| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Natalie Landeck, Aage Kristian Olsen Alstrup, Steen Jakobsen, Kim Vang, Doris J Doudet, David J Brooks, Deniz Kirik, Rainer Hinz, Jens Christian Sørensen, Anne M Landa. In vivo quantification of glial activation in minipigs overexpressing human α-synuclein. Synapse (New York, N.Y.). vol 72. issue 12. 2019-09-10. PMID:30009467. |
parkinson's disease is characterized by a progressive loss of substantia nigra (sn) dopaminergic neurons and the formation of lewy bodies containing accumulated alpha-synuclein (α-syn). |
2019-09-10 |
2023-08-13 |
human |
| Alex Yen-Yu Chen, Tim Tull. A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P. Neurobiology of disease. vol 114. 2019-09-06. PMID:29524599. |
parkinson's disease (pd) is a progressive motor neurodegenerative disorder, characterized by a selective loss of dopaminergic neurons in the substantia nigra. |
2019-09-06 |
2023-08-13 |
mouse |
| Linhao You, Jing Wang, Tianqing Liu, Yinlong Zhang, Xuexiang Han, Ting Wang, Shanshan Guo, Tianyu Dong, Junchao Xu, Gregory J Anderson, Qiang Liu, Yan-Zhong Chang, Xin Lou, Guangjun Ni. Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice. ACS nano. vol 12. issue 5. 2019-09-05. PMID:29617109. |
excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one of the major vulnerability factors in parkinson's disease (pd). |
2019-09-05 |
2023-08-13 |
mouse |
| D N Voronkov, R M Khudoerkov, O V Sal'nikova, A V Stavrovskaya, A S Ol'shanskii, A S Gushchin. Immunohistochemical Assessment of the Compensatory Responses in Rat Olfactory Bulbs after 6-Hydroxydopamine-Induced Lesion of the Substantia Nigra. Bulletin of experimental biology and medicine. vol 166. issue 6. 2019-09-03. PMID:31020581. |
destruction of the substantia nigra shifted differentiation of neuronal progenitors towards the dopaminergic phenotype and increased their survival in the olfactory bulbs, which can be explained by increased expression of psa-ncam. |
2019-09-03 |
2023-08-13 |
rat |
| Qian Wang, Jianfang Liu, Yikun Guo, Guanzhong Dong, Wenying Zou, Zhuoyou Che. Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 8. 2019-09-03. PMID:31365694. |
brain-derived neurotrophic factor (bdnf) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. |
2019-09-03 |
2023-08-13 |
Not clear |
| Matteo Dal Ben, Rosario Bongiovanni, Simone Tuniz, Emanuela Fioriti, Claudio Tiribelli, Rita Moretti, Silvia Gazzi. Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra. International journal of molecular sciences. vol 20. issue 9. 2019-08-20. PMID:31064126. |
earliest mechanisms of dopaminergic neurons sufferance in a novel slow progressing ex vivo model of parkinson disease in rat organotypic cultures of substantia nigra. |
2019-08-20 |
2023-08-13 |
human |
| M M Rudenok, A Kh Alieva, M A Nikolaev, A A Kolacheva, M V Ugryumov, S N Pchelina, P A Slominsky, M I Shadrin. [Possible Involvement of Genes Related to Lysosomal Storage Disorders in the Pathogenesis of Parkinson's Disease]. Molekuliarnaia biologiia. vol 53. issue 1. 2019-08-15. PMID:30895950. |
parkinson's disease (pd) characterized with slow continuous degeneration of dopaminergic neurons in the substantia nigra is one of the most common neurodegenerative diseases, but its etiology and pathogenesis are not fully understood. |
2019-08-15 |
2023-08-13 |
mouse |
| Dennis Paliga, Fabian Raudzus, Stephen H Leppla, Rolf Heumann, Sebastian Neuman. Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30121937. |
the orphan transcription factor nuclear receptor-related 1 protein (nurr1, also known as nr4a2) plays a key role in embryonic development and maintenance of mesencephalic dopaminergic neurons in the substantia nigra. |
2019-08-13 |
2023-08-13 |
mouse |
| Rose B Creed, Matthew S Goldber. New Developments in Genetic rat models of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 5. 2019-08-12. PMID:29418019. |
initially, pd animal models were generated primarily by chemical neurotoxins that induce acute loss of dopaminergic neurons in the substantia nigra. |
2019-08-12 |
2023-08-13 |
mouse |
| Rose B Creed, Matthew S Goldber. New Developments in Genetic rat models of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 5. 2019-08-12. PMID:29418019. |
nevertheless, compared with mice with the same mutations, many genetic rat animal models of pd better reproduce key aspects of pd including progressive loss of dopaminergic neurons in the substantia nigra, locomotor behavior deficits, and age-dependent formation of abnormal α-synuclein protein aggregates. |
2019-08-12 |
2023-08-13 |
mouse |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. |
the effect of propofol and isoflurane on the dopaminergic neurotransmitter phenotype in the substantia nigra (sn) was studied using tyrosine hydroxylase immunohistochemistry. |
2019-08-12 |
2023-08-13 |
Not clear |
| Mani Sugumar, Murugan Sevanan, Sathiya Seka. Neuroprotective effect of naringenin against MPTP-induced oxidative stress. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433834. |
parkinson's disease is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to excitotoxicity, oxidative stress and many other factors may contribute to mptp- and pd-related neurodegeneration. |
2019-08-12 |
2023-08-13 |
mouse |
| Takaya Ogasawara, Masafumi Nejime, Masahiko Takada, Masayuki Matsumot. Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition. Neuron. vol 100. issue 6. 2019-08-08. PMID:30415993. |
subsets of dopamine neurons in the substantia nigra and striatal neurons receiving the dopaminergic input were activated when the monkey was required to cancel a planned saccadic eye movement. |
2019-08-08 |
2023-08-13 |
monkey |
| Yoshikuni Tabata, Hideyuki Okan. [Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 8. 2019-08-07. PMID:31346144. |
parkinson's disease (pd), a common neurodegenerative disorder, is characterized by selective degeneration of dopaminergic neurons in the substantia nigra. |
2019-08-07 |
2023-08-13 |
human |
| Eldris Iglesias, Alba Pesini, Nuria Garrido-Pérez, Patricia Meade, M Pilar Bayona-Bafaluy, Julio Montoya, Eduardo Ruiz-Pesin. Prenatal exposure to oxidative phosphorylation xenobiotics and late-onset Parkinson disease. Ageing research reviews. vol 45. 2019-08-05. PMID:29689408. |
up to 80% of dopaminergic neurons of the substantia nigra are lost before motor features of the disorder begin to appear. |
2019-08-05 |
2023-08-13 |
Not clear |
| Sumit Sarkar, Edward Lu, James Raymick, Joseph Hanig, Qiang G. ERK/MAP Kinase Activation is Evident in Activated Microglia of the Striatum and Substantia Nigra in an Acute and Chronically-Induced Mouse Model of Parkinson's Disease. Current neurovascular research. vol 15. issue 4. 2019-07-30. PMID:30468126. |
parkinson's disease (pd) is a debilitating, age-related disorder characterized by selective degeneration of dopaminergic neurons in the midbrain substantia nigra (snc). |
2019-07-30 |
2023-08-13 |
mouse |
| Patricia Sheehan, Zhenyu Yu. Deregulation of autophagy and vesicle trafficking in Parkinson's disease. Neuroscience letters. vol 697. 2019-07-24. PMID:29627340. |
parkinson's disease (pd) is a common neurodegenerative disease characterized pathologically by the selective loss of dopaminergic neurons in the substantia nigra and the intracellular accumulation of α-synuclein in the lewy bodies. |
2019-07-24 |
2023-08-13 |
Not clear |
| Mixia Wang, Yilin Song, Song Zhang, Shengwei Xu, Guihua Xiao, Ziyue Li, Fei Gao, Yu Zhang, Feng Yue, Piu Chan, Xinxia Ca. Abnormal Spontaneous Neuronal Discharge and Local Field Potential both in Cortex and Striatum of a Non- human Primate of Parkinson's Disease using Implantable Microelectrode Arrays. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2018. 2019-07-19. PMID:30440282. |
parkinson's disease (pd) is a neurodegenerative disease with the loss of dopaminergic neurons in substantia nigra. |
2019-07-19 |
2023-08-13 |
human |
| Sara Castro-Sánchez, Ángel J García-Yagüe, Tresa López-Royo, Maria Casarejos, José Luis Lanciego, Isabel Lastres-Becke. Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease. Glia. vol 66. issue 8. 2019-07-18. PMID:29624735. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by the degeneration of dopaminergic neurons of the substantia nigra and the accumulation of protein aggregates, called lewy bodies, where the most abundant is alpha-synuclein (α-syn). |
2019-07-18 |
2023-08-13 |
mouse |
| Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook O. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30031172. |
parkinson's disease (pd) is a progressive neurodegenerative disorder accompanied by movement deficits with selective degeneration of dopaminergic neurons in the substantia nigra (sn). |
2019-07-18 |
2023-08-13 |
mouse |