| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oeystein R Brekk, Joanna A Korecka, Cecile C Crapart, Mylene Huebecker, Zachary K MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A Priestman, Frances M Platt, Ole Isacson, Penelope J Hallet. Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32762772. |
in a neurodegenerative model of overexpression of asyn in rats, increasing hex activity by aav6 gene transfer in the substantia nigra reduced asyn embedding in lipid compartments and rescued dopaminergic neurons from degeneration. |
2021-05-31 |
2023-08-13 |
mouse |
| Hyongjun Jeon, Chang-Hwan Bae, Yukyoung Lee, Hee-Young Kim, Seungtae Ki. Korean red ginseng suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced inflammation in the substantia nigra and colon. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33662500. |
parkinson's disease (pd) is a neurodegenerative disease involving dopaminergic neuronal death in the substantia nigra (sn); recent studies have shown that interactions between gut and brain play a critical role in the pathogenesis of pd. |
2021-05-28 |
2023-08-13 |
mouse |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
the results confirm that the unilateral injection of fipronil into the substantia nigra caused the degeneration of nigrostriatal dopaminergic neurons, which leads to a decrease around 50 % in striatal dopamine content and substantia nigra th imunoreactivity. |
2021-05-20 |
2023-08-13 |
rat |
| Aida Zulueta, Alessandra Mingione, Paola Signorelli, Anna Caretti, Riccardo Ghidoni, Marco Trincher. Simple and Complex Sugars in Parkinson's Disease: a Bittersweet Taste. Molecular neurobiology. vol 57. issue 7. 2021-05-19. PMID:32430844. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor and non-motor symptoms associated with the loss of dopaminergic neurons in the pars compacta of the substantia nigra. |
2021-05-19 |
2023-08-13 |
Not clear |
| Amira Mohammed Ali, Hiroshi Kunug. Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly. Oxidative medicine and cellular longevity. vol 2020. 2021-05-19. PMID:33123309. |
pd is a widespread disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra, which encompasses a wide range of debilitating motor, emotional, cognitive, and physical symptoms. |
2021-05-19 |
2023-08-13 |
bee |
| Tiago F Outeiro, Peter Heutink, Erwan Bezard, Angela M Cenc. From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 4. 2021-05-19. PMID:33200446. |
parkinson's disease (pd) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. |
2021-05-19 |
2023-08-13 |
Not clear |
| Patricia García-Sanz, Johannes M F G Aerts, Rosario Moratall. The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 5. 2021-05-19. PMID:33219714. |
parkinson's disease (pd) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. |
2021-05-19 |
2023-08-13 |
Not clear |
| Jinghua Piao, Susan Zabierowski, Brittany N Dubose, Ellen J Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Taba. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell stem cell. vol 28. issue 2. 2021-05-19. PMID:33545080. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra leading to disabling deficits. |
2021-05-19 |
2023-08-13 |
mouse |
| Huiqing Wang, Shanshan Dou, Junge Zhu, Ziqi Shao, Chunmei Wang, Xudong Xu, Baohua Chen. Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway. Neuropeptides. vol 87. 2021-05-18. PMID:33639357. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra and the deposition of lewy bodies. |
2021-05-18 |
2023-08-13 |
Not clear |
| Yong Hui Nies, Nor Haliza Mohamad Najib, Wei Ling Lim, Mohd Amir Kamaruzzaman, Mohamad Fairuz Yahaya, Seong Lin Teo. MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994934. |
in pd patients, it was found that striatal brain tissue and dopaminergic neurons from the substantia nigra demonstrated dysregulated mirnas expression profiles. |
2021-05-18 |
2023-08-13 |
Not clear |
| Li-Mei Song, Zhi-Xin Xiao, Na Zhang, Xiao-Qi Yu, Wei Cui, Jun-Xia Xie, Hua-Min X. Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis. iScience. vol 24. issue 5. 2021-05-18. PMID:33997705. |
results showed that apoferritin remarkably improved mptp-induced motor deficits by rescuing dopaminergic neurodegeneration in the substantia nigra. |
2021-05-18 |
2023-08-13 |
mouse |
| José Fidel Baizabal-Carvallo, Marlene Alonso-Juare. The Link between Gut Dysbiosis and Neuroinflammation in Parkinson's Disease. Neuroscience. vol 432. 2021-05-14. PMID:32112917. |
despite its high frequency the etiology is still unclear; several lines of evidence show that an inflammatory process is implicated in the pathogenesis of this disorder; where activation of brain microglia plays a central role in the damage of dopaminergic neurons of the substantia nigra. |
2021-05-14 |
2023-08-13 |
Not clear |
| Irene Fasciani, Francesco Petragnano, Gabriella Aloisi, Francesco Marampon, Mario Rossi, Maria Francesca Coppolino, Rodolfo Rossi, Biancamaria Longoni, Marco Scarselli, Roberto Maggi. A New Threat to Dopamine Neurons: The Downside of Artificial Light. Neuroscience. vol 432. 2021-05-14. PMID:32142863. |
despite, a large number of studies in rodent and monkey models of parkinson's disease have reported that near infrared light has neuroprotective effects on dopaminergic neurons, recent findings have shown that prolonged exposure of rodents and birds to fluorescent artificial light results in an increase of neuromelanin granules in substantia nigra and loss of dopaminergic neurons. |
2021-05-14 |
2023-08-13 |
human |
| Rose B Creed, Matthew S Goldber. Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils. Neuroscience. vol 437. 2021-05-14. PMID:32353461. |
the main neuropathological hallmarks of parkinson's disease (pd) are loss of dopaminergic neurons in the substantia nigra and intraneuronal protein aggregates immunoreactive for α-synuclein phosphorylated at serine 129 (ps129). |
2021-05-14 |
2023-08-13 |
mouse |
| Rose B Creed, Matthew S Goldber. Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils. Neuroscience. vol 437. 2021-05-14. PMID:32353461. |
four weeks post-injection, pffs caused significant loss of dopaminergic neurons in the substantia nigra of pink1 ko rats, but not wt controls. |
2021-05-14 |
2023-08-13 |
mouse |
| Nian-Ting Yao, Qian Zheng, Zi-Qian Xu, Jian-Hong Yin, Lin-Guang Lu, Qi Zuo, Su Yang, Chun-Lin Zhang, Ling Jia. Positron emission computed tomography/single photon emission computed tomography in Parkinson disease. Chinese medical journal. vol 133. issue 12. 2021-05-14. PMID:32404694. |
its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a lewy body, leading to a decreased dopamine level. |
2021-05-14 |
2023-08-13 |
Not clear |
| Abir A Rahman, Alejandro Soto-Avellaneda, Hyun Yong Jin, Iva Stojkovska, Nathan K Lai, Joshua E Albright, Abby R Webb, Emily Oe, Jacob P Valarde, Alexandra E Oxford, Paige E Urquhart, Brandon Wagner, Connor Brown, Isabella Amado, Peyton Vasquez, Nicholas Lehning, Veselin Grozdanov, Xinzhu Pu, Karin M Danzer, Brad E Morriso. Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N. Neuroscience. vol 441. 2021-05-14. PMID:32540366. |
the motor features of parkinson's disease (pd) result from the loss of dopaminergic (da) neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Li Liu, Mingchao Li, Mingze Xu, Zhen Wang, Zhi Zeng, Yunqing Li, Yi Zhang, Rong You, Chu-Hua Li, Yan-Qing Gua. Actively targeted gold nanoparticle composites improve behavior and cognitive impairment in Parkinson's disease mice. Materials science & engineering. C, Materials for biological applications. vol 114. 2021-05-14. PMID:32994016. |
parkinson's disease (pd) is characterized by motor and non-motor symptoms, primarily affecting dopaminergic neurons (daergic neurons) in substantia nigra (sn). |
2021-05-14 |
2023-08-13 |
mouse |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Tamara Kobiec, Matilde Otero-Losada, Guenson Chevalier, Lucas Udovin, Sofía Bordet, Camila Menéndez-Maissonave, Francisco Capani, Santiago Pérez-Llore. The Renin-Angiotensin System Modulates Dopaminergic Neurotransmission: A New Player on the Scene. Frontiers in synaptic neuroscience. vol 13. 2021-05-13. PMID:33967734. |
a progressive loss of dopaminergic neurons in the substantia nigra late in the neurodegeneration leads to developing motor symptoms like bradykinesia, tremor, and rigidity. |
2021-05-13 |
2023-08-13 |
Not clear |