| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, Per Svenningsso. Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-18. PMID:28137881. |
in a different set of postmortem brains, p11 mrna expression was measured in dopaminergic cells from the substantia nigra. |
2018-04-18 |
2023-08-13 |
Not clear |
| Xingzhi Guo, Tingting Liu, Diandian Zhao, Xiaofeng Wang, Dongmei Liu, Yang He, Chang Shan, Yingying Kong, Weiwei Hu, Bei Tao, Lihao Sun, Hongyan Zhao, Shengtian Li, Jianmin Li. FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease. Neuroscience. vol 356. 2018-04-12. PMID:28504195. |
dopaminergic neuronal injury in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd). |
2018-04-12 |
2023-08-13 |
rat |
| Ellen Buckley, Azeem Siddique, Alisdair McNeil. Hyposmia, symptoms of rapid eye movement sleep behavior disorder, and parkinsonian motor signs suggest prodromal neurodegeneration in 22q11 deletion syndrome. Neuroreport. vol 28. issue 11. 2018-04-05. PMID:28574926. |
the characteristic motor features of pd begin when more than 50% of dopaminergic neurons in the substantia nigra have degenerated. |
2018-04-05 |
2023-08-13 |
human |
| Ole-Bjørn Tysnes, Anette Storstei. Epidemiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 8. 2018-04-02. PMID:28150045. |
the main neuropathological finding is α-synuclein-containing lewy bodies and loss of dopaminergic neurons in the substantia nigra, manifesting as reduced facilitation of voluntary movements. |
2018-04-02 |
2023-08-13 |
Not clear |
| Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Christopher Simon, Quan Fu Gan, Vui King Vincent-Chong, Vasudevan Mani, Kesavanarayanan Krishnan Selvarajan, Vellayan Subramaniam, Sabri Musa, Noor Hayaty Abu Kasi. Effect of dental pulp stem cells in MPTP-induced old-aged mice model. European journal of clinical investigation. vol 47. issue 6. 2018-03-26. PMID:28369799. |
parkinson's disease (pd) is a neurodegenerative disease caused by the loss of dopaminergic (da-ergic) neurons in the substantia nigra (sn) and represented as a huge threat to the geriatric population. |
2018-03-26 |
2023-08-13 |
mouse |
| Likun Yang, Changfeng Guo, Jie Zhu, Yi Feng, Weiliang Chen, Zhizhong Feng, Dan Wang, Shibai Sun, Wei Lin, Yuhai Wan. Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson's Disease Patients: Search for a Disease Indicator. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-26. PMID:28624842. |
background parkinson's disease (pd) is the second most prevalent neurodegenerative disorder and it arises when most of the dopaminergic neurons of substantia nigra region die. |
2018-03-26 |
2023-08-13 |
Not clear |
| Nadya Pyatigorskaya, Rahul Gaurav, Dario Arnaldi, Smaranda Leu-Semenescu, Lydia Yahia-Cherif, Romain Valabregue, Marie Vidailhet, Isabelle Arnulf, Stephane Lehéric. Magnetic Resonance Imaging Biomarkers to Assess Substantia Nigra Damage in Idiopathic Rapid Eye Movement Sleep Behavior Disorder. Sleep. vol 40. issue 11. 2018-03-26. PMID:28958075. |
at pd onset, 40 to 70% of the dopaminergic neurons in the substantia nigra (sn) are already lost. |
2018-03-26 |
2023-08-13 |
human |
| V V Pavshintsev, L S Podshivalova, O Y Frolova, M V Belopolskaya, O A Averina, E A Kushnir, N V Marmiy, M L Lova. Effects of Mitochondrial Antioxidant SkQ1 on Biochemical and Behavioral Parameters in a Parkinsonism Model in Mice. Biochemistry. Biokhimiia. vol 82. issue 12. 2018-03-23. PMID:29486701. |
skq1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the parkinson-like condition. |
2018-03-23 |
2023-08-13 |
mouse |
| Mari H Savolainen, Katrina Albert, Mikko Airavaara, Timo T Myöhäne. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse. Experimental brain research. vol 235. issue 7. 2018-03-22. PMID:28439627. |
we found that lactacystin induced a parkinson's disease-like motor phenotype 5-7 days after injection in young and adult mice, and this was associated with widespread neuroinflammation based on glial cell markers, asyn accumulation in substantia nigra, striatal dopamine decrease, and loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2018-03-22 |
2023-08-13 |
mouse |
| Jia Liu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang, Hui Yan. Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model. Oncotarget. vol 7. issue 38. 2018-03-19. PMID:27572322. |
we found that pip treatment attenuated rotenone-induced motor deficits, and rescued the loss of dopaminergic neurons in the substantia nigra. |
2018-03-19 |
2023-08-13 |
mouse |
| Zeynep Sena Agim, Jason R Canno. Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure. Toxicology letters. vol 287. 2018-03-19. PMID:29378243. |
quantification of intracellular nitrotyrosine revealed higher levels of oxidative damage in dopaminergic neurons in the substantia nigra after phip exposure, while other neuronal populations were less sensitive. |
2018-03-19 |
2023-08-13 |
rat |
| Karamjit Singh Dolt, Fella Hammachi, Tilo Kunat. Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations. Brain pathology (Zurich, Switzerland). vol 27. issue 4. 2018-03-16. PMID:28585381. |
there are multiple neuronal subtypes affected in pd including the midbrain dopaminergic (mda) neurons of the substantia nigra. |
2018-03-16 |
2023-08-13 |
human |
| Daijiro Yanagisawa, Keisuke Oda, Masatoshi Inden, Shigehiro Morikawa, Toshiro Inubushi, Takashi Taniguchi, Masanori Hijioka, Yoshihisa Kitamura, Ikuo Tooyam. Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease. Journal of neuroscience research. vol 95. issue 7. 2018-03-12. PMID:27792255. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra projecting to the striatum. |
2018-03-12 |
2023-08-13 |
rat |
| Alexandre Sales Barros, Rafael Yuri Gouveia Crispim, Juliana Uchoa Cavalcanti, Ricardo Basto Souza, Jonatas Cavalcante Lemos, Gerardo Cristino Filho, Mirna Marques Bezerra, Thales Fontenele Moraes Pinheiro, Silvânia Maria Mendes de Vasconcelos, Danielle Silveira Macêdo, Glauce Socorro de Barros Viana, Lissiana Magna Vasconcelos Aguia. Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats. Basic & clinical pharmacology & toxicology. vol 120. issue 6. 2018-03-07. PMID:27883274. |
parkinson's disease (pd) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. |
2018-03-07 |
2023-08-13 |
rat |
| Jing Li, Lan Ma, Ying Fan, Yina Zhang, Dianjun Sun, Bo W. Crosstalk between 6-OHDA-induced autophagy and apoptosis in PC12 cells is mediated by phosphorylation of Raf-1/ERK1/2. Die Pharmazie. vol 71. issue 8. 2018-03-07. PMID:29442034. |
parkinson's disease (pd) is a degenerative brain disorder characterized by motor symptoms and loss of dopaminergic (da) neurons in the substantia nigra. |
2018-03-07 |
2023-08-13 |
Not clear |
| Qing Gao, Zhou Ou, Teng Jiang, You-Yong Tian, Jun-Shan Zhou, Liang Wu, Jian-Quan Shi, Ying-Dong Zhan. Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson's disease. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28445961. |
loss of dopaminergic neurons within the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), which leads to the onset of motor symptoms. |
2018-03-05 |
2023-08-13 |
rat |
| Xiaofei Zhao, Jun Wang, Song Hu, Renping Wang, Yongjun Mao, Junxia Xi. Neuroprotective effect of resveratrol on rotenone-treated C57BL/6 mice. Neuroreport. vol 28. issue 9. 2018-03-05. PMID:28471847. |
the aim of the present study was to investigate whether resveratrol could reduce nigral iron levels to prevent the degeneration of dopaminergic neurons in the substantia nigra (sn) of c57bl/6 mice induced by rotenone. |
2018-03-05 |
2023-08-13 |
mouse |
| Joel H Ellwanger, Silvia I R Franke, Diana L Bordin, Daniel Prá, João A P Henrique. Biological functions of selenium and its potential influence on Parkinson's disease. Anais da Academia Brasileira de Ciencias. vol 88. issue 3 Suppl. 2018-03-02. PMID:27556332. |
parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. |
2018-03-02 |
2023-08-13 |
Not clear |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
parkinson's disease (pd) is a neurodegenerative condition caused by age-related death of dopaminergic (da) neurons in the substantia nigra (sn). |
2018-02-22 |
2023-08-13 |
mouse |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
mitochondrial dna (mtdna) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of the substantia nigra and overlap with dying neurons. |
2018-02-22 |
2023-08-13 |
mouse |