| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariel Pietri, Alaeddine Djillani, Jean Mazella, Marc Borsotto, Catherine Heurteau. First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology. vol 158. 2020-07-20. PMID:31325429. |
mini-spadin prevented the loss of body weight and the delayed dopaminergic degeneration in substantia nigra and improved the motor and cognitive ischemia-induced deficits. |
2020-07-20 |
2023-08-13 |
mouse |
| Jia Lu, Fangfang Dou, Zhihua Y. The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson's disease. Journal of neuroinflammation. vol 16. issue 1. 2020-07-14. PMID:31878950. |
recent studies described a critical role for microglia in parkinson's disease (pd), where these central nerve system resident immune cells participate in the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss in the substantia nigra. |
2020-07-14 |
2023-08-13 |
mouse |
| Yong-Bo Hu, Yong-Fang Zhang, Hao Wang, Ru-Jing Ren, Hai-Lun Cui, Wan-Ying Huang, Qi Cheng, Hong-Zhuan Chen, Gang Wan. miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell death & disease. vol 10. issue 8. 2020-07-13. PMID:31383850. |
a major hallmark of parkinson's disease (pd) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. |
2020-07-13 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. |
2020-07-06 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
olfactory dysfunction is a major non-motor symptom that appears during the early stages of parkinson's disease (pd), a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2020-07-06 |
2023-08-13 |
mouse |
| Omar Collazo-Navarrete, David Hernández-García, Gilda Guerrero-Flores, René Drucker-Colín, Magdalena Guerra-Crespo, Luis Covarrubia. The Substantia Nigra Is Permissive and Gains Inductive Signals When Lesioned for Dopaminergic Differentiation of Embryonic Stem Cells. Stem cells and development. vol 28. issue 16. 2020-07-02. PMID:31140356. |
the substantia nigra is permissive and gains inductive signals when lesioned for dopaminergic differentiation of embryonic stem cells. |
2020-07-02 |
2023-08-13 |
Not clear |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, T Petteri Piepponen, Sari Ahola, Raimo K Tuominen, Christopher Richie, Brandon K Harvey, Mikko Airavaar. Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30548446. |
adeno-associated virus (aav) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (sn) results in increased expression of α-syn protein in the sn and striatum which can progressively degenerate dopaminergic neurons. |
2020-07-01 |
2023-08-13 |
human |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Michaela E Johnson, Xin-Fu Zhou, Larisa Bobrovskay. The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: Relevance to early Parkinson's disease. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30690135. |
loss of dopaminergic neurons in the substantia nigra (sn) is one of the pathological hallmarks in parkinson's disease (pd). |
2020-06-26 |
2023-08-13 |
rat |
| Zhi-Lan Zhou, Xue-Bing Jia, Meng-Fei Sun, Ying-Li Zhu, Chen-Meng Qiao, Bo-Ping Zhang, Li-Ping Zhao, Qin Yang, Chun Cui, Xue Chen, Yan-Qin She. Neuroprotection of Fasting Mimicking Diet on MPTP-Induced Parkinson's Disease Mice via Gut Microbiota and Metabolites. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 3. 2020-06-25. PMID:30815845. |
here, we report a fasting mimicking diet (fmd), fasting 3 days followed by 4 days of refeeding for three 1-week cycles, which accelerated the retention of motor function and attenuated the loss of dopaminergic neurons in the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (mptp)-induced pd mice. |
2020-06-25 |
2023-08-13 |
mouse |
| Kyung-Ah Park, Nuri Yun, Young J O. Anamorsin attenuates cupric chloride-induced dopaminergic neuronal cell death. Biochemical and biophysical research communications. vol 520. issue 1. 2020-06-23. PMID:31582212. |
because dopaminergic neurons in the substantia nigra are vulnerable to ros, dysregulation of metals and the resulting accumulation of ros could be a cause of dopaminergic neurodegeneration. |
2020-06-23 |
2023-08-13 |
Not clear |
| Ludivine S Breger, Marie T Fuzzati Armenter. Genetically engineered animal models of Parkinson's disease: From worm to rodent. The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:30552719. |
parkinson's disease (pd) is a progressive neurological disorder characterised by aberrant accumulation of insoluble proteins, including alpha-synuclein, and a loss of dopaminergic neurons in the substantia nigra. |
2020-06-22 |
2023-08-13 |
mouse |
| Jayden A O'Brien, Paul J Austi. Effect of Photobiomodulation in Rescuing Lipopolysaccharide-Induced Dopaminergic Cell Loss in the Male Sprague-Dawley Rat. Biomolecules. vol 9. issue 8. 2020-06-22. PMID:31430990. |
we investigated whether transcranial pbm could protect against dopaminergic cell death within the substantia nigra in male sprague-dawley rats following supranigral lps injection. |
2020-06-22 |
2023-08-13 |
rat |
| Dongping Huang, Qing Li, Yi Wang, Zhaolin Liu, Zishan Wang, Heng Li, Jinghui Wang, Jing Su, Yuanyuan Ma, Mei Yu, Jian Fei, Fang Huan. Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson's disease. Aging. vol 11. issue 10. 2020-06-17. PMID:31147527. |
degeneration of the dopaminergic neurons in the substantia nigra and the resultant dopamine depletion from the striatum are the hallmarks of parkinson's disease (pd) and are responsible for the disease's cardinal motor symptoms. |
2020-06-17 |
2023-08-13 |
mouse |
| Oliver Kaut, Klaus Kuchelmeister, Christoph Moehl, Ullrich Wüllne. 5-methylcytosine and 5-hydroxymethylcytosine in brains of patients with multiple system atrophy and patients with Parkinson's disease. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30557654. |
the brain stem and substantia nigra, and in particular the dopaminergic neurons, showed unchanged levels of both 5-mc- and 5-hmc-immunoreactivity in all groups. |
2020-06-15 |
2023-08-13 |
human |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Jing Gong, Éva M Szego, Andrei Leonov, Eva Benito, Stefan Becker, Andre Fischer, Markus Zweckstetter, Tiago Outeiro, Anja Schneide. Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 19. 2020-06-11. PMID:30796158. |
parkinson's disease is a movement disorder with characteristic motor features that arise due to the loss of dopaminergic neurons from the substantia nigra. |
2020-06-11 |
2023-08-13 |
mouse |
| Henrique de Oliveira Amaral, Victoria Monge-Fuentes, Andréia Biolchi Mayer, Gabriel Avohay Alves Campos, Kamila Soares Lopes, Luana C Camargo, Matheus Ferroni Schwartz, Priscilla Galante, Márcia R Mortar. Animal venoms: therapeutic tools for tackling Parkinson's disease. Drug discovery today. vol 24. issue 11. 2020-06-09. PMID:31539640. |
parkinson's disease (pd) is a neurodegenerative pathology of the central nervous system, mainly involving the selective and progressive loss of dopaminergic neurons from the substantia nigra, resulting in motor and non-motor symptoms. |
2020-06-09 |
2023-08-13 |
Not clear |
| Tanusree Das, Jaclyn J Hwang, Kathleen L Posto. Episodic recognition memory and the hippocampus in Parkinson's disease: A review. Cortex; a journal devoted to the study of the nervous system and behavior. vol 113. 2020-06-08. PMID:30660957. |
the hallmark pathophysiology includes the development of neuronal lewy bodies in the substantia nigra of the midbrain with subsequent loss of dopaminergic neurons. |
2020-06-08 |
2023-08-13 |
Not clear |
| Kelvin C Lu. Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression. The Journal of clinical investigation. vol 129. issue 9. 2020-06-08. PMID:31380806. |
patients with parkinson's disease (pd) show selective degeneration of dopaminergic neurons in the substantia nigra and cholinergic neurons in the dorsal motor nucleus (dmnx), but the drivers of this specific susceptibility are unknown. |
2020-06-08 |
2023-08-13 |
Not clear |