| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Jiang, Zhentang Cao, Huizi Ma, Guihong Wang, Xuemei Wang, Zhan Wang, Yaqin Yang, Huiqing Zhao, Genliang Liu, Longling Li, Tao Fen. Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson's Disease. Neurochemical research. vol 43. issue 11. 2018-12-19. PMID:30311182. |
the aim of this study was to evaluate the effects of auricular vagus nerve stimulation (avns) on substantia nigra (sn) dopaminergic neurodegeneration and the associated neuroinflammation and immune responses in a rat pd model. |
2018-12-19 |
2023-08-13 |
rat |
| Yan Zhou, Jialei Zhu, Yang Lv, Chenghuan Song, Jianhua Ding, Ming Xiao, Ming Lu, Gang H. Kir6.2 Deficiency Promotes Mesencephalic Neural Precursor Cell Differentiation via Regulating miR-133b/GDNF in a Parkinson's Disease Mouse Model. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29564810. |
the loss of dopaminergic (da) neurons in the substantia nigra (sn) is a major feature in the pathology of parkinson's disease (pd). |
2018-12-17 |
2023-08-13 |
mouse |
| Jeongah Kim, Sangwon Jang, Mijung Choi, Sooyoung Chung, Youngshik Choe, Han Kyoung Choe, Gi Hoon Son, Kunsoo Rhee, Kyungjin Ki. Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration. Molecules and cells. vol 41. issue 8. 2018-12-17. PMID:30078232. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (daergic) neurons, particularly in the substantia nigra (sn). |
2018-12-17 |
2023-08-13 |
mouse |
| Patricia Villacé, Rosa M Mella, Meritxell Roura-Ferrer, María Valcárcel, Clarisa Salado, Amaia Castilla, Danel Kortaza. Fluorescent Parkin Cell-Based Assay Development for the Screening of Drugs against Parkinson Disease. SLAS discovery : advancing life sciences R & D. vol 22. issue 1. 2018-12-11. PMID:27703082. |
parkinson disease (pd) is a prevalent neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra, causing tremor and motor impairment. |
2018-12-11 |
2023-08-13 |
Not clear |
| Shuei Sugama, Yoshihiko Kakinum. Letter to the Editor Re: "Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?" by Ong et al. Brain Behavior and Immunity, 2016. Brain, behavior, and immunity. vol 60. 2018-12-11. PMID:27915071. |
letter to the editor re: "reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? |
2018-12-11 |
2023-08-13 |
Not clear |
| Lin Kooi Ong, Michael Nilsson, Frederick R Walke. Authors' response re: "Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?" by Ong et al. Brain Behavior and Immunity, 2016. Brain, behavior, and immunity. vol 60. 2018-12-11. PMID:27915072. |
authors' response re: "reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? |
2018-12-11 |
2023-08-13 |
Not clear |
| Debashis Dutta, Nilufar Ali, Emili Banerjee, Raghavendra Singh, Amit Naskar, Ramesh Kumar Paidi, Kochupurackal P Mohanakuma. Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28062948. |
low levels of prohibitin in substantia nigra makes dopaminergic neurons vulnerable in parkinson's disease. |
2018-12-11 |
2023-08-13 |
mouse |
| Debashis Dutta, Nilufar Ali, Emili Banerjee, Raghavendra Singh, Amit Naskar, Ramesh Kumar Paidi, Kochupurackal P Mohanakuma. Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28062948. |
since substantia nigra (sn) and ventral tegmental area (vta) dopaminergic neurons are, respectively, susceptible or largely unaffected in parkinson's disease (pd), we searched for protein(s) that regulates this differential sensitivity. |
2018-12-11 |
2023-08-13 |
mouse |
| Edna Grünblatt, Josefine Ruder, Camelia Maria Monoranu, Peter Riederer, Moussa Bh Youdim, Silvia A Mande. Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29218503. |
we were able to confirm cell-specific reductions in the protein content of alhd1a1 and skp1a in the dopaminergic neurons of the substantia nigra of parkinsonian patients compared to alzheimer's and control subjects. |
2018-12-11 |
2023-08-13 |
human |
| Edna Grünblatt, Josefine Ruder, Camelia Maria Monoranu, Peter Riederer, Moussa Bh Youdim, Silvia A Mande. Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29218503. |
furthermore, we observed particular distribution for hsc70 and psmc4 in the cytoplasm and accumulation within lewy body in the dopaminergic neurons of the substantia nigra in parkinson patients. |
2018-12-11 |
2023-08-13 |
human |
| Li Zou, Yingchao Xue, Michael Jones, Thomas Heinbockel, Mingyao Ying, Xiping Zha. The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons. Neurotoxicity research. vol 34. issue 1. 2018-12-11. PMID:29285614. |
as dopaminergic neurons are implicated to play a role in all of these diseases, we tested the toxicity of quinine on induced dopaminergic (ida) neurons derived from human pluripotent stem cells (ipscs) and primary dopaminergic (da) neurons of substantia nigra from mice brain slices. |
2018-12-11 |
2023-08-13 |
mouse |
| Juliana C Lima, Luiz M Oliveira, Marina T Botelho, Thiago S Moreira, Ana C Takakur. The involvement of the pathway connecting the substantia nigra, the periaqueductal gray matter and the retrotrapezoid nucleus in breathing control in a rat model of Parkinson's disease. Experimental neurology. vol 302. 2018-12-11. PMID:29305892. |
parkinson's disease (pd) is characterized by a reduction in the number of dopaminergic neurons of the substantia nigra (snpc), accompanied by motor and non-motor deficiencies such as respiratory failure. |
2018-12-11 |
2023-08-13 |
rat |
| Jin Gyu Choi, Namkwon Kim, In Gyoung Ju, Hyeyoon Eo, Su-Min Lim, Se-Eun Jang, Dong-Hyun Kim, Myung Sook O. Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29352191. |
administration of p. mirabilis isolated from pd mice significantly induced motor deficits, selectively caused dopaminergic neuronal damage and inflammation in substantia nigra and striatum, and stimulated α-synuclein aggregation in the brain as well as in the colon. |
2018-12-11 |
2023-08-13 |
mouse |
| Liping Zhang, Lingyu Zhang, Lin Li, Christian Hölsche. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. vol 71. 2018-12-11. PMID:30017231. |
in addition, both glp-1 analogues rescued the decrease of tyrosine hydroxylase (th) levels, alleviated the inflammation response, reduced lipid peroxidation, inhibited the apoptosis pathway, and also increased autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. |
2018-12-11 |
2023-08-13 |
mouse |
| Jon W Werner-Allen, Jenna F DuMond, Rodney L Levine, Ad Ba. Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein. Angewandte Chemie (International ed. in English). vol 55. issue 26. 2018-11-27. PMID:27158766. |
parkinson's disease has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coincidental appearance of lewy bodies containing oligomerized forms of α-synuclein. |
2018-11-27 |
2023-08-13 |
Not clear |
| Fanpeng Zhao, Wenzhang Wang, Chunyu Wang, Sandra L Siedlak, Hisashi Fujioka, Beisha Tang, Xiongwei Zh. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-27. PMID:28215578. |
more importantly, pq-induced oxidative damage and stress signaling as well as selective loss of dopaminergic (da) neurons in the substantia nigra and axonal terminals in striatum was also inhibited in transgenic mice overexpressing hmfn2. |
2018-11-27 |
2023-08-13 |
mouse |
| Li Cheng, Lin Chen, Xinbing Wei, Yimeng Wang, Zhiping Ren, Shenglan Zeng, Xiumei Zhang, Haitao Wen, Chengjiang Gao, Huiqing Li. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-11-26. PMID:30157869. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with inflammation. |
2018-11-26 |
2023-08-13 |
Not clear |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30138818. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2018-11-16 |
2023-08-13 |
Not clear |
| Guifang Wang, Weibin Ma, Jingwei D. β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-11-13. PMID:29710667. |
parkinson's disease (pd) is one of the most common neurodegenerative diseases resulting from the continuous death of dopaminergic neurons in substantia nigra. |
2018-11-13 |
2023-08-13 |
Not clear |
| Meng-Ling Chen, Ruey-Meei W. LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review. Journal of biomedical science. vol 25. issue 1. 2018-11-08. PMID:29903014. |
pathologically, pd is characterized by selective loss of dopaminergic neurons in the substantia nigra and the formation of intracellular inclusions containing α-synuclein and ubiquitin called lewy bodies. |
2018-11-08 |
2023-08-13 |
Not clear |