| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anup K Srivastava, Subhasree Roy Choudhury, Surajit Karmaka. Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson's disease therapy. Biomaterials science. vol 8. issue 5. 2020-11-23. PMID:31912833. |
the therapeutic assessment on ex vivo organotypic brain slice culture, and in vivo experimental pd model confirmed the superior brain targeting, collective neuroprotection on dopaminergic neurons with reduced alpha-synuclein phosphorylation and deposition in the hippocampal and substantia nigra region of the brain. |
2020-11-23 |
2023-08-13 |
Not clear |
| Carmen Diaz-Ruiz, Begoña Villar-Cheda, Antonio Dominguez-Meijide, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garci. Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 3. 2020-11-20. PMID:30412227. |
treatment with the specific sirt3 inhibitor agk7 induced overexpression of at1 and at2 in substantia nigra (sn) of rats, and in dopaminergic neuronal mes23.5 and microglial n9 cell lines. |
2020-11-20 |
2023-08-13 |
mouse |
| I I Coloman, A Sh Chimagomedov. [The influence of motor asymmetry on cognitive functions in Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 120. issue 10. Vyp. 2. 2020-11-20. PMID:33205934. |
the asymmetry of motor symptoms in parkinson's disease (pd) reflects the asymmetry of the degenerative process and death of nigrostriatal dopaminergic neurons in the substantia nigra, which is confirmed by the data of functional neuroimaging. |
2020-11-20 |
2023-08-13 |
Not clear |
| Benedetta Conio, Matteo Martino, Paola Magioncalda, Andrea Escelsior, Matilde Inglese, Mario Amore, Georg Northof. Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders. Molecular psychiatry. vol 25. issue 1. 2020-11-17. PMID:30953003. |
in particular, the dopaminergic substantia nigra (snc)-related nigrostriatal pathway is structurally and functionally connected with core regions of the smn, whereas the ventral tegmental area (vta)-related mesocorticolimbic pathway with core regions of the sn. |
2020-11-17 |
2023-08-13 |
Not clear |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
long-term effects of maternal deprivation on the volume of dopaminergic nuclei and number of dopaminergic neurons in substantia nigra and ventral tegmental area in rats. |
2020-11-17 |
2023-08-13 |
rat |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
the volume of dopaminergic nuclei and the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta) were analyzed in three representative coordinates. |
2020-11-17 |
2023-08-13 |
rat |
| Xinyao Liu, Weidong L. Profiling Non-motor Symptoms in Monogenic Parkinson's Disease. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192488. |
parkinson's disease (pd) is the second most common neurodegenerative disease in the elder population, pathologically characterized by the progressive loss of dopaminergic neurons in the substantia nigra. |
2020-11-17 |
2023-08-13 |
Not clear |
| Usman Saeed, Anthony E Lang, Mario Maselli. Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes. Frontiers in neurology. vol 11. 2020-11-13. PMID:33178113. |
in this article, an updated presentation of well-established and emerging neuroimaging biomarkers are reviewed from the following modalities: (1) structural magnetic resonance imaging (mri), (2) diffusion-weighted and diffusion tensor mri, (3) resting-state and task-based functional mri, (4) proton magnetic resonance spectroscopy, (5) transcranial b-mode sonography for measuring substantia nigra and lentiform nucleus echogenicity, (6) single photon emission computed tomography for assessing the dopaminergic system and cerebral perfusion, and (7) positron emission tomography for quantifying nigrostriatal functions, glucose metabolism, amyloid, tau and α-synuclein molecular imaging, as well as neuroinflammation. |
2020-11-13 |
2023-08-13 |
Not clear |
| Francesca Palese, Silvia Pontis, Natalia Realini, Daniele Piomell. A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31685899. |
nape, but not fae, accumulation is enhanced in mice lacking nape-pld, which display a substantial reduction in 6-ohda-induced neurotoxicity, as shown by increased survival of substantia nigra dopamine neurons, integrity of striatal dopaminergic fibers, and striatal dopamine metabolite content. |
2020-11-03 |
2023-08-13 |
mouse |
| E Maruthi Prasad, Shih-Ya Hun. Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 9. issue 10. 2020-11-03. PMID:33081318. |
in pd, continuous loss of dopaminergic neurons in the substantia nigra causes dopamine depletion in the striatum, promotes the primary motor symptoms of resting tremor, bradykinesia, muscle rigidity, and postural instability. |
2020-11-03 |
2023-08-13 |
Not clear |
| Sara Brignani, Divya D A Raj, Ewoud R E Schmidt, Özge Düdükcü, Youri Adolfs, Anna A De Ruiter, Mateja Rybiczka-Tesulov, Marieke G Verhagen, Christiaan van der Meer, Mark H Broekhoven, Juan A Moreno-Bravo, Laurens M Grossouw, Emilie Dumontier, Jean-François Cloutier, Alain Chédotal, R Jeroen Pasterkam. Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. vol 107. issue 4. 2020-11-02. PMID:32562661. |
remotely produced and axon-derived netrin-1 instructs gabaergic neuron migration and dopaminergic substantia nigra development. |
2020-11-02 |
2023-08-13 |
Not clear |
| Michinori Koebisu, Takayuki Ishid. [Safinamide Mesilate (Equfina Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 4. 2020-11-02. PMID:32612042. |
[safinamide mesilate (equfina parkinson's disease is a neurodegenerative disorder characterized by the degenerative loss of dopaminergic neurons in the substantia nigra. |
2020-11-02 |
2023-08-13 |
rat |
| Paulina Troncoso-Escudero, Denisse Sepulveda, Rodrigo Pérez-Arancibia, Alejandra V Parra, Javiera Arcos, Felipe Grunenwald, Rene L Vida. On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101007. |
these symptoms are due to the loss principally of dopaminergic neurons of the substantia nigra (sn) par compacta and the gabaergic neurons of the striatum in pd and hd, respectively. |
2020-10-28 |
2023-08-13 |
Not clear |
| Tommaso Nuzzo, Daniela Punzo, Paola Devoto, Elena Rosini, Silvia Paciotti, Silvia Sacchi, Qin Li, Marie-Laure Thiolat, Celine Véga, Massimo Carella, Manolo Carta, Fabrizio Gardoni, Paolo Calabresi, Loredano Pollegioni, Erwan Bezard, Lucilla Parnetti, Francesco Errico, Alessandro Usiell. The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31222058. |
conversely, dopaminergic denervation is associated with selective d-serine reduction in the substantia nigra. |
2020-10-27 |
2023-08-13 |
monkey |
| Takuya Uehara, Chi-Jing Choong, Masayuki Nakamori, Hideki Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, Kousuke Baba, Tetsuya Nagata, Takanori Yokota, Hiroshi Tsuda, Satoshi Obika, Hideki Mochizuk. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31110191. |
parkinson's disease (pd) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. |
2020-10-14 |
2023-08-13 |
mouse |
| Xingyun Xu, Rui Wang, Zongbing Hao, Guanghui Wang, Chenchen Mu, Jianqing Ding, Wanping Sun, Haigang Re. DJ-1 regulates tyrosine hydroxylase expression through CaMKKβ/CaMKIV/CREB1 pathway in vitro and in vivo. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31232473. |
lack of dopamine production and neurodegeneration of dopaminergic neurons in the substantia nigra are considered as the major characteristics of parkinson's disease, a prevalent movement disorder worldwide. |
2020-10-13 |
2023-08-13 |
Not clear |
| Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalep. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30918302. |
postmortem studies of brains from pd patients have revealed the degeneration of noradrenergic neurons in the locus coeruleus (lc) to the same or even greater extent than that observed in the dopaminergic neurons of substantia nigra (sn) and ventral tegmental area (vta). |
2020-10-05 |
2023-08-13 |
mouse |
| H-M Guo, Z-Y Zhou, Y-Q Huang, X Li, X-J Wan. Investigation of the roles of dysbindin-1 and SATB2 in the progression of Parkinson's disease. European review for medical and pharmacological sciences. vol 23. issue 17. 2020-10-05. PMID:31539139. |
parkinson's disease is a neurodegenerative disease that typically results in the loss of dopaminergic neurons, especially in an area of the brain known as the substantia nigra. |
2020-10-05 |
2023-08-13 |
Not clear |
| Yingqing Wang, Chun Chen, Wanling Huang, Maoxin Huang, Juhua Wang, Xiaochun Chen, Qinyong Y. Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity. Aging. vol 11. issue 20. 2020-10-02. PMID:31634150. |
beneficial effects of pgc-1α in the substantia nigra of a mouse model of mptp-induced dopaminergic neurotoxicity. |
2020-10-02 |
2023-08-13 |
mouse |
| Daniela Impellizzeri, Michela Campolo, Giuseppe Bruschetta, Rosalia Crupi, Marika Cordaro, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposit. Traumatic Brain Injury Leads to Development of Parkinson's Disease Related Pathology in Mice. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:27790086. |
moreover, tbi is a risk factor for neurodegeneration and can e.g., increase the risk for parkinson's disease (pd), a late-onset neurodegenerative disorder with loss of dopaminergic neurons in substantia nigra. |
2020-10-01 |
2023-08-13 |
mouse |