| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeny A Budygin, Erik B Oleson, Yun Beom Lee, Lawrence C Blume, Michael J Bruno, Allyn C Howlett, Alexis C Thompson, Caroline E Bas. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Frontiers in behavioral neuroscience. vol 10. 2020-10-01. PMID:28154530. |
the present study takes a different approach using rna interference (rnai) to knockdown the expression of the d2 receptors (d2r) in the substantia nigra (sn), including dopaminergic neurons, which project primarily to the dorsal striatum (dstr) in adult rats. |
2020-10-01 |
2023-08-13 |
mouse |
| Laura Hühner, Jennifer Rilka, Ralf Gilsbach, Xiaolai Zhou, Venissa Machado, Björn Spitta. Interleukin-4 Protects Dopaminergic Neurons Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28337124. |
parkinson's disease (pd) is one the most common neurodegenerative disease and is characterized by the progressive loss of midbrain dopaminergic (mda) neurons in the substantia nigra resulting in bradykinesia, tremor, and rigidity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Li. Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats. Journal of exercise rehabilitation. vol 13. issue 1. 2020-10-01. PMID:28349030. |
parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. |
2020-10-01 |
2023-08-13 |
rat |
| Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu, Xianshu Ju, Min Jeong Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweon, Jun Young He. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities. Experimental neurobiology. vol 26. issue 2. 2020-10-01. PMID:28442947. |
a dopaminergic neuronal pathway from the substantia nigra (sn) to the striatum is responsible for regulating grip strength and motor initiation through tyrosine hydroxylase (th) activity-dependent dopamine release. |
2020-10-01 |
2023-08-13 |
mouse |
| Shuifen Ye, Ho Kee Koon, Wen Fan, Yihui Xu, Wei Wei, Chuanshan Xu, Jing Ca. Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP Parkinson's disease. vol 2017. 2020-10-01. PMID:28607800. |
effect of a traditional chinese herbal medicine formulation on cell survival and apoptosis of mpp progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is implicated in parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Sudhakar R Subramaniam, Howard J Federof. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28642697. |
parkinson's disease (pd) is a chronic and progressive disorder characterized neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular proteinaceous inclusions, reduction of dopaminergic terminals in the striatum, and increased neuroinflammatory cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ana I Ramirez, Rosa de Hoz, Elena Salobrar-Garcia, Juan J Salazar, Blanca Rojas, Daniel Ajoy, Inés López-Cuenca, Pilar Rojas, Alberto Triviño, José M Ramíre. The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28729832. |
pd is a neurodegenerative locomotor disorder with the progressive loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storc. Early Postnatal but Not Late Adult Neurogenesis Is Impaired in the Pitx3-Mutant Animal Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28883785. |
as dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (sn) in pd may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (svz) and dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Abir A Rahman, Nathan K Lai, Joshua E Albright, Paige E Urquhart, Abby R Webb, Brad E Morriso. Nigral dopaminergic neuron replenishment in adult mice through VE-cadherin-expressing neural progenitor cells. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239333. |
the function of dopaminergic neurons in the substantia nigra is of central importance to the coordination of movement by the brain's basal ganglia circuitry. |
2020-10-01 |
2023-08-13 |
mouse |
| Shu-Ju Wang, Qi Wang, Jun Ma, Pei-Hao Yu, Zhong-Ming Wang, Bin Wan. Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats. Neural regeneration research. vol 13. issue 1. 2020-10-01. PMID:29451215. |
defects in autophagy-mediated clearance of α-synuclein may be one of the key factors leading to progressive loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
rat |
| Bahar Güntekin, Lütfü Hanoğlu, Dilan Güner, Nesrin H Yılmaz, Fadime Çadırcı, Nagihan Mantar, Tuba Aktürk, Derya D Emek-Savaş, Fahriye F Özer, Görsev Yener, Erol Başa. Cognitive Impairment in Parkinson's Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination. Frontiers in psychology. vol 9. 2020-10-01. PMID:29515489. |
parkinson's disease (pd) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
human |
| Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu Chidambaram, Giles J Guillemi. Demethoxycurcumin, a Natural Derivative of Curcumin Abrogates Rotenone-induced Dopamine Depletion and Motor Deficits by Its Antioxidative and Anti-inflammatory Properties in Parkinsonian Rats. Pharmacognosy magazine. vol 14. issue 53. 2020-10-01. PMID:29576695. |
parkinson's disease (pd) is a progressive neurodegenerative disorder (ndd) associated with the loss of dopaminergic neurons in the substantia nigra and subsequently has an effect on motor function and coordination. |
2020-10-01 |
2023-08-13 |
rat |
| Anna-Elisa Roser, Lucas Caldi Gomes, Rashi Halder, Gaurav Jain, Fabian Maass, Lars Tönges, Lars Tatenhorst, Mathias Bähr, André Fischer, Paul Lingo. miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons. Molecular therapy. Nucleic acids. vol 11. 2020-10-01. PMID:29858093. |
one major hallmark of pd is the degeneration of dopaminergic (da) neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Amy K Reeve, John P Grady, Eve M Cosgrave, Emma Bennison, Chun Chen, Philippa D Hepplewhite, Christopher M Morri. Mitochondrial dysfunction within the synapses of substantia nigra neurons in Parkinson's disease. NPJ Parkinson's disease. vol 4. 2020-10-01. PMID:29872690. |
the loss of dopaminergic substantia nigra neurons in parkinson's disease is associated with loss of synapses within the striatum, and this may precede neuronal loss. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lan-Xiang Liu, Dan Du, Zhan-Qiu Wang, Yuan Fang, Tao Zheng, Yan-Chao Dong, Qing-Lei Shi, Min Zhao, Fang Xiao, Juan D. Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson's disease models. Neural regeneration research. vol 13. issue 7. 2020-10-01. PMID:30028338. |
they not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition. |
2020-10-01 |
2023-08-13 |
rat |
| Anna Elisa Roser, Lucas Caldi Gomes, Jonas Schünemann, Fabian Maass, Paul Lingo. Circulating miRNAs as Diagnostic Biomarkers for Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30233304. |
its main neuropathological hallmarks are the degeneration of dopaminergic neurons in the substantia nigra and alpha-synuclein containing protein inclusions, called lewy bodies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Minrui Weng, Xiaoji Xie, Chao Liu, Kah-Leong Lim, Cheng-Wu Zhang, Lin L. The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson's Disease. Parkinson's disease. vol 2018. 2020-10-01. PMID:30245802. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Irene García-Domínguez, Karolina Veselá, Juan García-Revilla, Alejandro Carrillo-Jiménez, María Angustias Roca-Ceballos, Marti Santiago, Rocío M de Pablos, José L Vener. Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30459561. |
our results showed that combinative treatment exacerbates microglia activation and enhances (i) the appearance of galectin-3-positive microglia, recently identified as microglial disease-associated phenotypic marker, (ii) the up-regulation of pro-inflammatory cytokines, (iii) the occurrence of a1 neurotoxic astrocytes, (iv) the breakdown of the bbb, and (v) the loss of dopaminergic neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Roya Varmazyar, Ali Noori-Zadeh, Farzad Rajaei, Shahram Darabi, Salar Bakhtiyar. 17 β-Estradiol Oxidative Stress Attenuation and Autophagy-Induced Dopaminergic Neuroprotection. Cell journal. vol 21. issue 1. 2020-10-01. PMID:30507082. |
degeneration of dopaminergic neurons in the substantia nigra of the brain stem is the main pathological aspect of parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
rat |