| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola J Rutherford, Amanda N Sacino, Mieu Brooks, Carolina Ceballos-Diaz, Thomas B Ladd, Jasie K Howard, Todd E Golde, Benoit I Giasso. Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice. Molecular neurodegeneration. vol 10. 2016-03-21. PMID:26223783. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that is pathologically characterized by loss of dopaminergic neurons from the substantia nigra, the presence of aggregated α-synuclein (αs) and evidence of neuroinflammation. |
2016-03-21 |
2023-08-13 |
mouse |
| Yun-Lian Lin, Huey-Jen Tsay, Tzu-Hsuan Lai, Tsai-Teng Tzeng, Young-Ji Shia. Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways. Journal of biomedical science. vol 22. 2016-03-10. PMID:26018660. |
the main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. |
2016-03-10 |
2023-08-13 |
Not clear |
| Rhona Clarke, Louise Adermar. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural plasticity. vol 2015. 2016-03-08. PMID:26246915. |
the ventral striatum (nucleus accumbens (nac)) and its reciprocal connection with the ventral tegmental area (vta) represent a primary component of the reward system, but reward-guided learning also involves the dorsal striatum and dopaminergic inputs from the substantia nigra. |
2016-03-08 |
2023-08-13 |
Not clear |
| Cristian Follmer, Eduardo Coelho-Cerqueira, Danilo Y Yatabe-Franco, Gabriel D T Araujo, Anderson S Pinheiro, Gilberto B Domont, David Elieze. Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL). The Journal of biological chemistry. vol 290. issue 46. 2016-03-07. PMID:26381411. |
when injected into the substantia nigra of rat brains, dopal causes the loss of dopaminergic neurons accompanied by the accumulation of potentially toxic oligomers of the presynaptic protein α-synuclein (as), potentially explaining the synergistic toxicity described for dopamine metabolism and as aggregation. |
2016-03-07 |
2023-08-13 |
rat |
| Fabiana Miraglia, Laura Betti, Lionella Palego, Gino Giannaccin. Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge. Central nervous system agents in medicinal chemistry. vol 15. issue 2. 2016-03-01. PMID:25896035. |
in pd they are known as lewy bodies (lbs) and lewy neurites (lns), discovered in dopaminergic neurons of substantia nigra (pars compacta) as well as in other regions of the central and peripheral nervous systems. |
2016-03-01 |
2023-08-13 |
Not clear |
| Gurdeep Marwarha, Othman Ghrib. Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? Experimental gerontology. vol 68. 2016-02-22. PMID:25261765. |
parkinson's disease (pd), the most common movement disorder, is characterized by the aggregation of α-synuclein protein in lewy body inclusions and the death of dopaminergic neurons in the substantia nigra. |
2016-02-22 |
2023-08-13 |
Not clear |
| Kyoung Hoon Jeong, Jin Han Nam, Byung Kwan Jin, Sang Ryong Ki. Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo. PloS one. vol 10. issue 3. 2016-02-22. PMID:25799580. |
it is still unclear whether the levels of cntfrα change in the substantia nigra of parkinson's disease (pd) patients, but cntf expression shows the remarkable decrease in dopaminergic neurons in the substantia nigra pars compacta (snpc), suggesting that the support of cntf/cntfrα signaling pathway may be a useful neuroprotective strategy for the nigrostriatal dopaminergic projection in the adult brain. |
2016-02-22 |
2023-08-13 |
human |
| Tsung-Hsun Hsieh, Ying-Zu Huang, Alexander Rotenberg, Alvaro Pascual-Leone, Yung-Hsiao Chiang, Jia-Yi Wang, Jia-Jin J Che. Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 7. 2016-02-19. PMID:24451657. |
functional dopaminergic neurons in substantia nigra are required for transcranial magnetic stimulation-induced motor plasticity. |
2016-02-19 |
2023-08-12 |
human |
| Tsung-Hsun Hsieh, Ying-Zu Huang, Alexander Rotenberg, Alvaro Pascual-Leone, Yung-Hsiao Chiang, Jia-Yi Wang, Jia-Jin J Che. Functional Dopaminergic Neurons in Substantia Nigra are Required for Transcranial Magnetic Stimulation-Induced Motor Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 7. 2016-02-19. PMID:24451657. |
moreover, dopaminergic neurons in substantia nigra and rotation behavior were assessed to correlate with the amount of itbs-induced plasticity. |
2016-02-19 |
2023-08-12 |
human |
| Raghav Gupta, Christopher Kim, Nitin Agarwal, Bryan Lieber, Edward A Monac. Understanding the Influence of Parkinson Disease on Adolf Hitler's Decision-Making during World War II. World neurosurgery. vol 84. issue 5. 2016-02-16. PMID:26093359. |
parkinson disease (pd) is a common neurodegenerative disorder characterized by the presence of lewy bodies and a reduction in the number of dopaminergic neurons in the substantia nigra of the basal ganglia. |
2016-02-16 |
2023-08-13 |
Not clear |
| Abdul Qayyum Rana, Uzma S Ahmed, Zishan M Chaudry, Sai Vasa. Parkinson's disease: a review of non-motor symptoms. Expert review of neurotherapeutics. vol 15. issue 5. 2016-02-12. PMID:25936847. |
parkinson's disease (pd) is a neurodegenerative disorder resulting from degeneration of the substantia nigra and the dopaminergic nigrostriatal pathway. |
2016-02-12 |
2023-08-13 |
Not clear |
| W Ding, L-J Ding, F-F Li, Y Han, L M. Neurodegeneration and cognition in Parkinson's disease: a review. European review for medical and pharmacological sciences. vol 19. issue 12. 2016-02-12. PMID:26166654. |
parkinsons disease (pd) is a neurodegenerative disorder of the dopaminergic neurons in the substantia nigra. |
2016-02-12 |
2023-08-13 |
Not clear |
| Stefan Jean-Pierre Haas, Xiaolai Zhou, Venissa Machado, Andreas Wree, Kerstin Krieglstein, Björn Spitta. Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease. Frontiers in molecular neuroscience. vol 9. 2016-02-12. PMID:26869879. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by loss of midbrain dopaminergic (mda) neurons in the substantia nigra (sn). |
2016-02-12 |
2023-08-13 |
mouse |
| Ritwik Burai, Nadine Ait-Bouziad, Anass Chiki, Hilal A Lashue. Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis. Journal of the American Chemical Society. vol 137. issue 15. 2016-02-09. PMID:25768729. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneuronal inclusions consisting of aggregated and post-translationally modified α-synuclein (α-syn). |
2016-02-09 |
2023-08-13 |
Not clear |
| Ludger Schöls, Matthias Reimold, Kay Seidel, Christoph Globas, Kathrin Brockmann, Till Karsten Hauser, Georg Auburger, Katrin Bürk, Wilfred den Dunnen, Gerald Reischl, Horst-Werner Korf, Ewout R Brunt, Udo Rü. No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26362908. |
no parkinsonism in sca2 and sca3 despite severe neurodegeneration of the dopaminergic substantia nigra. |
2016-02-09 |
2023-08-13 |
Not clear |
| Ludger Schöls, Matthias Reimold, Kay Seidel, Christoph Globas, Kathrin Brockmann, Till Karsten Hauser, Georg Auburger, Katrin Bürk, Wilfred den Dunnen, Gerald Reischl, Horst-Werner Korf, Ewout R Brunt, Udo Rü. No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26362908. |
although previous post-mortem studies repeatedly revealed a consistent neurodegeneration of the dopaminergic substantia nigra in patients with sca2 and with sca3, parkinsonian motor features evolve only rarely. |
2016-02-09 |
2023-08-13 |
Not clear |
| Ludger Schöls, Matthias Reimold, Kay Seidel, Christoph Globas, Kathrin Brockmann, Till Karsten Hauser, Georg Auburger, Katrin Bürk, Wilfred den Dunnen, Gerald Reischl, Horst-Werner Korf, Ewout R Brunt, Udo Rü. No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26362908. |
the post-mortem investigation revealed, in addition to an extensive neuronal loss in the dopaminergic substantia nigra of all patients with spinocerebellar ataxia, a consistent affection of the thalamic ventral anterior and ventral lateral nuclei, the pallidum and the cholinergic pedunculopontine nucleus. |
2016-02-09 |
2023-08-13 |
Not clear |
| Ludger Schöls, Matthias Reimold, Kay Seidel, Christoph Globas, Kathrin Brockmann, Till Karsten Hauser, Georg Auburger, Katrin Bürk, Wilfred den Dunnen, Gerald Reischl, Horst-Werner Korf, Ewout R Brunt, Udo Rü. No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26362908. |
our observation that lesions of the motor territory of the subthalamic nucleus were consistently associated with the prevention of parkinsonism in our sca2 and sca3 patients matches the clinical experience that selective targeting of the motor territory of the subthalamic nucleus by focal lesions or deep brain stimulation can ameliorate parkinsonian motor features and is likely to counteract the manifestation of parkinsonism in sca2 and sca3 despite a severe neurodegeneration of the dopaminergic substantia nigra. |
2016-02-09 |
2023-08-13 |
Not clear |
| Danqing Xia. Acupuncture for Parkinson's Disease: a review of clinical, animal, and functional Magnetic Resonance Imaging studies. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 35. issue 6. 2016-02-09. PMID:26742319. |
restoration of function seems to involve activation of certain compensatory brain regions as a mechanism at the network level to correct the imbalances to the nervous system resulting from loss of dopaminergic neurons in substantia nigra. |
2016-02-09 |
2023-08-13 |
Not clear |
| Rhiannon L Schroeder, Kay L Double, Jacobus P Gerbe. Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical review. Journal of chemical neuroanatomy. vol 64-65. 2016-02-03. PMID:25681296. |
parkinson's disease is characterised pathologically by a relatively selective death of dopaminergic neurons in the substantia nigra of the brain. |
2016-02-03 |
2023-08-13 |
Not clear |