| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Botsakis, S Theodoritsi, K Grintzalis, F Angelatou, I Antonopoulos, C D Georgiou, M Margarity, N A Matsokis, N T Panagopoulo. 17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency. Neuroscience. vol 320. 2016-12-13. PMID:26852701. |
in the present study, long-term treatment (from p1 to p21) with 17β-estradiol (17β-estradiol) significantly protected the dopaminergic neurons in the substantia nigra (sn) of weaver mouse by 54%, as was detected by immunohistochemical experiments, using the specific antibody against tyrosine hydroxylase (th). |
2016-12-13 |
2023-08-13 |
mouse |
| Juan Camilo Jurado-Coronel, Marco Avila-Rodriguez, Francisco Capani, Janneth Gonzalez, Valentina Echeverria Moran, George E Barret. Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease. Current pharmaceutical design. vol 22. issue 10. 2016-12-13. PMID:26972289. |
parkinson's disease (pd) is a relatively common disorder of the central nervous system (cns), whose etiology is characterized by a selective and progressive degeneration of dopaminergic neurons, and the presence of lewy bodies in the pars compacta of the substantia nigra, and gaping dopamine depletion in the striatum. |
2016-12-13 |
2023-08-13 |
Not clear |
| T V Tarasova, O A Lytkina, A Yu Roman, S O Bachurin, A A Ustyugo. The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. vol 466. 2016-12-13. PMID:27021360. |
the role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area. |
2016-12-13 |
2023-08-13 |
Not clear |
| T V Tarasova, O A Lytkina, A Yu Roman, S O Bachurin, A A Ustyugo. The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. vol 466. 2016-12-13. PMID:27021360. |
the progressive loss of dopaminergic (da) neurons is characteristic of pd and the most severe damage occurs in the substantia nigra (sn). |
2016-12-13 |
2023-08-13 |
Not clear |
| Riccardo Montioli, Carla B Voltattorni, Mariarita Bertold. Parkinson's Disease: Recent Updates in the Identification of Human Dopa Decarboxylase Inhibitors. Current drug metabolism. vol 17. issue 5. 2016-12-13. PMID:27025882. |
backround: parkinson's disease is a pathology involving the progressive degeneration of dopaminergic neurons in the substantia nigra of the brain. |
2016-12-13 |
2023-08-13 |
human |
| Xu Jing, Xinbing Wei, Manru Ren, Lingtian Wang, Xiumei Zhang, Haiyan Lo. Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson's Disease Through Upregulating Nrf2. Neurochemical research. vol 41. issue 4. 2016-11-10. PMID:26537816. |
moreover, in the in vivo experiment, t-i treatment significantly attenuated 6-ohda-induced striatal oxidative stress and ameliorated dopaminergic neurotoxicity in 6-ohda-lesioned mice, as evidenced by western blot analysis of tyrosine hydroxylase (th) and th immunostaining of dopaminergic neurons in the substantia nigra and the striatum. |
2016-11-10 |
2023-08-13 |
mouse |
| Milena Pinto, Nadee Nissanka, Susana Peralta, Roberta Brambilla, Francisca Diaz, Carlos T Morae. Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:27038906. |
the cause of the motor symptoms is the loss of dopaminergic neurons in the substantia nigra with consequent depletion of dopamine in the striatum. |
2016-11-08 |
2023-08-13 |
mouse |
| Daniel J Minnema, Kim Z Travis, Charles B Breckenridge, Nicholas C Sturgess, Mark Butt, Jeffrey C Wolf, Dan Zadory, Mark T Herberth, Scott L Watson, Andrew R Cook, Philip A Botha. Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice. Regulatory toxicology and pharmacology : RTP. vol 75. 2016-11-02. PMID:26683030. |
dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of c57bl/6j mice. |
2016-11-02 |
2023-08-13 |
mouse |
| Lifei Xing, Dongtao Wang, Lihong Wang, Wenjie Lan, Suyue Pa. Differential proteomics analysis of mononuclear cells in cerebrospinal fluid of Parkinson's disease. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-24. PMID:26823915. |
parkinson's disease (pd) is one common neurodegenerative disease featured with degeneration of dopaminergic neurons in substantia nigra. |
2016-10-24 |
2023-08-13 |
Not clear |
| Filipe C Matheus, Daniel Rial, Joana I Real, Cristina Lemos, Juliana Ben, Gisele O Guaita, Inês R Pita, Ana C Sequeira, Frederico C Pereira, Roger Walz, Reinaldo N Takahashi, Leandro J Bertoglio, Cláudio Da Cunha, Rodrigo A Cunha, Rui D Predige. Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats. Behavioural brain research. vol 301. 2016-10-20. PMID:26707254. |
the bilateral injection of 6-ohda (20μg/hemisphere) in the dls caused a marked loss of dopaminergic neurons in the substantia nigra (>80%) and decreased monoamine levels in the striatum and pfc, accompanied by motor deficits evaluated after 21 days in the open field and accelerated rotarod. |
2016-10-20 |
2023-08-13 |
rat |
| Filipe C Matheus, Daniel Rial, Joana I Real, Cristina Lemos, Juliana Ben, Gisele O Guaita, Inês R Pita, Ana C Sequeira, Frederico C Pereira, Roger Walz, Reinaldo N Takahashi, Leandro J Bertoglio, Cláudio Da Cunha, Rodrigo A Cunha, Rui D Predige. Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats. Behavioural brain research. vol 301. 2016-10-20. PMID:26707254. |
a lower dose of 6-ohda (10μg/hemisphere) only induced a partial degeneration (about 60%) of dopaminergic neurons in the substantia nigra with no gross motor impairments, thus mimicking an early premotor stage of pd. |
2016-10-20 |
2023-08-13 |
rat |
| Manoj A Upadhya, Gajanan P Shelkar, Nishikant K Subhedar, Dadasaheb M Kokar. CART modulates the effects of levodopa in rat model of Parkinson's disease. Behavioural brain research. vol 301. 2016-10-20. PMID:26771081. |
parkinson's disease (pd) is an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of substantia nigra (sn). |
2016-10-20 |
2023-08-13 |
rat |
| Alon Simchovitz, Lilach Soreq, Hermona Sore. Transcriptome profiling in Parkinson's leukocytes: from early diagnostics to neuroimmune therapeutic prospects. Current opinion in pharmacology. vol 26. 2016-10-13. PMID:26609801. |
parkinson's disease (pd) involves motor symptoms reflecting the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2016-10-13 |
2023-08-13 |
human |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
intrastriatal 6-ohda injections decreased the number of dopaminergic, but not serotonergic neurons in the dr. 6-ohda reduced the dat binding in the cp, and sert binding in the nigrostriatal system (cp, substantia nigra (sn)), limbic system (ventral tegmental area (vta), nucleus accumbens (nac), amygdala, prefrontal cortex (pfcx), habenula, hippocampus) and dr. a significant positive correlation was found between dat and sert binding in the cp. |
2016-10-13 |
2023-08-13 |
rat |
| Weibo Shi, Chunling Ma, Qian Qi, Lizhe Liu, Haitao Bi, Bin Cong, Yingmin L. The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats. Neurotoxicology. vol 51. 2016-10-12. PMID:26386147. |
therefore, this study investigated th changes in dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn), as well as the morphine effects on dopaminergic neurons induced by different durations of morphine dependence. |
2016-10-12 |
2023-08-13 |
rat |
| Sarah J Stednitz, Briana Freshner, Samantha Shelton, Tori Shen, Donovan Black, Ethan Gahta. Selective toxicity of L-DOPA to dopamine transporter-expressing neurons and locomotor behavior in zebrafish larvae. Neurotoxicology and teratology. vol 52. issue Pt A. 2016-10-12. PMID:26546233. |
the primary neuropathology in pd involves the death of dopaminergic cells in the substantia nigra (sn), an anatomical region of the brain implicated in dopamine production and voluntary motor control. |
2016-10-12 |
2023-08-13 |
zebrafish |
| Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, Hideki Mochizuk. A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease. Neurobiology of aging. vol 37. 2016-09-26. PMID:26545632. |
furthermore, pre- and post-oral administration of k560 to mice prevented mptp-induced loss of dopaminergic neurons in substantia nigra, suggesting that selective inhibition of hdac1 and hdac2 by k560 may pave the way to new strategies for parkinson's disease treatment. |
2016-09-26 |
2023-08-13 |
mouse |
| Paula Trujillo, Alex K Smith, Paul E Summers, Luca M Mainardi, Sergio Cerutti, Seth A Smith, Antonella Cost. High-resolution quantitative imaging of the substantia nigra. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2015. 2016-09-26. PMID:26737519. |
there is a growing interest in identifying neuroimaging-based biomarkers for parkinson's disease (pd), a progressive neurodegenerative disorder in which the major pathologic substrate is the loss of pigmented dopaminergic neurons in the substantia nigra (sn). |
2016-09-26 |
2023-08-13 |
human |
| Jih-Ing Chuang, Jui-Yen Huang, Shaw-Jenq Tsai, H Sunny Sun, Shang-Hsun Yang, Pei-Chin Chuang, Bu-Miin Huang, Cheng-Hsin Chin. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free radical biology & medicine. vol 89. 2016-09-22. PMID:26424114. |
an in vivo study consistently showed that fgf9 overexpression using a lentivirus delivery system induced erk1/2 phosphorylation and ho-1 upregulation and protected dopaminergic neurons against mpp(+) toxicity in rat substantia nigra. |
2016-09-22 |
2023-08-13 |
rat |
| G Levandis, B Balestra, F Siani, V Rizzo, C Ghezzi, G Ambrosi, S Cerri, A Bonizzi, R Vicini, M Vairetti, A Ferrigno, O Pastoris, F Blandin. Response of colonic motility to dopaminergic stimulation is subverted in rats with nigrostriatal lesion: relevance to gastrointestinal dysfunctions in Parkinson's disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 27. issue 12. 2016-09-20. PMID:26433214. |
in this study, we investigated whether a pd-like degeneration of dopaminergic neurons of the substantia nigra can influence peristalsis in colonic segments of rats by impacting on enteric dopaminergic transmission. |
2016-09-20 |
2023-08-13 |
rat |