| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maryam Bigham, Abbas Mohammadipour, Mahmoud Hosseini, Amir Mohammad Malvandi, Alireza Ebrahimzadeh-Bideska. Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson's disease: motor and non-motor outcomes. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33656625. |
neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of parkinson's disease: motor and non-motor outcomes. |
2021-06-22 |
2023-08-13 |
rat |
| Elena Ferrari, Antonella Cardinale, Barbara Picconi, Fabrizio Gardon. From cell lines to pluripotent stem cells for modelling Parkinson's Disease. Journal of neuroscience methods. vol 340. 2021-06-21. PMID:32311374. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by loss of dopaminergic (daergic) neurons in the substantia nigra (sn) that contributes to the main motor symptoms of the disease. |
2021-06-21 |
2023-08-13 |
mouse |
| Muqddas Tariq, Hao Liu, David P Ibañez, Yunpan Li, Shuhan Chen, Mengling Jiang, Wenxia Fan, Ping Zhao, Zhiwei Luo, Dongye Wang, Shahzina Kanwa. Generation of three induced pluripotent stem cell lines from a Parkinson's disease patient with mutant PARKIN (p. C253Y). Stem cell research. vol 45. 2021-06-21. PMID:32387897. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by the progressive degeneration of dopaminergic (da) neurons in the substantia nigra. |
2021-06-21 |
2023-08-13 |
Not clear |
| Hossein Khaleghzadeh-Ahangar, Mina Rashvand, Abbas Haghparas. Role of D1- and D2-like dopamine receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of acute pain. Physiology & behavior. vol 229. 2021-06-21. PMID:33091437. |
for this purpose, the hf receives dopaminergic inputs originated from the substantia nigra and the ventral tegmental area. |
2021-06-21 |
2023-08-13 |
rat |
| Danielle Walu Kasongo, Gioacchino de Leo, Nunzio Vicario, Giampiero Leanza, Giuseppe Legnam. Chronic α-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393581. |
no pathologic α-syn deposits were found within the substantia nigra (sn), the ventral tegmental area (vta), or the striatum, nor was any loss of dopaminergic, noradrenergic, or cholinergic neurons detected in α-syn-injected animals, compared with controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Dinesh Kumar Verma, Anurupa Ghosh, Lindsey Ruggiero, Etienne Cartier, Eric Janezic, Dionne Williams, Eui-Gil Jung, Michael Moore, Jong Bok Seo, Yong-Hwan Ki. The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models. eNeuro. vol 7. issue 5. 2021-06-18. PMID:32887693. |
in immunohistochemistry, dopaminergic axon tips in the striatum and cell bodies in the substantia nigra from ubc9-overexpressing transgenic mice were protected from mptp toxicities compared with wild-type (wt) siblings. |
2021-06-18 |
2023-08-13 |
mouse |
| Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chan. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33248265. |
in contrast to the predicted neuroprotective role of nrf2 in oxidative stress-related diseases, we found that nrf2 ko remarkably improved the motor coordination of aged mice, which was associated with the reduced ros level and decreased apoptosis of dopaminergic neurons in substantia nigra (sn) of 18-month-old nrf2 ko mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Briana R De Miranda, Emily M Rocha, Sandra L Castro, J Timothy Greenamyr. Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-18. PMID:33293540. |
dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesized to be an early and fundamental pathogenic mechanism in parkinson's disease (pd). |
2021-06-18 |
2023-08-13 |
human |
| Briana R De Miranda, Emily M Rocha, Sandra L Castro, J Timothy Greenamyr. Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-18. PMID:33293540. |
to this end, we established an exogenous co-expression system, utilizing aav2 vectors to overexpress human α-synuclein and tom20, individually or together, in the adult lewis rat substantia nigra to assess whether tom20 overexpression attenuates α-synuclein-induced dopaminergic neurodegeneration. |
2021-06-18 |
2023-08-13 |
human |
| Jing Liu, Fei Xu, Zhiyan Nie, Lei Sha. Gut Microbiota Approach-A New Strategy to Treat Parkinson's Disease. Frontiers in cellular and infection microbiology. vol 10. 2021-06-17. PMID:33194809. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by neuronal loss and dysfunction of dopaminergic neurons located in the substantia nigra, which contain a variety of misfolded α-synuclein (α-syn). |
2021-06-17 |
2023-08-13 |
Not clear |
| Vladislav A Petyuk, Lei Yu, Heather M Olson, Fengchao Yu, Geremy Clair, Wei-Jun Qian, Joshua M Shulman, David A Bennet. Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss. Journal of proteome research. vol 20. issue 5. 2021-06-17. PMID:33900085. |
proteomic profiling of the substantia nigra to identify determinants of lewy body pathology and dopaminergic neuronal loss. |
2021-06-17 |
2023-08-13 |
human |
| Victoria Sofie Witzig, Daniel Komnig, Björn H Falkenburge. Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible. Cells. vol 9. issue 11. 2021-06-16. PMID:33182316. |
the classical motor symptoms of parkinson's disease (pd) are caused by degeneration of dopaminergic neurons in the substantia nigra, which is followed by secondary dendritic pruning and spine loss at striatal medium spiny neurons (msn). |
2021-06-16 |
2023-08-13 |
mouse |
| Victoria Sofie Witzig, Daniel Komnig, Björn H Falkenburge. Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible. Cells. vol 9. issue 11. 2021-06-16. PMID:33182316. |
degeneration of dopaminergic neurons was confirmed by counting th-positive neurons in the substantia nigra and by analyzing striatal catecholamines. |
2021-06-16 |
2023-08-13 |
mouse |
| Laurence Lemelle, Alexandre Simionovici, Philippe Colin, Graham Knott, Sylvain Bohic, Peter Cloetens, Bernard L Schneide. Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson's disease. Communications biology. vol 3. issue 1. 2021-06-15. PMID:32647232. |
elemental composition of different organelles is compared to cytoplasmic and nuclear compartments in dopaminergic neurons of rat substantia nigra. |
2021-06-15 |
2023-08-13 |
rat |
| Marie-Amandine Bonte, Fatima El Idrissi, Bernard Gressier, David Devos, Karim Belarb. Protein network exploration prioritizes targets for modulating neuroinflammation in Parkinson's disease. International immunopharmacology. vol 95. 2021-06-15. PMID:33756233. |
parkinson's disease is a progressive neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. |
2021-06-15 |
2023-08-13 |
Not clear |
| Adina N MacMahon Copas, Sarah F McComish, Jean M Fletcher, Maeve A Caldwel. The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes? Frontiers in neurology. vol 12. 2021-06-15. PMID:34122308. |
these cells infiltrate the cns, and accumulate in the substantia nigra, where they secrete pro-inflammatory cytokines, stimulate surrounding immune cells, and induce dopaminergic neuronal cell death. |
2021-06-15 |
2023-08-13 |
Not clear |
| Jeswinder Sian-Hulsmann, Peter Riedere. The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 5. 2021-06-14. PMID:32318880. |
in addition, loss of energy supply may contribute to the alteration in activity of enzymes involved in the mitochondrial respiratory chain and would, therefore, confer a vulnerability to the dopaminergic neurons in the substantia nigra. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ting Sun, Zhe-Xu Ding, Xin Luo, Qing-Shan Liu, Yong Chen. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2020. 2021-06-08. PMID:33294121. |
results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of pd model mice was rescued by the exosome treatment. |
2021-06-08 |
2023-08-13 |
mouse |
| Lorena Jiménez-Sánchez, Javier Blesa, Natalia L Del Rey, Mariana H G Monje, José A Obeso, Carmen Cavad. Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease. Neuropharmacology. vol 170. 2021-06-03. PMID:31589886. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra and dopamine depletion in the striatum. |
2021-06-03 |
2023-08-13 |
monkey |
| Luis O Soto-Rojas, Irma A Martínez-Dávila, Claudia Luna-Herrera, María E Gutierrez-Castillo, Francisco E Lopez-Salas, Bismark Gatica-Garcia, Guadalupe Soto-Rodriguez, María Elena Bringas Tobon, Gonzalo Flores, America Padilla-Viveros, Cecilia Bañuelos, Víctor Manuel Blanco-Alvarez, José Dávila-Ayala, David Reyes-Corona, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-López, Daniel Martinez-Fon. Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32321590. |
in the injured substantia nigra, bssg caused a progressive α-synuclein aggregation and dopaminergic neurodegeneration caused by senescence and apoptosis. |
2021-05-31 |
2023-08-13 |
rat |