| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth Bautista, Natanael Zarco, Nicolás Aguirre-Pineda, Manuel Lara-Lozano, Paula Vergara, Juan Antonio González-Barrios, Raúl Aguilar-Roblero, José Segovi. Expression of Gas1 in Mouse Brain: Release and Role in Neuronal Differentiation. Cellular and molecular neurobiology. vol 38. issue 4. 2018-09-04. PMID:29110208. |
we found that gas1 is expressed in gabaergic and glutamatergic neurons in the purkinje-molecular layer of the cerebellum, hippocampus, thalamus, and fastigial nucleus, as well as in dopaminergic neurons of the substantia nigra. |
2018-09-04 |
2023-08-13 |
mouse |
| Christian Dölle, Irene Flønes, Gonzalo S Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Laurence A Bindoff, Charalampos Tzouli. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature communications. vol 7. 2018-08-29. PMID:27874000. |
here, we study the complete spectrum of mtdna changes, including deletions, copy-number variation and point mutations, in single neurons from the dopaminergic substantia nigra and other brain areas of individuals with parkinson disease and neurologically healthy controls. |
2018-08-29 |
2023-08-13 |
mouse |
| Christian Dölle, Irene Flønes, Gonzalo S Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Laurence A Bindoff, Charalampos Tzouli. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature communications. vol 7. 2018-08-29. PMID:27874000. |
we show that in dopaminergic substantia nigra neurons of healthy individuals, mtdna copy number increases with age, maintaining the pool of wild-type mtdna population in spite of accumulating deletions. |
2018-08-29 |
2023-08-13 |
mouse |
| Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng F. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences. vol 19. issue 1. 2018-08-20. PMID:29267220. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn). |
2018-08-20 |
2023-08-13 |
rat |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? |
2018-08-16 |
2023-08-13 |
mouse |
| Lin Kooi Ong, Zidan Zhao, Murielle Kluge, Clifford TeBay, Katarzyna Zalewska, Phillip W Dickson, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe? Brain, behavior, and immunity. vol 60. 2018-08-16. PMID:27717686. |
exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (sn) and may in fact initiate the loss of dopaminergic neurons within the sn. |
2018-08-16 |
2023-08-13 |
mouse |
| Woom-Yee Bae, Jae-Sun Choi, Joo-Won Jeon. The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 19. issue 2. 2018-08-08. PMID:29439518. |
in the present study, we found that the selective dopaminergic neuronal death in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse models was prevented by ca. |
2018-08-08 |
2023-08-13 |
mouse |
| Silke Frahm, Valeria Melis, David Horsley, Janet E Rickard, Gernot Riedel, Paula Fadda, Maria Scherma, Charles R Harrington, Claude M Wischik, Franz Theuring, Karima Schwa. Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29180135. |
interestingly, there was no detectable α-syn expression in dopaminergic neurones of the substantia nigra, but strong human α-syn reactivity in glutamatergic synapses. |
2018-08-07 |
2023-08-13 |
mouse |
| Vedad Delic, Jeddidiah W D Griffin, Sandra Zivkovic, Yumeng Zhang, Tam-Anh Phan, Henry Gong, Dale Chaput, Christian Reynes, Vinh B Dinh, Josean Cruz, Eni Cvitkovic, Devon Placides, Ernide Frederic, Hamed Mirzaei, Stanley M Stevens, Umesh Jinwal, Daniel C Lee, Patrick C Bradsha. Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28620826. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by alpha-synuclein accumulation and loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2018-08-06 |
2023-08-13 |
human |
| ZhenXiang Zhao, JianFeng Wang, LingLing Wang, XiaoMei Yao, YiLin Liu, Ye Li, Si Chen, Tao Yue, XiaoTang Wang, WenFei Yu, YiMing Li. Capsaicin Protects Against Oxidative Insults and Alleviates Behavioral Deficits in Rats with 6-OHDA-Induced Parkinson's Disease via Activation of TRPV1. Neurochemical research. vol 42. issue 12. 2018-08-02. PMID:28861768. |
and the immunostaining of substantia nigra further suggested that capsaicin might protect against dopaminergic neuronal loss. |
2018-08-02 |
2023-08-13 |
rat |
| Jasem Estakhr, Danya Abazari, Kaitlyn Frisby, J Michael McIntosh, Raad Nashm. Differential Control of Dopaminergic Excitability and Locomotion by Cholinergic Inputs in Mouse Substantia Nigra. Current biology : CB. vol 27. issue 13. 2018-07-31. PMID:28648825. |
differential control of dopaminergic excitability and locomotion by cholinergic inputs in mouse substantia nigra. |
2018-07-31 |
2023-08-13 |
mouse |
| Qing Ye, Xiaolei Yuan, Jie Zhou, Canxing Yuan, Xuming Yan. Effect of Zishenpingchan granule prepared from Chinese medicinal substances on the c-Jun N-terminal protein kinase pathway in micewith Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 37. issue 2. 2018-07-31. PMID:29960635. |
to investigate the regulatory mechanism of the c-jun n-terminal protein kinase (jnk)signaling pathway in substantia nigra (sn) dopaminergic neurons inflammation and apoptosis, andthe neuroprotective effect of zishenpingchan granules in mice with parkinson's disease (pd) inducedby 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2018-07-31 |
2023-08-13 |
mouse |
| Katja Stahl, Soulmaz Rahmani, Agnete Prydz, Nadia Skauli, Nanna MacAulay, Maria N Mylonakou, Reidun Torp, Øivind Skare, Torill Berg, Trygve B Leergaard, Ragnhild E Paulsen, Ole P Ottersen, Mahmood Amiry-Moghadda. Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PloS one. vol 13. issue 3. 2018-07-27. PMID:29566083. |
gradual loss of dopaminergic neurons of substantia nigra is the main cause of morbidity in this disease. |
2018-07-27 |
2023-08-13 |
mouse |
| Ori J Lieberman, Se Joon Choi, Ellen Kanter, Anastasia Saverchenko, Micah D Frier, Giulia M Fiore, Min Wu, Jyothisri Kondapalli, Enrico Zampese, D James Surmeier, David Sulzer, Eugene V Mosharo. α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin. eNeuro. vol 4. issue 6. 2018-07-25. PMID:29177188. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (sn). |
2018-07-25 |
2023-08-13 |
mouse |
| Karim Belarbi, Elodie Cuvelier, Alain Destée, Bernard Gressier, Marie-Christine Chartier-Harli. NADPH oxidases in Parkinson's disease: a systematic review. Molecular neurodegeneration. vol 12. issue 1. 2018-07-24. PMID:29132391. |
parkinson's disease (pd) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. |
2018-07-24 |
2023-08-13 |
Not clear |
| Wensheng Yan, Yunxiao Kang, Xiaoming Ji, Shuangcheng Li, Yingkun Li, Guoliang Zhang, Huixian Cui, Geming Sh. Testosterone Upregulates the Expression of Mitochondrial ND1 and ND4 and Alleviates the Oxidative Damage to the Nigrostriatal Dopaminergic System in Orchiectomized Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-07-19. PMID:29138672. |
the present studies showed that testosterone deficiency impaired the mitochondrial function in the substantia nigra and induced the oxidative damage to the substantia nigra as well as the deficits in the nigrostriatal dopaminergic system. |
2018-07-19 |
2023-08-13 |
rat |
| Franziska Richter, Sudhakar R Subramaniam, Iddo Magen, Patrick Lee, Jane Hayes, Aida Attar, Chunni Zhu, Nicholas R Franich, Nicholas Bove, Krystal De La Rosa, Jacky Kwong, Frank-Gerrit Klärner, Thomas Schrader, Marie-Françoise Chesselet, Gal Bita. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 14. issue 4. 2018-07-17. PMID:28585223. |
proteinase-k-resistant, insoluble α-synuclein deposits remained unchanged in the substantia nigra, whereas levels of diffuse cytoplasmic α-synuclein in dopaminergic neurons increased in mice receiving clr01 compared with vehicle. |
2018-07-17 |
2023-08-13 |
mouse |
| Caroline Cristiano Real, Priscila Crespo Garcia, Luiz R G Britt. Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28801819. |
parkinson's disease (pd) involves loss of dopaminergic neurons in the substantia nigra (sn), which can be correlated to neuroinflammatory changes with the aging of the nervous system. |
2018-06-27 |
2023-08-13 |
rat |
| Jiangkun Lu, Yan Xu, Zhenzhen Quan, Zixuan Chen, Zhenzhen Sun, Hong Qin. Dysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease. Neuroscience. vol 365. 2018-06-22. PMID:28964753. |
parkinson's disease is a debilitating neurodegenerative movement disorder, characterized by the progressive and selective loss of dopaminergic neurons located in the substantia nigra, leading to clinical motor symptoms. |
2018-06-22 |
2023-08-13 |
Not clear |
| Hannah Hamburg, Svenja V Trossbach, Verian Bader, Caroline Chwiesko, Anja Kipar, Magdalena Sauvage, William R Crum, Anthony C Vernon, Hans J Bidmon, Carsten Kort. Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific reports. vol 6. 2018-06-20. PMID:27721451. |
neuroanatomical analysis revealed a reduced density of dopaminergic neurons in the substantia nigra and reduced dopaminergic fibres in the striatum. |
2018-06-20 |
2023-08-13 |
human |