| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deeksha Varma, Dwaipayan Se. Role of the unfolded protein response in the pathogenesis of Parkinson's disease. Acta neurobiologiae experimentalis. vol 75. issue 1. 2015-09-16. PMID:25856519. |
it is is characterized by loss of dopaminergic neurons in the striatum and substantia nigra, coupled with the formation of intracellular lewy bodies in degenerating neurons. |
2015-09-16 |
2023-08-13 |
human |
| X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang, H Lo. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. vol 286. 2015-09-14. PMID:25449120. |
moreover, dmf ameliorated dopaminergic neurotoxicity in 6-ohda-induced pd animal models as evidenced by amelioration of locomotor dysfunction, loss in striatal dopamine, and reductions in dopaminergic neurons in the substantia nigra and striatum. |
2015-09-14 |
2023-08-13 |
mouse |
| b' Selva Moheb Saadat, \\xc4\\xb0rfan De\\xc4\\x9firmenci, Serhat \\xc3\\x96zkan, Faruk Saydam, Zeynep \\xc3\\x96zdemir K\\xc3\\xb6ro\\xc4\\x9flu, Ertu\\xc4\\x9frul \\xc3\\x87olak, Hasan Veysi G\\xc3\\xbcne\\xc5\\x9. Is the 1254T>C polymorphism in the DMT1 gene associated with Parkinson\'s disease? Neuroscience letters. vol 594. 2015-09-14. PMID:25817364.' |
the main pathological characteristic of pd is the death of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2015-09-14 |
2023-08-13 |
Not clear |
| Carolina Cebrián, John D Loike, David Sulze. Neuroinflammation in Parkinson's disease animal models: a cell stress response or a step in neurodegeneration? Current topics in behavioral neurosciences. vol 22. 2015-09-10. PMID:25293443. |
the motor symptoms of parkinson's disease are due to the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2015-09-10 |
2023-08-13 |
Not clear |
| Ashley A Vena, Rueben A Gonzale. Temporal profiles dissociate regional extracellular ethanol versus dopamine concentrations. ACS chemical neuroscience. vol 6. issue 1. 2015-09-10. PMID:25537116. |
in vivo monitoring of dopamine via microdialysis has demonstrated that acute, systemic ethanol increases extracellular dopamine in regions innervated by dopaminergic neurons originating in the ventral tegmental area and substantia nigra. |
2015-09-10 |
2023-08-13 |
Not clear |
| Xiao Feng Luo, Bei Lin Zhang, Ji Cheng Li, Ying Ying Yang, Yan Fei Sun, Hua Zha. Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease. Brain research bulletin. vol 110. 2015-09-09. PMID:25499570. |
pd is associated with not only degenerative changes in dopaminergic neurons in the substantia nigra but also changes in serotonergic neurons in the raphe nuclei. |
2015-09-09 |
2023-08-13 |
rat |
| Xiao Feng Luo, Bei Lin Zhang, Ji Cheng Li, Ying Ying Yang, Yan Fei Sun, Hua Zha. Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease. Brain research bulletin. vol 110. 2015-09-09. PMID:25499570. |
thus, lhb contributes to the depressive-like behavior in pd rats via mediating the effects of dopaminergic neurons in the substantia nigra on serotonergic neurons in the raphe nuclei. |
2015-09-09 |
2023-08-13 |
rat |
| Wenyu Fu, Wenxin Zhuang, Shuanhu Zhou, Xin Wan. Plant-derived neuroprotective agents in Parkinson's disease. American journal of translational research. vol 7. issue 7. 2015-09-02. PMID:26328004. |
the disease is caused by the slow deterioration of the dopaminergic neurons in the substantia nigra. |
2015-09-02 |
2023-08-13 |
Not clear |
| Limamanen Phom, Bovito Achumi, Debasmita P Alone, Muralidhara, Sarat Chandra Yenisett. Curcumin's neuroprotective efficacy in Drosophila model of idiopathic Parkinson's disease is phase specific: implication of its therapeutic effectiveness. Rejuvenation research. vol 17. issue 6. 2015-08-31. PMID:25238331. |
selective degeneration of dopaminergic neurons in the substantia nigra underlies the basic motor impairments of parkinson's disease (pd). |
2015-08-31 |
2023-08-13 |
human |
| Erin F Wolff, Levent Mutlu, Efi E Massasa, John D Elsworth, D Eugene Redmond, Hugh S Taylo. Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease. Journal of cellular and molecular medicine. vol 19. issue 1. 2015-08-31. PMID:25283241. |
parkinson's disease (pd) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. |
2015-08-31 |
2023-08-13 |
monkey |
| YuYing Huang, JunFang Chen, Ying Chen, YingHan Zhuang, Mu Sun, Thomas Behnisc. The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300734. |
a common view is that mptp is metabolized to 1-methyl-4-phenylpyridinium ion (mpp(+)) to induce its neurodegenerative effects on dopaminergic neurons in the substantia nigra (sn). |
2015-08-24 |
2023-08-13 |
mouse |
| Kristian Wing. Lower urinary tract dysfunction in patients with parkinsonism and other neurodegenerative disorders. Handbook of clinical neurology. vol 130. 2015-08-21. PMID:26003253. |
in parkinson's disease (pd), the specific loss of dopaminergic neurons in the substantia nigra and possibly also in the ventral tegmental area induces loss of neurogenic bladder control through dysfunction of a complex network in which selective disinhibition of bladder reflexes is lost. |
2015-08-21 |
2023-08-13 |
Not clear |
| Christof von Wrangel, Kerstin Schwabe, Nadine John, Joachim K Krauss, Mesbah Ala. The rotenone-induced rat model of Parkinson's disease: behavioral and electrophysiological findings. Behavioural brain research. vol 279. 2015-08-20. PMID:25446762. |
exposure to rotenone leads to parkinsonian features, such as loss of dopaminergic neurons in the substantia nigra and motor impairment, however, the validity of this model has recently been questioned. |
2015-08-20 |
2023-08-13 |
rat |
| Liang Tan, Hongfei Ge, Jun Tang, Chuhua Fu, Wangsheng Duanmu, Yujie Chen, Rong Hu, Jianfeng Sui, Xin Liu, Hua Fen. Amantadine preserves dopamine level and attenuates depression-like behavior induced by traumatic brain injury in rats. Behavioural brain research. vol 279. 2015-08-20. PMID:25447294. |
the da concentration in the striatum of the injured rats, as well as the degeneration and apoptosis of dopaminergic neurons in the substantia nigra (sn), were checked along with the depression-like behavior. |
2015-08-20 |
2023-08-13 |
rat |
| Sandra Elincx-Benizri, Rivka Inzelberg, Lior Greenbaum, Oren S Cohen, Gilad Yahalom, Yael Laitman, Ruth Djaldetti, Yael Orlev, Alon Scope, Esther Azizi, Eitan Friedman, Sharon Hassin-Bae. The melanocortin 1 receptor (Mc1r) variants do not account for the co-occurrence of Parkinson's disease and malignant melanoma. Journal of molecular neuroscience : MN. vol 54. issue 4. 2015-08-14. PMID:25284244. |
parkinson's disease (pd) is characterized by loss of melanin-positive dopaminergic neurons in the substantia nigra. |
2015-08-14 |
2023-08-13 |
Not clear |
| Yuka Hama, Ichiro Yabe, Koichi Wakabayashi, Takahiro Kano, Makoto Hirotani, Yuriko Iwakura, Jun Utsumi, Hidenao Sasak. Level of plasma neuregulin-1 SMDF is reduced in patients with idiopathic Parkinson's disease. Neuroscience letters. vol 587. 2015-08-10. PMID:25524406. |
parkinson's disease (pd) is characterised by the progressive loss of dopaminergic neurons, neurons that are regulated by the development, protection and function of neuregulin-1 (nrg1)-erbb4 signals, in the substantia nigra (sn). |
2015-08-10 |
2023-08-13 |
Not clear |
| Lanying Song, Gino Cortopass. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain research. vol 1594. 2015-08-04. PMID:25446449. |
parkinson׳s disease (pd) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) of midbrain. |
2015-08-04 |
2023-08-13 |
mouse |
| Ulrika Nordströma, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L Joshi, Jack W Lipton, Andrew Roholt, Satish Medicetty, Timothy N Feinstein, Jennifer A Steiner, Martha L Escobar Galvis, Alain Prochiantz, Patrik Brundi. Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease. Neurobiology of disease. vol 73. 2015-07-29. PMID:25281317. |
several weeks before a significant loss of dopaminergic neurons in the substantia nigra could be detected, we found that striatal terminals expressing high levels of dopaminergic neuron markers th, vmat2, and dat were dystrophic and swollen. |
2015-07-29 |
2023-08-13 |
mouse |
| Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaj. MRI can detect nigral volume loss in patients with Parkinson's disease: evidence from a meta-analysis. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24577503. |
parkinson's disease (pd) involves the degeneration of dopaminergic neurons in substantia nigra (sn) compacta. |
2015-07-27 |
2023-08-12 |
Not clear |
| Zhi-Yong Wang, Hui Lian, Qing-Qing Cai, Hai-Yan Song, Xiao-Li Zhang, Li Zhou, Yi-Min Zhang, Li-Fei Zheng, Jin-Xia Zh. No direct projection is observed from the substantia nigra to the dorsal vagus complex in the rat. Journal of Parkinson's disease. vol 4. issue 3. 2015-07-27. PMID:24613863. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons in the substantia nigra (sn). |
2015-07-27 |
2023-08-12 |
rat |