| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleanor Sinclair, Drupad K Trivedi, Depanjan Sarkar, Caitlin Walton-Doyle, Joy Milne, Tilo Kunath, Anouk M Rijs, Rob M A de Bie, Royston Goodacre, Monty Silverdale, Perdita Barra. Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease. Nature communications. vol 12. issue 1. 2021-03-24. PMID:33707447. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. |
2021-03-24 |
2023-08-13 |
human |
| Darren M O'Hara, Minesh Kapadia, Susan Ping, Suneil K Kalia, Lorraine V Kali. Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis. Journal of visualized experiments : JoVE. issue 168. 2021-03-22. PMID:33616088. |
estimation of the number of dopaminergic neurons in the substantia nigra is a key method in pre-clinical parkinson's disease research. |
2021-03-22 |
2023-08-13 |
rat |
| Helena Xicoy, Cornelius Jhm Klemann, Ward De Witte, Marijn B Martens, Gerard Jm Martens, Geert Poelman. Shared genetic etiology between Parkinson's disease and blood levels of specific lipids. NPJ Parkinson's disease. vol 7. issue 1. 2021-03-20. PMID:33674605. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra and the formation of lewy bodies. |
2021-03-20 |
2023-08-13 |
Not clear |
| Margaux Teil, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, Benjamin Deha. Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32138193. |
parkinson's disease (pd) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called lewy bodies. |
2021-03-18 |
2023-08-13 |
Not clear |
| Ryo Kikuoka, Ikuko Miyazaki, Natsuki Kubota, Megumi Maeda, Daiki Kagawa, Masaaki Moriyama, Asuka Sato, Shinki Murakami, Yoshihisa Kitamura, Toshiaki Sendo, Masato Asanum. Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection. Scientific reports. vol 10. issue 1. 2021-03-18. PMID:33244123. |
mirtazapine administration attenuated the loss of dopaminergic neurons in the substantia nigra and increased the expression of the antioxidative molecule metallothionein (mt) in the striatal astrocytes of 6-hydroxydopamine (6-ohda)-injected parkinsonian mice via 5-ht1a receptors. |
2021-03-18 |
2023-08-13 |
mouse |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Mohamed A Eldeeb, Mohamed A Raghe. N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase. Current genetics. vol 66. issue 4. 2021-03-11. PMID:32157382. |
parkinson's disease (pd) is a progressive neurodegenerative condition characterized by a gradual loss of a specific group of dopaminergic neurons in the substantia nigra. |
2021-03-11 |
2023-08-13 |
Not clear |
| Violina Kakoty, Sarathlal K C, Ruei-Dun Tang, Chih Hao Yang, Sunil Kumar Dubey, Rajeev Taliya. Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361164. |
the predominant pathological hallmark is progressive loss of dopaminergic (da) neurones in the substantia nigra (sn) complicated by aggregation of misfolded forms of alpha-synuclein (α-syn). |
2021-03-11 |
2023-08-13 |
Not clear |
| Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zh. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in International journal of molecular medicine. vol 47. issue 4. 2021-03-10. PMID:33649797. |
mir‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-10 |
2023-08-13 |
Not clear |
| Edward Pajarillo, James Johnson, Asha Rizor, Ivan Nyarko-Danquah, Getinet Adinew, Julia Bornhorst, Michael Stiboller, Tania Schwerdtle, Deok-Soo Son, Michael Aschner, Eunsook Le. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. The Journal of biological chemistry. vol 295. issue 46. 2021-03-09. PMID:32893191. |
astrocyte-specific deletion of the transcription factor yin yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. |
2021-03-09 |
2023-08-13 |
Not clear |
| Yi Li, Ning Chen, Chao Wu, Yongquan Lu, Ge Gao, Chunli Duan, Hui Yang, Lingling L. Galectin-1 attenuates neurodegeneration in Parkinson's disease model by modulating microglial MAPK/IκB/NFκB axis through its carbohydrate-recognition domain. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31669519. |
and prevented the degeneration of dopaminergic neurons in the substantia nigra. |
2021-03-08 |
2023-08-13 |
mouse |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-08 |
2023-08-13 |
Not clear |
| Luiz Alexandre Viana Magno, Mélcar Collodetti, Helia Tenza-Ferrer, Marco Aurélio Romano-Silv. Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson's Disease. Bio-protocol. vol 9. issue 16. 2021-03-05. PMID:33654842. |
parkinson's disease is a progressive neurodegenerative movement disorder that happens due to the loss of dopaminergic neurons in the substantia nigra. |
2021-03-05 |
2023-08-13 |
mouse |
| Marta Pajares, Ana I Rojo, Gina Manda, Lisardo Boscá, Antonio Cuadrad. Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications. Cells. vol 9. issue 7. 2021-03-04. PMID:32674367. |
parkinson's disease (pd) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra |
2021-03-04 |
2023-08-13 |
Not clear |
| b' Jordi Galiano-Landeira, Albert Torra, Miquel Vila, Jordi Bov\\xc3\\xa. CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson\'s disease. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33118032.' |
in the earliest stage of the disease, when substantia nigra α-synuclein aggregation is absent, we found a robust cd8 t cell infiltration and no dopaminergic neuronal death yet. |
2021-03-01 |
2023-08-13 |
human |
| Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhan. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 Aging. vol 12. issue 9. 2021-02-25. PMID:32396526. |
hotair drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of parkinson's disease by elevating nptx2 parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive cell loss, largely confined to mesencephalic dopamine neurons of the substantia nigra. |
2021-02-25 |
2023-08-13 |
mouse |
| Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chan. Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability. Cells. vol 9. issue 5. 2021-02-24. PMID:32429337. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective dopaminergic (daergic) neuronal degeneration in the substantia nigra (sn) and proteinaceous α-synuclein-positive lewy bodies and lewy neuritis. |
2021-02-24 |
2023-08-13 |
mouse |
| Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, Dong-Kug Choi, In-Su Ki. GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell. International journal of molecular sciences. vol 21. issue 20. 2021-02-24. PMID:33053856. |
in parkinson's disease, mitochondrial oxidative stress-mediated apoptosis is a major cause of dopaminergic neuronal loss in the substantia nigra (sn). |
2021-02-24 |
2023-08-13 |
Not clear |
| Yanyan Zhang, Jie Li, Xiao Zhang, Dongdong Song, Tian Tia. Advances of Mechanisms-Related Metabolomics in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-02-23. PMID:33613180. |
parkinson's disease (pd) is a multifactorial disorder characterized by progressively debilitating dopaminergic neurodegeneration in the substantia nigra and the striatum, along with various metabolic dysfunctions and molecular abnormalities. |
2021-02-23 |
2023-08-13 |
human |
| Takeya Kitta, Mifuka Ouchi, Hiroki Chiba, Madoka Higuchi, Mio Togo, Yui Abe-Takahashi, Naohisa Kusakabe, Nobuo Shinohar. Animal Model for Lower Urinary Tract Dysfunction in Parkinson's Disease. International journal of molecular sciences. vol 21. issue 18. 2021-02-22. PMID:32906613. |
although parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, various non-motor symptoms often precede these other symptoms. |
2021-02-22 |
2023-08-13 |
Not clear |