| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Duraisamy Kempuraj, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Smita Zaheer, Keerthana Kuppamma Kumar, Anudeep Yelam, Harleen Kaur, Iuliia Dubova, Sudhanshu P Raikwar, Shankar S Iyer, Asgar Zahee. Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation. Journal of Alzheimer's disease : JAD. vol 66. issue 3. 2019-11-14. PMID:30372685. |
parkinson's disease (pd) is characterized by the presence of inflammation-mediated dopaminergic neurodegeneration in the substantia nigra. |
2019-11-14 |
2023-08-13 |
mouse |
| Kazumasa Wakamatsu, Kenta Nakao, Hitomi Tanaka, Yuki Kitahori, Yui Tanaka, Makoto Ojika, Shosuke It. The Oxidative Pathway to Dopamine-Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson's Disease. International journal of molecular sciences. vol 20. issue 10. 2019-11-14. PMID:31130632. |
neuromelanin (nm) is a dark brown pigment found in dopaminergic neurons of the substantia nigra (sn) and in norepinephrinergic neurons of the locus coeruleus (lc). |
2019-11-14 |
2023-08-13 |
Not clear |
| Laura A Struzyna, Kevin D Browne, Zachary D Brodnik, Justin C Burrell, James P Harris, H Isaac Chen, John A Wolf, Kate V Panzer, James Lim, John E Duda, Rodrigo A España, D Kacy Culle. Tissue engineered nigrostriatal pathway for treatment of Parkinson's disease. Journal of tissue engineering and regenerative medicine. vol 12. issue 7. 2019-11-13. PMID:29766664. |
this strategy may improve parkinson's disease treatment by simultaneously replacing lost dopaminergic neurons in the substantia nigra and reconstructing their long-projecting axonal tracts to the striatum. |
2019-11-13 |
2023-08-13 |
human |
| Courtney K Walker, Joy K Roche, Vidushi Sinha, Rosalinda C Robert. Substantia nigra ultrastructural pathology in schizophrenia. Schizophrenia research. vol 197. 2019-11-08. PMID:29274737. |
dopamine is thought to play a role in schizophrenia pathology, yet the substantia nigra (sn), the origin of dopaminergic pathways, has not been studied extensively in schizophrenia. |
2019-11-08 |
2023-08-13 |
human |
| Ling Wang, Juan Hong, Yajuan Wu, George Liu, Wenfeng Yu, Ling Che. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29670081. |
the levels of αsyn oligomers and oligomer phosphorylation (s129), but not αsyn monomers, were elevated in dopaminergic neurons and substantia nigra of seipin-nko mice. |
2019-11-07 |
2023-08-13 |
mouse |
| Yong-Ting Liu, Ming-Hao Sun, Chun-Wei Cai, Chao Ren, Hai-Chen Ni. [Research progress on neural mechanism of peripheral inflammation in Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 5. 2019-11-05. PMID:31646327. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (da) neurons in the dense part of the substantia nigra (snpc). |
2019-11-05 |
2023-08-13 |
Not clear |
| Ian F Harrison, Nicholas M Powell, David T Dexte. The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30269333. |
we therefore hypothesize that nicotinamide, being a selective inhibitor of hdac class iii as well as having modulatory effects on mitochondrial energy metabolism, would be neuroprotective in the lactacystin rat model of pd, which recapitulates the formation of neurotoxic accumulation of altered proteins within the substantia nigra to cause progressive dopaminergic cell death. |
2019-10-28 |
2023-08-13 |
rat |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30295916. |
prolonged impairment of astrocytic functions could increase the vulnerability of dopaminergic neurons in the substantia nigra (sn), accelerate their degeneration and affect ability to compensate for partial degeneration at the presymptomatic stages of the disease. |
2019-10-28 |
2023-08-13 |
Not clear |
| Xiang-Xing Zhu, Yi-Zhi Zhong, Yao-Wen Ge, Ke-Huan Lu, Sheng-Sheng L. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127453. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder characterized by classical motor dysfunction and is associated with α-synuclein-immunopositive pathology and the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-24 |
2023-08-13 |
Not clear |
| Menglan Zhao, Jialong Chen, Kanmin Mao, Hua She, Yixian Ren, Chen Gui, Xian Wu, Fei Zou, Wenjun L. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-22. PMID:30594390. |
mitochondrial calcium dysfunction contributes to autophagic cell death induced by mpp parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. |
2019-10-22 |
2023-08-13 |
Not clear |
| Sujung Yeo, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model. The American journal of Chinese medicine. vol 47. issue 3. 2019-10-17. PMID:30966771. |
parkinson's disease (pd), a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-17 |
2023-08-13 |
mouse |
| Richard Gordon, Eduardo A Albornoz, Daniel C Christie, Monica R Langley, Vinod Kumar, Susanna Mantovani, Avril A B Robertson, Mark S Butler, Dominic B Rowe, Luke A O'Neill, Anumantha G Kanthasamy, Kate Schroder, Matthew A Cooper, Trent M Woodruf. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science translational medicine. vol 10. issue 465. 2019-10-11. PMID:30381407. |
parkinson's disease (pd) is characterized by a profound loss of dopaminergic neurons in the substantia nigra, accompanied by chronic neuroinflammation, mitochondrial dysfunction, and widespread accumulation of α-synuclein-rich protein aggregates in the form of lewy bodies. |
2019-10-11 |
2023-08-13 |
mouse |
| Sarah E M Stephenson, Timothy D Aumann, Juliet M Taylor, Jessica R Riseley, Ruili Li, Jeffrey R Mann, Doris Tomas, Paul J Lockhar. Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29760428. |
subsequent neuropathological examination suggested there was no gross abnormality of the dopaminergic system in the substantia nigra and no significant difference in the number of dopaminergic neurons in either knockout model compared to wildtype mice. |
2019-10-09 |
2023-08-13 |
mouse |
| Jia Liu, Weijin Liu, Yongquan Lu, Hao Tian, Chunli Duan, Lingling Lu, Ge Gao, Xia Wu, Xiaomin Wang, Hui Yan. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy. vol 14. issue 5. 2019-10-03. PMID:29433359. |
we found that plg administration (2 and 4 mg/kg) for 4 wk attenuated motor deficits in mice and prevented the loss of dopaminergic neurons in the substantia nigra induced by oral administration of rotenone (10 mg/kg) for 6 wk. |
2019-10-03 |
2023-08-13 |
mouse |
| Yuan-Yuan Liu, Yi-Nan Zhang, Qing-Shan Yan. Downregulated expression of microRNA-329 inhibits apoptosis of nigral dopaminergic neurons by regulating CDKN2D expression via the FoxO3a signaling pathway in rats with Parkinson's disease. Journal of cellular physiology. vol 233. issue 11. 2019-09-26. PMID:29761857. |
parkinson's disease (pd) is a common neurodegenerative disorder due to the loss of dopaminergic neurons in the substantia nigra. |
2019-09-26 |
2023-08-13 |
rat |
| Bingxu Huang, Juxiong Liu, Tianyu Meng, Yuhang Li, Dewei He, Xin Ran, Guangxin Chen, Wenjin Guo, Xingchi Kan, Shoupeng Fu, Wei Wang, Dianfeng Li. Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis. Frontiers in immunology. vol 9. 2019-09-26. PMID:30455692. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (sn). |
2019-09-26 |
2023-08-13 |
rat |
| S L Sison, S C Vermilyea, M E Emborg, A D Eber. Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes. Current neurology and neuroscience reports. vol 18. issue 12. 2019-09-24. PMID:30284665. |
the specific cause underlying dopaminergic (da) neuron loss in the substantia nigra, a pathological hallmark of pd, remains elusive. |
2019-09-24 |
2023-08-13 |
Not clear |
| Yoshikuni Tabata, Yoichi Imaizumi, Michiko Sugawara, Tomoko Andoh-Noda, Satoe Banno, MuhChyi Chai, Takefumi Sone, Kazuto Yamazaki, Masashi Ito, Kappei Tsukahara, Hideyuki Saya, Nobutaka Hattori, Jun Kohyama, Hideyuki Okan. T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease. Stem cell reports. vol 11. issue 5. 2019-09-20. PMID:30344006. |
parkinson disease (pd) is a progressive neurological disease caused by selective degeneration of dopaminergic (da) neurons in the substantia nigra. |
2019-09-20 |
2023-08-13 |
Not clear |
| Jing Su, Haoyue Wang, Yufang Yang, Jinghui Wang, Heng Li, Dongping Huang, Li Huang, Xiaochen Bai, Mei Yu, Jian Fei, Fang Huan. RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease. Neurochemistry international. vol 118. 2019-09-16. PMID:29964075. |
the loss of dopaminergic neurons was markedly alleviated, and the activation of glial cells was inhibited in the substantia nigra of ko mice challenged with mptp. |
2019-09-16 |
2023-08-13 |
mouse |
| Clara Ortega-de San Luis, Manuel A Sanchez-Garcia, Jose Luis Nieto-Gonzalez, Pablo García-Junco-Clemente, Adoracion Montero-Sanchez, Rafael Fernandez-Chacon, Alberto Pascua. Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits. Aging cell. vol 17. issue 5. 2019-09-12. PMID:30058223. |
the glial cell line-derived neurotrophic factor (gdnf), synthesized by striatal interneurons, and sonic hedgehog (shh), produced by the dopaminergic neurons of the substantia nigra (da snpc), are both involved in the nigrostriatal maintenance but the reciprocal neurotrophic relationships among these neurons are only partially understood. |
2019-09-12 |
2023-08-13 |
mouse |