| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Löser, Julia Luthardt, Michael Rullmann, David Weise, Osama Sabri, Jürgen Meixensberger, Swen Hesse, Dirk Winkle. Striatal dopamine transporter availability and individual clinical course within the 1-year follow-up of deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. Journal of neurosurgery. 2021-02-19. PMID:33607613. |
degeneration of dopaminergic neurons in the substantia nigra projecting to the striatum is responsible for the motor symptoms in parkinson's disease (pd). |
2021-02-19 |
2023-08-13 |
Not clear |
| Darryl S Watkins, Jason D True, Amber L Mosley, Anthony J Baucu. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Proteomes. vol 6. issue 4. 2021-02-18. PMID:30562941. |
glutamatergic projections from the cortex and dopaminergic projections from the substantia nigra or ventral tegmental area synapse on dendritic spines of specific gabaergic medium spiny neurons (msns) in the striatum. |
2021-02-18 |
2023-08-13 |
mouse |
| Gaurav Bhatia, Jatinder Singh, Bimla Nehr. Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease. Environmental science and pollution research international. vol 28. issue 8. 2021-02-18. PMID:33145730. |
pathogenesis of parkinson's disease (pd) specifically involves the degeneration of dopaminergic neurons in the substantia nigra region, which mainly begun with the overwhelmed oxidative stress and neuroinflammation. |
2021-02-18 |
2023-08-13 |
Not clear |
| Simone Mesman, Marten P Smid. Acquisition of the Midbrain Dopaminergic Neuronal Identity. International journal of molecular sciences. vol 21. issue 13. 2021-02-16. PMID:32629812. |
the mesodiencephalic dopaminergic (mdda) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (sn) and ventral tegmental area (vta) are the best known, due to the selective degeneration of the sn during parkinson's disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Mehmet Senel, Esma Dervisevic, Sammy Alhassen, Muamer Dervisevic, Amal Alachkar, Victor J Cadarso, Nicolas H Voelcke. Microfluidic Electrochemical Sensor for Cerebrospinal Fluid and Blood Dopamine Detection in a Mouse Model of Parkinson's Disease. Analytical chemistry. vol 92. issue 18. 2021-02-16. PMID:32786441. |
parkinson's disease (pd) is a progressive neurodegenerative disorder involving dopaminergic neurons from the substantia nigra. |
2021-02-16 |
2023-08-13 |
mouse |
| Ava Nasrolahi, Fatemeh Safari, Mehdi Farhoudi, Afra Khosravi, Fereshteh Farajdokht, Saiyad Bastaminejad, Siamak Sandoghchian Shotorbani, Javad Mahmoud. Immune system and new avenues in Parkinson's disease research and treatment. Reviews in the neurosciences. vol 30. issue 7. 2021-02-15. PMID:30796849. |
parkinson's disease (pd) is a progressive neurological disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. |
2021-02-15 |
2023-08-13 |
Not clear |
| Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeon. Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. Stem cells international. vol 2021. 2021-02-10. PMID:33552161. |
pd is a chronic age-related neurodegenerative disease (ndd) characterized by loss of dopaminergic neurons in the substantia nigra (sn) and abnormal accumulation of |
2021-02-10 |
2023-08-13 |
human |
| Babita Singh, Shivani Pandey, Mohammad Rumman, Abbas Ali Mahd. Neuroprotective effects of Bacopa monnieri in Parkinson's disease model. Metabolic brain disease. vol 35. issue 3. 2021-02-02. PMID:31834548. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of α-synuclein aggregates in the striatum and surrounding areas of brain. |
2021-02-02 |
2023-08-13 |
Not clear |
| Xiao-Le Wang, Si-Tong Feng, Ya-Ting Wang, Yu-He Yuan, Zhi-Peng Li, Nai-Hong Chen, Zhen-Zhen Wang, Yi Zhan. Mitophagy, a Form of Selective Autophagy, Plays an Essential Role in Mitochondrial Dynamics of Parkinson's Disease. Cellular and molecular neurobiology. 2021-02-02. PMID:33528716. |
parkinson's disease (pd) is a severe neurodegenerative disorder caused by the progressive loss of dopaminergic neurons in the substantia nigra and affects millions of people. |
2021-02-02 |
2023-08-13 |
Not clear |
| Thomas R Barber, Ludovica Griffanti, Kevin M Bradley, Daniel R McGowan, Christine Lo, Clare E Mackay, Michele T Hu, Johannes C Klei. Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline. Annals of clinical and translational neurology. vol 7. issue 1. 2021-02-01. PMID:31820587. |
here, we investigate the utility of susceptibility-weighted mri (swi) to detect abnormalities of the substantia nigra in rbd, and explore their association with striatal dopaminergic deficits. |
2021-02-01 |
2023-08-13 |
Not clear |
| Azizul Haque, Supriti Samantaray, Varduhi H Knaryan, Mollie Capone, Azim Hossain, Denise Matzelle, Raghavendar Chandran, Donald C Shields, Ariana Q Farrand, Heather A Boger, Naren L Bani. Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease. Experimental neurology. vol 330. 2021-02-01. PMID:32302678. |
parkinson's disease (pd), a debilitating progressive degenerative movement disorder associated with loss of dopaminergic (da) neurons in the substantia nigra (sn), afflicts approximately one million people in the u.s., including a significant number of veterans. |
2021-02-01 |
2023-08-13 |
mouse |
| Jana Janssens, Yannick Vermeiren, Martijn van Faassen, Claude van der Ley, Ido P Kema, Peter P De Dey. Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32130630. |
the dopaminergic commonalities observed in ftd and als might relate to a disturbance of dopaminergic nerve terminals in projection areas of the substantia nigra and/or ventral tegmental area, although these findings should first be confirmed in brain tissue. |
2021-01-29 |
2023-08-13 |
human |
| Kecheng Lei, Yijue Shen, Yijing He, Liwen Zhang, Jingxing Zhang, Weifang Tong, Yichun Xu, Lingjing Ji. Baicalin Represses C/EBP Oxidative medicine and cellular longevity. vol 2020. 2021-01-27. PMID:32566108. |
baicalin represses c/ebp parkinson's disease (pd) is a neurodegenerative disease characterized by the gradual loss of dopaminergic (da) neurons in the substantia nigra (sn) and the formation of intracellular lewy bodies (lb) in the brain, which aggregates |
2021-01-27 |
2023-08-13 |
Not clear |
| Chellappan Praveen Rajneesh, Jian-Chiun Liou, Tsung-Hsun Hsieh, Jia-Hong Lin, Chih-Wei Pen. The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections. PloS one. vol 15. issue 12. 2021-01-26. PMID:33270757. |
these significant changes in motor, behavioral, bladder function and ve were due to an extensive degeneration of dopaminergic neurons in the substantia nigra region on both sides of the brain. |
2021-01-26 |
2023-08-13 |
rat |
| Yuki Kishimoto, Wandi Zhu, Waki Hosoda, Jyoti M Sen, Mark P Mattso. Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31079293. |
levels of the dopaminergic neuron marker tyrosine hydroxylase in the striatum and numbers of dopaminergic neurons in the substantia nigra were reduced in pd mice with gut inflammation. |
2021-01-22 |
2023-08-13 |
mouse |
| Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrd. Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. NPJ Parkinson's disease. vol 7. issue 1. 2021-01-16. PMID:33398042. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor and non-motor symptoms and loss of dopaminergic neurons of the substantia nigra. |
2021-01-16 |
2023-08-13 |
Not clear |
| Bianca L B Marino, Lucilene R de Souza, Kessia P A Sousa, Jaderson V Ferreira, Elias C Padilha, Carlos H T P da Silva, Carlton A Taft, Lorane I S Hage-Meli. Parkinson's Disease: A Review from Pathophysiology to Treatment. Mini reviews in medicinal chemistry. vol 20. issue 9. 2021-01-15. PMID:31686637. |
pd is caused by the necrosis of dopaminergic neurons in the substantia nigra, which is the brain region responsible for the synthesis of the neurotransmitter dopamine (da), resulting in its decrease in the synaptic cleft. |
2021-01-15 |
2023-08-13 |
Not clear |
| Daisuke Taguchi, Ayuka Ehara, Taro Kadowaki, Shin-Ichi Sakakibara, Kazuhiko Nakadate, Koichi Hirata, Shuichi Ued. Minocycline Alleviates Cluster Formation of Activated Microglia and Age-dependent Dopaminergic Cell Death in the Substantia Nigra of Zitter Mutant Rat. Acta histochemica et cytochemica. vol 53. issue 6. 2021-01-14. PMID:33437100. |
minocycline alleviates cluster formation of activated microglia and age-dependent dopaminergic cell death in the substantia nigra of zitter mutant rat. |
2021-01-14 |
2023-08-13 |
rat |
| Fumiaki Yokoi, Janneth Oleas, Hong Xing, Yuning Liu, Kelly M Dexter, Carly Misztal, Melinda Gerard, Iakov Efimenko, Patrick Lynch, Matthew Villanueva, Raul Alsina, Shiv Krishnaswamy, David E Vaillancourt, Yuqing L. Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice. Neurobiology of disease. vol 134. 2021-01-13. PMID:31618684. |
the dyt1 d2ko mice also showed significant reductions of striatal d2r dimers and tyrosine hydroxylase without significant alteration in striatal monoamine contents or the number of dopaminergic neurons in the substantia nigra. |
2021-01-13 |
2023-08-13 |
mouse |
| Emily M Rocha, Briana R De Miranda, Sandra Castro, Robert Drolet, Nathan G Hatcher, Lihang Yao, Sean M Smith, Matthew T Keeney, Roberto Di Maio, Julia Kofler, Teresa G Hastings, J Timothy Greenamyr. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31618685. |
in ipd, dopaminergic neurons within the substantia nigra are characterized by increased lrrk2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesicles with incompletely degraded substrates, including α-synuclein. |
2021-01-13 |
2023-08-13 |
human |