| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Preeti Umarao, Samrat Bose, Supti Bhattacharyya, Anil Kumar, Suman Jai. Neuroprotective Potential of Superparamagnetic Iron Oxide Nanoparticles Along with Exposure to Electromagnetic Field in 6-OHDA Rat Model of Parkinson's Disease. Journal of nanoscience and nanotechnology. vol 16. issue 1. 2016-08-18. PMID:27398453. |
parkinson's disease (pd) is a progressive neurodegenerative disorder affecting mainly the dopaminergic neurons of the substantia nigra leading to various motor and non-motor deficits. |
2016-08-18 |
2023-08-13 |
rat |
| Ning Yao, Yanhong Wu, Yan Zhou, Lili Ju, Yujun Liu, Rongkai Ju, Deyi Duan, Qunyuan X. Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease. Brain research. vol 1625. 2016-08-15. PMID:26342895. |
the degeneration of noradrenergic neurons in the locus coeruleus (lc) commonly occurs in patients with parkinson's disease (pd), which is characterized by a selective injury of dopaminergic neurons in the substantia nigra (sn). |
2016-08-15 |
2023-08-13 |
mouse |
| Afrah A K Ismaiel, Ana M Espinosa-Oliva, Martiniano Santiago, Albert García-Quintanilla, María J Oliva-Martín, Antonio J Herrera, José L Venero, Rocío M de Pablo. Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system. Toxicology and applied pharmacology. vol 298. 2016-08-15. PMID:26971375. |
the aim of this study was to determine the effect of metformin on the dopaminergic neurons of the substantia nigra of mice using the animal model of parkinson's disease based on the injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an inhibitor of the mitochondrial complex i. |
2016-08-15 |
2023-08-13 |
mouse |
| Sarah Y Branch, Cang Chen, Ramaswamy Sharma, James D Lechleiter, Senlin Li, Michael J Beckstea. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053209. |
dopaminergic neurons of the substantia nigra (sn) play a vital role in everyday tasks, such as reward-related behavior and voluntary movement, and excessive loss of these neurons is a primary hallmark of parkinson's disease (pd). |
2016-08-15 |
2023-08-13 |
mouse |
| Elvira Valera, Michael Mante, Scott Anderson, Edward Rockenstein, Eliezer Maslia. Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25966683. |
pd is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons in substantia nigra, which leads to neurodegeneration and neuroinflammation. |
2016-08-08 |
2023-08-13 |
Not clear |
| Hocine Rekaik, François-Xavier Blaudin de Thé, Julia Fuchs, Olivia Massiani-Beaudoin, Alain Prochiantz, Rajiv L Josh. Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress. Cell reports. vol 13. issue 2. 2016-08-04. PMID:26411690. |
engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. |
2016-08-04 |
2023-08-13 |
mouse |
| Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi It. Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density. PloS one. vol 11. issue 3. 2016-08-03. PMID:26954690. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major pathophysiological feature of patients with parkinson's disease (pd). |
2016-08-03 |
2023-08-13 |
human |
| Qingqing Zhou, Yongping Chen, Qianqian Wei, Huifang Shan. [Parkinson's disease and nucleolar stress]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 33. issue 3. 2016-08-02. PMID:27264829. |
the classic pathogenic feature of pd is preferential loss of dopaminergic neurons in the substantia nigra. |
2016-08-02 |
2023-08-13 |
Not clear |
| Brad E Morriso. Discovery of nigral dopaminergic neurogenesis in adult mice. Neural regeneration research. vol 11. issue 6. 2016-08-02. PMID:27482200. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2016-08-02 |
2023-08-13 |
mouse |
| Ajit Ray, Neha Sehgal, Smitha Karunakaran, Govindan Rangarajan, Vijayalakshmi Ravindranat. MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model. Free radical biology & medicine. vol 87. 2016-08-01. PMID:26164633. |
activation of apoptosis signal-regulating kinase 1 (ask1)-p38 mapk death signaling cascade is implicated in the death of dopaminergic neurons in substantia nigra in parkinson's disease (pd). |
2016-08-01 |
2023-08-13 |
mouse |
| Saori Tsujii, Mitsue Ishisaka, Hideaki Har. Modulation of endoplasmic reticulum stress in Parkinson's disease. European journal of pharmacology. vol 765. 2016-08-01. PMID:26297973. |
parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. |
2016-08-01 |
2023-08-13 |
Not clear |
| Koichi Hasegawa, Toru Yasuda, Chinatsu Shiraishi, Kazushiro Fujiwara, Serge Przedborski, Hideki Mochizuki, Kazuaki Yoshikaw. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nature communications. vol 7. 2016-07-27. PMID:26971449. |
moreover, overexpression of necdin in the substantia nigra in vivo of adult mice protects dopaminergic neurons against degeneration in experimental parkinson's disease. |
2016-07-27 |
2023-08-13 |
mouse |
| Judith Mylius, Max F K Happel, Alexander G Gorkin, Ying Huang, Henning Scheich, Michael Brosc. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain structure & function. vol 220. issue 6. 2016-07-25. PMID:25084746. |
motivated by the increasing evidence that auditory cortex is under control of dopaminergic cell structures of the ventral midbrain, we studied how the ventral tegmental area and substantia nigra affect neuronal activity in auditory cortex. |
2016-07-25 |
2023-08-13 |
monkey |
| Shiqing Zhang, Jiang Xie, Ying Xia, Shu Yu, Zhili Gu, Ruili Feng, Guanghong Luo, Dong Wang, Kai Wang, Meng Jiang, Xiao Cheng, Hai Huang, Wu Zhang, Tieqiao We. LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration. Scientific reports. vol 5. 2016-07-21. PMID:26220523. |
parkinson's disease (pd) is a movement disorder due to the loss of dopaminergic (da) neurons in the substantia nigra. |
2016-07-21 |
2023-08-13 |
human |
| Joshua E Albright, Iva Stojkovska, Abir A Rahman, Connor J Brown, Brad E Morriso. Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice. Neuroscience letters. vol 615. 2016-07-14. PMID:26806039. |
the primary clinical motor symptoms of parkinson's disease (pd) result from loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2016-07-14 |
2023-08-13 |
mouse |
| Nazli Yalçınkaya, Hazal Haytural, Başar Bilgiç, Özkan Özdemir, Haşmet Hanağası, Cem İsmail Küçükali, Zeynep Özbek, Uğur Akcan, Halil Atilla İdrisoğlu, Hakan Gürvit, Erdem Tüzü. Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease. Neuroscience letters. vol 615. 2016-07-14. PMID:26806867. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive degeneration of the dopaminergic neurons in substantia nigra, presumably due to increased apoptosis and oxidative stress. |
2016-07-14 |
2023-08-13 |
mouse |
| Tian Tian, Zhaoming Li, Hong L. Common pathophysiology affecting diabetic retinopathy and Parkinson's disease. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26141638. |
parkinson's disease (pd) is a chronic progressive neurodegenerative movement disorder characterized by progressive loss of dopaminergic neurons in substantia nigra of midbrain. |
2016-07-12 |
2023-08-13 |
mouse |
| Olle Lindval. Treatment of Parkinson's disease using cell transplantation. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 370. issue 1680. 2016-07-12. PMID:26416681. |
importantly, dopaminergic neurons of the correct substantia nigra phenotype can now be generated from human embryonic stem cells in large numbers and standardized preparations, and will soon be ready for application in patients. |
2016-07-12 |
2023-08-13 |
human |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| Marcio S Medeiros, Arthur Schumacher-Schuh, Andreia Machado Cardoso, Guilherme Vargas Bochi, Jucimara Baldissarelli, Aline Kegler, Daniel Santana, Carolina Maria Martins Behle Soares Chaves, Maria Rosa Chitolina Schetinger, Rafael Noal Moresco, Carlos R M Rieder, Michele Rechia Figher. Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers. PloS one. vol 11. issue 1. 2016-06-30. PMID:26751079. |
parkinson's disease (pd) is characterized by progressive motor impairment attributed to progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2016-06-30 |
2023-08-13 |
cat |