| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mustafa Makav, Hüseyin Avni Eroğl. Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats. Environmental science and pollution research international. vol 28. issue 17. 2021-05-12. PMID:33410082. |
parkinson's disease (pd) is described as the loss of dopaminergic neurons located in the substantia nigra (sn) region of the brain and a progressive motor failure. |
2021-05-12 |
2023-08-13 |
rat |
| Sreus A G Naidu, Taylor C Wallace, Kelvin J A Davies, A Satyanarayan Naid. Lactoferrin for Mental Health: Neuro-Redox Regulation and Neuroprotective Effects across the Blood-Brain Barrier with Special Reference to Neuro-COVID-19. Journal of dietary supplements. 2021-05-12. PMID:33977807. |
lactoferrin, an innate metal-transport protein, synthesized in the substantia nigra, particularly in dopaminergic neurons and activated microglia is vital for brain physiology. |
2021-05-12 |
2023-08-13 |
Not clear |
| Min Kyung Song, Joo Hee Lee, Jinil Kim, Ji Hyun Kim, Soonhye Hwang, Yoon-Seong Kim, Youn-Jung Ki. Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model. Neuroscience letters. vol 740. 2021-05-07. PMID:33075422. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-05-07 |
2023-08-13 |
mouse |
| Thiago Hissnauer Leal Baltus, Nayara Rampazzo Morelli, Carine Coneglian de Farias, Kleber Paiva Trugilo, Nádia Calvo Martins Okuyama, Karen Brajão de Oliveira, Lucio Baena de Melo, Suhaila Mahmoud Smaili, Décio Sabbatini Barbos. Association of -94 ATTG insertion/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson's Disease. Neuroscience letters. vol 740. 2021-05-07. PMID:33161109. |
parkinson's disease (pd) is a complex neurodegenerative disorder, resulting dopaminergic neuronal cell death in the substantia nigra. |
2021-05-07 |
2023-08-13 |
human |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33911050. |
these pathological and inflammatory changes, including microglial activation and dopaminergic cell loss in the substantia nigra (sn) area were reversed by papaverine (pap) administration. |
2021-05-07 |
2023-08-13 |
mouse |
| Anupam Raina, Kristian Leite, Sofia Guerin, Sameehan U Mahajani, Kalyan S Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, Sebastian Kügle. Dopamine promotes the neurodegenerative potential of β-synuclein. Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:32730640. |
β-syn has long been considered to be an attenuator of the neurotoxic effects of α-syn, but in a rodent model of pd β-syn induced robust neurodegeneration in dopaminergic neurons of the substantia nigra. |
2021-05-04 |
2023-08-13 |
human |
| Rebekah C Evans, Emily L Twedell, Manhua Zhu, Jefferson Ascencio, Renshu Zhang, Zayd M Khali. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell reports. vol 32. issue 11. 2021-05-04. PMID:32937133. |
substantia nigra (snc) dopaminergic neurons respond to aversive stimuli with inhibitory pauses in firing followed by transient rebound activation. |
2021-05-04 |
2023-08-13 |
Not clear |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Protective effect of thioredoxin reductase 1 in Parkinson's disease. Neuroscience letters. vol 741. 2021-05-04. PMID:33171211. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-05-04 |
2023-08-13 |
mouse |
| Khairiah Razali, Noratikah Othman, Mohd Hamzah Mohd Nasir, Abd Almonem Doolaanea, Jaya Kumar, Wisam Nabeel Ibrahim, Norlinah Mohamed Ibrahim, Wael M Y Mohame. The Promise of the Zebrafish Model for Parkinson's Disease: Today's Science and Tomorrow's Treatment. Frontiers in genetics. vol 12. 2021-05-04. PMID:33936174. |
mptp is metabolized by monoamine oxidase b (mao b) to mpp + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. |
2021-05-04 |
2023-08-13 |
human |
| Mark F McCarty, Aaron Lerne. Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin. Advances in nutrition (Bethesda, Md.). vol 12. issue 2. 2021-05-03. PMID:32945884. |
mitochondrial dysfunction in dopaminergic neurons of the substantia nigra (sn) appears to be a key mediating feature of parkinson's disease (pd), a complex neurodegenerative disorder of still unknown etiology. |
2021-05-03 |
2023-08-13 |
Not clear |
| Sunita Chawla, Dnyaneshwar Kalyane, Vishakha Tambe, Pran Kishore Deb, Kiran Kalia, Rakesh K Tekad. Evolving nanoformulation strategies for diagnosis and clinical interventions for Parkinson's disease. Drug discovery today. vol 25. issue 2. 2021-04-30. PMID:31877354. |
parkinson's disease (pd) is the most common neurodegenerative disease and is associated with a loss of dopaminergic neurons in the substantia nigra. |
2021-04-30 |
2023-08-13 |
Not clear |
| Jianing Jin, Li Xue, Xinling Bai, Xiaona Zhang, Qingwu Tian, Anmu Xi. Association between epidermal growth factor receptor gene polymorphisms and susceptibility to Parkinson's disease. Neuroscience letters. vol 736. 2021-04-30. PMID:32712352. |
the progressive loss of dopaminergic neurons in the mesencephalic substantia nigra is recognized as an important pathological feature of parkinson's disease (pd). |
2021-04-30 |
2023-08-13 |
Not clear |
| Yuri Inose, Yasuhiko Izumi, Yuki Takada-Takatori, Akinori Akaike, Yutaka Koyama, Shuji Kaneko, Toshiaki Kum. Protective effects of Nrf2-ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1. Neuroscience letters. vol 736. 2021-04-30. PMID:32712353. |
parkinson disease (pd) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra, and oxidative stress is thought to contribute to this pathogenesis. |
2021-04-30 |
2023-08-13 |
mouse |
| Yang Xie, Shujiang Zhang, Zhiyu Lv, Ting Long, Ying Luo, Zuoxiao L. SOX21-AS1 modulates neuronal injury of MMP Neuroscience letters. vol 746. 2021-04-29. PMID:33421490. |
sox21-as1 modulates neuronal injury of mmp parkinson's disease (pd), caused by the decreased number of dopaminergic neurons in the substantia nigra, is identified as the second most familiar age-dependent neurodegenerative disease to the public. |
2021-04-29 |
2023-08-13 |
Not clear |
| Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarr. A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes. Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-04-28. PMID:33808343. |
parkinson's disease (pd) is a degenerative disorder of the nervous system due to unceasing impairment of dopaminergic neurons situated in the substantia nigra. |
2021-04-28 |
2023-08-13 |
human |
| Aditi Verma, Ajit Ray, Deepti Bapat, Latha Diwakar, Reddy Peera Kommaddi, Bernard L Schneider, Etienne C Hirsch, Vijayalakshmi Ravindranat. Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 10. 2021-04-27. PMID:32618039. |
glutaredoxin 1 downregulation in the substantia nigra leads to dopaminergic degeneration in mice. |
2021-04-27 |
2023-08-13 |
mouse |
| Yingchuan Chen, Guanyu Zhu, Defeng Liu, Xin Zhang, Yuye Liu, Tianshuo Yuan, Tingting Du, Jianguo Zhan. Subthalamic nucleus deep brain stimulation suppresses neuroinflammation by Fractalkine pathway in Parkinson's disease rat model. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32726685. |
we found that motor deficits were alleviated by stn-dbs, with increased survival of dopaminergic neurons in the substantia nigra (sn). |
2021-04-27 |
2023-08-13 |
rat |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
next, we found that acupuncture increased the levels of dopaminergic fibers and neurons in the striatum and the substantia nigra, respectively. |
2021-04-27 |
2023-08-13 |
mouse |
| Enrico Zampese, D James Surmeie. Calcium, Bioenergetics, and Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-27. PMID:32911641. |
degeneration of substantia nigra (sn) dopaminergic (daergic) neurons is responsible for the core motor deficits of parkinson's disease (pd). |
2021-04-27 |
2023-08-13 |
Not clear |
| David Devos, Etienne Hirsch, Richard Wys. Seven Solutions for Neuroprotection in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 2. 2021-04-27. PMID:33184908. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra and accumulation of iron and alpha-synuclein; it follows a characteristic pattern throughout the nervous system. |
2021-04-27 |
2023-08-13 |
Not clear |