| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Zhang, Chengwu Li, Ting Zhang, Yaping Ge, Xiaojuan Han, Sifan Sun, Jianhua Ding, Ming Lu, Gang H. Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Molecular and cellular neurosciences. vol 92. 2019-03-05. PMID:30171894. |
k-atp channels in mature substantia nigra (sn) dopaminergic (da) neurons are composed of inwardly rectifying potassium channel (kir) subunit 6.2 and sulfonylurea receptor 1 (sur1). |
2019-03-05 |
2023-08-13 |
mouse |
| O F Elabi, K Duskova, J S Davies, E L Lan. The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat. Neuroscience. vol 395. 2019-03-05. PMID:30414880. |
the presence of the ghrelin receptor (ghsr1a) on the dopaminergic neurons of the substantia nigra raises the possibility that a potential application for this property of ghrelin may be as an adjunctive neuroprotective agent to enhance and support the survival and integration of dopaminergic cells transplanted into the striatum. |
2019-03-05 |
2023-08-13 |
rat |
| Jae-Sun Choi, Woom-Yee Bae, Seungyoon Nam, Joo-Won Jeon. New Targets for Parkinson's Disease: Adhesion G Protein-Coupled Receptor B1 is Downregulated by AMP-Activated Protein Kinase Activation. Omics : a journal of integrative biology. vol 22. issue 7. 2019-03-04. PMID:30004846. |
we report in this study that adgrb1 is decreased in pd and that the adgrb1 level is specifically decreased in dopaminergic neurons in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-intoxicated mice. |
2019-03-04 |
2023-08-13 |
mouse |
| Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Saka. The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 2. 2019-02-28. PMID:29167402. |
protein kinase cγ (pkcγ) knock-out (ko) animals exhibit symptoms of parkinson's disease (pd), including dopaminergic neuronal loss in the substantia nigra. |
2019-02-28 |
2023-08-13 |
Not clear |
| Nagasundaram Nagarajan, Jaynthy Chellam, Rajaretinam Rajesh Kanna. Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29369408. |
parkinson's disease (pd) is a disorder of the central nervous system that is caused due to the death of the dopaminergic neurons in the region of the brain called substantia nigra. |
2019-02-27 |
2023-08-13 |
Not clear |
| Robert W Ledeen, Gusheng W. Gangliosides, α-Synuclein, and Parkinson's Disease. Progress in molecular biology and translational science. vol 156. 2019-02-27. PMID:29747823. |
we begin with a brief review of some of the milestone discoveries that helped to elucidate pd neuropathology, including the fibrous inclusions of lewy that characterize the degenerating dopaminergic neurons of the substantia nigra and the presence of αsyn as a major constituent of these lewy bodies and neurites. |
2019-02-27 |
2023-08-13 |
mouse |
| Yan Chen, Ningning Zhang, Dujuan Ji, Yiwei Hou, Chao Chen, Yong Fu, Ruli Ge, Qi Zheng, Jinbo Chen, Hongcai Wan. Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways. Neuroreport. vol 29. issue 14. 2019-02-27. PMID:30059366. |
in response to the rotenone, increased intracellular α-syn levels and autophagic flux monitored by lc3 ii turnover were induced in dopaminergic neurons (th-positive) of rat substantia nigra and ventral tegmental area. |
2019-02-27 |
2023-08-13 |
rat |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowack. Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28466266. |
prolonged dysfunction of astrocytes and activation of microglia accelerate degeneration of dopaminergic neurons in the rat substantia nigra and block compensation of early motor dysfunction induced by 6-ohda. |
2019-02-26 |
2023-08-13 |
rat |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowack. Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28466266. |
progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is the underlying cause of parkinson's disease (pd). |
2019-02-26 |
2023-08-13 |
rat |
| Esraa A Kandil, Rabab H Sayed, Lamiaa A Ahmed, Mai A Abd El Fattah, Bahia M El-Saye. Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-26. PMID:28585189. |
as well, de enhanced nurr1 expression in substantia nigra along with increasing transcriptional activation of nurr1-controlled genes namely tyrosine hydroxylase, vascular monoamine transporter, glial cell line-derived neurotrophic factor, and its receptor gene c-ret, which are critical for development and maintenance of dopaminergic neurons. |
2019-02-26 |
2023-08-13 |
rat |
| Justin N Weilnau, Michael A Carcella, Kristin M Miner, Tarun N Bhatia, Daniel F Hutchison, Deepti B Pant, Negin Nouraei, Rehana K Lea. Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease. Brain structure & function. vol 223. issue 3. 2019-02-26. PMID:29103154. |
similarly, loss of dopaminergic somata in the contralateral substantia nigra was also abolished, according to two blinded measurements. |
2019-02-26 |
2023-08-13 |
Not clear |
| Lijun Zhang, Ming Wang, Nicholas W Sterling, Eun-Young Lee, Paul J Eslinger, Daymond Wagner, Guangwei Du, Mechelle M Lewis, Young Truong, F DuBois Bowman, Xuemei Huan. Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM transactions on computational biology and bioinformatics. vol 15. issue 2. 2019-02-21. PMID:29610105. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), and pathologically by the loss of dopaminergic neurons in the substantia nigra of the basal ganglia. |
2019-02-21 |
2023-08-13 |
human |
| Eugene L Boshoff, Edward J R Fletcher, Susan Dut. Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner. Neuropharmacology. vol 137. 2019-02-20. PMID:29698669. |
we set out to examine whether manipulation of the fgf20 system affected nigrostriatal tract integrity in rats, to identify which fibroblast growth factor receptors (fgfrs) might reside on dopaminergic neurons and to discover the source of endogenous fgf20 in the substantia nigra (sn). |
2019-02-20 |
2023-08-13 |
human |
| Vincent Perlbarg, Justine Lambert, Benjamin Butler, Mehdi Felfli, Romain Valabrègue, Anne-Laure Privat, Stéphane Lehéricy, Alexandra Petie. Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI. PloS one. vol 13. issue 9. 2019-02-19. PMID:30188909. |
no correlations were found between the number of th-stained dopaminergic neurons and mri measurements in the substantia nigra. |
2019-02-19 |
2023-08-13 |
rat |
| Yuki Inoue, Hirokazu Hara, Yukari Mitsugi, Eiji Yamaguchi, Tetsuro Kamiya, Akichika Itoh, Tetsuo Adach. 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways. Neurochemistry international. vol 112. 2019-02-15. PMID:28823537. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. |
2019-02-15 |
2023-08-13 |
human |
| Emily L Gill, Jeremy P Koelmel, Richard A Yost, Michael S Okun, Vinata Vedam-Mai, Timothy J Garret. Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson's Disease: Current Progress and Future Perspectives. Analytical chemistry. vol 90. issue 5. 2019-02-11. PMID:29384654. |
parkinson's disease (pd) is a neurodegenerative disorder resulting from the loss of dopaminergic neurons of the substantia nigra as well as degeneration of motor and nonmotor basal ganglia circuitries. |
2019-02-11 |
2023-08-13 |
Not clear |
| Mychal S Grames, Robert D Dayton, Kasey L Jackson, Adam D Richard, Xiaohong Lu, Ronald L Klei. Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 8. 2019-02-11. PMID:29513569. |
a number of studies have used aav to express pathological disease-related proteins in the dopaminergic neurons of the substantia nigra in situ ( e.g., α-synuclein to model aspects of parkinson's disease). |
2019-02-11 |
2023-08-13 |
rat |
| C de Baat, M A E van Stiphout, F Lobbezoo, K D van Dijk, H W Berends. [Parkinson's disease: pathogenesis, aetiology, symptoms, diagnostics, and its course]. Nederlands tijdschrift voor tandheelkunde. vol 125. issue 10. 2019-02-11. PMID:30317371. |
pathologically, the disease is characterised by neural degeneration in specific brain regions, including the dopaminergic neurons of the pars compacta of the substantia nigra. |
2019-02-11 |
2023-08-13 |
Not clear |
| Emi Nagosh. International journal of molecular sciences. vol 19. issue 11. 2019-02-05. PMID:30373150. |
parkinson's disease (pd) is the most common cause of movement disorders and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2019-02-05 |
2023-08-13 |
Not clear |
| Maria A Costa-Besada, Rita Valenzuela, Pablo Garrido-Gil, Begoña Villar-Cheda, Juan A Parga, Jose L Lanciego, Jose L Labandeira-Garci. Paracrine and Intracrine Angiotensin 1-7/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29086247. |
in the present study, we observed mas receptor labeling in dopaminergic neurons and glial cells in rat mesencephalic primary cultures; substantia nigra of rats, monkeys, and humans; and human induced pluripotent stem (ips) cells derived from healthy controls and sporadic pd patients. |
2019-02-04 |
2023-08-13 |
rat |