| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Hanna Kim, Carles Calatayud, Sanjib Guha, Irene Fernández-Carasa, Laura Berkowitz, Iria Carballo-Carbajal, Mario Ezquerra, Rubén Fernández-Santiago, Pankaj Kapahi, Ángel Raya, Antonio Miranda-Vizuete, Jose Miguel Lizcano, Miquel Vila, Kim A Caldwell, Guy A Caldwell, Antonella Consiglio, Esther Dalf. The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29429047. |
parkinson's disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the substantia nigra of brain patients. |
2019-02-04 |
2023-08-13 |
human |
| Ivan Carrera, Lucia Fernandez-Novoa, Carolina Sampedro, Vadim V Tarasov, Gjumrakch Aliev, Ramon Cacabelo. Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease. Current medicinal chemistry. vol 25. issue 39. 2019-02-01. PMID:29637853. |
atremorine, a novel plant-derived nutraceutical, probably with a neuroprotective effect in the dopaminergic neurons of the substantia nigra (pars compacta), is a prototype of this new category of bioproducts with potential effects in pd. |
2019-02-01 |
2023-08-13 |
Not clear |
| Rainer Knörl. Neuromelanin in Parkinson's Disease: from Fenton Reaction to Calcium Signaling. Neurotoxicity research. vol 33. issue 2. 2019-01-31. PMID:28879408. |
a common theory is the formation of reactive oxygen species through the fenton reaction catalyzed by neuromelanin-bound iron ions and subsequent death of the dopaminergic cells in the substantia nigra. |
2019-01-31 |
2023-08-13 |
Not clear |
| Jimena Hebe Martinez, Agustina Alaimo, Roxana Mayra Gorojod, Soledad Porte Alcon, Federico Fuentes, Federico Coluccio Leskow, Mónica Lidia Kotle. Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein. Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29414102. |
parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. |
2019-01-31 |
2023-08-13 |
Not clear |
| Ji Won Han, Yebin D Ahn, Won-Seok Kim, Cheol Min Shin, Seong Jin Jeong, Yoo Sung Song, Yun Jung Bae, Jong-Min Ki. Psychiatric Manifestation in Patients with Parkinson's Disease. Journal of Korean medical science. vol 33. issue 47. 2019-01-30. PMID:30450025. |
although its major manifestation is motor symptoms, resulting from the loss of dopaminergic neurons in the substantia nigra, psychiatric symptoms, such as depression, anxiety, hallucination, delusion, apathy and anhedonia, impulsive and compulsive behaviors, and cognitive dysfunction, may also manifest in most patients with pd. |
2019-01-30 |
2023-08-13 |
Not clear |
| Sonia Abad, Carla Ramon, David Pubill, Jorge Camarasa, Antonio Camins, Elena Escubed. Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice. Biochimica et biophysica acta. vol 1862. issue 9. 2019-01-28. PMID:27344237. |
adolescent exposure to mdma induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of appswe/ps1de9 mice. |
2019-01-28 |
2023-08-13 |
mouse |
| Sonia Abad, Carla Ramon, David Pubill, Jorge Camarasa, Antonio Camins, Elena Escubed. Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice. Biochimica et biophysica acta. vol 1862. issue 9. 2019-01-28. PMID:27344237. |
our mdma schedule produced a genotype-independent decrease in dopaminergic neurons in the substantia nigra that remained at least 3months. |
2019-01-28 |
2023-08-13 |
mouse |
| Irina V Ekimova, Daria V Plaksina, Yuri F Pastukhov, Ksenia V Lapshina, Vladimir F Lazarev, Elena R Mikhaylova, Sergey G Polonik, Bibhusita Pani, Boris A Margulis, Irina V Guzhova, Evgeny Nudle. New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease. Experimental neurology. vol 306. 2019-01-28. PMID:29704482. |
we show that the knock-down of hsp70 (hspa1a) in dopaminergic neurons of the substantia nigra causes an almost 2-fold increase in neuronal death and multiple motor disturbances in animals. |
2019-01-28 |
2023-08-13 |
rat |
| Hucheng Chen, Jiyu Xu, Yuan Lv, Ping He, Chunyan Liu, Jie Jiao, Shiwei Li, Xuhua Mao, Xue Xu. Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30272275. |
the pathological alterations of parkinson's disease (pd) predominantly manifest as a loss of dopaminergic neurons in the substantia nigra, which may be caused by oxidative stress damage. |
2019-01-28 |
2023-08-13 |
mouse |
| Luisa Aring, Simone Steinbach, Katrin Marcus, Caroline Ma. Isolation of Distinct Types of Neurons from Fresh Brain Tissue Using Laser Microdissection in Combination with High-Performance Liquid Chromatography-Mass Spectrometry. Methods in molecular biology (Clifton, N.J.). vol 1723. 2019-01-16. PMID:29344865. |
for example, parkinson's disease is characterized by a slowly progressive degeneration of dopaminergic neurons in the substantia nigra whereas the entorhinal cortex is first affected in alzheimer's disease. |
2019-01-16 |
2023-08-13 |
human |
| Won Sik Eum, Min Jea Shin, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Duk-Soo Kim, Oh Shin Kwon, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Dae Won Kim, Soo Young Cho. Neuroprotective effects of Tat-ATOX1 protein against MPP Biochimie. vol 156. 2019-01-09. PMID:30352250. |
neuroprotective effects of tat-atox1 protein against mpp parkinson's disease (pd), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (sn) of the brain and it is well known that the pathogenesis of pd is related to a number of risk factors including oxidative stress. |
2019-01-09 |
2023-08-13 |
Not clear |
| Anastasiia Bohush, Grazyna Niewiadomska, Anna Filipe. Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease. International journal of molecular sciences. vol 19. issue 10. 2019-01-07. PMID:30274251. |
a shortage of dopamine, which is predominantly produced by the dopaminergic neurons within the substantia nigra, causes clinical symptoms such as reduction of muscle mass, impaired body balance, akinesia, bradykinesia, tremors, postural instability, etc. |
2019-01-07 |
2023-08-13 |
Not clear |
| Dong-Xia Wang, Jun-Xia Xie, Ning Son. [GBA mutations and Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 3. 2019-01-04. PMID:29926071. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra and the intraneuronal lewy bodies in this area. |
2019-01-04 |
2023-08-13 |
Not clear |
| S R Burstein, F Valsecchi, H Kawamata, M Bourens, R Zeng, A Zuberi, T A Milner, S M Cloonan, C Lutz, A Barrientos, G Manfred. In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29112723. |
in mice, chchd10 is expressed in many tissues, most abundantly in heart, skeletal muscle, liver, and in specific cns regions, notably the dopaminergic neurons of the substantia nigra and spinal cord neurons, which is consistent with the pathology associated with chchd10 mutations. |
2019-01-02 |
2023-08-13 |
mouse |
| Saba Khanam, Falaq Naz, Fahad Ali, Rahul Smita Jyoti, Ambreen Fatima, Wasi Khan, Braj Raj Singh, A H Naqvi, Yasir Hasan Siddiqu. Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease. Toxicology mechanisms and methods. vol 28. issue 9. 2018-12-26. PMID:30019977. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2018-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Pawanrat Chalorak, Prapaporn Jattujan, Saksit Nobsathian, Tanate Poomtong, Prasert Sobhon, Krai Meemo. Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing. Nutritional neuroscience. vol 21. issue 6. 2018-12-24. PMID:28276260. |
parkinson's disease (pd) is associated with aggregation of α-synuclein and selective death of dopaminergic (da) neurons in the substantia nigra, thereby leading to cognitive and motor impairments. |
2018-12-24 |
2023-08-13 |
caenorhabditis_elegans |
| Thea P Lillethorup, Andreas N Glud, Aage K O Alstrup, Trine W Mikkelsen, Erik H Nielsen, Hamed Zaer, Doris J Doudet, David J Brooks, Jens Christian H Sørensen, Dariusz Orlowski, Anne M Landa. Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs. Experimental neurology. vol 303. 2018-12-20. PMID:29428213. |
parkinson's disease (pd) is characterized by degeneration of dopaminergic neurons in the substantia nigra leading to slowness and stiffness of limb movement with rest tremor. |
2018-12-20 |
2023-08-13 |
Not clear |
| Xiaotian Sun, Pascaline Aimé, David Dai, Nagendran Ramalingam, John F Crary, Robert E Burke, Lloyd A Greene, Oren A Lev. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Experimental neurology. vol 303. 2018-12-20. PMID:29432724. |
we found that gadd34 is strongly induced by 6-ohda, and that gadd34 localization is dramatically altered in dopaminergic substantia nigra neurons in pd cases. |
2018-12-20 |
2023-08-13 |
mouse |
| Xiaotian Sun, Pascaline Aimé, David Dai, Nagendran Ramalingam, John F Crary, Robert E Burke, Lloyd A Greene, Oren A Lev. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Experimental neurology. vol 303. 2018-12-20. PMID:29432724. |
we further demonstrated that guanabenz attenuates 6-hydroxydopamine (6-ohda) induced cell death of differentiated pc12 cells and primary ventral midbrain dopaminergic neurons in culture, and of dopaminergic neurons in the substantia nigra of mice. |
2018-12-20 |
2023-08-13 |
mouse |