| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongpeng Guan, Hongkuan Yang, Mingchun Yang, Daijiro Yanagisawa, Jean-Pierre Bellier, Masaki Mori, Shogo Takahata, Takashi Nonaka, Shiguang Zhao, Ikuo Tooyam. Mitochondrial ferritin protects SH-SY5Y cells against H Experimental neurology. vol 291. 2017-05-16. PMID:28163159. |
previous studies have shown that ftmt is expressed by dopaminergic neurons in the substantia nigra and that it may be involved in the pathology of parkinson's disease. |
2017-05-16 |
2023-08-13 |
human |
| Yuta Masaki, Yasuhiko Izumi, Atsuko Matsumura, Akinori Akaike, Toshiaki Kum. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. European journal of pharmacology. vol 798. 2017-05-15. PMID:28167258. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra (sn), and oxidative stress is thought to contribute to the pathogenesis. |
2017-05-15 |
2023-08-13 |
mouse |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
the tau tangle ligand (18)f-av-1451 ((18)f-t807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. |
2017-05-10 |
2023-08-13 |
human |
| Charalampos Tzoulis, Thomas Schwarzlmüller, Martin Biermann, Kristoffer Haugarvoll, Laurence A Bindof. Mitochondrial DNA homeostasis is essential for nigrostriatal integrity. Mitochondrion. vol 28. 2017-05-09. PMID:26979109. |
our findings demonstrate that dopaminergic neurons of the substantia nigra are specifically vulnerable to defective mtdna replication/repair or quality control and not to primary point mutations of mtdna. |
2017-05-09 |
2023-08-13 |
Not clear |
| Chandran Anusha, Thangarajan Sumathi, Leena Dennis Josep. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. Chemico-biological interactions. vol 269. 2017-05-09. PMID:28389404. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra which is associated with oxidative stress, neuroinflammation and apoptosis. |
2017-05-09 |
2023-08-13 |
rat |
| Andrew G Yee, Peter S Freestone, Ji-Zhong Bai, Janusz Lipsk. Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone. Experimental neurology. vol 287. issue Pt 1. 2017-05-08. PMID:27771354. |
parkinson's disease (pd) is not only associated with degeneration of dopaminergic (daergic) neurons in the substantia nigra, but also with profound loss of noradrenergic neurons in the locus coeruleus (lc). |
2017-05-08 |
2023-08-13 |
rat |
| Rosanna Palmeri, Viviana Lo Buono, Francesco Corallo, Maria Foti, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marin. Nonmotor Symptoms in Parkinson Disease: A Descriptive Review on Social Cognition Ability. Journal of geriatric psychiatry and neurology. vol 30. issue 2. 2017-05-02. PMID:28073327. |
nonmotor symptoms include cognitive deficits and impairment in emotions recognition ability associated with loss of dopaminergic neurons in the substantia nigra and with alteration in frontostriatal circuits. |
2017-05-02 |
2023-08-13 |
Not clear |
| William M Johnson, Marcin Golczak, Kyonghwan Choe, Pierce L Curran, Olga Gorelenkova Miller, Chen Yao, Wenzhang Wang, Jiusheng Lin, Nicole M Milkovic, Ajit Ray, Vijayalakshmi Ravindranath, Xiongwei Zhu, Mark A Wilson, Amy L Wilson-Delfosse, Shu G Chen, John J Mieya. Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease. Biochemistry. vol 55. issue 32. 2017-05-01. PMID:26894491. |
parkinson's disease (pd) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. |
2017-05-01 |
2023-08-13 |
mouse |
| Imène Achour, Anne-Marie Arel-Dubeau, Justine Renaud, Manon Legrand, Everaldo Attard, Marc Germain, Maria-Grazia Martinol. Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model. International journal of molecular sciences. vol 17. issue 8. 2017-05-01. PMID:27517912. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, primarily affecting dopaminergic neurons in the substantia nigra. |
2017-05-01 |
2023-08-13 |
Not clear |
| Adel Jungling, Dora Reglodi, Zsofia Nozomi Karadi, Gabor Horvath, Jozsef Farkas, Balazs Gaszner, Andrea Tama. Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28216584. |
treatment with 6-ohda led to a significant cell loss in the substantia nigra of control animals, however, postnatal enriched circumstances could rescue the dopaminergic cells. |
2017-04-28 |
2023-08-13 |
rat |
| Enéas G Ferrazoli, Héllio D N de Souza, Isis C Nascimento, Ágatha Oliveira-Giacomelli, Telma T Schwindt, Luiz R Britto, Henning Ulric. Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease. Cell transplantation. vol 26. issue 4. 2017-04-28. PMID:28403913. |
parkinson's disease (pd) is a neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra and their projections to the striatum. |
2017-04-28 |
2023-08-13 |
rat |
| Xin-Hong Wang, Xin Xie, Xiao-Guang Luo, Hong Shang, Zhi-Yi H. Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28035410. |
parkinson's disease (pd) is a common neurodegenerative disorder, which is characterized by the selective and progressive death of dopaminergic (da) neurons in the substantia nigra. |
2017-04-21 |
2023-08-13 |
rat |
| Xuan Yan, Dian-Feng Liu, Xiang-Yang Zhang, Dong Liu, Shi-Yao Xu, Guang-Xin Chen, Bing-Xu Huang, Wen-Zhi Ren, Wei Wang, Shou-Peng Fu, Ju-Xiong Li. Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-κB Signaling Pathway. International journal of molecular sciences. vol 18. issue 2. 2017-04-20. PMID:28208679. |
in vivo, we firstly established rat models of pd by unilateral injection of lps into substantia nigra (sn), and then examined the role of vanillin in motor dysfunction, microglial activation and degeneration of dopaminergic neurons. |
2017-04-20 |
2023-08-13 |
rat |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Nuramatjan Ablat, Deyong Lv, Rutong Ren, Yilixiati Xiaokaiti, Xiang Ma, Xin Zhao, Yi Sun, Hui Lei, Jiamin Xu, Yingcong Ma, Xianrong Qi, Min Ye, Feng Xu, Hongbin Han, Xiaoping P. Neuroprotective Effects of a Standardized Flavonoid Extract from Safflower against a Rotenone-Induced Rat Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27563865. |
parkinson's disease (pd) is a major age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra par compacta (snpc). |
2017-04-17 |
2023-08-13 |
mouse |
| Luke A Morgan, Oliver Grundman. Preclinical and Potential Applications of Common Western Herbal Supplements as Complementary Treatment in Parkinson's Disease. Journal of dietary supplements. vol 14. issue 4. 2017-04-17. PMID:28095073. |
they may treat the disease at the cellular level by decreasing microglia activation, attenuating damage from radical oxygen species, supporting correct protein folding, chelating iron, increasing the substantia nigra blood flow, and promoting dopaminergic cell growth. |
2017-04-17 |
2023-08-13 |
human |
| Tourandokht Baluchnejadmojarad, Nida Jamali-Raeufy, Sedigheh Zabihnejad, Nafiseh Rabiee, Mehrdad Roghan. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson's disease: Possible involvement of PI3K/ERβ signaling. European journal of pharmacology. vol 801. 2017-04-17. PMID:28284752. |
parkinson's disease (pd) is a neurodegenerative disease with progressive loss of mesencephalic dopaminergic neurons of the substantia nigra and with multiple incapacitating motor and non-motor symptoms. |
2017-04-17 |
2023-08-13 |
rat |
| Chenghua Wu, Guoguang Fan, Chunli Wu, Guibo Yu, Zixuan L. Morphologic changes within the cerebellar cortex in the unilateral 6-hydroxydopamine lesioned rat model for Parkinson disease. Histology and histopathology. vol 31. issue 12. 2017-04-14. PMID:26996233. |
parkinson's disease (pd) is a common neurodegenerative disorder caused by the progressive loss of dopaminergic neurons in the substantia nigra. |
2017-04-14 |
2023-08-13 |
rat |
| Satoshi Okuyama, Tomoki Semba, Nobuki Toyoda, Francesco Epifano, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. International journal of molecular sciences. vol 17. issue 10. 2017-04-07. PMID:27763495. |
in patients with parkinson's disease (pd), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (sn), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequential motor functional impairments. |
2017-04-07 |
2023-08-13 |
mouse |
| Qiong Zhang, Yong-Fei Zhao, Jian-Ying Xi, Wen-Bo Yu, Bao-Guo Xia. Rho kinase II interference by small hairpin RNA ameliorates 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine‑induced parkinsonism in mice. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27840922. |
to elucidate the importance of rockii in the pathogenesis of dopaminergic (da) neuron loss and to investigate the efficacy of rock inhibitors in pd, rockii expression in the substantia nigra (sn) of mice was silenced through the injection of a lentivirus‑based small hairpin rna system. |
2017-04-07 |
2023-08-13 |
mouse |