| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhiro Nakata, Atsuko Sakamoto, Akihiro Kawat. Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease. Neuroradiology. vol 62. issue 11. 2021-07-07. PMID:32556403. |
pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (sn) pars compacta in mjd/sca3 patients. |
2021-07-07 |
2023-08-13 |
Not clear |
| Efthalia Angelopoulou, Yam Nath Paudel, Christina Piper. Role of Liver Growth Factor (LGF) in Parkinson's Disease: Molecular Insights and Therapeutic Opportunities. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33608826. |
accumulating evidence suggests that intracerebral and peripheral administration of lgf can enhance the outgrowth of nigrostriatal dopaminergic axonal terminals; promote the survival, migration, and differentiation of neuronal stem cells; and partially protect against dopaminergic neuronal loss in the substantia nigra of pd animal models. |
2021-07-06 |
2023-08-13 |
Not clear |
| Susan R Goulding, Martin Lévesque, Aideen M Sullivan, Louise M Collins, Gerard W O'Keeff. Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33713017. |
bmp2 is a neurotrophic factor that is expressed in the human substantia nigra; exogenous bmp2 administration protects against dopaminergic degeneration in in vitro models of pd. |
2021-07-06 |
2023-08-13 |
human |
| Thai Q Tran, Chrissa Kiouss. Pitx genes in development and disease. Cellular and molecular life sciences : CMLS. vol 78. issue 11. 2021-07-06. PMID:33844046. |
pitx3 is essential for lens development and migration and survival of the dopaminergic neurons of the substantia nigra. |
2021-07-06 |
2023-08-13 |
mouse |
| Zhuangzhuang Xiao, Tong Lei, Yanyan Liu, Yanjie Yang, Wangyu Bi, Hongwu D. The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson's disease. Stem cell research & therapy. vol 12. issue 1. 2021-07-05. PMID:33407864. |
parkinson's disease (pd), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (daergic) neurons in the substantia nigra resulting in a series of motor or non-motor disorders. |
2021-07-05 |
2023-08-13 |
human |
| Paola Feraco, Cesare Gagliardo, Giuseppe La Tona, Eleonora Bruno, Costanza D'angelo, Maurizio Marrale, Anna Del Poggio, Maria Chiara Malaguti, Laura Geraci, Roberta Baschi, Benedetto Petralia, Massimo Midiri, Roberto Monaster. Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review. Brain sciences. vol 11. issue 6. 2021-07-05. PMID:34207681. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, characterized by motor and non-motor symptoms due to the degeneration of the pars compacta of the substantia nigra (snc) with dopaminergic denervation of the striatum. |
2021-07-05 |
2023-08-13 |
Not clear |
| Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalo. Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease. Neural regeneration research. vol 16. issue 6. 2021-07-03. PMID:33269756. |
although no effect was noticed in the amphetamine-induced rotation test, our data has shown that the pha/pre treatment induced partial protection of the dopaminergic neurons (15-20%), assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra. |
2021-07-03 |
2023-08-13 |
rat |
| Han Deng, Shang Liu, Dong Pan, Yi Jia, Ze-Gang M. Myricetin reduces cytotoxicity by suppressing hepcidin expression in MES23.5 cells. Neural regeneration research. vol 16. issue 6. 2021-07-03. PMID:33269757. |
multiple studies implicate iron accumulation in the substantia nigra in the degeneration of dopaminergic neurons in parkinson's disease. |
2021-07-03 |
2023-08-13 |
Not clear |
| Zhao-Ji Chen, Cheng-Yu Liang, Li-Qing Yang, Si-Min Ren, Yan-Min Xia, Lei Cui, Xiao-Fang Li, Bu-Lang Ga. Association of Parkinson's Disease With Microbes and Microbiological Therapy. Frontiers in cellular and infection microbiology. vol 11. 2021-07-02. PMID:33763383. |
the main pathological changes of pd are damage of dopaminergic neurons in substantia nigra of the central nervous system and formation of lewy bodies. |
2021-07-02 |
2023-08-13 |
Not clear |
| Nailyam Nasirova, Lely A Quina, Shoshana Novik, Eric E Turne. Genetically Targeted Connectivity Tracing Excludes Dopaminergic Inputs to the Interpeduncular Nucleus from the Ventral Tegmentum and Substantia Nigra. eNeuro. vol 8. issue 3. 2021-07-02. PMID:34088738. |
genetically targeted connectivity tracing excludes dopaminergic inputs to the interpeduncular nucleus from the ventral tegmentum and substantia nigra. |
2021-07-02 |
2023-08-13 |
Not clear |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
the current medications provide symptomatic relief but do not stimulate the production of new dopaminergic neurons in the substantia nigra. |
2021-07-02 |
2023-08-13 |
mouse |
| Zhuang-Yao D Wei, Ashok K Shett. Treating Parkinson's disease by astrocyte reprogramming: Progress and challenges. Science advances. vol 7. issue 26. 2021-07-02. PMID:34162545. |
such in vivo astrocyte reprogramming in the mouse model of pd has successfully added new dopaminergic neurons to the substantia nigra and increased dopamine levels associated with axonal projections into the striatum. |
2021-07-02 |
2023-08-13 |
mouse |
| Khadga Raj, G D Gupta, Shamsher Sing. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. Drug and chemical toxicology. 2021-07-02. PMID:34210222. |
parkinson's disease (pd) is the second most prevalent progressive neurodegenerative disease, characterized by loss of dopaminergic neurons in substantia nigra, with deficiency of dopamine in the striatum. |
2021-07-02 |
2023-08-13 |
rat |
| Tony Valente, Guido Dentesano, Mario Ezquerra, Ruben Fernandez-Santiago, Jonatan Martinez-Martin, Edurne Gallastegui, Carla Domuro, Yaroslau Compta, Maria J Martí, Oriol Bachs, Leonardo Márquez-Kisinousky, Marco Straccia, Carme Solà, Josep Saur. CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein. Cell death and differentiation. vol 27. issue 2. 2021-07-01. PMID:31209363. |
finally, decreased cebpd expression was observed in the substantia nigra and in ipsc-derived dopaminergic neurons from parkinson patients resulting in a significant negative correlation between snca and cebpd levels. |
2021-07-01 |
2023-08-13 |
mouse |
| Meghan L Bucher, Caitlyn W Barrett, Connor J Moon, Amanda D Mortimer, Edward A Burton, J Timothy Greenamyre, Teresa G Hasting. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. NPJ Parkinson's disease. vol 6. issue 1. 2021-06-30. PMID:33298952. |
utilizing adeno-associated virus (serotype 2), viral-mediated small-hairpin rna interference of endogenous vesicular monoamine transporter 2 (vmat2) expression resulted in a loss of vmat2 protein expression in transduced dopaminergic cell bodies in the substantia nigra with a corresponding loss of vmat2 protein within the striatal terminals. |
2021-06-30 |
2023-08-13 |
rat |
| Yuki Kitamura, Mayuko Sakanashi, Azuki Ozawa, Yuri Saeki, Ayano Nakamura, Yuiho Hara, Ken-Ichi Saeki, Sakae Arimoto-Kobayash. Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice. Biochemical and biophysical research communications. vol 555. 2021-06-30. PMID:33819745. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. |
2021-06-30 |
2023-08-13 |
mouse |
| Yuki Kitamura, Mayuko Sakanashi, Azuki Ozawa, Yuri Saeki, Ayano Nakamura, Yuiho Hara, Ken-Ichi Saeki, Sakae Arimoto-Kobayash. Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice. Biochemical and biophysical research communications. vol 555. 2021-06-30. PMID:33819745. |
the degeneration of dopaminergic neurons in the substantia nigra was induced by mptp (30 mg/kg, i. p.) once daily for five consecutive days. |
2021-06-30 |
2023-08-13 |
mouse |
| Maritza Oñate, Alejandra Catenaccio, Natalia Salvadores, Cristian Saquel, Alexis Martinez, Ines Moreno-Gonzalez, Nazaret Gamez, Paulina Soto, Claudio Soto, Claudio Hetz, Felipe A Cour. The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease. Cell death and differentiation. vol 27. issue 4. 2021-06-29. PMID:31591470. |
parkinson's disease (pd) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. |
2021-06-29 |
2023-08-13 |
mouse |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Vandana Zaman, Donald C Shields, Ramsha Shams, Kelsey P Drasites, Denise Matzelle, Azizul Haque, Narendra L Bani. Cellular and molecular pathophysiology in the progression of Parkinson's disease. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33599945. |
parkinson's disease (pd) is a neurodegenerative disorder etiologically linked to the loss of substantia nigra (sn) dopaminergic neurons in the mid-brain. |
2021-06-22 |
2023-08-13 |
human |