| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucia M Wagner, Sheyna M Nathwani, Patrick P Ten Eyck, Georgina M Aldridg. Local cortical overexpression of human wild-type alpha-synuclein leads to increased dendritic spine density in mouse. Neuroscience letters. vol 733. 2021-04-26. PMID:32417387. |
these aggregates are thought to cause the death of dopaminergic neurons in the substantia nigra and other vulnerable cell types in patients, leading to parkinsonism. |
2021-04-26 |
2023-08-13 |
mouse |
| Lucia M Wagner, Sheyna M Nathwani, Patrick P Ten Eyck, Georgina M Aldridg. Local cortical overexpression of human wild-type alpha-synuclein leads to increased dendritic spine density in mouse. Neuroscience letters. vol 733. 2021-04-26. PMID:32417387. |
there is evidence from mice that localized overexpression of wild-type α-syn leads to dopaminergic cell death in the substantia nigra. |
2021-04-26 |
2023-08-13 |
mouse |
| Rixin Luo, Lihong Zhu, Zhaohao Zeng, Ruiyi Zhou, Jiawei Zhang, Shu Xiao, Wei B. Dl-butylphthalide inhibits rotenone-induced oxidative stress in microglia via regulation of the Keap1/Nrf2/HO-1 signaling pathway. Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-24. PMID:33884035. |
activated microglia are a source of superoxide which often increases oxidative stress in the brain microenvironment, increase production of reactive oxygen species (ros) and directly or indirectly lead to dopaminergic neuronal death in the substantia nigra. |
2021-04-24 |
2023-08-13 |
Not clear |
| Anastasiia Bohush, Wiesława Leśniak, Serge Weis, Anna Filipe. Calmodulin and Its Binding Proteins in Parkinson's Disease. International journal of molecular sciences. vol 22. issue 6. 2021-04-23. PMID:33809535. |
at the microscopic level it is characterized by formation of specific intraneuronal inclusions, called lewy bodies (lbs), and by a progressive loss of dopaminergic neurons in the striatum and substantia nigra. |
2021-04-23 |
2023-08-13 |
Not clear |
| Banabihari Giri, Marissa Seamon, Aditi Banerjee, Sneha Chauhan, Sharad Purohit, John Morgan, Babak Baban, Chandramohan Wakad. Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease. Metabolic brain disease. 2021-04-21. PMID:33881722. |
the loss of dopaminergic neurons in the substantia nigra, which leads to the motor symptoms seen in pd, is associated with the deposition of aggregated, misfolded α-synuclein (α-syn, snca) proteins forming lewy bodies. |
2021-04-21 |
2023-08-13 |
human |
| Leah Mursaleen, Satyanarayana Somavarapu, Mohammed Gulrez Zariwal. Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity. Journal of Parkinson's disease. vol 10. issue 1. 2021-04-19. PMID:31868679. |
reduced glutathione and excess free iron within dopaminergic, substantia nigra neurons in parkinson's disease (pd) can drive accumulation of toxic hydroxyl radicals resulting in sustained oxidative stress and cellular damage. |
2021-04-19 |
2023-08-13 |
Not clear |
| Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeon. Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells. International journal of molecular sciences. vol 22. issue 5. 2021-04-16. PMID:33652595. |
parkinson's disease (pd) is an age-related neurodegenerative disease (ndd) characterized by the degenerative loss of dopaminergic neurons in the substantia nigra along with aggregation of α-synuclein (α-syn). |
2021-04-16 |
2023-08-13 |
human |
| Yingzhuo Ding, Yan Li, Gaurav Chhetri, Xiaoxin Peng, Jing Wu, Zejian Wang, Bo Zhao, Wenjuan Zhao, Xueyi L. Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread. Cells. vol 10. issue 4. 2021-04-16. PMID:33800686. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder, characterized by progressive loss of dopaminergic neurons in the substantia nigra, intraneuronal deposition of misfolded proteins known as lewy bodies, and chronic neuroinflammation. |
2021-04-16 |
2023-08-13 |
Not clear |
| Yumin Zheng, Li Dong, Na Liu, Xiaoguang Luo, Zhiyi H. Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. BioMed research international. vol 2020. 2021-04-15. PMID:33204711. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons in the substantia nigra. |
2021-04-15 |
2023-08-13 |
Not clear |
| Helena Xicoy, Jos F Brouwers, Bé Wieringa, Gerard J M Marten. Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-12. PMID:32858884. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons from the substantia nigra (sn) that project to the dorsal striatum (caudate-putamen). |
2021-04-12 |
2023-08-13 |
Not clear |
| Tingting Du, Le Wang, Weijin Liu, Guanyu Zhu, Yingchuan Chen, Jianguo Zhan. Biomarkers and the Role of α-Synuclein in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-04-10. PMID:33833675. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-syn)-rich lewy bodies (lbs) and the preferential loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta (snpc). |
2021-04-10 |
2023-08-13 |
Not clear |
| Natalie Landeck, Melissa Conti Mazza, Megan Duffy, Christopher Bishop, Caryl E Sortwell, Mark R Cookso. Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease. Journal of visualized experiments : JoVE. issue 168. 2021-04-09. PMID:33682858. |
parkinson's disease (pd) is a progressive disorder traditionally defined by resting tremor and akinesia, primarily due to loss of dopaminergic neurons in the substantia nigra. |
2021-04-09 |
2023-08-13 |
Not clear |
| Peipei Mu, Yuting Liu, Shimin Jiang, Jin Gao, Shen Sun, Li Li, Dianshuai Ga. Glial cell line-derived neurotrophic factor alters lipid composition and protein distribution in MPP+-injured differentiated SH-SY5Y cells. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32356318. |
parkinson's disease (pd) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra and striatum. |
2021-04-06 |
2023-08-13 |
Not clear |
| Ka Young Kim, Keun-A Chan. Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-06. PMID:33440873. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. |
2021-04-06 |
2023-08-13 |
mouse |
| Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mende. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. Neuropharmacology. vol 166. 2021-04-02. PMID:31870855. |
blockade of the dopaminergic neurotransmission with ampt and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. |
2021-04-02 |
2023-08-13 |
Not clear |
| Abbas Mohammadipour, Hossein Haghir, Alireza Ebrahimzadeh Bideska. A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful? Reviews on environmental health. vol 35. issue 4. 2021-03-30. PMID:32681785. |
they can damage neurons, in particular dopaminergic neurons in the substantia nigra (sn) and striatal neurons which their lesion is associated with parkinson's disease (pd). |
2021-03-30 |
2023-08-13 |
Not clear |
| Hideki Mochizuki, Chi-Jing Choong, Kousuke Bab. Parkinson's disease and iron. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 2. 2021-03-26. PMID:32025811. |
the substantia nigra of pd patients, where the selective loss of dopaminergic neurons occurs, show a fairly selective and significant elevation in iron contents. |
2021-03-26 |
2023-08-13 |
Not clear |
| Weixing Xu, Yinxi Wang, Huihui Quan, Dan Liu, Huifeng Zhang, Yuze Qi, Qingru Li, Jieying Liao, Hui-Ming Gao, Hui Zhou, Jing Huan. Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-26. PMID:33046245. |
double-stranded rna-induced dopaminergic neuronal loss in the substantia nigra in the presence of mac1 receptor. |
2021-03-26 |
2023-08-13 |
Not clear |
| Hyunjun Park, Keun-A Chan. Therapeutic Potential of Repeated Intravenous Transplantation of Human Adipose-Derived Stem Cells in Subchronic MPTP-Induced Parkinson's Disease Mouse Model. International journal of molecular sciences. vol 21. issue 21. 2021-03-26. PMID:33143234. |
parkinson's disease (pd) is the second most common neurodegenerative disease, which is clinically and pathologically characterized by motor dysfunction and the loss of dopaminergic neurons in the substantia nigra, respectively. |
2021-03-26 |
2023-08-13 |
mouse |
| Yong Wang, Qian Wang, Ruobing Yu, Qi Zhang, Zhonghai Zhang, Haiying Li, Chao Ren, Rongli Yang, Haichen Ni. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging. vol 12. issue 14. 2021-03-24. PMID:32706757. |
the mαsyn expression leads to the loss of dopaminergic neurons in the substantia nigra (sn) and consequent motor dysfunctions. |
2021-03-24 |
2023-08-13 |
human |