| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Douglas G Walker, Lih-Fen Lue, Geidy Serrano, Charles H Adler, John N Caviness, Lucia I Sue, Thomas G Beac. Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases. Frontiers in neuroscience. vol 9. 2016-02-02. PMID:26834537. |
dopaminergic neurons in the substantia nigra (sn) pars compacta, whose loss results in the clinical symptoms associated with pd, are particularly susceptible to inflammatory damage and oxidative stress. |
2016-02-02 |
2023-08-13 |
human |
| Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang L. Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Human molecular genetics. vol 24. issue 8. 2016-02-01. PMID:25552648. |
although the major neuropathologic feature of pd is the degeneration of dopaminergic (da) neurons in the substantia nigra, non-motor symptoms including anxiety, cognitive defect and sleep disorder precede the onset of motor impairment, and many clinical symptoms of pd are not caused by degeneration of da neurons. |
2016-02-01 |
2023-08-13 |
monkey |
| Neda Masoudi, Pablo Ibanez-Cruceyra, Sarah-Lena Offenburger, Alexander Holmes, Anton Gartne. Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. PLoS genetics. vol 10. issue 12. 2016-01-29. PMID:25474638. |
parkinson's disease (pd), the second most prevalent neurodegenerative disease after alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra. |
2016-01-29 |
2023-08-13 |
caenorhabditis_elegans |
| Omar Mamad, Claire Delaville, Wail Benjelloun, Abdelhamid Benazzou. Dopaminergic control of the globus pallidus through activation of D2 receptors and its impact on the electrical activity of subthalamic nucleus and substantia nigra reticulata neurons. PloS one. vol 10. issue 3. 2016-01-28. PMID:25742005. |
the globus pallidus (gp) receives dopaminergic afferents from the pars compacta of substantia nigra and several studies suggested that dopamine exerts its action in the gp through presynaptic d2 receptors (d2rs). |
2016-01-28 |
2023-08-13 |
rat |
| R Khang, C Park, J-H Shi. Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice. Neuroscience. vol 294. 2016-01-28. PMID:25779963. |
parkinson's disease (pd) is characterized by selective loss of dopaminergic neurons in the substantia nigra (sn). |
2016-01-28 |
2023-08-13 |
mouse |
| Sambuddha Basu, Goun Je, Yoon-Seong Ki. Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease. Experimental & molecular medicine. vol 47. 2016-01-26. PMID:26315598. |
oxidative damage to dna in the form of oxidized guanine (8-oxodg) accumulates in both the mitochondrial and nuclear dna of dopaminergic neurons of the substantia nigra in pd. |
2016-01-26 |
2023-08-13 |
Not clear |
| Xiao-Feng Yin, Hua-Min Xu, Yun-Xia Jiang, Yun-Lai Zhi, Yu-Xiu Liu, Heng-Wei Xiang, Kai Liu, Xiao-Dong Ding, Peng Su. Lentivirus-mediated Persephin over-expression in Parkinson's disease rats. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807117. |
in this study, dopaminergic neurons in the substantia nigra of rats were transfected with the persephin gene. |
2016-01-25 |
2023-08-13 |
rat |
| Xiao-Feng Yin, Hua-Min Xu, Yun-Xia Jiang, Yun-Lai Zhi, Yu-Xiu Liu, Heng-Wei Xiang, Kai Liu, Xiao-Dong Ding, Peng Su. Lentivirus-mediated Persephin over-expression in Parkinson's disease rats. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807117. |
results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with persephin gene. |
2016-01-25 |
2023-08-13 |
rat |
| H Mirendil, E A Thomas, C De Loera, K Okada, Y Inomata, J Chu. LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Translational psychiatry. vol 5. 2016-01-20. PMID:25849980. |
behavioral alterations in amphetamine-induced locomotion, prepulse inhibition, thigmotaxis and social interaction--in addition to increases in tyrosine hydroxylase-positive dopaminergic cells in the substantia nigra and ventral tegmental area and decreases in parvalbumin-positive cells in the prefrontal cortex--were induced upon prenatal serum exposure. |
2016-01-20 |
2023-08-13 |
mouse |
| Xiu-Qi Bao, Liang-Yu Wu, Xiao-Liang Wang, Hua Sun, Dan Zhan. Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 5. 2016-01-19. PMID:25678053. |
parkinson's disease (pd) is a chronic, progressive neurodegenerative disorder characterized by motor impairments and loss of dopaminergic neurons in the substantia nigra. |
2016-01-19 |
2023-08-13 |
mouse |
| Carine Ciron, Lu Zheng, Wojciech Bobela, Graham W Knott, Teresa C Leone, Daniel P Kelly, Bernard L Schneide. PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:25853296. |
pgc-1α, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as a possible therapeutic target for parkinson's disease, with important roles in the function and survival of dopaminergic neurons in the substantia nigra. |
2016-01-13 |
2023-08-13 |
Not clear |
| Hui Shu, Guo-qing Zheng, Xiaona Wang, Yanyun Sun, Yushan Liu, John Michael Weaver, Xianzhi Shen, Wenlan Liu, Xinchun Ji. Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26263395. |
the hippocampus receives dopaminergic projections from the ventral tegmental area (vta) and substantia nigra. |
2016-01-11 |
2023-08-13 |
rat |
| Lih-Shen Chin, Lian L. Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment. Translational neurodegeneration. vol 5. 2016-01-07. PMID:26740872. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder, characterized primarily by the loss of dopaminergic neurons in substantia nigra. |
2016-01-07 |
2023-08-13 |
Not clear |
| Neil A Harrison, Mara Cercignani, Valerie Voon, Hugo D Critchle. Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25154706. |
the dopaminergic substantia nigra (sn) is implicated in the drive to explore novel stimuli and situations. |
2016-01-05 |
2023-08-13 |
human |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Tam Duong, Jaetaek Kim, H Earl Ruley, Daewoong J. Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals. PloS one. vol 9. issue 7. 2016-01-01. PMID:25019626. |
parkinson's disease (pd) is a neurodegenerative disorder of complex etiology characterized by the selective loss of dopaminergic neurons, particularly in the substantia nigra. |
2016-01-01 |
2023-08-13 |
mouse |
| L Barros-Miñones, B Goñi-Allo, V Suquia, G Beitia, N Aguirre, E Puert. Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25666033. |
methylenedioxymethamphetamine (mdma) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. |
2016-01-01 |
2023-08-13 |
mouse |
| Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashim. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25627674. |
the globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. |
2015-12-31 |
2023-08-13 |
human |
| S Mitra, N Chakrabarti, S S Dutta, S Ray, P Bhattacharya, P Sinha, A Bhattacharyy. Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson's disease. Neuroscience. vol 292. 2015-12-16. PMID:25592425. |
rotenone (rt) produces reactive oxygen species (ros) by inhibiting the mitochondrial electron transport chain; causing dopaminergic (da) cell death in the substantia nigra (sn) and simulates other models of induced parkinson's disease (pd). |
2015-12-16 |
2023-08-13 |
mouse |
| Jie Zhang, Hongmei Dai, Yuanying Deng, Jing Tian, Chen Zhang, Zhiping Hu, Guoying Bing, Lingling Zha. Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats. Toxicology. vol 336. 2015-12-15. PMID:26215101. |
the effect of cpf on dopaminergic neurons, microglia, astrocyte, nuclear factor-κb (nf-κb) p. 65 and p. 38 mitogen-activated protein kinase (mapk) signaling pathways was analyzed in the substantia nigra of rats at 12h, 24h, 72 h, 16d and 46 d after exposure. |
2015-12-15 |
2023-08-13 |
rat |