| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doo Chul Choi, Myungsik Yoo, Savan Kabaria, Eunsung Jun. MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy. Neuroscience letters. vol 678. 2019-04-15. PMID:29738845. |
alpha-synuclein (α-syn) is an important protein in the pathogenesis of parkinson disease (pd) as it accumulates as fibrillar inclusions in affected brain regions including dopaminergic neurons in the substantia nigra. |
2019-04-15 |
2023-08-13 |
Not clear |
| Eugene Bok, Young Cheul Chung, Ki-Suk Kim, Hyung Hwan Baik, Won-Ho Shin, Byung Kwan Ji. Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo. Experimental & molecular medicine. vol 50. issue 7. 2019-04-11. PMID:29968707. |
modulation of m1/m2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo. |
2019-04-11 |
2023-08-13 |
rat |
| Gincy George, Snijesh Valiya Parambath, Sowmya Bekshe Lokappa, Jobin Varke. Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene. vol 697. 2019-04-11. PMID:30776463. |
parkinson's disease (pd) is a complex neurodegenerative movement disorder that primarily results due to the loss of dopaminergic neurons in the substantia nigra region. |
2019-04-11 |
2023-08-13 |
Not clear |
| Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vil. Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis. Nature communications. vol 10. issue 1. 2019-04-09. PMID:30846695. |
here we report that overexpression of human tyrosinase in rat substantia nigra results in age-dependent production of human-like neuromelanin within nigral dopaminergic neurons, up to levels reached in elderly humans. |
2019-04-09 |
2023-08-13 |
human |
| D E Korzhevskii, I P Grigor'ev, E G Sukhorukova, V V Gusel'nikov. [Immunohistochemical characteristics of the substantia nigra neurons of the human]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 4. 2019-04-08. PMID:28617379. |
to determine the cytochemical characteristics of unchanged neurons of the human substantia nigra using a wide range of immunocytochemical markers some of which (glutamate decarboxylase-65, pgp 9.5, non-phosphorylated neurofilament proteins, alpa-tubulin) have never been used for study of human dopaminergic neurons. |
2019-04-08 |
2023-08-13 |
human |
| Elisabeth G Hain, Maria Sparenberg, Justyna Rasińska, Charlotte Klein, Levent Akyüz, Barbara Steine. Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29803225. |
parkinson's disease (pd) is characterized by dopaminergic cell loss and inflammation in the substantia nigra (sn) leading to motor deficits but also to hippocampus-associated non-motor symptoms such as spatial learning and memory deficits. |
2019-04-08 |
2023-08-13 |
mouse |
| Chuxin Huang, Lixia Qin, Hainan Zhan. [Structure and function of DJ-1 and its role in Parkinson's disease]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 1. 2019-04-04. PMID:30837411. |
parkinson's disease (pd) is a neurodegenerative movement disorder mainly due to degeneration of dopaminergic neurons in the substantia nigra. |
2019-04-04 |
2023-08-13 |
mouse |
| Li-Fan Zhang, Xiao-Lin Yu, Mei Ji, Shu-Ying Liu, Xiao-Ling Wu, Yu-Jiong Wang, Rui-Tian Li. Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease. Food & function. vol 9. issue 12. 2019-04-03. PMID:30462117. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by lewy pathology and progressive loss of dopaminergic neurons in the substantia nigra. |
2019-04-03 |
2023-08-13 |
mouse |
| Amirah E-E Aly, Brendan T Harmon, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Barbara L Waszcza. Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson's Disease. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29779176. |
three to four weeks after the lesion, amphetamine-induced rotational behavior was reduced, and dopaminergic fiber density and cell counts in the lesioned substantia nigra and nerve terminal density in the lesioned striatum were significantly preserved in rats given intranasal pgdnf. |
2019-04-01 |
2023-08-13 |
human |
| Rizwana Qadri, Manju Namdeo, Madhuri Behari, Vinay Goyal, Subhadra Sharma, Asok Kumar Mukhopadhya. Alterations in mitochondrial membrane potential in peripheral blood mononuclear cells in Parkinson's Disease: Potential for a novel biomarker. Restorative neurology and neuroscience. vol 36. issue 6. 2019-04-01. PMID:30282380. |
progressive apoptosis in the dopaminergic neurons of substantia nigra lead to parkinson's disease. |
2019-04-01 |
2023-08-13 |
Not clear |
| Fangfang Dou, Xinkun Chu, Bei Zhang, Liang Liang, Guoqiang Lu, Jianqing Ding, Shengdi Che. EriB targeted inhibition of microglia activity attenuates MPP Molecular brain. vol 11. issue 1. 2019-04-01. PMID:30563578. |
with the progressive and selective degeneration of dopaminergic (da) neurons, proinflammatory cytokines are elevated in the substantia nigra (sn) of pd patients. |
2019-04-01 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Denche. Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26844379. |
in parkinson's disease (pd) motor symptoms are not observed until loss of 70% of dopaminergic neurons in substantia nigra (sn), preventing early diagnosis. |
2019-03-28 |
2023-08-13 |
rat |
| Edward Pajarillo, James Johnson, Judong Kim, Pratap Karki, Deok-Soo Son, Michael Aschner, Eunsook Le. 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. vol 65. 2019-03-27. PMID:29183790. |
the results showed that both e2 and tx attenuated mn-induced motor deficits and reversed the mn-induced loss of dopaminergic neurons in the substantia nigra. |
2019-03-27 |
2023-08-13 |
mouse |
| Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heuman. Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons. International journal of molecular sciences. vol 19. issue 12. 2019-03-26. PMID:30558189. |
in parkinson's disease, dopaminergic neuronal cell bodies degenerate in the substantia nigra. |
2019-03-26 |
2023-08-13 |
human |
| Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heuman. Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons. International journal of molecular sciences. vol 19. issue 12. 2019-03-26. PMID:30558189. |
grafting dopaminergic precursor neurons directly into the degenerating substantia nigra is discussed as a novel concept aiming to guide axonal growth by activating gtpase signaling through protein-functionalized intracellular magnetic nanoparticles responding to external magnets. |
2019-03-26 |
2023-08-13 |
human |
| Ayesha Aziz, Muhammad Asif, Muhammad Azeem, Ghazala Ashraf, Zhengyun Wang, Fei Xiao, Hongfang Li. Self-stacking of exfoliated charged nanosheets of LDHs and graphene as biosensor with real-time tracking of dopamine from live cells. Analytica chimica acta. vol 1047. 2019-03-26. PMID:30567650. |
unfortunately majority of dopaminergic neurons present in substantia nigra of pd patients are destroyed before it is being clinically diagnosed, so early stages pd diagnosis is essential. |
2019-03-26 |
2023-08-13 |
human |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
parkinson's disease (pd) is a neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction. |
2019-03-18 |
2023-08-13 |
mouse |
| Juciano Gasparotto, Camila Tiefensee Ribeiro, Rafael Calixto Bortolin, Nauana Somensi, Thallita Kelly Rabelo, Alice Kunzler, Natália Cabral Souza, Matheus Augusto de Bittencourt Pasquali, José Claudio Fonseca Moreira, Daniel Pens Gelai. Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28821831. |
targeted inhibition of rage in substantia nigra of rats blocks 6-ohda-induced dopaminergic denervation. |
2019-03-15 |
2023-08-13 |
rat |
| Chiara Monti, Ilaria Colugnat, Leonardo Lopiano, Adriano Chiò, Tiziana Alberi. Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2019-03-12. PMID:28004338. |
progressive loss of dopaminergic neurons in the substantia nigra causes an impairment of the motor control. |
2019-03-12 |
2023-08-13 |
Not clear |
| Ramandeep Kaur, Sidharth Mehan, Shamsher Sing. Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 1. 2019-03-11. PMID:30267336. |
the loss of substantia nigra, pars compacta (snpc) neurons and deficiency of striatal dopaminergic neurons produces stables motor deficient. |
2019-03-11 |
2023-08-13 |
Not clear |