| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward Pajarillo, Asha Rizor, Jayden Lee, Michael Aschner, Eunsook Le. The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 8. 2020-03-03. PMID:30481588. |
pd is characterized by dopaminergic neurodegeneration in the substantia nigra, but its etiology has yet to be established. |
2020-03-03 |
2023-08-13 |
Not clear |
| Arndt von Twickel, Daniel Kowatschew, Mehmet Saltürk, Maria Schauer, Brita Robertson, Sigrun Korsching, Wolfgang Walkowiak, Sten Grillner, Juan Pérez-Fernánde. Individual Dopaminergic Neurons of Lamprey SNc/VTA Project to Both the Striatum and Optic Tectum but Restrict Co-release of Glutamate to Striatum Only. Current biology : CB. vol 29. issue 4. 2020-03-03. PMID:30713108. |
dopaminergic neurons in the substantia nigra (snc) innervate both striatum and the superior colliculus in mammals, as well as its homolog the optic tectum in lampreys, belonging to the oldest group of living vertebrates [1-3]. |
2020-03-03 |
2023-08-13 |
Not clear |
| Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit Lis. Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease. Nature communications. vol 10. issue 1. 2020-03-03. PMID:31704946. |
degeneration of dopaminergic neurons in the substantia nigra causes the motor symptoms of parkinson's disease. |
2020-03-03 |
2023-08-13 |
Not clear |
| Yixi He, Zhongwang Yu, Shengdi Che. Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30183251. |
parkinson's disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as lewy bodies, which are primarily composed of α-synuclein. |
2020-02-26 |
2023-08-13 |
Not clear |
| Shun Zhang, Rui Wang, Guanghui Wan. Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30592597. |
the characteristic feature of pd is the progressive degeneration of the dopaminergic (daergic) neurons in the substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
mouse |
| Mehmet Bülbül, Osman Sinen, Ayşe Özkan, Mutay Aydın Aslan, Aysel Ağa. Central neuropeptide-S treatment improves neurofunctions of 6-OHDA-induced Parkinsonian rats. Experimental neurology. vol 317. 2020-02-26. PMID:30825442. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
rat |
| Shen-Zhao Lu, Yong-Shun Guo, Pei-Zhou Liang, Shu-Zhen Zhang, Shu Yin, Yan-Qing Yin, Xiao-Min Wang, Fei Ding, Xiao-Song Gu, Jia-Wei Zho. Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Translational neurodegeneration. vol 8. 2020-02-25. PMID:30675347. |
parkinson's disease (pd) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (lewy bodies) within some remaining neurons in the substantia nigra. |
2020-02-25 |
2023-08-13 |
Not clear |
| Hanming Ge, Zhongjun Yan, Haochun Zhu, Hang Zha. MiR-410 exerts neuroprotective effects in a cellular model of Parkinson's disease induced by 6-hydroxydopamine via inhibiting the PTEN/AKT/mTOR signaling pathway. Experimental and molecular pathology. vol 109. 2020-02-25. PMID:31067440. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. |
2020-02-25 |
2023-08-13 |
Not clear |
| Douglas G Walker, Lih-Fen Lue, Thomas G Beach, Ikuo Tooyam. Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin. Cells. vol 8. issue 7. 2020-02-24. PMID:31340569. |
in substantia nigra, strong microglial cd105 staining was observed in microglia associated with degenerating dopaminergic neurons and neuromelanin. |
2020-02-24 |
2023-08-13 |
human |
| Qusai Hassan, ShaoPei Li, Celia Ferrag, Kagan Kerma. Electrochemical biosensors for the detection and study of α-synuclein related to Parkinson's disease - A review. Analytica chimica acta. vol 1089. 2020-02-24. PMID:31627816. |
parkinson's disease (pd) is a long-term degenerative disorder that affects predominately dopaminergic neurons in the substantia nigra, which mainly control movement. |
2020-02-24 |
2023-08-13 |
Not clear |
| Weitong Cui, Yuxi Zhan, Xiaoru Shao, Wei Fu, Dexuan Xiao, Junyao Zhu, Xin Qin, Tianyi Zhang, Mei Zhang, Yi Zhou, Yunfeng Li. Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson's Disease ACS applied materials & interfaces. vol 11. issue 36. 2020-02-11. PMID:31424187. |
pd is caused by dysfunction of basal ganglia, decrease of dopaminergic neurons in substantia nigra, and abnormal accumulation of lewy bodies and lewy neurites. |
2020-02-11 |
2023-08-13 |
Not clear |
| Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & function. vol 10. issue 9. 2020-02-11. PMID:31482900. |
biochemical and immunohistochemical analysis verified the thsg-mediated restoration of the fgf2-akt and bdnf-trkb signaling axis in the substantia nigra and corpus striatum and the recovery of dopaminergic neurons. |
2020-02-11 |
2023-08-13 |
mouse |
| Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V Lafuente, Cristina Miguelez, Luisa Uged. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia. International review of neurobiology. vol 146. 2020-02-03. PMID:31349930. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, the depletion of striatal dopamine and the presence of lewy aggregates containing alpha-synuclein. |
2020-02-03 |
2023-08-13 |
Not clear |
| Pei-En Jiang, Qiu-Han Lang, Qin-Yi Yu, Xin-Yu Tang, Qian-Qian Liu, Xin-Yu Li, Xi-Zeng Fen. Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson's Disease Model. Journal of visualized experiments : JoVE. issue 143. 2020-01-31. PMID:30663689. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) can lead to some parkinson's-like symptoms by destroying dopaminergic neurons in the substantia nigra of the brain. |
2020-01-31 |
2023-08-13 |
mouse |
| Parisa Gazeran. Probiotics for Parkinson's Disease. International journal of molecular sciences. vol 20. issue 17. 2020-01-23. PMID:31450864. |
parkinson's disease (pd) is a complex neurological disorder classically characterized by impairments in motor system function associated with loss of dopaminergic neurons in the substantia nigra. |
2020-01-23 |
2023-08-13 |
Not clear |
| Sunil Bhurtel, Nikita Katila, Sunil Srivastav, Sabita Neupane, Dong-Young Cho. Mechanistic comparison between MPTP and rotenone neurotoxicity in mice. Neurotoxicology. vol 71. 2020-01-09. PMID:30605763. |
mptp clearly produced dopaminergic lesions in both the substantia nigra and the striatum as shown by loss of dopaminergic neurons, depletion of striatal dopamine, activation of glial cells in the nigrostriatal pathway and behavioral impairment. |
2020-01-09 |
2023-08-13 |
mouse |
| Sujung Yeo, Jongbeom Song, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Advances in experimental medicine and biology. vol 1232. 2020-01-08. PMID:31893437. |
parkinson's disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-01-08 |
2023-08-13 |
mouse |
| F Vitale, A Capozzo, P Mazzone, E Scarnat. Neurophysiology of the pedunculopontine tegmental nucleus. Neurobiology of disease. vol 128. 2020-01-06. PMID:29524600. |
finally, we discuss the possibility that the pptg may be involved in excitotoxic degeneration of the dopaminergic neurons of the substantia nigra through the glutamatergic monosynaptic input that it provides to these neurons. |
2020-01-06 |
2023-08-13 |
Not clear |
| Yun Li, Yue Zhang, Xiao-Li Zhang, Xiao-Yan Feng, Chen-Zhe Liu, Xiu-Neng Zhang, Zhu-Sheng Quan, Jing-Ting Yan, Jin-Xia Zh. Dopamine promotes colonic mucus secretion through dopamine D American journal of physiology. Cell physiology. vol 316. issue 3. 2020-01-06. PMID:30624983. |
mice injected intraperitoneally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) destroying enteric dopamine (da) neurons, rats microinjected with 6-hydroxydopamine (6-ohda) into the bilateral substantia nigra damaging central dopaminergic neurons, and dopamine d |
2020-01-06 |
2023-08-13 |
mouse |
| Kazuya Miyanishi, Mohammed E Choudhury, Minori Watanabe, Madoka Kubo, Masahiro Nomoto, Hajime Yano, Junya Tanak. Behavioral tests predicting striatal dopamine level in a rat hemi-Parkinson's disease model. Neurochemistry international. vol 122. 2019-12-26. PMID:30419255. |
although its main pathology is progressive dopaminergic (dargic) neuron loss in the substantia nigra, motor deficits are thought not to become apparent until most dargic neurons are lost, probably due to compensatory mechanisms that overcome the decline of da level in the striatum. |
2019-12-26 |
2023-08-13 |
rat |