis, Csaba Leranth, Patrick J Hurley, Robert H Roth, D Eugene Redmon. Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates. Cell transplantation. vol 23. issue 8. 2015-05-27. PMID:23562290. |
expression of the dopaminergic marker tyrosine hydroxylase was not maintained in hesc-derived neural grafts in either the striatum or substantia nigra, despite a neuronal morphology and expression of β-iii-tubulin. |
2015-05-27 |
2023-08-12 |
human |
| Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. |
2015-05-21 |
2023-08-13 |
rat |
| Nina Daschil, Christian Humpe. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain research. vol 1581. 2015-05-21. PMID:25038562. |
however, nimodipine and nifedipine significantly enhanced the survival of dopaminergic substantia nigra (sn) but not ventral tegmental area (vta) neurons, while nicardipine, isradipine and verapamil had no effect. |
2015-05-21 |
2023-08-13 |
rat |
| Hashem Haghdoost-Yazdi, Mohammad Sarookhani, Ayda Faraj, Negin Fraidouni, Tahereh Dargahi, Mohammad Hosein Yaghoubidoust, Hassan Azhdari-Zarmehr. Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24992727. |
considering the direct correlation between the severity of rotational behavior and the degree of lesion in the substantia nigra (sn), our data indicate that higher thcy values can predict higher sn dopaminergic neurodegeneration. |
2015-05-19 |
2023-08-13 |
rat |
| Michael M Wördehoff, Oliver Bannach, Hamed Shaykhalishahi, Andreas Kulawik, Stephanie Schiefer, Dieter Willbold, Wolfgang Hoyer, Eva Birkman. Single fibril growth kinetics of α-synuclein. Journal of molecular biology. vol 427. issue 6 Pt B. 2015-05-19. PMID:25659910. |
fibrils of α-syn are a major pathological hallmark of pd and certain aggregation intermediates are postulated to cause synaptic failure and cell death of dopaminergic neurons in the substantia nigra. |
2015-05-19 |
2023-08-13 |
Not clear |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
[estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. |
2015-05-16 |
2023-08-12 |
human |
| Jin-Lan Meng, Yuan-Yi Ma, Hai-Yun Luo, Shu-Zhen Kong, Yong-Wen He, Bao-Cai Dong, Shi-Hao Wu, Min H. [Estrogen protects the dopaminergic neurons in substantia nigra against damage induced by 6-hydroxydopamine]. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 3. 2015-05-16. PMID:18560728. |
until now there is lack of animal experimental data on the supportive effect of estrogen on function of dopaminergic neurons in substantia nigra (sn) in physiological state. |
2015-05-16 |
2023-08-12 |
human |
| Zhentao Zhang, Zhaohui Zhang, Hongcai Wang, Guoxin Zhang, Dan Hu, Jing Xiong, Nian Xiong, Tao Wang, Xuebing Cao, Ling Ma. Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death. PloS one. vol 9. issue 9. 2015-05-14. PMID:25184665. |
the mechanisms leading to dopaminergic neuronal loss in the substantia nigra of patients with parkinson disease (pd) remain poorly understood. |
2015-05-14 |
2023-08-13 |
Not clear |
| Shun Yu, Piu Cha. Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease. Essays in biochemistry. vol 56. 2015-05-12. PMID:25131591. |
then, we introduce recent research progress related to the pathogenic role of α-syn in pd, with special emphasis on how α-syn oligomers cause the preferential degeneration of dopaminergic neurons in the substantia nigra and the spreading of α-syn pathology in the brain of pd patients. |
2015-05-12 |
2023-08-13 |
Not clear |
| Jorge S Valadas, Melissa Vos, Patrik Verstreke. Therapeutic strategies in Parkinson's disease: what we have learned from animal models. Annals of the New York Academy of Sciences. vol 1338. 2015-05-11. PMID:25515068. |
parkinson's disease (pd), the second most common neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra, as well as in other brain areas. |
2015-05-11 |
2023-08-13 |
Not clear |
| Thomas Foltyni. Can Parkinson's disease be cured by stimulating neurogenesis? The Journal of clinical investigation. vol 125. issue 3. 2015-05-11. PMID:25689259. |
previous work suggests that these new cells are not themselves dopaminergic but have trophic effects on residual dopaminergic cells in the substantia nigra. |
2015-05-11 |
2023-08-13 |
Not clear |
| Shin Hisahara, Shun Shimoham. Dopamine receptors and Parkinson's disease. International journal of medicinal chemistry. vol 2011. 2015-05-08. PMID:25954517. |
pathologically, this disease is characterized by the selective dopaminergic (daergic) neuronal degeneration in the substantia nigra. |
2015-05-08 |
2023-08-13 |
Not clear |
| Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasie. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of disease. vol 70. 2015-04-21. PMID:24969022. |
these results demonstrate that inactivation of the pink1 or dj-1 genes in the rat produces progressive neurodegeneration and early behavioral deficits, suggesting that these recessive genes may be essential for the survival of dopaminergic neurons in the substantia nigra (sn). |
2015-04-21 |
2023-08-13 |
rat |
| Jie Li, Terence Duarte, Arif Kocabas, Melissa Works, Susan K McConnell, Mary A Hyne. Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24867253. |
there are two main subgroups of midbrain dopaminergic (da) neurons: the more medially located ventral tegmental area (vta) da neurons, which have axons that innervate the ventral-lateral (vl) striatum, and the more laterally located substantia nigra (sn) da neurons, which preferentially degenerate in parkinson's disease (pd) and have axons that project to the dorsal-medial (dm) striatum. |
2015-04-15 |
2023-08-13 |
mouse |
| Eduard Bentea, Anke Van der Perren, Joeri Van Liefferinge, Anissa El Arfani, Giulia Albertini, Thomas Demuyser, Ellen Merckx, Yvette Michotte, Ilse Smolders, Veerle Baekelandt, Ann Massi. Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein. Frontiers in behavioral neuroscience. vol 9. 2015-04-15. PMID:25873870. |
we report that unilateral administration of 3 μg lactacystin to the substantia nigra of mice leads to partial (~40%) dopaminergic cell loss and concurrent striatal dopamine depletion, accompanied by increased expression of ser129-phosphorylated α-synuclein. |
2015-04-15 |
2023-08-13 |
mouse |
| Dilek Guvenc, Yonca Betil Kabak, Enes Atmaca, Abdurrahman Aksoy, Tolga Guven. Biological significance of the overexpression of HSP70 and alpha B-crystallin in rat substantia nigra exposed to different doses of permethrin. Arhiv za higijenu rada i toksikologiju. vol 64. issue 1. 2015-04-13. PMID:23612524. |
tunel positive apoptotic cells were not detected in the dopaminergic neurons of the substantia nigra after treatment with permethrin; however, upon immunofluorescent staining, intense positive reactions for hsp70 and αbc were observed in all of the treated groups. |
2015-04-13 |
2023-08-12 |
rat |
| Jorge Cancela, Matteo Pastorino, Maria T Arredondo, Konstantina S Nikita, Federico Villagra, Maria A Pasto. Feasibility study of a wearable system based on a wireless body area network for gait assessment in Parkinson's disease patients. Sensors (Basel, Switzerland). vol 14. issue 3. 2015-04-06. PMID:24608005. |
the dopaminergic denervation of the striatum, due to substantia nigra neuronal loss, compromises the speed, the automatism and smoothness of movements of pd patients. |
2015-04-06 |
2023-08-12 |
Not clear |
| Guoshuai Feng, Zhijian Zhang, Qingqing Bao, Zaijun Zhang, Libing Zhou, Jie Jiang, Sha L. Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:24871044. |
consistently, chinonin reduced loss of dopaminergic neurons in the substantia nigra and prevented depletion of dopamine and its metabolites 3-methoxy-4-hydroxy-phenylacetic acid and homovanillic acid in the striatum of mice. |
2015-04-06 |
2023-08-13 |
mouse |
| Hemi Dimant, Suneil K Kalia, Lorraine V Kalia, Liya N Zhu, Laura Kibuuka, Darius Ebrahimi-Fakhari, Nikolaus R McFarland, Zhanyun Fan, Bradley T Hyman, Pamela J McLea. Direct detection of alpha synuclein oligomers in vivo. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252244. |
models were developed using toxins such as mptp or 6-ohda to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the substantia nigra. |
2015-03-31 |
2023-08-12 |
rat |
| Ngoc-Duy Dinh, Ya-Yu Chiang, Heike Hardelauf, Sarah Waide, Dirk Janasek, Jonathan Wes. Preparation of neuronal co-cultures with single cell precision. Journal of visualized experiments : JoVE. issue 87. 2015-03-30. PMID:24894871. |
however, conventional systems require significant cellular inputs (many thousands per compartment), inadequate for studying low abundance cells, such as primary dopaminergic substantia nigra, spiral ganglia, and drosophilia melanogaster neurons, and impractical for high throughput experimentation. |
2015-03-30 |
2023-08-13 |
drosophila_melanogaster |