| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumit Sarkar, James Raymick, Syed Ima. Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives. International journal of molecular sciences. vol 17. issue 6. 2017-04-06. PMID:27338353. |
typical neuropathological features of parkinson's disease (pd) include degeneration of dopaminergic neurons located in the pars compacta of the substantia nigra that project to the striatum (nigro-striatal pathway) and depositions of cytoplasmic fibrillary inclusions (lewy bodies) which contain ubiquitin and α-synuclein. |
2017-04-06 |
2023-08-13 |
Not clear |
| Sumit Sarkar, James Raymick, Syed Ima. Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives. International journal of molecular sciences. vol 17. issue 6. 2017-04-06. PMID:27338353. |
several different mechanisms play an important role in generation of lewy bodies; endoplasmic reticulum (er) stress induced unfolded proteins, neuroinflammation and eventual loss of dopaminergic neurons in the substantia nigra of mid brain in pd. |
2017-04-06 |
2023-08-13 |
Not clear |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |
| Md Zeeshan Rasheed, Heena Tabassum, Suhel Parve. Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease. Protoplasma. vol 254. issue 1. 2017-03-27. PMID:26825389. |
among the neurodegenerative diseases (nd), parkinson's disease affects 6.3 million people worldwide characterized by the progressive loss of dopaminergic neurons in substantia nigra. |
2017-03-27 |
2023-08-13 |
Not clear |
| Giulia Sita, Patrizia Hrelia, Andrea Tarozzi, Fabiana Morron. Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27598127. |
parkinson's disease (pd) is recognized as the second most common neurodegenerative disorder and is characterized by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra. |
2017-03-23 |
2023-08-13 |
Not clear |
| X Wang, H A Yang, X N Wang, Y F D. Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson's disease. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-16. PMID:27173342. |
the most significant pathological feature of parkinson's disease (pd) is the progressive degeneration of dopaminergic (da) neurons in the substantia nigra. |
2017-03-16 |
2023-08-13 |
rat |
| José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesino. Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs. Planta medica. vol 82. issue 11-12. 2017-03-16. PMID:27224274. |
the reduction of dopamine levels produces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| F Marxreiter, A Storch, J Winkle. [Cellular replacement strategies and adult neurogenesis in idiopathic Parkinson's disease]. Der Nervenarzt. vol 87. issue 8. 2017-03-15. PMID:27389601. |
motor symptoms are associated with a distinct striatal dopaminergic deficit resulting from axonal dysfunction and neuronal loss in the substantia nigra (sn). |
2017-03-15 |
2023-08-13 |
Not clear |
| Veronne de Vrind, Jacqueline Scuvée-Moreau, Guillaume Drion, Cyrine Hmaied, Fabian Philippart, Dominique Engel, Vincent Seuti. Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European journal of pharmacology. vol 788. 2017-03-10. PMID:27364758. |
we addressed this question using intracellular and extracellular recordings from substantia nigra, pars compacta (snc), dopaminergic neurons in rat midbrain slices. |
2017-03-10 |
2023-08-13 |
rat |
| Can Zhao, Hui Li, Xian-Jing Zhao, Zheng-Xia Liu, Ping Zhou, Ying Liu, Mei-Jiang Fen. Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson's disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26758268. |
parkinson's disease (pd) is a neurodegenerative disorder that is caused by a loss of dopaminergic (daergic) neurons in mesencephalic substantia nigra (sn). |
2017-03-06 |
2023-08-13 |
human |
| Jan Luzny, Katerina Ivanov. DatSCAN In Differential Diagnostics of Lewy Body Disease. Archives of Iranian medicine. vol 19. issue 6. 2017-03-02. PMID:27293063. |
datscan showed deficient dopaminergic presynaptic transport in substantia nigra and striatum. |
2017-03-02 |
2023-08-13 |
Not clear |
| Jan Luzny, Katerina Ivanov. DatSCAN In Differential Diagnostics of Lewy Body Disease. Archives of Iranian medicine. vol 19. issue 6. 2017-03-02. PMID:27293063. |
deficient dopaminergic presynaptic transport in substantia nigra and striatum is typical for lewy body disease. |
2017-03-02 |
2023-08-13 |
Not clear |
| Cornelius J H M Klemann, Gerard J M Martens, Geert Poelmans, Jasper E Visse. Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease. Molecular neurobiology. vol 53. issue 3. 2017-03-01. PMID:25676140. |
parkinson's disease (pd) is characterized by dopaminergic (da) neuron death in the substantia nigra (sn) and subsequent striatal adaptations. |
2017-03-01 |
2023-08-13 |
mouse |
| Randy Hunter, Uttam Ojha, Sunil Bhurtel, Guoying Bing, Dong-Young Cho. Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway. Neuroscience research. vol 114. 2017-02-27. PMID:27667002. |
finally, we found significant loss of dopaminergic neurons in the substantia nigra one week after lps injection. |
2017-02-27 |
2023-08-13 |
rat |
| Se Won Oh, Na-Young Shin, Jae Jung Lee, Seung-Koo Lee, Phil Hyu Lee, Soo Mee Lim, Jin Woo Ki. Correlation of 3D FLAIR and Dopamine Transporter Imaging in Patients With Parkinsonism. AJR. American journal of roentgenology. vol 207. issue 5. 2017-02-20. PMID:27489952. |
the purpose of this study is to evaluate direct in vivo visualization of nigrosome-1 in substantia nigra (sn) with 3d flair imaging and its diagnostic value in predicting the intactness of presynaptic dopaminergic function of the nigrostriatal pathway. |
2017-02-20 |
2023-08-13 |
Not clear |
| Hitoshi Sasajima, Sadaharu Miyazono, Tomohiro Noguchi, Makoto Kashiwayanag. Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra. Biological & pharmaceutical bulletin. vol 40. issue 1. 2017-02-03. PMID:28049942. |
intranasal administration of rotenone to mice induces dopaminergic neurite degeneration of dopaminergic neurons in the substantia nigra. |
2017-02-03 |
2023-08-13 |
mouse |
| Guohua Zhang, Yuhu Zhang, Chengguo Zhang, Yukai Wang, Guixian Ma, Kun Nie, Haiqun Xie, Jianping Liu, Lijuan Wan. Striatal silent lacunar infarction is associated with changes to the substantia nigra in patients with early-stage Parkinson's disease: A diffusion kurtosis imaging study. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 33. 2017-02-01. PMID:27499120. |
a recent study has shown that striatal silent infarction may occur secondary to the degeneration of dopaminergic neurons in the substantia nigra (sn) of mice. |
2017-02-01 |
2023-08-13 |
mouse |
| Shirley D Wenker, María Celeste Leal, María Isabel Farías, Xianmin Zeng, Fernando J Pitoss. Cell therapy for Parkinson's disease: Functional role of the host immune response on survival and differentiation of dopaminergic neuroblasts. Brain research. vol 1638. issue Pt A. 2017-01-31. PMID:26239914. |
parkinson's disease (pd) is a neurodegenerative disorder, whose cardinal pathology is the loss of dopaminergic neurons in the substantia nigra. |
2017-01-31 |
2023-08-13 |
Not clear |
| Takuya Konno, Joanna Siuda, Zbigniew K Wszole. Genetics of Parkinson's disease: a review of SNCA and LRRK2. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 69. issue 3 Pt 1. 2017-01-31. PMID:27486710. |
the loss of dopaminergic neurons in the substantia nigra and lewy bodies in remaining neurons are pathological characteristics of pd. |
2017-01-31 |
2023-08-13 |
Not clear |
| E R Mingazov, M V Ugrumo. Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system. Doklady. Biochemistry and biophysics. vol 470. issue 1. 2017-01-25. PMID:27817030. |
degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. |
2017-01-25 |
2023-08-13 |
Not clear |