| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Hong, Ling Wang, Tingting Zhang, Baofeng Zhang, Ling Che. Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. Neurobiology of aging. vol 59. 2018-01-08. PMID:28870519. |
sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. |
2018-01-08 |
2023-08-13 |
Not clear |
| Kirsten E Schoonover, Lesley A McCollum, Rosalinda C Robert. Protein Markers of Neurotransmitter Synthesis and Release in Postmortem Schizophrenia Substantia Nigra. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550734. |
the substantia nigra (sn) provides the largest dopaminergic input to the brain, projects to the striatum (the primary locus of action for antipsychotic medication), and receives gabaergic and glutamatergic inputs. |
2018-01-05 |
2023-08-13 |
human |
| Alpana Singh, Poonam Verma, Gillela Balaji, Supriti Samantaray, Kochupurackal P Mohanakuma. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochemistry international. vol 99. 2018-01-03. PMID:27395789. |
it attenuated mptp-induced loss of dopaminergic tyrosine hydroxylase positive neurons in substantia nigra, improved mitochondrial oxygen consumption and inhibited reactive oxygen species production in the striatal mitochondria measured using dichlorodihydrofluorescein fluorescence, but failed to block striatal dopamine depletion. |
2018-01-03 |
2023-08-13 |
mouse |
| Margaux Doria, Lucie Maugest, Thibault Moreau, Gérard Lizard, Anne Veju. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease. Free radical biology & medicine. vol 101. 2017-12-29. PMID:27836779. |
parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein (lewy bodies). |
2017-12-29 |
2023-08-13 |
Not clear |
| So-Yoon Won, Mee-Hee Park, Soon-Tae You, Seung-Won Choi, Hyong-Kyu Kim, Catriona McLean, Suk-Chul Bae, Sang Ryong Kim, Byung Kwan Jin, Kun Ho Lee, Eun-Young Shin, Eung-Gook Ki. Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson's disease. Science translational medicine. vol 8. issue 367. 2017-12-29. PMID:27903866. |
parkinson's disease (pd) is characterized by progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2017-12-29 |
2023-08-13 |
human |
| Yun Jung Bae, Jong-Min Kim, Eunhee Kim, Kyung Mi Lee, Seo Young Kang, Hyun Soo Park, Kyeong Joon Kim, Young Eun Kim, Eung Seok Oh, Ji Young Yun, Ji Seon Kim, Hye-Jin Jeong, Beomseok Jeon, Sang Eun Ki. Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With (123) I-FP-CIT SPECT. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 5. 2017-12-27. PMID:26990970. |
the aim of this study was to investigate whether 3 tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in parkinson's disease (pd), multiple system atrophy (msa), and progressive supranuclear palsy (psp) and to assess the concordance between the loss of nigral hyperintensity on 3 tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by (123) i-2β-carbomethoxy-3β-(4-iodophenyl)-n-(3-fluoropropyl)-nortropane single photon emission computerized tomography. |
2017-12-27 |
2023-08-13 |
Not clear |
| S Abad, J Camarasa, D Pubill, A Camins, E Escubed. Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687233. |
the treatment did not modify hippocampal tryptophan hydroxylase 2, a serotonergic indicator, but induced an initial reduction in dopaminergic markers in substantia nigra, which remained stable for at least 3 months. |
2017-12-25 |
2023-08-13 |
mouse |
| Vinod Kumar, Brajesh Kumar Singh, Amit Kumar Chauhan, Deepali Singh, Devendra Kumar Patel, Chetna Sing. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25764516. |
while neurobehavioral and biochemical indexes of pd and number of dopaminergic neurons were reduced, the number of microglial cells was increased in the substantia nigra of the zn-exposed animals. |
2017-12-22 |
2023-08-13 |
rat |
| Raquel Requejo-Aguilar, Juan P Bolaño. Mitochondrial control of cell bioenergetics in Parkinson's disease. Free radical biology & medicine. vol 100. 2017-12-22. PMID:27091692. |
parkinson disease (pd) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra. |
2017-12-22 |
2023-08-13 |
Not clear |
| Małgorzata Partyka, Jerzy Duszyński, Joanna Szczepanowsk. [Changes of mitochondrial dynamics as a response to mitochondrial stress in models of sporadic Parkinson's disease]. Postepy biochemii. vol 62. issue 2. 2017-12-22. PMID:28132469. |
degeneration of dopaminergic neurons in the substantia nigra and the stratium, are the hallmarks of the disease. |
2017-12-22 |
2023-08-13 |
Not clear |
| Yunjong Lee, Daniel A Stevens, Sung-Ung Kang, Haisong Jiang, Yun-Il Lee, Han Seok Ko, Leslie A Scarffe, George E Umanah, Hojin Kang, Sangwoo Ham, Tae-In Kam, Kathleen Allen, Saurav Brahmachari, Jungwoo Wren Kim, Stewart Neifert, Seung Pil Yun, Fabienne C Fiesel, Wolfdieter Springer, Valina L Dawson, Joo-Ho Shin, Ted M Dawso. PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell reports. vol 18. issue 4. 2017-12-21. PMID:28122242. |
conditional knockdown of pink1 in adult mouse brains leads to a progressive loss of dopaminergic neurons in the substantia nigra that is dependent on paris. |
2017-12-21 |
2023-08-13 |
mouse |
| Elisa Garbayo, Eduardo Ansorena, Hugo Lana, María Del Mar Carmona-Abellan, Irene Marcilla, José Luis Lanciego, María Rosario Luquin, María José Blanco-Priet. Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys. Biomaterials. vol 110. 2017-12-19. PMID:27697668. |
moreover, gdnf was retrogradely transported to the substantia nigra increasing bilaterally the number of dopaminergic and total neurons, regardless of the severe degeneration. |
2017-12-19 |
2023-08-13 |
monkey |
| Caroline Calice da Silva, Bárbara Nunes Azevedo, Denise Cantarelli Machado, Eduardo R Zimmer, Leo Anderson Meira Martins, Jaderson Costa da Cost. Dissociation between dopaminergic response and motor behavior following intrastriatal, but not intravenous, transplant of bone marrow mononuclear stem cells in a mouse model of Parkinson's disease. Behavioural brain research. vol 324. 2017-12-13. PMID:28167338. |
parkinson's disease is characterized by the progressive loss of dopaminergic neurons from the substantia nigra, a process that leads to a dopamine deficiency in the striatum. |
2017-12-13 |
2023-08-13 |
mouse |
| Alessandra Zanon, Sreehari Kalvakuri, Aleksandar Rakovic, Luisa Foco, Marianna Guida, Christine Schwienbacher, Alice Serafin, Franziska Rudolph, Michaela Trilck, Anne Grünewald, Nancy Stanslowsky, Florian Wegner, Valentina Giorgio, Alexandros A Lavdas, Rolf Bodmer, Peter P Pramstaller, Christine Klein, Andrew A Hicks, Irene Pichler, Philip Seible. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Human molecular genetics. vol 26. issue 13. 2017-12-11. PMID:28379402. |
mutations in the parkin gene (park2) have been linked to a recessive form of parkinson's disease (pd) characterized by the loss of dopaminergic neurons in the substantia nigra. |
2017-12-11 |
2023-08-13 |
human |
| Ping-Yue Pan, Xianting Li, Jing Wang, James Powell, Qian Wang, Yuanxi Zhang, Zhaoyu Chen, Bridget Wicinski, Patrick Hof, Timothy A Ryan, Zhenyu Yu. Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 47. 2017-12-04. PMID:29054882. |
parkinson's disease (pd) is characterized pathologically by the selective loss of substantia nigra (sn) dopaminergic (daergic) neurons. |
2017-12-04 |
2023-08-13 |
Not clear |
| Silvia Schneider, Katja Götz, Carmen Birchmeier, Herbert Schwegler, Thomas Roskode. Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model. Behavioural brain research. vol 322. issue Pt A. 2017-12-01. PMID:28089851. |
the number of dopaminergic and serotoninergic neurons did not differ in the investigated regions ventral tegmental area, substantia nigra, periaqueductal grey and raphe nuclei. |
2017-12-01 |
2023-08-13 |
mouse |
| C Klein, J Rasińska, L Empl, M Sparenberg, A Poshtiban, E G Hain, D Iggena, M Rivalan, Y Winter, B Steine. Physical exercise counteracts MPTP-induced changes in neural precursor cell proliferation in the hippocampus and restores spatial learning but not memory performance in the water maze. Behavioural brain research. vol 307. 2017-11-28. PMID:27012392. |
parkinson's disease (pd) is characterized by a continuous loss of dopaminergic neurons in the substantia nigra, which not only leads to characteristic motor symptoms but also to cognitive impairments. |
2017-11-28 |
2023-08-13 |
mouse |
| Eunju Im, Lang Yoo, Minju Hyun, Woo Hyun Shin, Kwang Chul Chun. Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin. Open biology. vol 6. issue 8. 2017-11-21. PMID:27534820. |
parkinson's disease (pd) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called lewy bodies. |
2017-11-21 |
2023-08-13 |
Not clear |
| Di Wen, Meiling An, Hongyan Gou, Xia Liu, Li Liu, Chunling Ma, Bin Con. Cholecystokinin-8 inhibits methamphetamine-induced neurotoxicity via an anti-oxidative stress pathway. Neurotoxicology. vol 57. 2017-11-21. PMID:27565679. |
we found that pretreatment of cholecystokinin-8 (cck-8) inhibited meth-induced brain cellular dopaminergic (da) damage in the striatum and substantia nigra, and related behavioural deficits and hyperthermia. |
2017-11-21 |
2023-08-13 |
Not clear |
| Chul Ju Hwang, Young Eun Kim, Dong Ju Son, Mi Hee Park, Dong-Young Choi, Pil-Hoon Park, Mats Hellström, Sang-Bae Han, Ki-Wan Oh, Eun Kyung Park, Jin Tae Hon. Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function. Redox biology. vol 11. 2017-11-20. PMID:28086194. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. |
2017-11-20 |
2023-08-13 |
mouse |