| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
the overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (vm), tissue placed within the substantia nigra (sn), into the striatum to reconstruct the nigrostriatal pathway in a hemi-parkinson's disease rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Sora Ahn, Quan Feng Liu, Jae-Hwan Jang, Jeonghun Park, Ha Jin Jeong, Youngman Kim, Dong-Hee Kim, Guwon Jeong, Seung Tack Oh, Seong-Uk Park, Seung-Yeon Cho, Hi-Joon Park, Songhee Jeo. Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31555122. |
moreover, gcf inhibited the reduction of dopaminergic neurons in the substantia nigra (sn) and fibers in the striatum (st) against mptp/p challenge. |
2020-09-30 |
2023-08-13 |
mouse |
| Hyunjung Baek, Hyun Il Jang, Hat Nim Jeon, Hyunsu Ba. Comparison of Administration Routes on the Protective Effects of Bee Venom Phospholipase A2 in a Mouse Model of Parkinson's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-29. PMID:29942256. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) and their synaptic terminal connections in the striatum are main characterizations of pd. |
2020-09-29 |
2023-08-13 |
mouse |
| Thomas B Stoker, Kelli M Torsney, Roger A Barke. Emerging Treatment Approaches for Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30349448. |
the movement disorder of pd occurs largely due to loss of dopaminergic neurons of the substantia nigra, resulting in striatal dopamine depletion. |
2020-09-29 |
2023-08-13 |
Not clear |
| Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M Papa, Keqiang Ye, Xuebing Ca. TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30555300. |
however, this effect has not been tested in the parkinson's disease (pd), which is characterized by the da deficiency due to the dopaminergic neurons loss in the substantia nigra. |
2020-09-29 |
2023-08-13 |
rat |
| Ana Luisa Gil-Martínez, Lorena Cuenca, Cristina Estrada, Consuelo Sánchez-Rodrigo, Emiliano Fernández-Villalba, María Trinidad Herrer. Unexpected Exacerbation of Neuroinflammatory Response After a Combined Therapy in Old Parkinsonian Mice. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30559650. |
interestingly, nac+ha-1077-based treatment produced a significant increase in dopaminergic neuronal death accompanied by an increase in microglial and astroglial activation in the substantia nigra |
2020-09-29 |
2023-08-13 |
mouse |
| Shih-Yin Ho, Yin-Hsiu Chien, Li-Kai Tsai, Shin-Ichi Muramatsu, Wuh-Liang Hwu, Horng-Huei Liou, Ni-Chung Le. Electrical Abnormalities in Dopaminergic Neurons of the Substantia Nigra in Mice With an Aromatic L-Amino Acid Decarboxylase Deficiency. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:30766478. |
electrical abnormalities in dopaminergic neurons of the substantia nigra in mice with an aromatic l-amino acid decarboxylase deficiency. |
2020-09-29 |
2023-08-13 |
mouse |
| Markey Olson, Thurmon E Lockhart, Abraham Lieberma. Motor Learning Deficits in Parkinson's Disease (PD) and Their Effect on Training Response in Gait and Balance: A Narrative Review. Frontiers in neurology. vol 10. 2020-09-29. PMID:30792688. |
parkinson's disease (pd) is a neurological disorder traditionally associated with degeneration of the dopaminergic neurons within the substantia nigra, which results in bradykinesia, rigidity, tremor, and postural instability and gait disability (pigd). |
2020-09-29 |
2023-08-13 |
Not clear |
| Yu Pei, Robert W Maitt. Alpha synuclein in hematopoiesis and immunity. Heliyon. vol 5. issue 10. 2020-09-29. PMID:31692680. |
parkinson's disease (pd) is the second most common neurodegenerative condition and intracellular deposition of lewy bodies in the substantia nigra (sn), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sandeep K Barodia, Laura J McMeekin, Rose B Creed, Elijah K Quinones, Rita M Cowell, Matthew S Goldber. PINK1 phosphorylates ubiquitin predominantly in astrocytes. NPJ Parkinson's disease. vol 5. 2020-09-29. PMID:31840043. |
loss-of-function mutations in pink1 are causally linked to recessively inherited parkinson's disease (pd), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. |
2020-09-29 |
2023-08-13 |
rat |
| Minjing Ke, Cheong-Meng Chong, Huanxing S. Using induced pluripotent stem cells for modeling Parkinson's disease. World journal of stem cells. vol 11. issue 9. 2020-09-28. PMID:31616540. |
parkinson's disease (pd) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (da) neurons in the substantia nigra. |
2020-09-28 |
2023-08-13 |
human |
| Wook Ji. Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease. Journal of clinical medicine. vol 9. issue 1. 2020-09-28. PMID:31963575. |
specifically, bdnf/trkb is highly expressed and activated in the dopaminergic neurons of the substantia nigra and plays a critical role in neurophysiological processes, including neuro-protection and maturation and maintenance of neurons. |
2020-09-28 |
2023-08-13 |
human |
| Marina De Rui, Emine Meral Inelmen, Caterina Trevisan, Sabrina Pigozzo, Enzo Manzato, Giuseppe Serg. Parkinson's disease and the non-motor symptoms: hyposmia, weight loss, osteosarcopenia. Aging clinical and experimental research. vol 32. issue 7. 2020-09-28. PMID:31989535. |
unfortunately, patients with these symptoms usually are not initially seen by a neurologist, and by the time they are consulted, nearly ~ 80% of the dopaminergic neurons in the substantia nigra have died. |
2020-09-28 |
2023-08-13 |
Not clear |
| Susan R Goulding, Aideen M Sullivan, Gerard W O'Keeffe, Louise M Collin. The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997802. |
the pathological hallmarks of parkinson's disease are the progressive degeneration of dopaminergic neurons in the substantia nigra and their axons which project to the striatum, and the aggregation of α-synuclein; these result in a range of debilitating motor and non-motor symptoms. |
2020-09-28 |
2023-08-13 |
human |
| Susan R Goulding, Aideen M Sullivan, Gerard W O'Keeffe, Louise M Collin. The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997802. |
here we discuss recent work showing that transcripts for the bmp receptors and bmp2 are co-expressed with several key markers of dopaminergic neurons in the human substantia nigra, and evidence for downregulation of bmp2 expression at distinct stages of parkinson's disease. |
2020-09-28 |
2023-08-13 |
human |
| Alexandre Iarkov, George E Barreto, J Alex Grizzell, Valentina Echeverri. Strategies for the Treatment of Parkinson's Disease: Beyond Dopamine. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32076403. |
parkinson's disease (pd) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yan Sun, Chuang Guo, Lin Yuan, Wen Li, Zhan-You Wang, Feng Yue, Jia-Yi L. Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson's Disease and Related Diseases. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32116510. |
in addition, in t2dm monkeys' brain, we observed concomitantly increased accumulation and phosphorylation of α-synuclein in the cortex, pre-commissural putamen and dopaminergic neurons in the substantia nigra, which interestingly showed high correlation with levels of fasting plasma glucose (fpg), triglyceride (tg), and high density lipoprotein (hdl). |
2020-09-28 |
2023-08-13 |
human |
| Nada Yousif, Peter G Bain, Dipankar Nandi, Roman Borisyu. A Population Model of Deep Brain Stimulation in Movement Disorders From Circuits to Cells. Frontiers in human neuroscience. vol 14. 2020-09-28. PMID:32210779. |
it is known that the loss of dopaminergic neurons in the substantia nigra leads to pd, while the exact impact of this on the brain dynamics is not fully understood, the presence of beta-band oscillatory activity is thought to be pathological. |
2020-09-28 |
2023-08-13 |
human |
| René A J Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M Massari, Víctor Fernández-Dueñas, Christophe P Stove, Francisco Ciruel. Striatal Dopamine D Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32231561. |
striatal dopamine d parkinson's disease (pd) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ovidijus Laucius, Renata Balnytė, Kęstutis Petrikonis, Vaidas Matijošaitis, Neringa Jucevičiūtė, Tadas Vanagas, Vytautas Danieliu. Ultrasonography of the Vagus Nerve in the Diagnosis of Parkinson's Disease. Parkinson's disease. vol 2020. 2020-09-28. PMID:32318257. |
it is currently impossible to diagnose parkinson's disease (pd) in the premotor phase even though at the time of motor symptom onset the number of already degenerated dopaminergic substantia nigra neurons is considerable. |
2020-09-28 |
2023-08-13 |
Not clear |