| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Duraisamy Kempuraj, Ramasamy Thangavel, Gvindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Smita Zaheer, Sudhanshu P Raikwar, Haris Zahoor, Daniyal Saeed, Iuliia Dubova, Gema Giler, Shelby Herr, Shankar S Iyer, Asgar Zahee. Mast Cell Proteases Activate Astrocytes and Glia-Neurons and Release Interleukin-33 by Activating p38 and ERK1/2 MAPKs and NF-κB. Molecular neurobiology. vol 56. issue 3. 2019-07-17. PMID:29916143. |
parkinson's disease (pd) is characterized by inflammation-dependent dopaminergic neurodegeneration in substantia nigra. |
2019-07-17 |
2023-08-13 |
Not clear |
| Bingyu Li, Pengli Xu, Shuyan Wu, Zhixian Jiang, Zhijian Huang, Qian Li, Danhong Che. Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting the TLR/NF-κB Pathway. Journal of Alzheimer's disease : JAD. vol 64. issue 3. 2019-07-15. PMID:29966203. |
parkinson's disease (pd) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. |
2019-07-15 |
2023-08-13 |
Not clear |
| Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeid. miR-7 Replacement Therapy in Parkinson's Disease. Current gene therapy. vol 18. issue 3. 2019-07-12. PMID:29714132. |
depletion of mir-7 in the substantia nigra of clinical samples is related to α-syn accumulation, loss of dopaminergic cells, and reduction of dopamine in the striatum. |
2019-07-12 |
2023-08-13 |
Not clear |
| Xiu-Ming Ding, Lian-Jiang Zhao, Han-Yong Qiao, Shao-Lan Wu, Xi-Hui Wan. Long non-coding RNA-p21 regulates MPP Chemico-biological interactions. vol 307. 2019-06-26. PMID:31004593. |
long non-coding rna-p21 regulates mpp parkinson's disease (pd), the second most prevalent age-related neurodegenerative disease, occurs as a result of the loss of dopaminergic neurons in the substantia nigra. |
2019-06-26 |
2023-08-13 |
human |
| Matthias Höllerhage, Claudia Moebius, Johannes Melms, Wei-Hua Chiu, Joachim N Goebel, Tasnim Chakroun, Thomas Koeglsperger, Wolfgang H Oertel, Thomas W Rösler, Marc Bickle, Günter U Höglinge. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Scientific reports. vol 7. issue 1. 2019-06-21. PMID:28904388. |
pde1 inhibition also rescued dopaminergic neurons from wild-type α-synuclein induced degeneration in the substantia nigra of mice. |
2019-06-21 |
2023-08-13 |
mouse |
| Yasuhiko Izum. [Establishment of a novel evaluation system for dopaminergic axonal outgrowth and its regulatory factor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 5. 2019-06-11. PMID:30393256. |
although several axon guidance cues have been reported to induce dopaminergic axons from the substantia nigra to the striatum, the mechanisms by which the dopaminergic axons extend in the striatum remain unclear. |
2019-06-11 |
2023-08-13 |
rat |
| Cong Zhang, Liyan Hou, Jie Yang, Yuning Che, Fuqiang Sun, Huihua Li, Qingshan Wan. 2,5-Hexanedione induces dopaminergic neurodegeneration through integrin α Cell death & disease. vol 9. issue 2. 2019-06-10. PMID:29352205. |
2,5-hexanedione induces dopaminergic neurodegeneration through integrin α recent study demonstrated that chronic exposure to solvents increases the risk of parkinson's disease (pd), the second most common neurodegenerative disorder characterized by progressive dopaminergic neurodegeneration in the substantia nigra (sn). |
2019-06-10 |
2023-08-13 |
rat |
| Tingting Liu, Panpan Hu, Ruihua Cao, Xing Ye, Yanghua Tian, Xianwen Chen, Kai Wan. Dopaminergic Modulation of Biological Motion Perception in patients with Parkinson's disease. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28860519. |
parkinson's disease (pd) is a progressive neurodegenerative disorder pathologically characterized by a selective loss of dopaminergic neurons in the substantia nigra. |
2019-06-04 |
2023-08-13 |
Not clear |
| Ying Chen, Qianhang Shao, Yu-He Yuan, Nai-Hong Che. Prion-like propagation of α-synuclein in the gut-brain axis. Brain research bulletin. vol 140. 2019-05-30. PMID:29894766. |
the progression of pd includes the degenerative loss of dopaminergic (da) neurons and aggregation of α-synuclein in the substantia nigra (sn). |
2019-05-30 |
2023-08-13 |
Not clear |
| Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknech. An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Archives of toxicology. vol 92. issue 1. 2019-05-24. PMID:29209747. |
the kes linking complex i inhibition to parkinsonian motor deficits are mitochondrial dysfunction, impaired proteostasis, neuroinflammation, and the degeneration of dopaminergic neurons of the substantia nigra. |
2019-05-24 |
2023-08-13 |
Not clear |
| Krishnapriya Madhu Varier, Thangarajan Sumath. Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30569287. |
parkinson's disease (pd) remarks its pathology by affecting the patient's movements and postural instability by dopaminergic loss in the substantia nigra of midbrain. |
2019-05-23 |
2023-08-13 |
Not clear |
| Felipe Patricio, Irving Parra, Isabel Martínez, Francisca Pérez-Severiano, Sergio Montes, José Aguilera, Ilhuicamina Daniel Limón, Yousef Tizabi, Liliana Mendiet. Effectiveness of Fragment C Domain of Tetanus Toxin and Pramipexole in an Animal Model of Parkinson's Disease. Neurotoxicity research. vol 35. issue 3. 2019-05-15. PMID:30607904. |
at day 31, the animals were sacrificed and the levels of tyrosine hydroxylase (th), reflecting dopaminergic activity in both striatum and substantia nigra, were evaluated. |
2019-05-15 |
2023-08-13 |
rat |
| Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Kun Cheng, Yi-Da Xu, Zhi-Lan Zhou, Pei-Hao Zhang, Chen-Meng Qiao, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin She. Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress. International immunopharmacology. vol 66. 2019-05-14. PMID:30419450. |
immunofluorescence assays showed that ast reduced the loss of dopaminergic neurons and the activation of microglia and astrocytes in the substantia nigra. |
2019-05-14 |
2023-08-13 |
mouse |
| Wei-Zhong Zhao, Hsiang-Tsui Wang, Hui-Ju Huang, Yu-Li Lo, Anya Maan-Yuh Li. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28866823. |
in the present study, the neuroprotective effect of baicalein (a phenolic flavonoid in the dried root of scutellaria baicalensis georgi) on acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using local infusion of acrolein in the substantia nigra (sn) of rat brain. |
2019-05-08 |
2023-08-13 |
rat |
| Anne M Nixon, Mark D Meadowcroft, Elizabeth B Neely, Amanda M Snyder, Carson J Purnell, Justin Wright, Regina Lamendella, Wint Nandar, Xuemei Huang, James R Conno. HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity. Journal of neurochemistry. vol 145. issue 4. 2019-05-08. PMID:29315562. |
parkinson's disease is marked clinically by motor dysfunction and pathologically by dopaminergic cell loss in the substantia nigra and iron accumulation in the substantia nigra. |
2019-05-08 |
2023-08-13 |
mouse |
| Tetsuya Maeda, Kazuhiro Iwaoka, Yasuo Terayam. Conceptual definition in the metamorphosing Parkinson's disease. Nihon rinsho. Japanese journal of clinical medicine. vol 75. issue 1. 2019-05-08. PMID:30566288. |
the discovery of lewy bodies in the substantia nigra and dopamine deficiency in the nigro- striatal dopaminergic system have confirmed the disease concept of parkinson's disease. |
2019-05-08 |
2023-08-13 |
Not clear |
| Maryam Talepoor Ardakani, Mahsa Rostamian Delavar, Masoud Baghi, Mohammad Hossein Nasr-Esfahani, Abbas Kiani-Esfahani, Kamran Ghaed. Upregulation of miR-200a and miR-204 in MPP Molecular genetics & genomic medicine. vol 7. issue 3. 2019-05-08. PMID:30712312. |
upregulation of mir-200a and mir-204 in mpp parkinson's disease (pd) is ranked as the second most common neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. |
2019-05-08 |
2023-08-13 |
Not clear |
| Ekaterina Zhurakovskaya, Juuso Leikas, Tiina Pirttimäki, Francesc Casas Mon, Mikko Gynther, Rubin Aliev, Tomi Rantamäki, Heikki Tanila, Markus M Forsberg, Olli Gröhn, Jaakko Paasonen, Aaro J Jalkane. Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease. eNeuro. vol 6. issue 1. 2019-04-18. PMID:30838323. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to striatal dopamine depletion. |
2019-04-18 |
2023-08-13 |
rat |
| Chunyan Cheng, Xiaoying Zh. Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway. Life sciences. vol 223. 2019-04-17. PMID:30790609. |
pd is characterized by the loss of dopaminergic (da) neurons in the substantia nigra. |
2019-04-17 |
2023-08-13 |
rat |
| François-Xavier Blaudin de Thé, Hocine Rekaik, Eugenie Peze-Heidsieck, Olivia Massiani-Beaudoin, Rajiv L Joshi, Julia Fuchs, Alain Prochiant. Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. The EMBO journal. vol 37. issue 15. 2019-04-16. PMID:29941661. |
we report that line-1 are expressed in substantia nigra ventral midbrain dopaminergic neurons, a class of neurons that degenerate in parkinson's disease. |
2019-04-16 |
2023-08-13 |
Not clear |