| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiromi Suzuki, Kenji Ono, Makoto Sawad. Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 11. 2015-11-04. PMID:24744047. |
ini-0602 treatment blocked not only dopaminergic loss in both the striatum and substantia nigra, but also apomorphine-induced rotational behavior. |
2015-11-04 |
2023-08-13 |
mouse |
| Tracy Ho, Andrew I Jobling, Ursula Greferath, Trinette Chuang, Archana Ramesh, Erica L Fletcher, Kirstan A Vesse. Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain. Frontiers in cellular neuroscience. vol 9. 2015-10-27. PMID:26500494. |
using immunohistochemistry, vnut was found to co-localize with tyrosine hydroxylase (th) positive, dopaminergic (da) neurons of the substantia nigra and ventral tegmental area, however, vnut expression in extranigral non-da neurons was also observed. |
2015-10-27 |
2023-08-13 |
mouse |
| Longfei Mao, Averina Nicolae, Miguel A P Oliveira, Feng He, Siham Hachi, Ronan M T Flemin. A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease. Computational and structural biotechnology journal. vol 13. 2015-10-27. PMID:26504511. |
one of the hallmarks of sporadic parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. |
2015-10-27 |
2023-08-13 |
Not clear |
| Antonio Boza-Serrano, Juan F Reyes, Nolwen L Rey, Hakon Leffler, Luc Bousset, Ulf Nilsson, Patrik Brundin, Jose Luis Venero, Miguel Angel Burguillos, Tomas Deierbor. The role of Galectin-3 in α-synuclein-induced microglial activation. Acta neuropathologica communications. vol 2. 2015-10-26. PMID:25387690. |
the neuropathology is characterized by intraneuronal protein aggregates of α-synuclein and progressive degeneration of dopaminergic neurons within the substantia nigra. |
2015-10-26 |
2023-08-13 |
Not clear |
| Gemma M Parkinson, Christopher V Dayas, Doug W Smit. Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat. Current aging science. vol 7. issue 3. 2015-10-26. PMID:25612740. |
the dopaminergic neurons of the substantia nigra (sn), which constitute the origin of the nigrostriatal system, are vulnerable to age-related degenerative processes. |
2015-10-26 |
2023-08-13 |
human |
| Xiaorong Pan, Chunxia Chen, Jianping Huang, Haiming Wei, Qiuping Fa. Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats. Neuroscience letters. vol 600. 2015-10-22. PMID:26101828. |
in the present study, we examined whether the combination of hyperbaric oxygen (hbo) and madopar therapy provided a neuroprotective effect on dopaminergic neurons in the substantia nigra using a rat model of pd. |
2015-10-22 |
2023-08-13 |
rat |
| Yu Deng, Congcong Jiao, Chao Mi, Bin Xu, Yuehui Li, Fei Wang, Wei Liu, Zhaofa X. Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24969583. |
administration of mncl2 (50 mg/kg) for 2 weeks significantly induced hypokinesis, dopaminergic neurons degeneration and loss, neuronal ultrastructural damage, and apoptosis in the substantia nigra and the striatum. |
2015-10-20 |
2023-08-13 |
mouse |
| Yu Deng, Congcong Jiao, Chao Mi, Bin Xu, Yuehui Li, Fei Wang, Wei Liu, Zhaofa X. Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24969583. |
in conclusion, mn treatment resulted in motor dysfunction and neuronal loss, possibly involving an interaction between oxidative stress and dopaminergic neurodegeneration in the substantia nigra and the striatum. |
2015-10-20 |
2023-08-13 |
mouse |
| Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekeland. Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice. Neurobiology of aging. vol 35. issue 11. 2015-10-19. PMID:25037286. |
silencing of pink1 expression in mouse substantia nigra using recombinant adeno-associated viral vectors did not induce dopaminergic neurodegeneration in a long-term study up to 10 months, nor did it enhance or accelerate dopaminergic neurodegeneration after alpha-synuclein overexpression. |
2015-10-19 |
2023-08-13 |
mouse |
| Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekeland. Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice. Neurobiology of aging. vol 35. issue 11. 2015-10-19. PMID:25037286. |
however, in pink1 knockout mice, overexpression of alpha-synuclein in the substantia nigra resulted in enhanced dopaminergic neurodegeneration as well as significantly higher levels of alpha-synuclein phosphorylation at serine 129 at 4 weeks postinjection. |
2015-10-19 |
2023-08-13 |
mouse |
| Yuqiang Lv, Zheng Zhang, Lin Hou, Li Zhang, Jinyu Zhang, Yuehua Wang, Cun Liu, Pingping Xu, Lu Liu, Xiaoying Gai, Tingxiu L. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neuroscience letters. vol 597. 2015-10-19. PMID:25929185. |
motor behavior test and tyrosine hydroxylase (th) immunohistochemistry method showed pa significantly inhibited mptp-induced dopaminergic cell loss in the substantia nigra (sn). |
2015-10-19 |
2023-08-13 |
mouse |
| I Boileau, D Payer, B Chugani, D S S Lobo, S Houle, A A Wilson, J Warsh, S J Kish, M Zac. In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO. Molecular psychiatry. vol 19. issue 12. 2015-10-15. PMID:24322203. |
importantly, dopaminergic response to amphetamine in gamblers was positively predicted by d3 receptor levels (measured in substantia nigra), and related to gambling severity, allowing for construction of a mechanistic model that could help explain da contributions to pg. |
2015-10-15 |
2023-08-12 |
human |
| Hikari Chiba, Haruka Sato, Kenji Abe, Toshiaki Saito, Yoshie Horiguchi, Hiroshi Nojima, Kyoji Taguch. Effects of 1,2,3,4-tetrahydroisoquinoline derivatives on dopaminergic spontaneous discharge in substantia nigra neurons in rats. Pharmacology. vol 95. issue 1-2. 2015-10-06. PMID:25633935. |
effects of 1,2,3,4-tetrahydroisoquinoline derivatives on dopaminergic spontaneous discharge in substantia nigra neurons in rats. |
2015-10-06 |
2023-08-13 |
human |
| Ji Ae Lee, Ji Hyun Kim, Seo Yeon Woo, Hyo Jin Son, Se Hee Han, Bo Ko Jang, Ji Won Choi, Dong Jin Kim, Ki Duk Park, Onyou Hwan. A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model. British journal of pharmacology. vol 172. issue 4. 2015-09-29. PMID:25297649. |
neuroinflammation through microglial activation is involved in the pathogenesis of neurodegenerative diseases including parkinson's disease (pd), a major neurodegenerative disorder characterized by dopaminergic neuronal death in the substantia nigra. |
2015-09-29 |
2023-08-13 |
Not clear |
| Fabrizio Gardoni, Monica Di Luc. Targeting glutamatergic synapses in Parkinson's disease. Current opinion in pharmacology. vol 20. 2015-09-28. PMID:25462288. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons of the substantia nigra and dramatic motor and cognitive impairments. |
2015-09-28 |
2023-08-13 |
Not clear |
| Brent J Ryan, Selim Hoek, Edward A Fon, Richard Wade-Martin. Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends in biochemical sciences. vol 40. issue 4. 2015-09-28. PMID:25757399. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterised by the preferential loss of dopaminergic neurons in the substantia nigra. |
2015-09-28 |
2023-08-13 |
Not clear |
| Alicia M Pickrell, Chiu-Hui Huang, Scott R Kennedy, Alban Ordureau, Dionisia P Sideris, Jake G Hoekstra, J Wade Harper, Richard J Youl. Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron. vol 87. issue 2. 2015-09-28. PMID:26182419. |
parkinson's disease (pd) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. |
2015-09-28 |
2023-08-13 |
mouse |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (sn). |
2015-09-21 |
2023-08-13 |
human |
| Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Canno. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25174649. |
at ages of 4, 8, and 12 months, our characterization showed that expression of g2019s lrrk2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons. |
2015-09-21 |
2023-08-13 |
human |
| Anna Kubesova, Hana Tejkalova, Kamila Syslova, Petr Kacer, Jana Vondrousova, Filip Tyls, Michaela Fujakova, Tomas Palenicek, Jiri Horace. Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology. PloS one. vol 10. issue 1. 2015-09-16. PMID:25602957. |
further, we focused on histopathological and morphological markers related to pathogenesis of brain diseases--glial cell activation, neurodegeneration, hippocampal volume reduction and dopaminergic synthesis in the substantia nigra. |
2015-09-16 |
2023-08-13 |
human |