| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
parkinson's disease (pd) is a progressive neurodegenerative disease, which shows distinct manifestations such as significant loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-29 |
2023-08-13 |
mouse |
| Jianli Zhao, Manyi Yang, Qi Li, Xiaorui Pei, Xiaodong Zh. miR-132-5p regulates apoptosis and autophagy in MPTP model of Parkinson's disease by targeting ULK1. Neuroreport. vol 31. issue 13. 2021-09-24. PMID:32658123. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by a loss of dopaminergic neurons in the substantia nigra of the brain. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yun Jung Bae, Jong-Min Kim, Chul-Ho Sohn, Ji-Hyun Choi, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Beomseok Jeon, Jae Hyoung Ki. Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes. Radiology. vol 300. issue 2. 2021-09-24. PMID:34100679. |
parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. |
2021-09-24 |
2023-08-13 |
Not clear |
| Young-Kyoung Ryu, Jun Go, Hye-Yeon Park, Young-Keun Choi, Yun Jeong Seo, Jung Hyeon Choi, Myungchull Rhee, Tae Geol Lee, Chul-Ho Lee, Kyoung-Shim Ki. Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. Neuropharmacology. vol 175. 2021-09-23. PMID:32497590. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms. |
2021-09-23 |
2023-08-13 |
mouse |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it is present in various areas of the human brain, most often in the substantia nigra (sn) pars compacta and the locus coeruleus, the main centers of dopaminergic and noradrenergic innervation, respectively. |
2021-09-23 |
2023-08-13 |
human |
| Isaac Deng, Michael D Wiese, Xin-Fu Zhou, Larisa Bobrovskay. The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice. Neurotoxicology. vol 85. 2021-09-22. PMID:34097939. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterised by the loss of dopaminergic neurons in the substantia nigra. |
2021-09-22 |
2023-08-13 |
mouse |
| Vasily Vorobyov, Alexander Deev, Frank Sengpiel, Vladimir Nebogatikov, Aleksey A Ustyugo. Cortical and Striatal Electroencephalograms and Apomorphine Effects in the FUS Mouse Model of Amyotrophic Lateral Sclerosis. Journal of Alzheimer's disease : JAD. vol 81. issue 4. 2021-09-20. PMID:33935079. |
maturation of locomotor networks is supported by dopaminergic (da) projections from substantia nigra to the spinal cord and striatum. |
2021-09-20 |
2023-08-13 |
mouse |
| Adaze Bijou Enogieru, William Haylett, Donavon Hiss, Okobi Ekp. Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:33978902. |
parkinson's disease (pd) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neurotoxic activity of 1-methyl-4-phenylpyridinium (mpp |
2021-09-20 |
2023-08-13 |
Not clear |
| Sara Ayman Moustafa, Shrouk Mohamed, Abdelhameed Dawood, Jihan Azar, Ekramy Elmorsy, Noura A M Rizk, Mohamed Salam. Gut brain axis: an insight into microbiota role in Parkinson's disease. Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:34370175. |
it is characterized neuropathologically by the presence of alpha-synuclein containing lewy bodies in the substantia nigra of the brain with loss of dopaminergic neurons in the pars compacta of the substantia nigra. |
2021-09-20 |
2023-08-13 |
Not clear |
| Barbara Calamini, Nathalie Geyer, Nathalie Huss-Braun, Annie Bernhardt, Véronique Harsany, Pierrick Rival, May Cindhuchao, Dietmar Hoffmann, Sabine Gratze. Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease. Disease models & mechanisms. vol 14. issue 6. 2021-09-18. PMID:34114604. |
parkinson's disease (pd) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic neurons of the substantia nigra in the ventral midbrain. |
2021-09-18 |
2023-08-13 |
human |
| Affif Zaccaria, Paola Antinori, Virginie Licker, Enikö Kövari, Johannes A Lobrinus, Pierre R Burkhar. Multiomic Analyses of Dopaminergic Neurons Isolated from Human Substantia Nigra in Parkinson's Disease: A Descriptive and Exploratory Study. Cellular and molecular neurobiology. 2021-09-16. PMID:34528139. |
multiomic analyses of dopaminergic neurons isolated from human substantia nigra in parkinson's disease: a descriptive and exploratory study. |
2021-09-16 |
2023-08-13 |
human |
| Taewoo Kim, Jeha Jeon, Jin-Sun Park, Yeongwon Park, Jooeui Kim, Haneul Noh, Hee-Sun Kim, Hyemyung Se. Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice. Biomolecules & therapeutics. vol 29. issue 5. 2021-09-14. PMID:34045367. |
parkinson's disease (pd) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-14 |
2023-08-13 |
mouse |
| Mao Kondo, Hirokazu Hara, Fuka Kamijo, Tetsuro Kamiya, Tetsuo Adach. 6-Hydroxydopamine disrupts cellular copper homeostasis in human neuroblastoma SH-SY5Y cells. Metallomics : integrated biometal science. vol 13. issue 7. 2021-09-09. PMID:34185060. |
parkinson's disease (pd) is a neurodegenerative disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. |
2021-09-09 |
2023-08-13 |
human |
| Maike Hartlage-Rübsamen, Alexandra Bluhm, Sandra Moceri, Lisa Machner, Janett Köppen, Mathias Schenk, Isabel Hilbrich, Max Holzer, Martin Weidenfeller, Franziska Richter, Roland Coras, Geidy E Serrano, Thomas G Beach, Stephan Schilling, Stephan von Hörsten, Wei Xiang, Anja Schulze, Steffen Roßne. A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies. Acta neuropathologica. vol 142. issue 3. 2021-09-09. PMID:34309760. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that is neuropathologically characterized by degeneration of dopaminergic neurons of the substantia nigra (sn) and formation of lewy bodies and lewy neurites composed of aggregated α-synuclein. |
2021-09-09 |
2023-08-13 |
mouse |
| Juliann D Jaumotte, Mart Saarma, Michael J Zigmon. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. PloS one. vol 16. issue 2. 2021-09-07. PMID:33534843. |
we have previously reported that no single neurotrophic factor we tested protected da neurons from the dopaminergic toxin 1-methyl-4-phenylpyridinium (mpp+) in dissociated cultures isolated from the p0 rat substantia nigra, but that a combination of five neurotrophic factors was protective. |
2021-09-07 |
2023-08-13 |
rat |
| Hayate Javed, M F Nagoor Meeran, Sheikh Azimullah, Lujain Bader Eddin, Vivek Dhar Dwivedi, Niraj Kumar Jha, Shreesh Ojh. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. vol 10. issue 10. 2021-09-06. PMID:33049992. |
bsb treatment significantly prevented rot-induced loss of dopaminergic neurons and fibers in the substantia nigra and striatum respectively. |
2021-09-06 |
2023-08-13 |
rat |
| T Tamilanban, K Manasa, V Chitr. In silico docking of Novel Phytoalkaloid Camalexin in the Management of Benomyl Induced Parkinson's disease and its In vivo Evaluation by Zebrafish Model. CNS & neurological disorders drug targets. 2021-09-03. PMID:34477539. |
parkinson's disease (pd) exhibits the extra pyramidal symptoms caused due to the dopaminergic neuronal degeneration in the substantia nigra of the brain and depletion of aldehyde dehydrogenase (aldh) enzyme. |
2021-09-03 |
2023-08-13 |
zebrafish |
| Weiwei Yang, Wenwen Hao, Zhuo Meng, Shiyan Ding, Xiaodi Li, Tao Zhang, Weixiao Huang, Lian Xu, Yu Zhang, Jian Yang, Xiaosong G. Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson's Disease Mice Model Revealed by Transcriptome. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32997292. |
transcriptional responses are orchestrated to regulate the expression of many genes in substantia nigra, such as ntf3, pitx3, th, and drd2, leading to the degeneration of dopaminergic neurons at last. |
2021-09-01 |
2023-08-13 |
mouse |
| Vaibhavi Peshattiwar, Suraj Muke, Aakruti Kaikini, Sneha Bagle, Vikas Dighe, Sadhana Sathay. Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson's disease- emphasizing the role of mitochondrial biogenesis. Brain research bulletin. vol 160. 2021-08-31. PMID:32147532. |
it is caused due to degeneration of dopaminergic neurons in substantia nigra (sn). |
2021-08-31 |
2023-08-13 |
rat |
| Jiali Pu, Ting Gao, Ran Zheng, Yi Fang, Yang Ruan, Chongyao Jin, Ting Shen, Jun Tian, Baorong Zhan. Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts. Brain research bulletin. vol 159. 2021-08-31. PMID:32156628. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders, and mainly characterized by the progressive degeneration of dopaminergic (da) neurons in the midbrain substantia nigra and non-da neurons in many other parts of the brain. |
2021-08-31 |
2023-08-13 |
mouse |