| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prafulla Chandra Tiwari, Rishi Pa. The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in clinical neuroscience. vol 19. issue 1. 2017-09-07. PMID:28566949. |
an increased level of inducible nitric oxide synthase observed in the substantia nigra and striatum of pd patients suggests that both cytokine-and chemokine-induced toxicity and inflammation lead to oxidative stress that contributes to degeneration of dopaminergic neurons and to disease progression. |
2017-09-07 |
2023-08-13 |
Not clear |
| Prafulla Chandra Tiwari, Rishi Pa. The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in clinical neuroscience. vol 19. issue 1. 2017-09-07. PMID:28566949. |
lipopolysaccharide activation of microglia in the proximity of dopaminergic neurons in the substantia nigra causes their degeneration, and this appears to be a selective vulnerability of dopaminergic neurons to inflammation. |
2017-09-07 |
2023-08-13 |
Not clear |
| Esraa A Kandil, Noha F Abdelkader, Bahia M El-Sayeh, Samira Sale. Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats. Neuroscience. vol 332. 2017-09-05. PMID:27365173. |
additionally, immunohistochemical examination revealed dopaminergic neuronal damage in substantia nigra. |
2017-09-05 |
2023-08-13 |
rat |
| Konstantinos Botsakis, Theodora Mourtzi, Vasiliki Panagiotakopoulou, Malamati Vreka, Georgios T Stathopoulos, Iosif Pediaditakis, Ioannis Charalampopoulos, Achilleas Gravanis, Foteini Delis, Katerina Antoniou, Dimitrios Zisimopoulos, Christos D Georgiou, Nikolaos T Panagopoulos, Nikolaos Matsokis, Fevronia Angelato. BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor. Neuropharmacology. vol 121. 2017-09-05. PMID:28461162. |
using the "weaver" mouse, a genetic model of pd, which exhibits progressive dopaminergic neurodegeneration in the substantia nigra (sn), we have shown that long-term administration (p1-p21) of bnn-20 almost fully protected the dopaminergic neurons and their terminals, via i) a strong anti-apoptotic effect, probably mediated through the tropomyosin receptor kinase b (trkb) neurotrophin receptor's pi3k-akt-nf-κb signaling pathway, ii) by exerting an efficient antioxidant effect, iii) by inducing significant anti-inflammatory activity and iv) by restoring brain-derived neurotrophic factor (bdnf) levels. |
2017-09-05 |
2023-08-13 |
mouse |
| Fernanda Carvalho Cagni, Clarissa Loureiro das Chagas Campêlo, Daniel Gomes Coimbra, Mayara Rodrigues Barbosa, Luiz Gonzaga Oliveira Júnior, Antônio Braz Silva Neto, Alessandra Mussi Ribeiro, Clécio de Oliveira Godeiro Júnior, Tiago Gomes de Andrade, Regina Helena Silv. Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. The Journal of neuropsychiatry and clinical neurosciences. vol 29. issue 2. 2017-08-25. PMID:27852165. |
bdnf is necessary for the survival of dopaminergic neurons in substantia nigra. |
2017-08-25 |
2023-08-13 |
human |
| Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Bora. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress. PloS one. vol 12. issue 2. 2017-08-25. PMID:28170429. |
altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (sn) region of the midbrain in pd. |
2017-08-25 |
2023-08-13 |
mouse |
| Noemie Tentillier, Anders Etzerodt, Mads N Olesen, F Sila Rizalar, Jan Jacobsen, Dirk Bender, Søren K Moestrup, Marina Romero-Ramo. Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 36. 2017-08-17. PMID:27605613. |
furthermore, these animals showed better survival of dopaminergic neurons in substantia nigra and an increased number of microglia expressing major histocompatibility complex ii. |
2017-08-17 |
2023-08-13 |
rat |
| Ajit Ray, Maltesh Kambali, Vijayalakshmi Ravindranat. Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease. Antioxidants & redox signaling. vol 25. issue 5. 2017-08-10. PMID:27121974. |
a single unilateral administration of the thiol oxidant, diamide (1.45 μmol) into substantia nigra (sn) of mice leads to locomotor deficits and degeneration of dopaminergic (da) neurons in sn pars compacta (snpc). |
2017-08-10 |
2023-08-13 |
mouse |
| Jiawen Yuan, Jinpeng Ren, Ying Wang, Xiao He, Yuwu Zha. Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease. PloS one. vol 11. issue 9. 2017-08-08. PMID:27632381. |
parkinson's disease (pd) is characterized by the progressive degeneration of the dopaminergic neurons in the substantia nigra (sn) region. |
2017-08-08 |
2023-08-13 |
rat |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. |
2017-08-07 |
2023-08-13 |
rat |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
dopaminergic neurodegeneration in the mouse is associated with decrease of viscoelasticity of substantia nigra tissue. |
2017-07-31 |
2023-08-13 |
mouse |
| Elisabeth G Hain, Charlotte Klein, Tonia Munder, Juergen Braun, Kerstin Riek, Susanne Mueller, Ingolf Sack, Barbara Steine. Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue. PloS one. vol 11. issue 8. 2017-07-31. PMID:27526042. |
thus, the objective of this study was to evaluate (1) the validity of mre to detect viscoelastic changes in small and specific brain regions: the substantia nigra (sn), midbrain and hippocampus in a mouse model of pd, and (2) if the induced dopaminergic neurodegeneration and inflammation in the sn is reflected by local changes in viscoelasticity. |
2017-07-31 |
2023-08-13 |
mouse |
| Ina Tesseur, Andy Nguyen, Betty Chang, Lulin Li, Nathaniel S Woodling, Tony Wyss-Coray, Jian Lu. Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 17. 2017-07-31. PMID:28363982. |
increasing tgf-β signaling in the substantia nigra through adeno-associated virus expressing a constitutively active type i receptor significantly reduces 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration and motor deficits. |
2017-07-31 |
2023-08-13 |
mouse |
| Cyril Monnot, Xiaoqun Zhang, Sahar Nikkhou-Aski, Peter Damberg, Per Svenningsso. Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism. Experimental neurology. vol 292. 2017-07-28. PMID:28223037. |
in accordance with a neurodegeneration of the nigrostriatal dopaminergic pathway, diffusion tensor imaging showed increased radial diffusivity and decreased fractional anisotropy in the lesioned substantia nigra. |
2017-07-28 |
2023-08-13 |
rat |
| Zhi Pan, Yingcai Niu, Yini Liang, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27229883. |
parkinson's disease (pd) is a neurological disorder pathologically characterized by loss of dopaminergic neurons in the substantia nigra. |
2017-07-26 |
2023-08-13 |
Not clear |
| Dandan Luo, Ying Shi, Jun Wang, Qing Lin, Yi Sun, Keqiang Ye, Qiao Yan, Hai Zhan. 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents. Neuroscience letters. vol 620. 2017-07-24. PMID:27019033. |
the results demonstrated that treatment with 7,8-dhf in drinking water for four weeks (two weeks before 6-ohda+two weeks after 6-ohda lesion) significantly improved dopamine-mediated behaviors in 6-ohda rat model, and prevented the loss of dopaminergic neurons in the substantia nigra (sn). |
2017-07-24 |
2023-08-13 |
mouse |
| Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A Goldber. Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053029. |
α-synuclein overexpression (asox) drives the formation of toxic aggregates in neurons vulnerable in parkinson's disease (pd), including dopaminergic neurons of the substantia nigra (sn) and cholinergic neurons of the dorsal motor nucleus of the vagus (dmv). |
2017-07-24 |
2023-08-13 |
mouse |
| Shih-Ying Wu, Yun-Wen Chen, Sheng-Feng Tsai, Sheng-Nan Wu, Yao-Hsiang Shih, Ya-Fen Jiang-Shieh, Ting-Ting Yang, Yu-Min Ku. Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K(+) channel. Scientific reports. vol 6. 2017-07-19. PMID:26960267. |
by comparing microglia and dopaminergic (da) neurons in the substantia nigra (sn) of male and female mice of different ages, we found that the degrees of microglial activation and da neuron loss increased with age in both genders, but were more pronounced in males, as were peripheral lipopolysaccharide (lps)-induced microglial activation and da neuron loss. |
2017-07-19 |
2023-08-13 |
mouse |
| Thiago Pereira da Silva, Anicleto Poli, Daniela Balz Hara, Reinaldo Naoto Takahash. Time course study of microglial and behavioral alterations induced by 6-hydroxydopamine in rats. Neuroscience letters. vol 622. 2017-07-19. PMID:27113204. |
these data extend our previous findings and suggest that the retrograde and partial damage of dopaminergic neurons in the substantia nigra can induce effects resembling premotor symptoms of pd, two and three weeks after injury. |
2017-07-19 |
2023-08-13 |
rat |